With the rapid development of technical textiles, more and more researchers have focused on developing high performance textiles to meet various needs. The automotive industry is a major market for technical textiles. Compared to other types of fabric, weft-knitted fabric has good extensibility and elasticity, as well as a hand-feel, and it is gradually becoming the preferred type of interior fabric for automobiles. This paper aims to develop an automotive fabric with good comfort and durability. Sixteen types of weft-knitted fabrics with eight different structures and two different materials (draw textured polyester and textured polyamide yarn) were fabricated using a computerized flat knitting machine. Their durability and level of comfort were examined by measuring the tensile and tear strengths, abrasion resistance and air permeability. A fuzzy comprehensive evaluation method was employed to compare the comprehensive properties of the fabric. The results indicated that the overall performance of DTPA fabric was better than DTPE fabric, and an optimum structure was selected for an automotive interior. Meanwhile, we found that the air permeability of the fabric could be increased by using tuck stitches and that the strength and dimensional stability of fabric could be increased by adding tuck stitches and weft-insert yarns. The findings contribute to the field of technical textiles and provide ideas for the development of high-performance textiles.