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Summary Background There is a worldwide shift towards increased consumption of ultra-processed foods (UPF) with concurrent rising prevalence of obesity. We examined the relationship between the consumption of UPF and weight gain and risk of obesity. Methods This prospective cohort included 348 748 men and women aged 25–70 years. Participants were recruited between 1992 and 2000 from 9 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Two body weight measures were available, at baseline and after a median follow-up time of 5 years. Foods and drinks were assessed at baseline by dietary questionnaires and classified according to their degree of processing using NOVA classification. Multilevel mixed linear regression was used to estimate the association between UPF consumption and body weight change (kg/5 years). To estimate the relative risk of becoming overweight or obese after 5 years we used Poisson regression stratified according to baseline body mass index (BMI). Results After multivariable adjustment, higher UPF consumption (per 1 SD increment) was positively associated with weight gain (0·12 kg/5 years, 95% CI 0·09 to 0·15). Comparing highest vs. lowest quintile of UPF consumption was associated with a 15% greater risk (95% CI 1·11, 1·19) of becoming overweight or obese in normal weight participants, and with a 16% greater risk (95% CI 1·09, 1·23) of becoming obese in participants who were overweight at baseline. Conclusions These results are supportive of public health campaigns to substitute UPF for less processed alternatives for obesity prevention and weight management.
Reynalda Cordova; Nathalie Kliemann; Inge Huybrechts; Fernanda Rauber; Eszter P. Vamos; Renata Bertazzi Levy; Karl-Heinz Wagner; Vivian Viallon; Corinne Casagrande; Geneviève Nicolas; Christina C. Dahm; Jie Zhang; Jytte Halkjær; Anne Tjønneland; Marie-Christine Boutron-Ruault; Francesca Romana Mancini; Nasser Laouali; Verena Katzke; Bernard Srour; Franziska Jannasch; Matthias B. Schulze; Giovanna Masala; Sara Grioni; Salvatore Panico; Yvonne T. van der Schouw; Jeroen W.G. Derksen; Charlotta Rylander; Guri Skeie; Paula Jakszyn; Miguel Rodriguez-Barranco; José María Huerta; Aurelio Barricarte; Lousie Brunkwall; Stina Ramne; Stina Bodén; Aurora Perez-Cornago; Alicia K. Heath; Paolo Vineis; Elisabete Weiderpass; Carlos Augusto Monteiro; Marc J. Gunter; Christopher Millett; Heinz Freisling. Consumption of ultra-processed foods associated with weight gain and obesity in adults: A multi-national cohort study. Clinical Nutrition 2021, 40, 5079 -5088.
AMA StyleReynalda Cordova, Nathalie Kliemann, Inge Huybrechts, Fernanda Rauber, Eszter P. Vamos, Renata Bertazzi Levy, Karl-Heinz Wagner, Vivian Viallon, Corinne Casagrande, Geneviève Nicolas, Christina C. Dahm, Jie Zhang, Jytte Halkjær, Anne Tjønneland, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Nasser Laouali, Verena Katzke, Bernard Srour, Franziska Jannasch, Matthias B. Schulze, Giovanna Masala, Sara Grioni, Salvatore Panico, Yvonne T. van der Schouw, Jeroen W.G. Derksen, Charlotta Rylander, Guri Skeie, Paula Jakszyn, Miguel Rodriguez-Barranco, José María Huerta, Aurelio Barricarte, Lousie Brunkwall, Stina Ramne, Stina Bodén, Aurora Perez-Cornago, Alicia K. Heath, Paolo Vineis, Elisabete Weiderpass, Carlos Augusto Monteiro, Marc J. Gunter, Christopher Millett, Heinz Freisling. Consumption of ultra-processed foods associated with weight gain and obesity in adults: A multi-national cohort study. Clinical Nutrition. 2021; 40 (9):5079-5088.
Chicago/Turabian StyleReynalda Cordova; Nathalie Kliemann; Inge Huybrechts; Fernanda Rauber; Eszter P. Vamos; Renata Bertazzi Levy; Karl-Heinz Wagner; Vivian Viallon; Corinne Casagrande; Geneviève Nicolas; Christina C. Dahm; Jie Zhang; Jytte Halkjær; Anne Tjønneland; Marie-Christine Boutron-Ruault; Francesca Romana Mancini; Nasser Laouali; Verena Katzke; Bernard Srour; Franziska Jannasch; Matthias B. Schulze; Giovanna Masala; Sara Grioni; Salvatore Panico; Yvonne T. van der Schouw; Jeroen W.G. Derksen; Charlotta Rylander; Guri Skeie; Paula Jakszyn; Miguel Rodriguez-Barranco; José María Huerta; Aurelio Barricarte; Lousie Brunkwall; Stina Ramne; Stina Bodén; Aurora Perez-Cornago; Alicia K. Heath; Paolo Vineis; Elisabete Weiderpass; Carlos Augusto Monteiro; Marc J. Gunter; Christopher Millett; Heinz Freisling. 2021. "Consumption of ultra-processed foods associated with weight gain and obesity in adults: A multi-national cohort study." Clinical Nutrition 40, no. 9: 5079-5088.
Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40–69 years in Europe. Methods and results We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking status, systolic blood pressure, and total- and HDL-cholesterol. We defined four risk regions in Europe according to country-specific CVD mortality, recalibrating models to each region using expected incidences and risk factor distributions. Region-specific incidence was estimated using CVD mortality and incidence data on 10 776 466 individuals. For external validation, we analysed data from 25 additional cohorts in 15 European countries (1 133 181 individuals, 43 492 CVD events). After applying the derived risk prediction models to external validation cohorts, C-indices ranged from 0.67 (0.65–0.68) to 0.81 (0.76–0.86). Predicted CVD risk varied several-fold across European regions. For example, the estimated 10-year CVD risk for a 50-year-old smoker, with a systolic blood pressure of 140 mmHg, total cholesterol of 5.5 mmol/L, and HDL-cholesterol of 1.3 mmol/L, ranged from 5.9% for men in low-risk countries to 14.0% for men in very high-risk countries, and from 4.2% for women in low-risk countries to 13.7% for women in very high-risk countries. Conclusion SCORE2—a new algorithm derived, calibrated, and validated to predict 10-year risk of first-onset CVD in European populations—enhances the identification of individuals at higher risk of developing CVD across Europe.
SCORE2 working group and ESC Cardiovascular risk collaboration; Steven Hageman; Lisa Pennells; Francisco Ojeda; Stephen Kaptoge; Kari Kuulasmaa; Tamar de Vries; Zhe Xu; Frank Kee; Ryan Chung; Angela Wood; John William McEvoy; Giovanni Veronesi; Thomas Bolton; Stephan Achenbach; Krasimira Aleksandrova; Pilar Amiano; Donostia-San Sebastian; Philippe Amouyel; Jonas Andersson; Stephan J L Bakker; Rui Bebiano Da Providencia Costa; Joline W J Beulens; Michael Blaha; Martin Bobak; Jolanda M A Boer; Catalina Bonet; Fabrice Bonnet; Marie-Christine Boutron-Ruault; Tonje Braaten; Hermann Brenner; Fabian Brunner; Eric J Brunner; Mattias Brunström; Julie Buring; Adam S Butterworth; Nadezda Capkova; Giancarlo Cesana; Christina Chrysohoou; Sandra Colorado-Yohar; Nancy R Cook; Cyrus Cooper; Christina C Dahm; Karina Davidson; Elaine Dennison; Augusto Di Castelnuovo; Chiara Donfrancesco; Marcus Dörr; Agnieszka Doryńska; Mats Eliasson; Gunnar Engström; Pietro Ferrari; Marco Ferrario; Ian Ford; Michael Fu; Ron T Gansevoort; Simona Giampaoli; Richard F Gillum; Agustin Gómez de la Cámara; Guido Grassi; Per-Olof Hansson; Radu Huculeci; Kristian Hveem; Licia Iacoviello; M Kamran Ikram; Torben Jørgensen; Bijoy Joseph; Pekka Jousilahti; J Wouter Jukema; Rudolf Kaaks; Verena Katzke; Maryam Kavousi; Stefan Kiechl; Jens Klotsche; Wolfgang König; Richard A Kronmal; Ruzena Kubinova; Anna Kucharska-Newton; Kristi Läll; Nils Lehmann; David Leistner; Allan Linneberg; David Lora Pablos; Thiess Lorenz; Wentian Lu; Dalia Luksiene; Magnus Lyngbakken; Christina Magnussen; Sofia Malyutina; Alejandro Marín Ibañez; Giovanna Masala; Ellisiv B Mathiesen; Kuni Matsushita; Tom W Meade; Olle Melander; Haakon E Meyer; Karel G M Moons; Conchi Moreno-Iribas; David Muller; Thomas Münzel; Yury Nikitin; Børge G Nordestgaard; Torbjørn Omland; Charlotte Onland; Kim Overvad; Chris Packard; Andrzej Pająk; Luigi Palmieri; Demosthenes Panagiotakos; Salvatore Panico; Aurora Perez-Cornago; Annette Peters; Arto Pietilä; Bruce M Psaty; Fosca Quarti-Trevano; J Ramón Quirós Garcia; Elio Riboli; Paul M Ridker; Beatriz Rodriguez; Miguel Rodriguez-Barranco; Annika Rosengren; Ronan Roussel; Carlotta Sacerdote; Susana Sans; Naveed Sattar; Catarina Schiborn; Börge Schmidt; Ben Schöttker; Matthias Schulze; Joseph E Schwartz; Randi Marie Selmer; Steven Shea; Martin J Shipley; Sabina Sieri; Stefan Söderberg; Reecha Sofat; Abdonas Tamosiunas; Barbara Thorand; Taavi Tillmann; Anne Tjønneland; Tammy Y N Tong; Antonia Trichopoulou; Rosario Tumino; Hugh Tunstall-Pedoe; Anne Tybjaerg-Hansen; Joanna Tzoulaki; Amber van der Heijden; Yvonne T van der Schouw; W M Monique Verschuren; Henry Völzke; Christoph Waldeyer; Nicholas J Wareham; Elisabete Weiderpass; Franz Weidinger; Philipp Wild; Johann Willeit; Peter Willeit; Tom Wilsgaard; Mark Woodward; Tanja Zeller; Dudan Zhang; Bin Zhou; Paul Dendale; Brian A Ference; Martin Halle; Adam Timmis; Panos Vardas; John Danesh; Ian Graham; Veikko Salomaa; Frank Visseren; Dirk De Bacquer; Stefan Blankenberg; Jannick Dorresteijn; Emanuele Di Angelantonio. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal 2021, 42, 2439 -2454.
AMA StyleSCORE2 working group and ESC Cardiovascular risk collaboration, Steven Hageman, Lisa Pennells, Francisco Ojeda, Stephen Kaptoge, Kari Kuulasmaa, Tamar de Vries, Zhe Xu, Frank Kee, Ryan Chung, Angela Wood, John William McEvoy, Giovanni Veronesi, Thomas Bolton, Stephan Achenbach, Krasimira Aleksandrova, Pilar Amiano, Donostia-San Sebastian, Philippe Amouyel, Jonas Andersson, Stephan J L Bakker, Rui Bebiano Da Providencia Costa, Joline W J Beulens, Michael Blaha, Martin Bobak, Jolanda M A Boer, Catalina Bonet, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Tonje Braaten, Hermann Brenner, Fabian Brunner, Eric J Brunner, Mattias Brunström, Julie Buring, Adam S Butterworth, Nadezda Capkova, Giancarlo Cesana, Christina Chrysohoou, Sandra Colorado-Yohar, Nancy R Cook, Cyrus Cooper, Christina C Dahm, Karina Davidson, Elaine Dennison, Augusto Di Castelnuovo, Chiara Donfrancesco, Marcus Dörr, Agnieszka Doryńska, Mats Eliasson, Gunnar Engström, Pietro Ferrari, Marco Ferrario, Ian Ford, Michael Fu, Ron T Gansevoort, Simona Giampaoli, Richard F Gillum, Agustin Gómez de la Cámara, Guido Grassi, Per-Olof Hansson, Radu Huculeci, Kristian Hveem, Licia Iacoviello, M Kamran Ikram, Torben Jørgensen, Bijoy Joseph, Pekka Jousilahti, J Wouter Jukema, Rudolf Kaaks, Verena Katzke, Maryam Kavousi, Stefan Kiechl, Jens Klotsche, Wolfgang König, Richard A Kronmal, Ruzena Kubinova, Anna Kucharska-Newton, Kristi Läll, Nils Lehmann, David Leistner, Allan Linneberg, David Lora Pablos, Thiess Lorenz, Wentian Lu, Dalia Luksiene, Magnus Lyngbakken, Christina Magnussen, Sofia Malyutina, Alejandro Marín Ibañez, Giovanna Masala, Ellisiv B Mathiesen, Kuni Matsushita, Tom W Meade, Olle Melander, Haakon E Meyer, Karel G M Moons, Conchi Moreno-Iribas, David Muller, Thomas Münzel, Yury Nikitin, Børge G Nordestgaard, Torbjørn Omland, Charlotte Onland, Kim Overvad, Chris Packard, Andrzej Pająk, Luigi Palmieri, Demosthenes Panagiotakos, Salvatore Panico, Aurora Perez-Cornago, Annette Peters, Arto Pietilä, Bruce M Psaty, Fosca Quarti-Trevano, J Ramón Quirós Garcia, Elio Riboli, Paul M Ridker, Beatriz Rodriguez, Miguel Rodriguez-Barranco, Annika Rosengren, Ronan Roussel, Carlotta Sacerdote, Susana Sans, Naveed Sattar, Catarina Schiborn, Börge Schmidt, Ben Schöttker, Matthias Schulze, Joseph E Schwartz, Randi Marie Selmer, Steven Shea, Martin J Shipley, Sabina Sieri, Stefan Söderberg, Reecha Sofat, Abdonas Tamosiunas, Barbara Thorand, Taavi Tillmann, Anne Tjønneland, Tammy Y N Tong, Antonia Trichopoulou, Rosario Tumino, Hugh Tunstall-Pedoe, Anne Tybjaerg-Hansen, Joanna Tzoulaki, Amber van der Heijden, Yvonne T van der Schouw, W M Monique Verschuren, Henry Völzke, Christoph Waldeyer, Nicholas J Wareham, Elisabete Weiderpass, Franz Weidinger, Philipp Wild, Johann Willeit, Peter Willeit, Tom Wilsgaard, Mark Woodward, Tanja Zeller, Dudan Zhang, Bin Zhou, Paul Dendale, Brian A Ference, Martin Halle, Adam Timmis, Panos Vardas, John Danesh, Ian Graham, Veikko Salomaa, Frank Visseren, Dirk De Bacquer, Stefan Blankenberg, Jannick Dorresteijn, Emanuele Di Angelantonio. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. European Heart Journal. 2021; 42 (25):2439-2454.
Chicago/Turabian StyleSCORE2 working group and ESC Cardiovascular risk collaboration; Steven Hageman; Lisa Pennells; Francisco Ojeda; Stephen Kaptoge; Kari Kuulasmaa; Tamar de Vries; Zhe Xu; Frank Kee; Ryan Chung; Angela Wood; John William McEvoy; Giovanni Veronesi; Thomas Bolton; Stephan Achenbach; Krasimira Aleksandrova; Pilar Amiano; Donostia-San Sebastian; Philippe Amouyel; Jonas Andersson; Stephan J L Bakker; Rui Bebiano Da Providencia Costa; Joline W J Beulens; Michael Blaha; Martin Bobak; Jolanda M A Boer; Catalina Bonet; Fabrice Bonnet; Marie-Christine Boutron-Ruault; Tonje Braaten; Hermann Brenner; Fabian Brunner; Eric J Brunner; Mattias Brunström; Julie Buring; Adam S Butterworth; Nadezda Capkova; Giancarlo Cesana; Christina Chrysohoou; Sandra Colorado-Yohar; Nancy R Cook; Cyrus Cooper; Christina C Dahm; Karina Davidson; Elaine Dennison; Augusto Di Castelnuovo; Chiara Donfrancesco; Marcus Dörr; Agnieszka Doryńska; Mats Eliasson; Gunnar Engström; Pietro Ferrari; Marco Ferrario; Ian Ford; Michael Fu; Ron T Gansevoort; Simona Giampaoli; Richard F Gillum; Agustin Gómez de la Cámara; Guido Grassi; Per-Olof Hansson; Radu Huculeci; Kristian Hveem; Licia Iacoviello; M Kamran Ikram; Torben Jørgensen; Bijoy Joseph; Pekka Jousilahti; J Wouter Jukema; Rudolf Kaaks; Verena Katzke; Maryam Kavousi; Stefan Kiechl; Jens Klotsche; Wolfgang König; Richard A Kronmal; Ruzena Kubinova; Anna Kucharska-Newton; Kristi Läll; Nils Lehmann; David Leistner; Allan Linneberg; David Lora Pablos; Thiess Lorenz; Wentian Lu; Dalia Luksiene; Magnus Lyngbakken; Christina Magnussen; Sofia Malyutina; Alejandro Marín Ibañez; Giovanna Masala; Ellisiv B Mathiesen; Kuni Matsushita; Tom W Meade; Olle Melander; Haakon E Meyer; Karel G M Moons; Conchi Moreno-Iribas; David Muller; Thomas Münzel; Yury Nikitin; Børge G Nordestgaard; Torbjørn Omland; Charlotte Onland; Kim Overvad; Chris Packard; Andrzej Pająk; Luigi Palmieri; Demosthenes Panagiotakos; Salvatore Panico; Aurora Perez-Cornago; Annette Peters; Arto Pietilä; Bruce M Psaty; Fosca Quarti-Trevano; J Ramón Quirós Garcia; Elio Riboli; Paul M Ridker; Beatriz Rodriguez; Miguel Rodriguez-Barranco; Annika Rosengren; Ronan Roussel; Carlotta Sacerdote; Susana Sans; Naveed Sattar; Catarina Schiborn; Börge Schmidt; Ben Schöttker; Matthias Schulze; Joseph E Schwartz; Randi Marie Selmer; Steven Shea; Martin J Shipley; Sabina Sieri; Stefan Söderberg; Reecha Sofat; Abdonas Tamosiunas; Barbara Thorand; Taavi Tillmann; Anne Tjønneland; Tammy Y N Tong; Antonia Trichopoulou; Rosario Tumino; Hugh Tunstall-Pedoe; Anne Tybjaerg-Hansen; Joanna Tzoulaki; Amber van der Heijden; Yvonne T van der Schouw; W M Monique Verschuren; Henry Völzke; Christoph Waldeyer; Nicholas J Wareham; Elisabete Weiderpass; Franz Weidinger; Philipp Wild; Johann Willeit; Peter Willeit; Tom Wilsgaard; Mark Woodward; Tanja Zeller; Dudan Zhang; Bin Zhou; Paul Dendale; Brian A Ference; Martin Halle; Adam Timmis; Panos Vardas; John Danesh; Ian Graham; Veikko Salomaa; Frank Visseren; Dirk De Bacquer; Stefan Blankenberg; Jannick Dorresteijn; Emanuele Di Angelantonio. 2021. "SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe." European Heart Journal 42, no. 25: 2439-2454.
(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
Heleen Van Puyvelde; Nikos Papadimitriou; Joanna Clasen; David Muller; Carine Biessy; Pietro Ferrari; Jytte Halkjær; Kim Overvad; Anne Tjønneland; Renée T. Fortner; Verena Katzke; Matthias B. Schulze; Paolo Chiodini; Giovanna Masala; Valeria Pala; Carlotta Sacerdote; Rosario Tumino; Marije F. Bakker; Antonio Agudo; Eva Ardanaz; María Dolores Chirlaque López; Maria-Jose Sánchez; Ulrika Ericson; Björn Gylling; Therese Karlsson; Jonas Manjer; Julie A. Schmidt; Geneviève Nicolas; Corinne Casagrande; Elisabete Weiderpass; Alicia K. Heath; Lode Godderis; Koen Van Herck; Dirk De Bacquer; Marc J. Gunter; Inge Huybrechts. Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Nutrients 2021, 13, 1843 .
AMA StyleHeleen Van Puyvelde, Nikos Papadimitriou, Joanna Clasen, David Muller, Carine Biessy, Pietro Ferrari, Jytte Halkjær, Kim Overvad, Anne Tjønneland, Renée T. Fortner, Verena Katzke, Matthias B. Schulze, Paolo Chiodini, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Marije F. Bakker, Antonio Agudo, Eva Ardanaz, María Dolores Chirlaque López, Maria-Jose Sánchez, Ulrika Ericson, Björn Gylling, Therese Karlsson, Jonas Manjer, Julie A. Schmidt, Geneviève Nicolas, Corinne Casagrande, Elisabete Weiderpass, Alicia K. Heath, Lode Godderis, Koen Van Herck, Dirk De Bacquer, Marc J. Gunter, Inge Huybrechts. Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Nutrients. 2021; 13 (6):1843.
Chicago/Turabian StyleHeleen Van Puyvelde; Nikos Papadimitriou; Joanna Clasen; David Muller; Carine Biessy; Pietro Ferrari; Jytte Halkjær; Kim Overvad; Anne Tjønneland; Renée T. Fortner; Verena Katzke; Matthias B. Schulze; Paolo Chiodini; Giovanna Masala; Valeria Pala; Carlotta Sacerdote; Rosario Tumino; Marije F. Bakker; Antonio Agudo; Eva Ardanaz; María Dolores Chirlaque López; Maria-Jose Sánchez; Ulrika Ericson; Björn Gylling; Therese Karlsson; Jonas Manjer; Julie A. Schmidt; Geneviève Nicolas; Corinne Casagrande; Elisabete Weiderpass; Alicia K. Heath; Lode Godderis; Koen Van Herck; Dirk De Bacquer; Marc J. Gunter; Inge Huybrechts. 2021. "Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)." Nutrients 13, no. 6: 1843.
Summary Background and aims Emerging evidence suggests a role of amino acids (AAs) in the development of various diseases including renal failure, liver cirrhosis, diabetes and cancer. However, mechanistic pathways and the effects of dietary AA intakes on circulating levels and disease outcomes are unclear. We aimed to compare protein and AA intakes, with their respective blood concentrations in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Dietary protein and AA intakes were assessed via the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR). A subsample of 3768 EPIC participants who were free of cancer had blood AA concentrations measured. To investigate how circulating levels relate to their respective intakes, dietary AA intake was examined in quintiles and ANOVA tests were run. Pearson correlations were examined for continous associations between intakes and blood concentrations. Results Dietary AA intakes (assessed with the DQ) and blood AA concentrations were not strongly correlated (−0.15 ≤ r ≤ 0.17) and the direction of the correlations depended on AA class: weak positive correlations were found for most essential AAs (isoleucine, leucine, lysine, methionine, threonine, tryptophan, and valine) and conditionally essential AAs (arginine and tyrosine), while negative associations were found for non-essential AAs. Similar results were found when using the 24-HDR. When conducting ANOVA tests for essential AAs, higher intake quintiles were linked to higher blood AA concentrations, except for histidine and phenylalanine. For non-essential AAs and glycine, an inverse relationship was observed. Conditionally-essential AAs showed mixed results. Conclusions Weak positive correlations and dose responses were found between most essential and conditionally essential AA intakes, and blood concentrations, but not for the non-essential AAs. These results suggest that intake of dietary AA might be related to physiological AA status, particularly for the essential AAs. However, these results should be further evaluated and confirmed in large-scale prospective studies.
Isabel Iguacel; Julie A. Schmidt; Aurora Perez-Cornago; Heleen Van Puyvelde; Ruth Travis; Magdalena Stepien; Augustin Scalbert; Corinne Casagrande; Elisabete Weiderpass; Elio Riboli; Matthias B. Schulze; Guri Skeie; Stina Bodén; Heiner Boeing; Amanda J. Cross; Sophia Harlid; Torill Enget Jensen; José M. Huerta; Verena Katzke; Tilman Kühn; Leila Lujan-Barroso; Giovanna Masala; Miguel Rodriguez-Barranco; Agnetha Linn Rostgaard-Hansen; Yvonne T. van der Schouw; Roel Vermeulen; Giovanna Tagliabue; Anne Tjønneland; Morena Trevisan; Pietro Ferrari; Marc J. Gunter; Inge Huybrechts. Associations between dietary amino acid intakes and blood concentration levels. Clinical Nutrition 2021, 40, 3772 -3779.
AMA StyleIsabel Iguacel, Julie A. Schmidt, Aurora Perez-Cornago, Heleen Van Puyvelde, Ruth Travis, Magdalena Stepien, Augustin Scalbert, Corinne Casagrande, Elisabete Weiderpass, Elio Riboli, Matthias B. Schulze, Guri Skeie, Stina Bodén, Heiner Boeing, Amanda J. Cross, Sophia Harlid, Torill Enget Jensen, José M. Huerta, Verena Katzke, Tilman Kühn, Leila Lujan-Barroso, Giovanna Masala, Miguel Rodriguez-Barranco, Agnetha Linn Rostgaard-Hansen, Yvonne T. van der Schouw, Roel Vermeulen, Giovanna Tagliabue, Anne Tjønneland, Morena Trevisan, Pietro Ferrari, Marc J. Gunter, Inge Huybrechts. Associations between dietary amino acid intakes and blood concentration levels. Clinical Nutrition. 2021; 40 (6):3772-3779.
Chicago/Turabian StyleIsabel Iguacel; Julie A. Schmidt; Aurora Perez-Cornago; Heleen Van Puyvelde; Ruth Travis; Magdalena Stepien; Augustin Scalbert; Corinne Casagrande; Elisabete Weiderpass; Elio Riboli; Matthias B. Schulze; Guri Skeie; Stina Bodén; Heiner Boeing; Amanda J. Cross; Sophia Harlid; Torill Enget Jensen; José M. Huerta; Verena Katzke; Tilman Kühn; Leila Lujan-Barroso; Giovanna Masala; Miguel Rodriguez-Barranco; Agnetha Linn Rostgaard-Hansen; Yvonne T. van der Schouw; Roel Vermeulen; Giovanna Tagliabue; Anne Tjønneland; Morena Trevisan; Pietro Ferrari; Marc J. Gunter; Inge Huybrechts. 2021. "Associations between dietary amino acid intakes and blood concentration levels." Clinical Nutrition 40, no. 6: 3772-3779.
Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: 389,220 EPIC participants with median age 52 years at recruitment (1991-2000) were included. Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for RCC incidence and mortality in relation to intakes of juices and total, sugar-sweetened, and artificially-sweetened soft drinks. Results: 888 incident RCCs and 356 RCC deaths were identified. In models including adjustment for body mass index and energy intake, there was no higher risk of incident RCC associated with consumption of juices (HR per 100 g/day increment=1.03, 95% CI 0.97-1.09), total soft drinks (HR=1.01, 0.98-1.05), sugar-sweetened soft drinks (HR=0.99, 0.94-1.05), or artificially-sweetened soft drinks (HR=1.02, 0.96-1.08). In these fully-adjusted models, none of the beverages were associated with RCC mortality (HR, 95% CI per 100 g/day increment 1.06, 0.97-1.16; 1.03, 0.98-1.09; 0.97, 0.89-1.07; and 1.06, 0.99-1.14, respectively). Conclusions: Consumption of juices or soft drinks was not associated with RCC incidence or mortality after adjusting for obesity. Impact: Soft drink and juice intakes are unlikely to play an independent role in RCC development or mortality.
Alicia K. Heath; Joanna L. Clasen; Nick P. Jayanth; Mazda Jenab; Anne Tjønneland; Kristina Elin Nielsen Petersen; Kim Overvad; Bernard Srour; Verena Katzke; Manuela M. Bergmann; Matthias B. Schulze; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Alberto Catalano; Fabrizio Pasanisi; Magritt Brustad; Karina Standahl Olsen; Guri Skeie; Leila Luján-Barroso; Miguel Rodríguez-Barranco; Pilar Amiano; Carmen Santiuste; Aurelio Barricarte Gurrea; Håkan Axelson; Stina Ramne; Börje Ljungberg; Eleanor L. Watts; Inge Huybrechts; Elisabete Weiderpass; Elio Riboli; David C. Muller. Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers & Prevention 2021, 30, 1270 -1274.
AMA StyleAlicia K. Heath, Joanna L. Clasen, Nick P. Jayanth, Mazda Jenab, Anne Tjønneland, Kristina Elin Nielsen Petersen, Kim Overvad, Bernard Srour, Verena Katzke, Manuela M. Bergmann, Matthias B. Schulze, Giovanna Masala, Vittorio Krogh, Rosario Tumino, Alberto Catalano, Fabrizio Pasanisi, Magritt Brustad, Karina Standahl Olsen, Guri Skeie, Leila Luján-Barroso, Miguel Rodríguez-Barranco, Pilar Amiano, Carmen Santiuste, Aurelio Barricarte Gurrea, Håkan Axelson, Stina Ramne, Börje Ljungberg, Eleanor L. Watts, Inge Huybrechts, Elisabete Weiderpass, Elio Riboli, David C. Muller. Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers & Prevention. 2021; 30 (6):1270-1274.
Chicago/Turabian StyleAlicia K. Heath; Joanna L. Clasen; Nick P. Jayanth; Mazda Jenab; Anne Tjønneland; Kristina Elin Nielsen Petersen; Kim Overvad; Bernard Srour; Verena Katzke; Manuela M. Bergmann; Matthias B. Schulze; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Alberto Catalano; Fabrizio Pasanisi; Magritt Brustad; Karina Standahl Olsen; Guri Skeie; Leila Luján-Barroso; Miguel Rodríguez-Barranco; Pilar Amiano; Carmen Santiuste; Aurelio Barricarte Gurrea; Håkan Axelson; Stina Ramne; Börje Ljungberg; Eleanor L. Watts; Inge Huybrechts; Elisabete Weiderpass; Elio Riboli; David C. Muller. 2021. "Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition." Cancer Epidemiology Biomarkers & Prevention 30, no. 6: 1270-1274.
Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Objectives We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Medthods Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. Results In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. Conclusions We found that 5 different markers, capturing different aspects of vitamin B6–related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
Joanna L Clasen; Alicia K Heath; Heleen Van Puyvelde; Inge Huybrechts; Jin Young Park; Pietro Ferrari; Mattias Johansson; Ghislaine Scelo; Arve Ulvik; Øivind Midttun; Per Magne Ueland; Christina C Dahm; Jytte Halkjær; Anja Olsen; Theron Johnson; Verena Katzke; Matthias B Schulze; Giovanna Masala; Francesco Segrado; Maria Santucci de Magistris; Carlotta Sacerdote; Marga C Ocké; Leila Luján-Barroso; Ana Ching-López; José María Huerta; Eva Ardanaz; Pilar Amiano; Ulrika Ericson; Jonas Manjer; Björn Gylling; Ingegerd Johansson; Julie Schmidt; Elisabete Weiderpass; Elio Riboli; Amanda J Cross; David C Muller. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American Journal of Clinical Nutrition 2021, 114, 338 -347.
AMA StyleJoanna L Clasen, Alicia K Heath, Heleen Van Puyvelde, Inge Huybrechts, Jin Young Park, Pietro Ferrari, Mattias Johansson, Ghislaine Scelo, Arve Ulvik, Øivind Midttun, Per Magne Ueland, Christina C Dahm, Jytte Halkjær, Anja Olsen, Theron Johnson, Verena Katzke, Matthias B Schulze, Giovanna Masala, Francesco Segrado, Maria Santucci de Magistris, Carlotta Sacerdote, Marga C Ocké, Leila Luján-Barroso, Ana Ching-López, José María Huerta, Eva Ardanaz, Pilar Amiano, Ulrika Ericson, Jonas Manjer, Björn Gylling, Ingegerd Johansson, Julie Schmidt, Elisabete Weiderpass, Elio Riboli, Amanda J Cross, David C Muller. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American Journal of Clinical Nutrition. 2021; 114 (1):338-347.
Chicago/Turabian StyleJoanna L Clasen; Alicia K Heath; Heleen Van Puyvelde; Inge Huybrechts; Jin Young Park; Pietro Ferrari; Mattias Johansson; Ghislaine Scelo; Arve Ulvik; Øivind Midttun; Per Magne Ueland; Christina C Dahm; Jytte Halkjær; Anja Olsen; Theron Johnson; Verena Katzke; Matthias B Schulze; Giovanna Masala; Francesco Segrado; Maria Santucci de Magistris; Carlotta Sacerdote; Marga C Ocké; Leila Luján-Barroso; Ana Ching-López; José María Huerta; Eva Ardanaz; Pilar Amiano; Ulrika Ericson; Jonas Manjer; Björn Gylling; Ingegerd Johansson; Julie Schmidt; Elisabete Weiderpass; Elio Riboli; Amanda J Cross; David C Muller. 2021. "A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study." The American Journal of Clinical Nutrition 114, no. 1: 338-347.
Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the non-enzymatic reaction between amino acids and reducing sugars, or dicarbonyls as intermediate compounds. Experimental studies suggest that AGEs may promote colorectal cancer, but prospective epidemiologic studies are inconclusive. We conducted a case–control study nested within a large European cohort. Plasma concentrations of three protein-bound AGEs—Nε-(carboxy-methyl)lysine (CML), Nε-(carboxy-ethyl)lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1)—were measured by ultra-performance liquid chromatography–tandem mass spectrometry in baseline samples collected from 1378 incident primary colorectal cancer cases and 1378 matched controls. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression for colorectal cancer risk associated with CML, CEL, MG-H1, total AGEs, and [CEL+MG-H1: CML] and [CEL:MG-H1] ratios. Inverse colorectal cancer risk associations were observed for CML (OR comparing highest to lowest quintile, ORQ5 versus Q1 = 0.40, 95% CI: 0.27–0.59), MG-H1 (ORQ5 versus Q1 = 0.73, 95% CI: 0.53–1.00) and total AGEs (OR Q5 versus Q1 = 0.52, 95% CI: 0.37–0.73), whereas no association was observed for CEL. A higher [CEL+MG-H1: CML] ratio was associated with colorectal cancer risk (ORQ5 versus Q1 = 1.91, 95% CI: 1.31–2.79). The associations observed did not differ by sex, or by tumour anatomical sub-site. Although individual AGEs concentrations appear to be inversely associated with colorectal cancer risk, a higher ratio of methylglyoxal-derived AGEs versus those derived from glyoxal (calculated by [CEL+MG-H1: CML] ratio) showed a strong positive risk association. Further insight on the metabolism of AGEs and their dicarbonyls precursors, and their roles in colorectal cancer development is needed.
Elom K Aglago; Casper G Schalkwijk; Heinz Freisling; Veronika Fedirko; David J Hughes; Li Jiao; Christina C Dahm; Anja Olsen; Anne Tjønneland; Verena Katzke; Theron Johnson; Matthias B Schulze; Krasimira Aleksandrova; Giovanna Masala; Sabina Sieri; Vittorio Simeon; Rosario Tumino; Alessandra Macciotta; Bas Bueno-De-Mesquita; Guri Skeie; Inger Torhild Gram; Torkjel Sandanger; Paula Jakszyn; Maria-Jose Sánchez; Pilar Amiano; Sandra M Colorado-Yohar; Aurelio Barricarte Gurrea; Aurora Perez-Cornago; Ana-Lucia Mayén; Elisabete Weiderpass; Marc J Gunter; Alicia K Heath; Mazda Jenab. Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study. Carcinogenesis 2021, 1 .
AMA StyleElom K Aglago, Casper G Schalkwijk, Heinz Freisling, Veronika Fedirko, David J Hughes, Li Jiao, Christina C Dahm, Anja Olsen, Anne Tjønneland, Verena Katzke, Theron Johnson, Matthias B Schulze, Krasimira Aleksandrova, Giovanna Masala, Sabina Sieri, Vittorio Simeon, Rosario Tumino, Alessandra Macciotta, Bas Bueno-De-Mesquita, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, Paula Jakszyn, Maria-Jose Sánchez, Pilar Amiano, Sandra M Colorado-Yohar, Aurelio Barricarte Gurrea, Aurora Perez-Cornago, Ana-Lucia Mayén, Elisabete Weiderpass, Marc J Gunter, Alicia K Heath, Mazda Jenab. Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study. Carcinogenesis. 2021; ():1.
Chicago/Turabian StyleElom K Aglago; Casper G Schalkwijk; Heinz Freisling; Veronika Fedirko; David J Hughes; Li Jiao; Christina C Dahm; Anja Olsen; Anne Tjønneland; Verena Katzke; Theron Johnson; Matthias B Schulze; Krasimira Aleksandrova; Giovanna Masala; Sabina Sieri; Vittorio Simeon; Rosario Tumino; Alessandra Macciotta; Bas Bueno-De-Mesquita; Guri Skeie; Inger Torhild Gram; Torkjel Sandanger; Paula Jakszyn; Maria-Jose Sánchez; Pilar Amiano; Sandra M Colorado-Yohar; Aurelio Barricarte Gurrea; Aurora Perez-Cornago; Ana-Lucia Mayén; Elisabete Weiderpass; Marc J Gunter; Alicia K Heath; Mazda Jenab. 2021. "Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study." Carcinogenesis , no. : 1.
We conducted a systematic review and meta-analysis of the association between somatic mutations of the TERT gene promoter and melanoma survival. Data from nineteen independent studies (>2,500 melanoma overall) were pooled using random effects meta-analysis models. TERT-mutated melanoma patients had a significantly worse overall survival (OS) (summary hazard ratio 1.43, 95 % confidence intervals (CI) 1.05–1.95) compared to wild-type ones. The association became stronger when combining risk estimates for overall and melanoma-specific survival (MSS) (1.52, 95 % CI 1.14–2.02), and when restricting the analysis to studies mostly based on invasive non-acral cutaneous melanomas (1.77, 95 % CI 1.00–3.15). Limited, yet suggestive evidence of a detrimental effect of TERT promoter mutations on melanoma prognosis emerged also for other survival measures (e.g. disease-free and distant metastasis-free survival). We found suggestive evidence of a detrimental effect of TERT mutations on melanoma patients’ survival.
Sara Gandini; Ines Zanna; Simone De Angelis; Domenico Palli; Sara Raimondi; Simone Ribero; Giovanna Masala; Mariano Suppa; Federica Bellerba; Federica Corso; Luigi Nezi; Eduardo Nagore; Saverio Caini. TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis. Critical Reviews in Oncology/Hematology 2021, 160, 103288 .
AMA StyleSara Gandini, Ines Zanna, Simone De Angelis, Domenico Palli, Sara Raimondi, Simone Ribero, Giovanna Masala, Mariano Suppa, Federica Bellerba, Federica Corso, Luigi Nezi, Eduardo Nagore, Saverio Caini. TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis. Critical Reviews in Oncology/Hematology. 2021; 160 ():103288.
Chicago/Turabian StyleSara Gandini; Ines Zanna; Simone De Angelis; Domenico Palli; Sara Raimondi; Simone Ribero; Giovanna Masala; Mariano Suppa; Federica Bellerba; Federica Corso; Luigi Nezi; Eduardo Nagore; Saverio Caini. 2021. "TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis." Critical Reviews in Oncology/Hematology 160, no. : 103288.
Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: To investigate the association between red blood cell (RBC) membrane FAs and risk of CRC in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1069 incident CRC cases were identified and matched to 1069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of CRC was estimated by multivariable adjusted conditional logistic regression models. Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for CRC (OR=1.23; 95% CI=1.07-1.42, per 1 mol%). Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent. Conclusions: The positive association between pre-diagnostic RBC stearic acid and CRC reflects putative differences in FA intake and metabolism between cancer cases and matched controls which deserve further investigation. The inverse relationship between EPA and CRC is in line with the repeatedly reported protective effect of fish consumption on CRC risk. Impact: These findings add to the evidence on CRC prevention.
Jakob Linseisen; Nina Grundmann; Dorothee Zoller; Tilman Kuehn; Eugène H.J.M. Jansen; Veronique Chajès; Veronika Fedirko; Elisabete Weiderpass; Christina C. Dahm; Kim Overvad; Anne Tjønneland; Marie-Christine Boutron-Ruault; Joseph A. Rothwell; Gianluca Severi; Rudolf Kaaks; Matthias B. Schulze; Krasimira Aleksandrova; Sabina Sieri; Salvatore Panico; Rosario Tumino; Giovanna Masala; Laura De Marco; Bas Bueno-De-Mesquita; Roel Vermeulen; Inger T. Gram; Guri Skeie; María-Dolores Chirlaque; Eva Ardanaz; Antonio Agudo; Maria-José Sánchez; Pilar Amiano; Maria Wennberg; Stina Bodén; Aurora Perez-Cornago; Elom Kouassivi Aglago; Marc J. Gunter; Mazda Jenab; Alicia K. Heath; Alexandra Nieters. Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology Biomarkers & Prevention 2021, 30, 874 -885.
AMA StyleJakob Linseisen, Nina Grundmann, Dorothee Zoller, Tilman Kuehn, Eugène H.J.M. Jansen, Veronique Chajès, Veronika Fedirko, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Anne Tjønneland, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Matthias B. Schulze, Krasimira Aleksandrova, Sabina Sieri, Salvatore Panico, Rosario Tumino, Giovanna Masala, Laura De Marco, Bas Bueno-De-Mesquita, Roel Vermeulen, Inger T. Gram, Guri Skeie, María-Dolores Chirlaque, Eva Ardanaz, Antonio Agudo, Maria-José Sánchez, Pilar Amiano, Maria Wennberg, Stina Bodén, Aurora Perez-Cornago, Elom Kouassivi Aglago, Marc J. Gunter, Mazda Jenab, Alicia K. Heath, Alexandra Nieters. Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology Biomarkers & Prevention. 2021; 30 (5):874-885.
Chicago/Turabian StyleJakob Linseisen; Nina Grundmann; Dorothee Zoller; Tilman Kuehn; Eugène H.J.M. Jansen; Veronique Chajès; Veronika Fedirko; Elisabete Weiderpass; Christina C. Dahm; Kim Overvad; Anne Tjønneland; Marie-Christine Boutron-Ruault; Joseph A. Rothwell; Gianluca Severi; Rudolf Kaaks; Matthias B. Schulze; Krasimira Aleksandrova; Sabina Sieri; Salvatore Panico; Rosario Tumino; Giovanna Masala; Laura De Marco; Bas Bueno-De-Mesquita; Roel Vermeulen; Inger T. Gram; Guri Skeie; María-Dolores Chirlaque; Eva Ardanaz; Antonio Agudo; Maria-José Sánchez; Pilar Amiano; Maria Wennberg; Stina Bodén; Aurora Perez-Cornago; Elom Kouassivi Aglago; Marc J. Gunter; Mazda Jenab; Alicia K. Heath; Alexandra Nieters. 2021. "Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC)." Cancer Epidemiology Biomarkers & Prevention 30, no. 5: 874-885.
Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (including 588 incident RCC cases), we evaluated a published RCC risk prediction model (including age, sex, BMI, and smoking status) in terms of discrimination (C-statistic) and calibration (observed probability as a function of predicted probability). We used a flexible parametric survival model to develop an expanded model including age, sex, BMI, and smoking status, with the addition of self-reported history of hypertension and measured blood pressure. Results: The previously published model yielded well-calibrated probabilities and good discrimination (C-statistic [95% CI]: 0.699 [0.679–0.721]). Our model had slightly improved discrimination (0.714 [0.694–0.735], bootstrap optimism-corrected C-statistic: 0.709). Despite this good performance, predicted risk was low for the vast majority of participants, with 70% of participants having 10-year risk less than 0.0025. Conclusions: Although the models performed well for the prediction of incident RCC, they are currently insufficiently powerful to identify individuals at substantial risk of RCC in a general population. Impact: Despite the promising performance of the EPIC RCC risk prediction model, further development of the model, possibly including biomarkers of risk, is required to enable risk stratification of RCC.
Rosie K. Singleton; Alicia K. Heath; Joanna L. Clasen; Ghislaine Scelo; Mattias Johansson; Florence Le Calvez-Kelm; Elisabete Weiderpass; Fredrik Liedberg; Börje Ljungberg; Justin Harbs; Anja Olsen; Anne Tjønneland; Christina C. Dahm; Rudolf Kaaks; Renée T. Fortner; Salvatore Panico; Giovanna Tagliabue; Giovanna Masala; Rosario Tumino; Fulvio Ricceri; Inger T. Gram; Carmen Santiuste; Catalina Bonet; Miguel Rodriguez-Barranco; Mattias B. Schulze; Manuela M. Bergmann; Ruth C. Travis; Ioanna Tzoulaki; Elio Riboli; David C. Muller. Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study. Cancer Epidemiology Biomarkers & Prevention 2020, 30, 507 -512.
AMA StyleRosie K. Singleton, Alicia K. Heath, Joanna L. Clasen, Ghislaine Scelo, Mattias Johansson, Florence Le Calvez-Kelm, Elisabete Weiderpass, Fredrik Liedberg, Börje Ljungberg, Justin Harbs, Anja Olsen, Anne Tjønneland, Christina C. Dahm, Rudolf Kaaks, Renée T. Fortner, Salvatore Panico, Giovanna Tagliabue, Giovanna Masala, Rosario Tumino, Fulvio Ricceri, Inger T. Gram, Carmen Santiuste, Catalina Bonet, Miguel Rodriguez-Barranco, Mattias B. Schulze, Manuela M. Bergmann, Ruth C. Travis, Ioanna Tzoulaki, Elio Riboli, David C. Muller. Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study. Cancer Epidemiology Biomarkers & Prevention. 2020; 30 (3):507-512.
Chicago/Turabian StyleRosie K. Singleton; Alicia K. Heath; Joanna L. Clasen; Ghislaine Scelo; Mattias Johansson; Florence Le Calvez-Kelm; Elisabete Weiderpass; Fredrik Liedberg; Börje Ljungberg; Justin Harbs; Anja Olsen; Anne Tjønneland; Christina C. Dahm; Rudolf Kaaks; Renée T. Fortner; Salvatore Panico; Giovanna Tagliabue; Giovanna Masala; Rosario Tumino; Fulvio Ricceri; Inger T. Gram; Carmen Santiuste; Catalina Bonet; Miguel Rodriguez-Barranco; Mattias B. Schulze; Manuela M. Bergmann; Ruth C. Travis; Ioanna Tzoulaki; Elio Riboli; David C. Muller. 2020. "Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study." Cancer Epidemiology Biomarkers & Prevention 30, no. 3: 507-512.
Chronic low-grade inflammation plays a role in the pathogenesis of several chronic diseases including cancer. Physical activity (PA) and diet have been supposed to modulate inflammatory markers. We evaluated the effects of a 24-month dietary and/or PA intervention on plasma levels of pro-inflammatory cytokines, a secondary analysis in the DAMA factorial trial. The 234 study participants (healthy postmenopausal women with high breast density, 50–69 years, non smokers, no hormone therapy) were randomised to four arms: (1) isocaloric dietary intervention mainly based on plant-foods; (2) moderate-intensity PA intervention with at least 1 h/week of supervised strenuous activity; (3) both interventions; (4) general recommendations on healthy dietary and PA patterns. Interleukins (IL)-1α, -1β, -6, tumor necrosis factor-α and C-reactive protein were measured at baseline and at the end of the intervention. Intention-to-treat-analyses were carried out using Tobit regression. Although all cytokines tended to increase over time, after 24 months women in the PA intervention (arms 2 + 3) showed lower levels of IL-1α (exp(β) = 0.66; p = 0.04) and IL-6 (exp(β) = 0.70; p = 0.01) in comparison with women in the control group (arms 1 + 4). No effects of the dietary intervention emerged. In healthy postmenopausal women with high breast density a moderate-intensity PA appears to slow the age-related increase of pro-inflammatory cytokines.
G. Masala; B. Bendinelli; C. Della Bella; M. Assedi; S. Tapinassi; I. Ermini; D. Occhini; M. Castaldo; C. Saieva; S. Caini; M. M. D’Elios; D. Palli. Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women. Scientific Reports 2020, 10, 1 -10.
AMA StyleG. Masala, B. Bendinelli, C. Della Bella, M. Assedi, S. Tapinassi, I. Ermini, D. Occhini, M. Castaldo, C. Saieva, S. Caini, M. M. D’Elios, D. Palli. Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women. Scientific Reports. 2020; 10 (1):1-10.
Chicago/Turabian StyleG. Masala; B. Bendinelli; C. Della Bella; M. Assedi; S. Tapinassi; I. Ermini; D. Occhini; M. Castaldo; C. Saieva; S. Caini; M. M. D’Elios; D. Palli. 2020. "Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women." Scientific Reports 10, no. 1: 1-10.
Background Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. Results There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90–0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95–1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82–0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85–0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91–0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95–1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. Conclusions In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.
Aurora Perez-Cornago; Francesca L Crowe; Paul N Appleby; Kathryn E Bradbury; Angela M Wood; Marianne Uhre Jakobsen; Laura Johnson; Carlotta Sacerdote; Marinka Steur; Elisabete Weiderpass; Anne Mette L Würtz; Tilman Kühn; Verena Katzke; Antonia Trichopoulou; Anna Karakatsani; Carlo La Vecchia; Giovanna Masala; Rosario Tumino; Salvatore Panico; Ivonne Sluijs; Guri Skeie; Liher Imaz; Dafina Petrova; J Ramón Quirós; Sandra Milena Colorado Yohar; Paula Jakszyn; Olle Melander; Emily Sonestedt; Jonas Andersson; Maria Wennberg; Dagfinn Aune; Elio Riboli; Matthias B Schulze; Emanuele di Angelantonio; Nicholas J Wareham; John Danesh; Nita G Forouhi; Adam S Butterworth; Timothy J Key. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. International Journal Of Epidemiology 2020, 50, 212 -222.
AMA StyleAurora Perez-Cornago, Francesca L Crowe, Paul N Appleby, Kathryn E Bradbury, Angela M Wood, Marianne Uhre Jakobsen, Laura Johnson, Carlotta Sacerdote, Marinka Steur, Elisabete Weiderpass, Anne Mette L Würtz, Tilman Kühn, Verena Katzke, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Giovanna Masala, Rosario Tumino, Salvatore Panico, Ivonne Sluijs, Guri Skeie, Liher Imaz, Dafina Petrova, J Ramón Quirós, Sandra Milena Colorado Yohar, Paula Jakszyn, Olle Melander, Emily Sonestedt, Jonas Andersson, Maria Wennberg, Dagfinn Aune, Elio Riboli, Matthias B Schulze, Emanuele di Angelantonio, Nicholas J Wareham, John Danesh, Nita G Forouhi, Adam S Butterworth, Timothy J Key. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. International Journal Of Epidemiology. 2020; 50 (1):212-222.
Chicago/Turabian StyleAurora Perez-Cornago; Francesca L Crowe; Paul N Appleby; Kathryn E Bradbury; Angela M Wood; Marianne Uhre Jakobsen; Laura Johnson; Carlotta Sacerdote; Marinka Steur; Elisabete Weiderpass; Anne Mette L Würtz; Tilman Kühn; Verena Katzke; Antonia Trichopoulou; Anna Karakatsani; Carlo La Vecchia; Giovanna Masala; Rosario Tumino; Salvatore Panico; Ivonne Sluijs; Guri Skeie; Liher Imaz; Dafina Petrova; J Ramón Quirós; Sandra Milena Colorado Yohar; Paula Jakszyn; Olle Melander; Emily Sonestedt; Jonas Andersson; Maria Wennberg; Dagfinn Aune; Elio Riboli; Matthias B Schulze; Emanuele di Angelantonio; Nicholas J Wareham; John Danesh; Nita G Forouhi; Adam S Butterworth; Timothy J Key. 2020. "Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort." International Journal Of Epidemiology 50, no. 1: 212-222.
We studied the determinants of motivation among post-menopausal women enrolled in a two-year diet and physical activity primary prevention randomized trial. Participants were requested to grade the importance attached to changing their lifestyle, their confidence about being able to implement the change, and their willingness to be involved in studies focusing on lifestyle. We used multi-adjusted regression to investigate the association between individual characteristics, study arm, and individual motivation at study entry and end. Participants (n = 234) were highly motivated both at entry and throughout the study. Women with pre-existing healthier eating habits and lifestyles (e.g., high consumption of fruit and vegetables, low red meat consumption, and physically active) were more motivated at entry and over the course of the study. Women assigned to any intervention arm were more motivated than those in the control arm. These findings may help enhance adherence to recommendations and improve effectiveness of community-based health promotion campaigns.
Saverio Caini; Melania Assedi; Elisa Grechi; Ilaria Ermini; Donatella Zagni; Daniela Occhini; Maria Castaldo; Benedetta Bendinelli; Domenico Palli; Giovanna Masala. Time Course and Determinants of Individual Motivation among Women Enrolled in a Diet and Physical Activity Primary Prevention Trial. International Journal of Environmental Research and Public Health 2020, 17, 8589 .
AMA StyleSaverio Caini, Melania Assedi, Elisa Grechi, Ilaria Ermini, Donatella Zagni, Daniela Occhini, Maria Castaldo, Benedetta Bendinelli, Domenico Palli, Giovanna Masala. Time Course and Determinants of Individual Motivation among Women Enrolled in a Diet and Physical Activity Primary Prevention Trial. International Journal of Environmental Research and Public Health. 2020; 17 (22):8589.
Chicago/Turabian StyleSaverio Caini; Melania Assedi; Elisa Grechi; Ilaria Ermini; Donatella Zagni; Daniela Occhini; Maria Castaldo; Benedetta Bendinelli; Domenico Palli; Giovanna Masala. 2020. "Time Course and Determinants of Individual Motivation among Women Enrolled in a Diet and Physical Activity Primary Prevention Trial." International Journal of Environmental Research and Public Health 17, no. 22: 8589.
Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
Lina Cai; Eleanor Wheeler; Nicola D. Kerrison; Jian’An Luan; Panos Deloukas; Paul W. Franks; Pilar Amiano; Eva Ardanaz; Catalina Bonet; Guy Fagherazzi; Leif C. Groop; Rudolf Kaaks; José María Huerta; Giovanna Masala; Peter M. Nilsson; Kim Overvad; Valeria Pala; Salvatore Panico; Miguel Rodriguez-Barranco; Olov Rolandsson; Carlotta Sacerdote; Matthias B. Schulze; Annemieke M. W. Spijkerman; Anne Tjonneland; Rosario Tumino; Yvonne T. Van Der Schouw; Stephen J. Sharp; Nita G. Forouhi; Elio Riboli; Mark I. McCarthy; Inês Barroso; Claudia Langenberg; Nicholas J. Wareham. Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study. Scientific Data 2020, 7, 1 -6.
AMA StyleLina Cai, Eleanor Wheeler, Nicola D. Kerrison, Jian’An Luan, Panos Deloukas, Paul W. Franks, Pilar Amiano, Eva Ardanaz, Catalina Bonet, Guy Fagherazzi, Leif C. Groop, Rudolf Kaaks, José María Huerta, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Valeria Pala, Salvatore Panico, Miguel Rodriguez-Barranco, Olov Rolandsson, Carlotta Sacerdote, Matthias B. Schulze, Annemieke M. W. Spijkerman, Anne Tjonneland, Rosario Tumino, Yvonne T. Van Der Schouw, Stephen J. Sharp, Nita G. Forouhi, Elio Riboli, Mark I. McCarthy, Inês Barroso, Claudia Langenberg, Nicholas J. Wareham. Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study. Scientific Data. 2020; 7 (1):1-6.
Chicago/Turabian StyleLina Cai; Eleanor Wheeler; Nicola D. Kerrison; Jian’An Luan; Panos Deloukas; Paul W. Franks; Pilar Amiano; Eva Ardanaz; Catalina Bonet; Guy Fagherazzi; Leif C. Groop; Rudolf Kaaks; José María Huerta; Giovanna Masala; Peter M. Nilsson; Kim Overvad; Valeria Pala; Salvatore Panico; Miguel Rodriguez-Barranco; Olov Rolandsson; Carlotta Sacerdote; Matthias B. Schulze; Annemieke M. W. Spijkerman; Anne Tjonneland; Rosario Tumino; Yvonne T. Van Der Schouw; Stephen J. Sharp; Nita G. Forouhi; Elio Riboli; Mark I. McCarthy; Inês Barroso; Claudia Langenberg; Nicholas J. Wareham. 2020. "Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study." Scientific Data 7, no. 1: 1-6.
Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case-control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively. Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59-1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42-0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68-1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82-0.99). Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk. Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.
Elom K. Aglago; Sabina Rinaldi; Heinz Freisling; Li Jiao; David J. Hughes; Veronika Fedirko; Casper G. Schalkwijk; Elisabete Weiderpass; Christina C. Dahm; Kim Overvad; Anne Kirstine Eriksen; Cecilie Kyrø; Marie-Christine Boutron-Ruault; Joseph A. Rothwell; Gianluca Severi; Verena Katzke; Tilman Kühn; Matthias B. Schulze; Krasimira Aleksandrova; Giovanna Masala; Vittorio Krogh; Salvatore Panico; Rosario Tumino; Alessio Naccarati; Bas Bueno-De-Mesquita; Carla H. van Gils; Torkjel M. Sandanger; Inger T. Gram; Guri Skeie; J. Ramón Quirós; Paula Jakszyn; Maria-Jose Sánchez; Pilar Amiano; José María Huerta; Eva Ardanaz; Ingegerd Johansson; Sophia Harlid; Aurora Perez-Cornago; Ana-Lucia Mayén; Reynalda Cordova; Marc J. Gunter; Paolo Vineis; Amanda J. Cross; Elio Riboli; Mazda Jenab. Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort. Cancer Epidemiology Biomarkers & Prevention 2020, 30, 182 -192.
AMA StyleElom K. Aglago, Sabina Rinaldi, Heinz Freisling, Li Jiao, David J. Hughes, Veronika Fedirko, Casper G. Schalkwijk, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Anne Kirstine Eriksen, Cecilie Kyrø, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Verena Katzke, Tilman Kühn, Matthias B. Schulze, Krasimira Aleksandrova, Giovanna Masala, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Alessio Naccarati, Bas Bueno-De-Mesquita, Carla H. van Gils, Torkjel M. Sandanger, Inger T. Gram, Guri Skeie, J. Ramón Quirós, Paula Jakszyn, Maria-Jose Sánchez, Pilar Amiano, José María Huerta, Eva Ardanaz, Ingegerd Johansson, Sophia Harlid, Aurora Perez-Cornago, Ana-Lucia Mayén, Reynalda Cordova, Marc J. Gunter, Paolo Vineis, Amanda J. Cross, Elio Riboli, Mazda Jenab. Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort. Cancer Epidemiology Biomarkers & Prevention. 2020; 30 (1):182-192.
Chicago/Turabian StyleElom K. Aglago; Sabina Rinaldi; Heinz Freisling; Li Jiao; David J. Hughes; Veronika Fedirko; Casper G. Schalkwijk; Elisabete Weiderpass; Christina C. Dahm; Kim Overvad; Anne Kirstine Eriksen; Cecilie Kyrø; Marie-Christine Boutron-Ruault; Joseph A. Rothwell; Gianluca Severi; Verena Katzke; Tilman Kühn; Matthias B. Schulze; Krasimira Aleksandrova; Giovanna Masala; Vittorio Krogh; Salvatore Panico; Rosario Tumino; Alessio Naccarati; Bas Bueno-De-Mesquita; Carla H. van Gils; Torkjel M. Sandanger; Inger T. Gram; Guri Skeie; J. Ramón Quirós; Paula Jakszyn; Maria-Jose Sánchez; Pilar Amiano; José María Huerta; Eva Ardanaz; Ingegerd Johansson; Sophia Harlid; Aurora Perez-Cornago; Ana-Lucia Mayén; Reynalda Cordova; Marc J. Gunter; Paolo Vineis; Amanda J. Cross; Elio Riboli; Mazda Jenab. 2020. "Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort." Cancer Epidemiology Biomarkers & Prevention 30, no. 1: 182-192.
Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D3) positively associated with T2D. Whether or not these observational associations are causal remains uncertain. We aimed to examine the potential causality of these associations using Mendelian randomisation (MR) analysis. We performed a meta-analysis of genome-wide association studies for total 25(OH)D (N = 120,618), 25(OH)D3 (N = 40,562), and C3-epi-25(OH)D3 (N = 40,562) in participants of European descent (European Prospective Investigation into Cancer and Nutrition [EPIC]–InterAct study, EPIC-Norfolk study, EPIC-CVD study, Ely study, and the SUNLIGHT consortium). We identified genetic variants for MR analysis to investigate the causal association of the 25(OH)D metabolites with T2D (including 80,983 T2D cases and 842,909 non-cases). We also estimated the observational association of 25(OH)D metabolites with T2D by performing random effects meta-analysis of results from previous studies and results from the EPIC-InterAct study. We identified 10 genetic loci associated with total 25(OH)D, 7 loci associated with 25(OH)D3 and 3 loci associated with C3-epi-25(OH)D3. Based on the meta-analysis of observational studies, each 1–standard deviation (SD) higher level of 25(OH)D was associated with a 20% lower risk of T2D (relative risk [RR]: 0.80; 95% CI 0.77, 0.84; p < 0.001), but a genetically predicted 1-SD increase in 25(OH)D was not significantly associated with T2D (odds ratio [OR]: 0.96; 95% CI 0.89, 1.03; p = 0.23); this result was consistent across sensitivity analyses. In EPIC-InterAct, 25(OH)D3 (per 1-SD) was associated with a lower risk of T2D (RR: 0.81; 95% CI 0.77, 0.86; p < 0.001), while C3-epi-25(OH)D3 (above versus below lower limit of quantification) was positively associated with T2D (RR: 1.12; 95% CI 1.03, 1.22; p = 0.006), but neither 25(OH)D3 (OR: 0.97; 95% CI 0.93, 1.01; p = 0.14) nor C3-epi-25(OH)D3 (OR: 0.98; 95% CI 0.93, 1.04; p = 0.53) was causally associated with T2D risk in the MR analysis. Main limitations include the lack of a non-linear MR analysis and of the generalisability of the current findings from European populations to other populations of different ethnicities. Our study found discordant associations of biochemically measured and genetically predicted differences in blood 25(OH)D with T2D risk. The findings based on MR analysis in a large sample of European ancestry do not support a causal association of total 25(OH)D or 25(OH)D metabolites with T2D and argue against the use of vitamin D supplementation for the prevention of T2D.
Ju-Sheng Zheng; Jian’An Luan; Eleni Sofianopoulou; Stephen J. Sharp; Felix R. Day; Fumiaki Imamura; Thomas E. Gundersen; Luca A. Lotta; Ivonne Sluijs; Isobel D. Stewart; Rupal L. Shah; Yvonne T. Van Der Schouw; Eleanor Wheeler; Eva Ardanaz; Heiner Boeing; Miren Dorronsoro; Christina C. Dahm; Niki Dimou; Douae El-Fatouhi; Paul W. Franks; Guy Fagherazzi; Sara Grioni; José María Huerta; Alicia K. Heath; Louise Hansen; Mazda Jenab; Paula Jakszyn; Rudolf Kaaks; Tilman Kühn; Kay-Tee Khaw; Nasser Laouali; Giovanna Masala; Peter M. Nilsson; Kim Overvad; Anja Olsen; Salvatore Panico; J. Ramón Quirós; Olov Rolandsson; Miguel Rodríguez-Barranco; Carlotta Sacerdote; Annemieke M. W. Spijkerman; Tammy Y. N. Tong; Rosario Tumino; Konstantinos K. Tsilidis; John Danesh; Elio Riboli; Adam S. Butterworth; Claudia Langenberg; Nita G. Forouhi; Nicholas J. Wareham. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis. PLOS Medicine 2020, 17, e1003394 .
AMA StyleJu-Sheng Zheng, Jian’An Luan, Eleni Sofianopoulou, Stephen J. Sharp, Felix R. Day, Fumiaki Imamura, Thomas E. Gundersen, Luca A. Lotta, Ivonne Sluijs, Isobel D. Stewart, Rupal L. Shah, Yvonne T. Van Der Schouw, Eleanor Wheeler, Eva Ardanaz, Heiner Boeing, Miren Dorronsoro, Christina C. Dahm, Niki Dimou, Douae El-Fatouhi, Paul W. Franks, Guy Fagherazzi, Sara Grioni, José María Huerta, Alicia K. Heath, Louise Hansen, Mazda Jenab, Paula Jakszyn, Rudolf Kaaks, Tilman Kühn, Kay-Tee Khaw, Nasser Laouali, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Anja Olsen, Salvatore Panico, J. Ramón Quirós, Olov Rolandsson, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Annemieke M. W. Spijkerman, Tammy Y. N. Tong, Rosario Tumino, Konstantinos K. Tsilidis, John Danesh, Elio Riboli, Adam S. Butterworth, Claudia Langenberg, Nita G. Forouhi, Nicholas J. Wareham. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis. PLOS Medicine. 2020; 17 (10):e1003394.
Chicago/Turabian StyleJu-Sheng Zheng; Jian’An Luan; Eleni Sofianopoulou; Stephen J. Sharp; Felix R. Day; Fumiaki Imamura; Thomas E. Gundersen; Luca A. Lotta; Ivonne Sluijs; Isobel D. Stewart; Rupal L. Shah; Yvonne T. Van Der Schouw; Eleanor Wheeler; Eva Ardanaz; Heiner Boeing; Miren Dorronsoro; Christina C. Dahm; Niki Dimou; Douae El-Fatouhi; Paul W. Franks; Guy Fagherazzi; Sara Grioni; José María Huerta; Alicia K. Heath; Louise Hansen; Mazda Jenab; Paula Jakszyn; Rudolf Kaaks; Tilman Kühn; Kay-Tee Khaw; Nasser Laouali; Giovanna Masala; Peter M. Nilsson; Kim Overvad; Anja Olsen; Salvatore Panico; J. Ramón Quirós; Olov Rolandsson; Miguel Rodríguez-Barranco; Carlotta Sacerdote; Annemieke M. W. Spijkerman; Tammy Y. N. Tong; Rosario Tumino; Konstantinos K. Tsilidis; John Danesh; Elio Riboli; Adam S. Butterworth; Claudia Langenberg; Nita G. Forouhi; Nicholas J. Wareham. 2020. "The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis." PLOS Medicine 17, no. 10: e1003394.
Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens. We aimed to quantify the mediating effects of adiponectin (anti-inflammatory adipocytokine); IL6, IL1-receptor antagonist, TNF receptor 1 and 2, and C-reactive protein (inflammatory status biomarkers); C-peptide (hyperinsulinemia biomarker); and free estradiol and estrone (estrogen biomarkers) in the adiposity-endometrial cancer link in postmenopausal women. We used data from a case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). Eligible women did not have cancer, hysterectomy, and diabetes; did not use oral contraceptives or hormone therapy; and were postmenopausal at recruitment. Mediating pathways from adiposity to endometrial cancer were investigated by estimating natural indirect (NIE) and direct (NDE) effects using sequential mediation analysis. The study included 163 cases and 306 controls. The adjusted OR for endometrial cancer for body mass index (BMI) ≥30 versus ≥18.5-<25 kg/m2 was 2.51 (95% confidence interval, 1.26-5.02). The ORsNIE were 1.95 (1.01-3.74) through all biomarkers [72% proportion mediated (PM)] decomposed as: 1.35 (1.06-1.73) through pathways originating with adiponectin (33% PM); 1.13 (0.71-1.80) through inflammation beyond (the potential influence of) adiponectin (13% PM); 1.05 (0.88-1.24) through C-peptide beyond adiponectin and inflammation (5% PM); and 1.22 (0.89-1.67) through estrogens beyond preceding biomarkers (21% PM). The ORNDE not through biomarkers was 1.29 (0.54-3.09). Waist circumference gave similar results. Reduced adiponectin and increased inflammatory biomarkers, C-peptide, and estrogens mediated approximately 70% of increased odds of endometrial cancer in women with obesity versus normal weight. If replicated, these results could have implications for identifying targets for intervention to reduce endometrial cancer risk in women with obesity.
S. Ghazaleh Dashti; Dallas R. English; Julie A. Simpson; Amalia Karahalios; Margarita Moreno-Betancur; Carine Biessy; Sabina Rinaldi; Pietro Ferrari; Anne Tjønneland; Jytte Halkjær; Christina C. Dahm; Helene Tilma Vistisen; Florence Menegaux; Vittorio Perduca; Gianluca Severi; Krasimira Aleksandrova; Matthias B. Schulze; Giovanna Masala; Sabina Sieri; Rosario Tumino; Alessandra Macciotta; Salvatore Panico; Anouk E. Hiensch; Anne M. May; J. Ramón Quirós; Antonio Agudo; Maria-Jose Sánchez; Pilar Amiano; Sandra Colorado-Yohar; Eva Ardanaz; Naomi E. Allen; Elisabete Weiderpass; Renée Turzanski Fortner; Sofia Christakoudi; Konstantinos K. Tsilidis; Elio Riboli; Rudolf Kaaks; Marc J. Gunter; Vivian Viallon; Laure Dossus. Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis. Cancer Epidemiology Biomarkers & Prevention 2020, 30, 104 -113.
AMA StyleS. Ghazaleh Dashti, Dallas R. English, Julie A. Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjønneland, Jytte Halkjær, Christina C. Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino, Alessandra Macciotta, Salvatore Panico, Anouk E. Hiensch, Anne M. May, J. Ramón Quirós, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Sandra Colorado-Yohar, Eva Ardanaz, Naomi E. Allen, Elisabete Weiderpass, Renée Turzanski Fortner, Sofia Christakoudi, Konstantinos K. Tsilidis, Elio Riboli, Rudolf Kaaks, Marc J. Gunter, Vivian Viallon, Laure Dossus. Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis. Cancer Epidemiology Biomarkers & Prevention. 2020; 30 (1):104-113.
Chicago/Turabian StyleS. Ghazaleh Dashti; Dallas R. English; Julie A. Simpson; Amalia Karahalios; Margarita Moreno-Betancur; Carine Biessy; Sabina Rinaldi; Pietro Ferrari; Anne Tjønneland; Jytte Halkjær; Christina C. Dahm; Helene Tilma Vistisen; Florence Menegaux; Vittorio Perduca; Gianluca Severi; Krasimira Aleksandrova; Matthias B. Schulze; Giovanna Masala; Sabina Sieri; Rosario Tumino; Alessandra Macciotta; Salvatore Panico; Anouk E. Hiensch; Anne M. May; J. Ramón Quirós; Antonio Agudo; Maria-Jose Sánchez; Pilar Amiano; Sandra Colorado-Yohar; Eva Ardanaz; Naomi E. Allen; Elisabete Weiderpass; Renée Turzanski Fortner; Sofia Christakoudi; Konstantinos K. Tsilidis; Elio Riboli; Rudolf Kaaks; Marc J. Gunter; Vivian Viallon; Laure Dossus. 2020. "Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis." Cancer Epidemiology Biomarkers & Prevention 30, no. 1: 104-113.
Background The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC. Methods We performed genome-wide single nucleotide polymorphism genotyping of European ancestry MBC case subjects and controls in 3 stages. Associations between directly genotyped and imputed single nucleotide polymorphisms with MBC were assessed using fixed-effects meta-analysis of 1380 cases and 3620 controls. Replication genotyping of 810 cases and 1026 controls was used to validate variants with P values less than 1 × 10–06. Genetic correlation with FBC was evaluated using linkage disequilibrium score regression, by comprehensively examining the associations of published FBC risk loci with risk of MBC and by assessing associations between a FBC polygenic risk score and MBC. All statistical tests were 2-sided. Results The genome-wide association study identified 3 novel MBC susceptibility loci that attained genome-wide statistical significance (P < 5 × 10–08). Genetic correlation analysis revealed a strong shared genetic basis with estrogen receptor–positive FBC. Men in the top quintile of genetic risk had a fourfold increased risk of breast cancer relative to those in the bottom quintile (odds ratio = 3.86, 95% confidence interval = 3.07 to 4.87, P = 2.08 × 10–30). Conclusions These findings advance our understanding of the genetic basis of MBC, providing support for an overlapping genetic etiology with FBC and identifying a fourfold high-risk group of susceptible men.
Sarah Maguire; Eleni Perraki; Katarzyna Tomczyk; Michael E Jones; Olivia Fletcher; Matthew Pugh; Timothy Winter; Kyle Thompson; Rosie Cooke; Alison Trainer; Paul James; Med Sci Stig Bojesen; Henrik Flyger; Heli Nevanlinna; Johanna Mattson; Eitan Friedman; Yael Laitman; Domenico Palli; Giovanna Masala; Ines Zanna; Laura Ottini; Valentina Silvestri; Antoinette Hollestelle; Maartje J Hooning; Srdjan Novaković; Mateja Krajc; Manuela Gago-Dominguez; Jose Esteban Castelao; Hakan Olsson; Ingrid Hedenfalk; Emmanouil Saloustros; Vasilios Georgoulias; Douglas F Easton; Paul Pharoah; Alison M Dunning; D Timothy Bishop; Susan L Neuhausen; Linda Steele; Alan Ashworth; Montserrat Garcia Closas; Richard Houlston; Anthony Swerdlow; Nick Orr; kConFab Consortium. Common Susceptibility Loci for Male Breast Cancer. Journal of the National Cancer Institute 2020, 113, 453 -461.
AMA StyleSarah Maguire, Eleni Perraki, Katarzyna Tomczyk, Michael E Jones, Olivia Fletcher, Matthew Pugh, Timothy Winter, Kyle Thompson, Rosie Cooke, Alison Trainer, Paul James, Med Sci Stig Bojesen, Henrik Flyger, Heli Nevanlinna, Johanna Mattson, Eitan Friedman, Yael Laitman, Domenico Palli, Giovanna Masala, Ines Zanna, Laura Ottini, Valentina Silvestri, Antoinette Hollestelle, Maartje J Hooning, Srdjan Novaković, Mateja Krajc, Manuela Gago-Dominguez, Jose Esteban Castelao, Hakan Olsson, Ingrid Hedenfalk, Emmanouil Saloustros, Vasilios Georgoulias, Douglas F Easton, Paul Pharoah, Alison M Dunning, D Timothy Bishop, Susan L Neuhausen, Linda Steele, Alan Ashworth, Montserrat Garcia Closas, Richard Houlston, Anthony Swerdlow, Nick Orr, kConFab Consortium. Common Susceptibility Loci for Male Breast Cancer. Journal of the National Cancer Institute. 2020; 113 (4):453-461.
Chicago/Turabian StyleSarah Maguire; Eleni Perraki; Katarzyna Tomczyk; Michael E Jones; Olivia Fletcher; Matthew Pugh; Timothy Winter; Kyle Thompson; Rosie Cooke; Alison Trainer; Paul James; Med Sci Stig Bojesen; Henrik Flyger; Heli Nevanlinna; Johanna Mattson; Eitan Friedman; Yael Laitman; Domenico Palli; Giovanna Masala; Ines Zanna; Laura Ottini; Valentina Silvestri; Antoinette Hollestelle; Maartje J Hooning; Srdjan Novaković; Mateja Krajc; Manuela Gago-Dominguez; Jose Esteban Castelao; Hakan Olsson; Ingrid Hedenfalk; Emmanouil Saloustros; Vasilios Georgoulias; Douglas F Easton; Paul Pharoah; Alison M Dunning; D Timothy Bishop; Susan L Neuhausen; Linda Steele; Alan Ashworth; Montserrat Garcia Closas; Richard Houlston; Anthony Swerdlow; Nick Orr; kConFab Consortium. 2020. "Common Susceptibility Loci for Male Breast Cancer." Journal of the National Cancer Institute 113, no. 4: 453-461.
Background: Fatty acids impact obesity, estrogens and inflammation, risk factors for ovarian cancer. Few epidemiological studies have investigated the association of fatty acids with ovarian cancer. Methods: Within the European Prospective Investigation into Cancer and nutrition, 1,486 incident ovarian cancer cases were identified. Cox Proportional Hazard models with adjustment for ovarian cancer risk factors were used to estimate hazard ratios of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate odds ratios of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case-control analysis. Results: A positive association was found between ovarian cancer and intake of industrial trans elaidic acid (Hazard Ratio comparing 5th with 1st quintileQ5-Q1=1.29; 95% CI=1.03-1.62; ptrend=0.02, q-value=0.06). Dietary intakes of n-6 linoleic acid (HRQ5-Q1=1.10; 95% CI=1.01-1.21; ptrend=0.03) and n-3 α-linolenic acid (HRQ5-Q1=1.18; 95% CI=1.05-1.34; ptrend=0.007) from deep frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (Odds Ratio comparing 3rd with 1st tertileT3-T1 = 1.39; 95% CI=0.99-1.94; ptrend=0.06) and α-linolenic acids (ORT3-T1=1.30; 95% CI=0.98-1.72; ptrend=0.06). Conclusions: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and α-linolenic acid from deep frying fat, may be associated with greater risk of ovarian cancer. Impact: If causal, eliminating industrial trans fatty acids could offer a straightforward public health action for reducing ovarian cancer.
Sahar Yammine; Inge Huybrechts; Carine Biessy; Laure Dossus; Elom K. Aglago; Sabine Naudin; Pietro Ferrari; Elisabete Weiderpass; Anne Tjønneland; Louise Hansen; Kim Overvad; Francesca Romana Mancini; Marie-Christine Boutron-Ruault; Marina Kvaskoff; Renée Turzanski Fortner; Rudolf Kaaks; Matthias B. Schulze; Heiner Boeing; Antonia Trichopoulou; Anna Karakatsani; Carlo La Vecchia; Vassiliki Benetou; Giovanna Masala; Vittorio Krogh; Amalia Mattiello; Alessandra Macciotta; Inger T. Gram; Guri Skeie; Jose R. Quirós; Antonio Agudo; Maria-Jose Sanchez-Perez; Maria-Dolores Chirlaque; Eva Ardanaz; Leire Gil; Hanna Sartor; Isabel Drake; Annika Idahl; Eva A Lundin; Dagfinn Aune; Heather A. Ward; Melissa A. Merritt; Naomi E. Allen; Marc J. Gunter; Véronique Chajès. Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers & Prevention 2020, 29, 1 .
AMA StyleSahar Yammine, Inge Huybrechts, Carine Biessy, Laure Dossus, Elom K. Aglago, Sabine Naudin, Pietro Ferrari, Elisabete Weiderpass, Anne Tjønneland, Louise Hansen, Kim Overvad, Francesca Romana Mancini, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Renée Turzanski Fortner, Rudolf Kaaks, Matthias B. Schulze, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Vassiliki Benetou, Giovanna Masala, Vittorio Krogh, Amalia Mattiello, Alessandra Macciotta, Inger T. Gram, Guri Skeie, Jose R. Quirós, Antonio Agudo, Maria-Jose Sanchez-Perez, Maria-Dolores Chirlaque, Eva Ardanaz, Leire Gil, Hanna Sartor, Isabel Drake, Annika Idahl, Eva A Lundin, Dagfinn Aune, Heather A. Ward, Melissa A. Merritt, Naomi E. Allen, Marc J. Gunter, Véronique Chajès. Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers & Prevention. 2020; 29 (9):1.
Chicago/Turabian StyleSahar Yammine; Inge Huybrechts; Carine Biessy; Laure Dossus; Elom K. Aglago; Sabine Naudin; Pietro Ferrari; Elisabete Weiderpass; Anne Tjønneland; Louise Hansen; Kim Overvad; Francesca Romana Mancini; Marie-Christine Boutron-Ruault; Marina Kvaskoff; Renée Turzanski Fortner; Rudolf Kaaks; Matthias B. Schulze; Heiner Boeing; Antonia Trichopoulou; Anna Karakatsani; Carlo La Vecchia; Vassiliki Benetou; Giovanna Masala; Vittorio Krogh; Amalia Mattiello; Alessandra Macciotta; Inger T. Gram; Guri Skeie; Jose R. Quirós; Antonio Agudo; Maria-Jose Sanchez-Perez; Maria-Dolores Chirlaque; Eva Ardanaz; Leire Gil; Hanna Sartor; Isabel Drake; Annika Idahl; Eva A Lundin; Dagfinn Aune; Heather A. Ward; Melissa A. Merritt; Naomi E. Allen; Marc J. Gunter; Véronique Chajès. 2020. "Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition." Cancer Epidemiology Biomarkers & Prevention 29, no. 9: 1.
Aim To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82–0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69–0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91–0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85–0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81–0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50 g/day, 1.07; 0.96–1.20, P-trend = 0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20 g/day, 1.25; 1.09–1.43, P-trend = 0.002). Conclusion Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately.
Tammy Y N Tong; Paul N Appleby; Timothy J Key; Christina C Dahm; Kim Overvad; Anja Olsen; Anne Tjønneland; Verena Katzke; Tilman Kühn; Heiner Boeing; Anna Karakatsani; Eleni Peppa; Antonia Trichopoulou; Elisabete Weiderpass; Giovanna Masala; Sara Grioni; Salvatore Panico; Rosario Tumino; Jolanda M A Boer; W M Monique Verschuren; J Ramón Quirós; Antonio Agudo; Miguel Rodríguez-Barranco; Liher Imaz; María-Dolores Chirlaque; Conchi Moreno-Iribas; Gunnar Engström; Emily Sonestedt; Marcus Lind; Julia Otten; Kay-Tee Khaw; Dagfinn Aune; Elio Riboli; Nicholas J Wareham; Fumiaki Imamura; Nita G Forouhi; Emanuele Di Angelantonio; Angela M Wood; Adam S Butterworth; Aurora Perez-Cornago. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries. European Heart Journal 2020, 41, 2632 -2640.
AMA StyleTammy Y N Tong, Paul N Appleby, Timothy J Key, Christina C Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Verena Katzke, Tilman Kühn, Heiner Boeing, Anna Karakatsani, Eleni Peppa, Antonia Trichopoulou, Elisabete Weiderpass, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Jolanda M A Boer, W M Monique Verschuren, J Ramón Quirós, Antonio Agudo, Miguel Rodríguez-Barranco, Liher Imaz, María-Dolores Chirlaque, Conchi Moreno-Iribas, Gunnar Engström, Emily Sonestedt, Marcus Lind, Julia Otten, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Nicholas J Wareham, Fumiaki Imamura, Nita G Forouhi, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, Aurora Perez-Cornago. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries. European Heart Journal. 2020; 41 (28):2632-2640.
Chicago/Turabian StyleTammy Y N Tong; Paul N Appleby; Timothy J Key; Christina C Dahm; Kim Overvad; Anja Olsen; Anne Tjønneland; Verena Katzke; Tilman Kühn; Heiner Boeing; Anna Karakatsani; Eleni Peppa; Antonia Trichopoulou; Elisabete Weiderpass; Giovanna Masala; Sara Grioni; Salvatore Panico; Rosario Tumino; Jolanda M A Boer; W M Monique Verschuren; J Ramón Quirós; Antonio Agudo; Miguel Rodríguez-Barranco; Liher Imaz; María-Dolores Chirlaque; Conchi Moreno-Iribas; Gunnar Engström; Emily Sonestedt; Marcus Lind; Julia Otten; Kay-Tee Khaw; Dagfinn Aune; Elio Riboli; Nicholas J Wareham; Fumiaki Imamura; Nita G Forouhi; Emanuele Di Angelantonio; Angela M Wood; Adam S Butterworth; Aurora Perez-Cornago. 2020. "The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries." European Heart Journal 41, no. 28: 2632-2640.