Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) have been recognized as potent antioxidant agents. Since SGLT2i are nephroprotective drugs, we aimed to examine the urine antioxidant status in patients with type 2 diabetes mellitus (T2DM). One hundred and one subjects participated in this study, including 37 T2DM patients treated with SGLT2i, 31 T2DM patients not using SGLT2i, and 33 healthy individuals serving as a control group. Total antioxidant capacity (TAC), superoxide dismutase (SOD), manganese superoxide dismutase (MnSOD), free thiol groups (R‐SH, sulfhydryl groups), and catalase (CAT) activity, as well as glucose concentration, were assessed in the urine of all participants. Urine SOD and MnSOD activity were significantly higher among T2DM patients treated with SGLT2i than T2DM patients without SGLT2i treatment (p = 0.009 and p = 0.003, respectively) and to the healthy controls (p = 0.002 and p = 0.001, respectively). TAC was significantly lower in patients with T2DM treated with SGLT2i when compared to those not treated and healthy subjects (p = 0.036 and p = 0.019, respectively). It could be hypothesized that the mechanism by which SGLT2i provides nephroprotective effects involves improvement of the SOD antioxidant activity. However, lower TAC might impose higher OS (oxidative stress), and elevation of SOD activity might be a compensatory mechanism.

Aim: The aim of this study was to evaluate health-promoting behaviors as a factor supporting life satisfaction and a protective factor against stress in a group of Polish medical students during the third wave of the SARS-CoV-2 pandemic. Material: The study was conducted in October–December 2021. There were 306 people, including 203 students in the 1st year of medicine, aged 20.42 ± 1.92 years, and 103 students in the 5th year of medicine, aged 24.88 ± 1.7 years. Methods: The following were used: the Satisfaction with Life Scale (SWLS), the Health Behavior Inventory (IZZ), and the Perceived Stress Scale (PSS-10). The survey was conducted online. Results: In the study group, the average result of 23.66 ± 5.97 was obtained in the life satisfaction questionnaire. In the overall assessment of health behaviors (IZZ), an average score of 80.06 ± 13.81 points was obtained. In the PSS-10 questionnaire, the respondents obtained an average of 21.10 ± 5.89 points. There were significant, negative correlations between the results obtained in the health behavior inventory with the results obtained in the stress scale and positive correlations with the results obtained in the life satisfaction scale. Moreover, in the assessment of the influence of prohealth behavior parameters on perceived stress and life satisfaction, a positive effect of PMA on life satisfaction was demonstrated, as well as a protective effect of Positive Mental Attitude (PMA) and Prohealth Activities (PhA) in relation to stress. Conclusions: Life in the period of the third wave of the pandemic was assessed by medical students as moderately satisfactory. Significant intensity of stress negatively correlated with life satisfaction. Health-promoting behaviors, and especially positive mental attitudes, seem to play a protective role in stressful situations and improve life satisfaction.

Summary: Insomnia is the most common sleep disorder in the adolescent population. Resulting from a complex interplay of genetic, biological, social, and environmental factors, it affects disturbances in everyday functioning in many aspects of life. The aim of the study was to analyze the factors related to the occurrence of insomnia among high school students. Material: The study was conducted among 2364 high school students aged between 14 and 19 years old (the average age 17.92 ± 1.10), of which there were 2068 girls and 295 boys. Method: Athens Insomnia Scale (AIS) and authorial demographic data questionnaire involved questions about physical activity during the day, smoking, frequency of upper respiratory tract infections, problems with concentration and memory, school achievements, and the use of mobile devices at bedtime were used to assess examined parameters. The scale and questionnaires were shared on-line via social media. Results: Analyzing the results obtained in the study group, the average score of 8.42 ± 4.16 was obtained in the AIS, which allows the assessment of sleep disorders bordering on normal. After division into groups of girls and boys, 8.38 ± 4.56 points were obtained, respectively for girls and 8.43 ± 4.27pts. for boys - the difference was not statistically significant. Similarly, statistically significant differences were not found when dividing the groups into the one in which adolescents used the phone just before bedtime and the one that did not use it. The act of sleeping alone or with another person in the room also did not differentiate the groups statistically, as well as the place of residence. Statistically significant worse results in the AIS scale were obtained by people who declared worse physical activity during the day and smoking cigarettes, as well as those who reported more frequent problems with concentration and memory, had worse school performance and suffered from upper respiratory infections more often. Conclusions: 1). Sleep disorders may be related to factors such as smoking cigarettes or lack of physical activity, as well as difficulties in concentrating attention, memory disorders or worse academic performance and a tendency to contract upper respiratory tract infections. 2). Elimination of factors that may adversely affect the quality of sleep is particularly important in the group of adolescents, in whom the developing structures of the central nervous system may be particularly sensitive to deficiencies in this area. 3). Exploration of the interplay of study duration, screen time, and semester-specific stressors on sleep quality could yield further insights.

Background: Ego-resiliency could play a protective role, especially in stressful situations. Such a situation is certainly the period of the COVID-19 pandemic. The beginning of the pandemic period was a source of significant stress for many people. Students, especially of medical faculties, were one of the social groups that could be particularly affected by the reorganization of everyday functioning. Effective coping with stress during this period could have been important for minimizing its negative effects. Aim: The aim of this study was to assess ego-resiliency as a factor enhancing life satisfaction and a protective factor against symptoms of anxiety and depression in a group of health students during the COVID-19 pandemic. Methods and Material: This study was conducted in the period from October 2020 to June 2021. The study group included 362 students of the medical faculty and 249 students of the Academy of Physical Education (APhE). The Ego Resiliency Scale (ER89-R12), the Life Satisfaction Scale (SWLS) and the Anxiety and Depression Scale (HADS) were used in this study. Among the statistical methods, the Mann–Whitney U test and Spearman’s rank correlation coefficient were used. Results: In the study group, medical students obtained an average score of 34.96 ± 5.19 points and APhE students obtained 36.49 ± 5.22 points on the ER-89-R12; the difference was statistically significant (p = 0.003). On the SWLS, the mean score was 23.65 ± 5.9 points for medical students and 22.35 ± 5.67 points for students of the APhE; the difference was also statistically significant (p = 0.005). In the assessment of anxiety, medical students obtained an average of 8.43 ± 4.34 points and students of the APhE 7.60 ± 4.27 points; the difference was statistically significant (p = 0.012). In the assessment of depression, medical students achieved 5.10 ± 3.77 points and students of APhE obtained about 4.77 ± 3.26 points; the difference was not statistically significant. There were significant, negative correlations in the scope of the results obtained on the ER-89-R12 with the results of anxiety and depression, and positive correlations with the results obtained on the SWLS scale for both groups. Conclusions: Life during the pandemic was assessed by students of pro-health faculties as moderately satisfactory. The severity of symptoms of anxiety and depression correlated negatively with life satisfaction. Ego-resiliency may be a factor enhancing life satisfaction and may be a protective factor against anxiety and depression symptoms.

Background and Objectives: In the difficult socio-economic situation of recent years, particular attention has been paid to factors that may have a protective effect on mental health. One of these factors is the individual resource known as ego-resiliency. The aim of the study was to assess ego-resiliency as a potential protective factor against stress symptoms and to determine effective coping strategies in a group of patients with Generalized Anxiety Disorder (GAD) during the COVID-19 pandemic. Materials and Methods: The study was conducted from March 2020 to March 2022 among patients attending a Mental Health Clinic in the Upper Silesian metropolitan area of Poland. A total of 68 participants with a confirmed diagnosis of GAD (42 women, 26 men) completed the Ego-Resiliency Scale (ER89-R12), the Coping Inventory for Stressful Situations (CISS), and the Perceived Stress Scale (PSS-10). Results: The mean score on the ER89-R12 was 32.85 ± 6.52 points, with no significant gender differences. The mean PSS-10 score was 22.48 ± 5.61, corresponding to a moderate to high perceived stress level. Significant negative correlations were found between ego-resiliency and perceived stress, and positive correlations between ego-resiliency and task-focused coping. Conclusions: Ego-resiliency may serve as a protective factor against stress and promote adaptive, task-focused coping strategies in patients with Generalized Anxiety Disorder. Strengthening ego-resiliency may be a relevant therapeutic target in clinical interventions.