Knowledge of the dielectric properties of human tissues is important for several biomedical applications, including imaging and hyperthermia treatment, as well as for determining safety thresholds in policy making. Breast tissues, both normal and tumorous, are of particular interest because of the medical and social impact of breast cancers. While experimental data is available up to 20 GHz, for higher frequencies, this information is missing, or has been extrapolated from models based on lower-frequency data. Emerging technologies and applications in the millimeter-wave region would benefit from experimental data that bridge this gap. This paper presents the characterization of dielectric properties of breast tissues for the frequency range from 0.5 to 50 GHz. Cole-Cole models are derived for normal and tumorous tissues based on experimental measurements on more than 220 tissue samples obtained at surgery (ex vivo) from a population exceeding 50 patients, covering a wide span of normal and tumorous tissues, from patients ranging in age from 28 to 85 years, with a time from excision to measurements under 3.5 h. This paper also presents a comprehensive analysis of the differences between normal and tumorous breast tissues at different frequencies in terms of sensitivity and specificity.

This letter presents one of the first examples of the exploitation of 3-D printing in the fabrication of microwave components and antennas. Additive manufacturing represents an enabling technology for a wide range of electronic devices, thanks to its inherent features of fast prototyping, the reasonable accuracy, fully 3-D topologies, and the low fabrication cost. A novel 3-D printable flexible filament, based on NinjaFlex, has been adopted for manufacturing the substrate of a 3-D printed patch antenna. NinjaFlex is a recently introduced material with extraordinary features in terms of mechanical strain, flexibility, and printability. Initially, the electrical properties of this material are investigated at 2.4 GHz using the ring resonator technique. The capability of selectively changing the dielectric constant by modifying the printed material density by fine-tuning printing infill percentage is verified experimentally. Subsequently, a square patch antenna is prototyped through 3-D printing and measured to validate the manufacturing technology. Finally, exploiting mechanical flexibility properties of NinjaFlex, the antenna is tested under different bending conditions.

Medical imaging currently relies on several techniques, including X-rays, magnetic resonance, and echography. However, these techniques exhibit drawbacks, and alternative approaches are required. Microwave imaging has been proposed as a possible solution, especially for breast cancer imaging. However, most of these systems work with a central frequency of a few gigahertz, and this leads to a suboptimum resolution, which can jeopardize the image quality. Millimeter waves can provide superior resolutions, at the cost of a lower penetration depth within the breast tissue. In addition, a significant fraction of the power generated by a mm-wave imaging system would be reflected back from the skin. For these reasons, and also considering that mm-wave transmitters and receivers have been historically outperformed by microwave counterparts in terms of available power and sensitivity, mm-wave imaging has not been considered a possible solution. This paper contributes to demonstrate a paradigm shift toward the possible use of mm-waves for breast cancer imaging of targets a few centimeter below the skin, a useful penetration depth for several cases. All key points are addressed using analytical, full-wave, and multiphysics simulations, including the system architecture (linear and conformal), the safety aspects (power density, specific absorption rate, and temperature increase), and the use of realistic breast models derived from ex vivo measurements.

Millimeter (mm)-wave imaging has been recently proposed as a new technique for breast cancer detection, based on the significant dielectric contrast between healthy and tumor tissues. Here we propose a procedure to fabricate, electromagnetically characterize and preserve realistic breast tissue-mimicking phantoms for testing mm-wave imaging prototypes. Low-cost, non-toxic and easy-to-produce mixtures made of sunflower oil, water and gelatin were prepared and their dielectric properties were for the first time measured in the (0.5–50) GHz frequency range using a coaxial probe kit. Different oil and gelatin percentages were tested. An alternative recipe based on a waste-oil hardener was also proposed. Finally, water and sunflower oil were investigated as preservation media. The mixtures electromagnetic properties were in good agreement with those of human breast ex vivo samples. By changing the ingredient concentrations or using different solidifying agents it was possible to mimic different tissue types. Besides, we show that sunflower oil represents an effective preservation medium for the developed materials. The first breast phantom mimicking a tumor mass into healthy tissues up to 50 GHz was also successfully fabricated. Results demonstrated the potential of the designed recipes to mimic breast tissues with different biological characteristics, preserving dielectric properties over time. Thus, this study represents a fundamental step towards the development of heterogeneous breast phantoms able to mimic the electromagnetic behavior of healthy and tumor tissues for mm-wave imaging applications.

Breast cancer represents one of the main reasons of death among women. As an alternative to the gold standard techniques for breast cancer diagnosis, microwave imaging has been proposed from research community and many microwave systems have been designed mainly to work at low microwave frequencies. Based both on the results of recent dielectric characterization campaigns on human breast ex-vivo tissues up to 50 GHz and on the promising feasibility studies of mm-wave imaging systems, in this article, we propose and test inverse scattering techniques as effective tool to process mm-wave data to image breast cancer. Differently from the radar techniques so far adopted in conjunction with mm-wave imaging system, inverse scattering techniques turn out to be more versatile and robust with respect to the reduction of the number of processed frequencies and eventually also able to characterize the anomaly in terms of electromagnetic properties. In particular, in the above, two image reconstruction techniques, the Linear Sampling Method and the Born Approximation, are proposed and compared against both simulated and experimental data.

This paper presents a study of losses in substrate-integrated waveguides (SIWs) and cavities. Three mechanisms of losses are considered and separately investigated, namely radiation leakage, ohmic loss, and dielectric loss. A systematic comparison of waveguides with different geometry, operating at different frequencies, is reported. This study permits to give a physical interpretation of the loss mechanisms and to identify design criteria to minimize losses. A similar analysis is also developed in this work for the case of SIW resonant cavities. For these structures, a different variation of losses with respect to frequency is found, which reduces the effectiveness of the design criteria established for SIWs.