It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a wide range of body mass index (BMI) and insulin resistance. In this cross-sectional study omentin-1 serum concentrations were evaluated using commercially available ELISA kit in 47 Polish girls with restrictive anorexia nervosa (AN), 50 with simple obesity (OB) and 39 healthy controls (C). The mean serum omentin-1 concentration in girls with AN was statistically significantly higher than that of C and OB girls. Statistically significant (P<0.0001) negative correlations between the serum concentrations of omentin-1 and body weight (r=−0.73), BMI (r=−0.75), standard deviation score for body mass index (BMI-SDS) (r=−0.75), insulin (r=−0.81) and HOMA-IR index (r=−0.82) were seen in the entire examined population. We conclude, that omentin-1 is the nutritional marker reflecting body weight and insulin resistance. Our findings support the hypothesized role of omentin in maintenance of body weight and regulation of appetite and suggest the adaptation of its secretion to body weight and glucose metabolism.

Purpose: Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis and thrombosis. The purpose of this study was to evaluate plasma homocysteine, red blood cell folate, plasma folate, and plasma vitamin B12 concentration in patients with exudative age-related macular degeneration (ARMD).Methods: The participants of this study included 30 patients aged 60 to llyears (mean age 66.2±3.6) with exudative ARMD. Plasma homocysteine levels were determined by high performance liquid chromatography (HPLC). Red blood cell folate, plasma folate, and plasma vitamin B12 concentration were determined using a standard kit (Dualcount Solid Phase No Boill radioassay kit for B12/folic acid, DPC Diagnostic, USA) by radioassay method.Results: The plasma concentration of Hey (14.88±6.23 μmol/L) in ARMD patients was significantly increased (p<0.0001) compared with the control group (8,.72±3,.34 μmol/L). We found not a significant decrease of the plasma vitamin B12 concentration in the ARMD group (476.88±220.91 pg/mL) compared with the control group (527.08±208.97 pg/mL). Red blood cell folate (158.44±56.30 ng/mL) and plasma folate (6.5±3.4 ng/mL) in ARMD patients were also not significantly decreased when compared with the control group (183.86±59.33 ng/mL and 7.93±5.05 ng/mL).Conclusions: Hyperhomocysteinemia might be one of the risk factors for the exudative form of ARMD.