Biosensors are a simple, low-cost, and reliable way to detect pesticides in food matrices to ensure consumer food safety. This systematic review lists which nanomaterials, biorecognition materials, transduction methods, pesticides, and foods have recently been studied with biosensors associated with analytical performance. A systematic search was performed in the Scopus (n = 388), Web of Science (n = 790), and Science Direct (n = 181) databases over the period 2016–2021. After checking the eligibility criteria, 57 articles were considered in this study. The most common use of nanomaterials (NMs) in these selected studies is noble metals in isolation, such as gold and silver, with 8.47% and 6.68%, respectively, followed by carbon-based NMs, with 20.34%, and nanohybrids, with 47.45%, which combine two or more NMs, uniting unique properties of each material involved, especially the noble metals. Regarding the types of transducers, the most used were electrochemical, fluorescent, and colorimetric, representing 71.18%, 13.55%, and 8.47%, respectively. The sensitivity of the biosensor is directly connected to the choice of NM and transducer. All biosensors developed in the selected investigations had a limit of detection (LODs) lower than the Codex Alimentarius maximum residue limit and were efficient in detecting pesticides in food. The pesticides malathion, chlorpyrifos, and paraoxon have received the greatest attention for their effects on various food matrices, primarily fruits, vegetables, and their derivatives. Finally, we discuss studies that used biosensor detection systems devices and those that could detect multi-residues in the field as a low-cost and rapid technique, particularly in areas with limited resources.

Design of Experiments (DoE) is a statistical tool used to plan and optimize experiments and is seen as a quality technology to achieve products excellence. Among the experimental designs (EDs), the mixture designs (MDs) stand out, being widely applied to improve conditions for processing, developing, or formulating novel products. This review aims to provide useful updated information on the capacity and diversity of MDs applications for the industry and scientific community in the areas of food, beverage, and pharmaceutical health. Recent works were selected following the Preferred Reporting Items for Systematic Review and Meta-Analyses statement (PRISMA) flow diagram. Data analysis was performed by self-organizing map (SOM) to check and understand which fields of application/countries/continents are using MDs. Overall, the SOM indicated that Brazil presented the largest number of works using MDs. Among the continents, America and Asia showed a predominance in applications with the same amount of work. Comparing the MDs application areas, the analysis indicated that works are prevalent in food and beverage science in the American continent, while in Asia, health science prevails. MDs were more used to develop functional/nutraceutical products and the formulation of drugs for several diseases. However, we briefly describe some promising research fields in that MDs can still be employed.