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Dr. Ligia Dominguez
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy

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0 Aging
0 Cardiovascular Disease
0 Nutrition
0 Type 2 Diabetes
0 Alzheimer

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Type 2 Diabetes
Cardiovascular Disease
Alzheimer
Nutrition

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Full papers
Published: 28 June 2021 in British Journal of Nutrition
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The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20,272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12.3 years of median follow-up (interquartile range: 6.8-15.0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) =2.82, 95% confidence interval (CI): 1.38-5.79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1.17 (95% CI: 1.08-1.26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose-response association with premature mortality (<65 years) in this young and highly-educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results.

ACS Style

Miguel A. Martínez-González; María Barbería-Latasa; Javier Pérez de Rojas; Ligia J. Domínguez; Alfredo Gea. Alcohol and early mortality (before 65 years) in the “Seguimiento Universidad de Navarra” (SUN) cohort: does any level reduce mortality? British Journal of Nutrition 2021, 1 -33.

AMA Style

Miguel A. Martínez-González, María Barbería-Latasa, Javier Pérez de Rojas, Ligia J. Domínguez, Alfredo Gea. Alcohol and early mortality (before 65 years) in the “Seguimiento Universidad de Navarra” (SUN) cohort: does any level reduce mortality? British Journal of Nutrition. 2021; ():1-33.

Chicago/Turabian Style

Miguel A. Martínez-González; María Barbería-Latasa; Javier Pérez de Rojas; Ligia J. Domínguez; Alfredo Gea. 2021. "Alcohol and early mortality (before 65 years) in the “Seguimiento Universidad de Navarra” (SUN) cohort: does any level reduce mortality?" British Journal of Nutrition , no. : 1-33.

Review
Published: 12 June 2021 in Nutrients
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The average life expectancy of the world population has increased remarkably in the past 150 years and it is still increasing. A long life is a dream of humans since the beginning of time but also a dream is to live it in good physical and mental condition. Nutrition research has focused on recent decades more on food combination patterns than on individual foods/nutrients due to the possible synergistic/antagonistic effects of the components in a dietary model. Various dietary patterns have been associated with health benefits, but the largest body of evidence in the literature is attributable to the traditional dietary habits and lifestyle followed by populations from the Mediterranean region. After the Seven Countries Study, many prospective observational studies and trials in diverse populations reinforced the beneficial effects associated with a higher adherence to the Mediterranean diet in reference to the prevention/management of age-associated non-communicable diseases, such as cardiovascular and metabolic diseases, neurodegenerative diseases, cancer, depression, respiratory diseases, and fragility fractures. In addition, the Mediterranean diet is ecologically sustainable. Therefore, this immaterial world heritage constitutes a healthy way of eating and living respecting the environment.

ACS Style

Ligia Dominguez; Giovanna Di Bella; Nicola Veronese; Mario Barbagallo. Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity. Nutrients 2021, 13, 2028 .

AMA Style

Ligia Dominguez, Giovanna Di Bella, Nicola Veronese, Mario Barbagallo. Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity. Nutrients. 2021; 13 (6):2028.

Chicago/Turabian Style

Ligia Dominguez; Giovanna Di Bella; Nicola Veronese; Mario Barbagallo. 2021. "Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity." Nutrients 13, no. 6: 2028.

Review
Published: 20 April 2021 in Metabolites
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Studies on vitamin/hormone D deficiency have received a vast amount of attention in recent years, particularly concerning recommendations, guidelines, and treatments. Moreover, vitamin D’s role as a hormone has been confirmed in various enzymatic, metabolic, physiological, and pathophysiological processes related to many organs and systems in the human body. This growing interest is mostly due to the evidence that modest-to-severe vitamin D deficiency is widely prevalent around the world. There is broad agreement that optimal vitamin D status is necessary for bones, muscles, and one’s general health, as well as for the efficacy of antiresorptive and anabolic bone-forming treatments. Food supplementation with vitamin D, or the use of vitamin D supplements, are current strategies to improve vitamin D levels and treat deficiency. This article reviews consolidated and emerging concepts about vitamin D/hormone D metabolism, food sources, deficiency, as well as the different vitamin D supplements available, and current recommendations on the proper use of these compounds.

ACS Style

Ligia Dominguez; Mario Farruggia; Nicola Veronese; Mario Barbagallo. Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites 2021, 11, 255 .

AMA Style

Ligia Dominguez, Mario Farruggia, Nicola Veronese, Mario Barbagallo. Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites. 2021; 11 (4):255.

Chicago/Turabian Style

Ligia Dominguez; Mario Farruggia; Nicola Veronese; Mario Barbagallo. 2021. "Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment." Metabolites 11, no. 4: 255.

Review
Published: 30 January 2021 in Nutrients
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Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer’s disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

ACS Style

Mario Barbagallo; Nicola Veronese; Ligia Dominguez. Magnesium in Aging, Health and Diseases. Nutrients 2021, 13, 463 .

AMA Style

Mario Barbagallo, Nicola Veronese, Ligia Dominguez. Magnesium in Aging, Health and Diseases. Nutrients. 2021; 13 (2):463.

Chicago/Turabian Style

Mario Barbagallo; Nicola Veronese; Ligia Dominguez. 2021. "Magnesium in Aging, Health and Diseases." Nutrients 13, no. 2: 463.

Review
Published: 08 January 2021 in Nutrients
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Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells. Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune cells involves Mg transport systems, such as the melastatin-like transient receptor potential 7 channel, the solute carrier family, and the magnesium transporter 1 (MAGT1). The functional importance of Mg transport in immunity was unknown until the description of the primary immunodeficiency XMEN (X-linked immunodeficiency with Mg defect, Epstein–Barr virus infection, and neoplasia) due to a genetic deficiency of MAGT1 characterized by chronic Epstein–Barr virus infection. This and other research reporting associations of Mg deficit with viral and bacterial infections indicate a possible role of Mg deficit in the recent coronavirus disease 2019 (COVID-19) and its complications. In this review, we will discuss the importance of Mg for the immune system and for infectious diseases, including the recent pandemic of COVID-19.

ACS Style

Ligia J. Dominguez; Nicola Veronese; Fernando Guerrero-Romero; Mario Barbagallo. Magnesium in Infectious Diseases in Older People. Nutrients 2021, 13, 180 .

AMA Style

Ligia J. Dominguez, Nicola Veronese, Fernando Guerrero-Romero, Mario Barbagallo. Magnesium in Infectious Diseases in Older People. Nutrients. 2021; 13 (1):180.

Chicago/Turabian Style

Ligia J. Dominguez; Nicola Veronese; Fernando Guerrero-Romero; Mario Barbagallo. 2021. "Magnesium in Infectious Diseases in Older People." Nutrients 13, no. 1: 180.

Review
Published: 31 December 2020 in Nutrients
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Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In recent decades, there has been an exceptional number of experimental, epidemiological, and clinical studies confirming a close relationship between magnesium deficit and high blood pressure. Multiple mechanisms may help to explain the bulk of evidence supporting a protective effect of magnesium against hypertension and its complications. Hypertension increases sharply with advancing age, hence older persons are those most affected by its negative consequences. They are also more frequently at risk of magnesium deficiency by multiple mechanisms, which may, at least in part, explain the higher frequency of hypertension and its long-term complications. The evidence for a favorable effect of magnesium on hypertension risk emphasizes the importance of broadly encouraging the intake of foods such as vegetables, nuts, whole cereals and legumes, optimal dietary sources of magnesium, and avoiding processed foods, which are very poor in magnesium and other fundamental nutrients, in order to prevent hypertension. In some cases, when diet is not enough to maintain an adequate magnesium status, magnesium supplementation may be of benefit and has been shown to be well tolerated.

ACS Style

Ligia J. Dominguez; Nicola Veronese; Mario Barbagallo. Magnesium and Hypertension in Old Age. Nutrients 2020, 13, 139 .

AMA Style

Ligia J. Dominguez, Nicola Veronese, Mario Barbagallo. Magnesium and Hypertension in Old Age. Nutrients. 2020; 13 (1):139.

Chicago/Turabian Style

Ligia J. Dominguez; Nicola Veronese; Mario Barbagallo. 2020. "Magnesium and Hypertension in Old Age." Nutrients 13, no. 1: 139.

Journal article
Published: 31 December 2020 in Nutrients
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Hypertension is the strongest independent modifiable risk factor for cardiovascular disease. We aimed to investigate the association of magnesium intake with incident hypertension in a Mediterranean population, and the potential modification of this association by body mass index BMI. We assessed 14,057 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (67.0% women) initially free of hypertension. At baseline, a validated 136-item food frequency questionnaire was administered. We used Cox models adjusted for multiple socio-demographic, anthropometric, and lifestyle factors, and prevalent conditions present at baseline. Among a mean 9.6 years of follow-up we observed 1406 incident cases of medically diagnosed hypertension. An inverse association in multivariable-adjusted models was observed for progressively higher magnesium intake up to 500 mg/d vs. intake < 200 mg/d, which was greater among those with a BMI > 27 kg/m2. Lean participants with magnesium intake < 200 mg/d vs. >200 mg/d also had a higher risk of incident hypertension. Adherence to the Mediterranean diet did not modify these associations. In conclusion, dietary magnesium intake < 200 mg/d was independently associated with a higher risk of developing hypertension in a Mediterranean cohort, stronger for overweight/obese participants. Our results emphasize the importance of encouraging the consumption of magnesium-rich foods (vegetables, nuts, whole cereals, legumes) in order to prevent hypertension.

ACS Style

Ligia J. Dominguez; Alfredo Gea; Liz Ruiz-Estigarribia; Carmen Sayón-Orea; Ujue Fresán; Mario Barbagallo; Miguel Ruiz-Canela; Miguel A. Martínez-González. Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project. Nutrients 2020, 13, 125 .

AMA Style

Ligia J. Dominguez, Alfredo Gea, Liz Ruiz-Estigarribia, Carmen Sayón-Orea, Ujue Fresán, Mario Barbagallo, Miguel Ruiz-Canela, Miguel A. Martínez-González. Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project. Nutrients. 2020; 13 (1):125.

Chicago/Turabian Style

Ligia J. Dominguez; Alfredo Gea; Liz Ruiz-Estigarribia; Carmen Sayón-Orea; Ujue Fresán; Mario Barbagallo; Miguel Ruiz-Canela; Miguel A. Martínez-González. 2020. "Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project." Nutrients 13, no. 1: 125.

Journal article
Published: 29 March 2020 in Sustainability
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Background: The Geriatric Unit of the University of Palermo developed the “Passiata Day” model, a green exercise intervention consisting of a one-hour walk, once/week, in a city park. The purpose of this study was to assess body balance in older people who walked regularly compared to sedentary people. Methods: 106 older people (75 women and 31 men; mean age: 72.3 ± 8.2 years) without fall history were invited to participate voluntarily in this natural environment walking program. After six months, both the participants who had taken part regularly in the walk (i.e., the physical activity group (PAG; n = 72; 54 women and 18 men; mean age: 70.7 ± 7.2 years)), and who had not accepted to be included in the outdoor walking program (i.e., the sedentary group (SG; n = 34; 21 women and 13 men; mean age: 75.5 ± 9.4 years)), performed a stabilometric test with open eyes (OE) and with closed eyes (CE). Results: Our preliminary results showed significant differences between groups on the ellipse sway area both in the OE (p < 0.05) and in CE condition (p < 0.01). Moreover, we found a significant difference on sway along the frontal plane both in the OE (p < 0.05) and in the CE condition (p < 0.01), and on sway along the sagittal plane for the test with CE (p < 0.01). Conclusion: Based on our preliminary findings, we suggest that walking regularly in an outdoor setting could lead to a greater body balance in older people and could be recommended by geriatricians for preventing the risk of falls. The next step will be to investigate the effect of an experimental outdoor walking program structured in terms of intensity, frequency and volume.

ACS Style

Giuseppe Battaglia; Valerio Giustino; Giuseppe Messina; Mariangela Faraone; Jessica Brusa; Anna Bordonali; Mario Barbagallo; Antonio Palma; Ligia-Juliana Dominguez. Walking in Natural Environments as Geriatrician’s Recommendation for Fall Prevention: Preliminary Outcomes from the “Passiata Day” Model. Sustainability 2020, 12, 2684 .

AMA Style

Giuseppe Battaglia, Valerio Giustino, Giuseppe Messina, Mariangela Faraone, Jessica Brusa, Anna Bordonali, Mario Barbagallo, Antonio Palma, Ligia-Juliana Dominguez. Walking in Natural Environments as Geriatrician’s Recommendation for Fall Prevention: Preliminary Outcomes from the “Passiata Day” Model. Sustainability. 2020; 12 (7):2684.

Chicago/Turabian Style

Giuseppe Battaglia; Valerio Giustino; Giuseppe Messina; Mariangela Faraone; Jessica Brusa; Anna Bordonali; Mario Barbagallo; Antonio Palma; Ligia-Juliana Dominguez. 2020. "Walking in Natural Environments as Geriatrician’s Recommendation for Fall Prevention: Preliminary Outcomes from the “Passiata Day” Model." Sustainability 12, no. 7: 2684.

Editorial
Published: 23 October 2019 in European Geriatric Medicine
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ACS Style

Mario Barbagallo; Ligia J. Dominguez. Gerontology is essential to the identity of geriatric medicine. European Geriatric Medicine 2019, 10, 835 -837.

AMA Style

Mario Barbagallo, Ligia J. Dominguez. Gerontology is essential to the identity of geriatric medicine. European Geriatric Medicine. 2019; 10 (6):835-837.

Chicago/Turabian Style

Mario Barbagallo; Ligia J. Dominguez. 2019. "Gerontology is essential to the identity of geriatric medicine." European Geriatric Medicine 10, no. 6: 835-837.

Encyclopedia
Published: 22 June 2019 in Reference Module in Biomedical Sciences
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Aging of the world populations embodies a remarkable success of humankind and a source of challenge. Aging is a complex, continuous, multifactorial process that is accompanied by a progressive loss of physical and mental functions and the onset of various age-related diseases, which are not caused by aging per se. Currently, an increasing number of people are asking to arrive at advanced age in good health overcoming the modifications elicited by aging (the dream of remaining young forever). In the past decades there have been remarkable advances in the understanding of the aging process from results of biogerontological research in experimental models, that is, life extension through genetic manipulation or caloric restriction, which have not yet demonstrated to prolong human life. Therefore, adhesion to a healthy lifestyle (i.e., smoking cessation, a balanced diet, regular physical and mental activity) is still the most prudent, clinically validated advice to promote healthy aging.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Anti-aging: Myth or Reality. Reference Module in Biomedical Sciences 2019, 1 .

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Anti-aging: Myth or Reality. Reference Module in Biomedical Sciences. 2019; ():1.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2019. "Anti-aging: Myth or Reality." Reference Module in Biomedical Sciences , no. : 1.

Encyclopedia
Published: 06 June 2019 in Reference Module in Biomedical Sciences
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Thyroid disorders are more frequent in old age, especially in women. Overt thyroid dysfunction may manifest as aging itself or as age-associated disorders of other organs. Therefore, an accurate clinical suspicion is essential for their detection in elders with multiple comorbidities, malnutrition, and chronic polypharmacy. Because chronic diseases are more prevalent in old age, nonthyroidal illness is also common in this age group. Most thyroid nodules in older persons are benign, yet a comprehensive individualized evaluation is needed in order to timely detect malignancy. While there is still debate on the decision to treat or not to treat subclinical thyroid disorders, current recommendations indicate the necessity of considering treatment on an individual bases, balancing the possible benefit on quality of life versus the risks in the older person. Extended screening and treatment in the community population aged 65 years and over is discouraged, but screening on at-risk populations is recommended.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Thyroid Disorders in Old Age. Reference Module in Biomedical Sciences 2019, 1 .

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Thyroid Disorders in Old Age. Reference Module in Biomedical Sciences. 2019; ():1.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2019. "Thyroid Disorders in Old Age." Reference Module in Biomedical Sciences , no. : 1.

Encyclopedia
Published: 21 March 2019 in Reference Module in Biomedical Sciences
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The world average life expectancy has increased remarkably in the past century and continues to increase relentlessly. A long life is desirable but best if lived in good physical and mental health. Among the various dietary patterns, a large body of research data suggest that the traditional dietary habits and lifestyle unique to the Mediterranean region are associated with lower incidence of chronic diseases and improve longevity. Starting with the first data from the Seven Countries Study, numerous observational, prospective, and trial-based investigations in different populations have thereafter supported the benefits of adhering to the Mediterranean dietary pattern regarding reduced mortality, and prevention and treatment of age-associated chronic disorders, such as cardiovascular and metabolic diseases, some types of cancer, neurodegenerative diseases, depression, hip fractures, and frailty. Furthermore, Mediterranean diet is also sustainable; hence, this intangible heritage configures a healthy way of eating and of living in harmony with the environment.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Mediterranean Diet and Longevity. Reference Module in Biomedical Sciences 2019, 1 .

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Mediterranean Diet and Longevity. Reference Module in Biomedical Sciences. 2019; ():1.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2019. "Mediterranean Diet and Longevity." Reference Module in Biomedical Sciences , no. : 1.

Chapter
Published: 14 November 2018 in Healthy Ageing and Longevity
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Reduced Magnesium (Mg) intake is a frequent cause of Mg deficit with age. A decreased intestinal Mg absorption and an increased Mg loss may also contribute, as well as the use of medicaments. Furthermore, Mg requirements may be higher with aging. Alterations of Mg metabolism with age, cellular Mg transport systems and problems with measurement methods are discussed. Mg contained in water is more bio-available than Mg in food and it is a possible alternative to Mg supplementation in the correction of Mg deficiencies. Mild to moderate Mg deficits are generally asymptomatic and clinical signs are usually absent or non-specific. Hyperemotionality, tremor, asthenia, sleep disorders, and amnesic and cognitive disturbances are frequent in older adults, and may be often overlooked or confused with age-related symptoms. Chronic Mg deficiency results in oxidative stress and chronic, low-grade inflammation, which may be linked to several age-related diseases, and to the aging process itself. Mg deficit-related conditions may involve different tissues and organs, including hypertension and cardiovascular diseases, diabetes mellitus and metabolic syndrome, asthma and airways constrictive syndromes, depression and psychiatric disorders, Alzheimer’s disease and neuromuscular diseases (chronic fatigue, muscle pain, fibromyalgia), fragility fractures, and cancer. Keeping an optimal Mg balance throughout life might help to prevent some chronic disease associated to aging, and to extend healthy life. This needs to be proven by future studies.

ACS Style

Mario Barbagallo; Ligia J. Dominguez. Magnesium Role in Health and Longevity. Healthy Ageing and Longevity 2018, 235 -264.

AMA Style

Mario Barbagallo, Ligia J. Dominguez. Magnesium Role in Health and Longevity. Healthy Ageing and Longevity. 2018; ():235-264.

Chicago/Turabian Style

Mario Barbagallo; Ligia J. Dominguez. 2018. "Magnesium Role in Health and Longevity." Healthy Ageing and Longevity , no. : 235-264.

Original contribution
Published: 26 October 2018 in European Journal of Nutrition
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To prospectively assess the association of dietary fiber intake (from different dietary sources) with all-cause mortality in a Mediterranean cohort. We assessed 19,703 participants of the SUN (Seguimiento Universidad de Navarra) cohort (mean follow-up: 10.1 years). A validated 136-item FFQ was administered at baseline. We used Cox proportional hazards models adjusted for multiple socio-demographic, anthropometric, lifestyle factors, and prevalent conditions at baseline. We observed 323 deaths during 198,341 person-years of follow-up. A significantly inverse linear trend in Cox models was observed for the association of total dietary fiber intake and all-cause mortality after adjustment for confounders (p for trend 0.017). Each additional intake of 5 g/1000 kcal of dietary fiber was associated with a 9% relative reduction in all-cause mortality risk (HR 0.91, 95% CI 0.84-0.99). Considering separate dietary sources in separate models, a significant inverse trend was apparent for fiber derived from vegetables (p for trend 0.001), but it was non-significant for fiber derived from fruit, legumes, cereals, or other sources. Soluble fiber was significantly inversely associated with all-cause mortality in the fully adjusted model (p for trend 0.007), and insoluble fiber was marginally significant (p for trend 0.08). A higher intake of total dietary fiber, and particularly fiber from vegetables, was related to a reduced all-cause mortality in our Mediterranean cohort. Dietary messages to increase the consumption of dietary patterns rich in fiber-rich foods should be broadly disseminated to decrease the alarming rate of chronic diseases and its derived mortality.

ACS Style

Ligia J. Dominguez; Maira Bes-Rastrollo; Estefania Toledo; Alfredo Gea; Ujue Fresán; Mario Barbagallo; Miguel A. Martínez-González. Dietary fiber intake and mortality in a Mediterranean population: the “Seguimiento Universidad de Navarra” (SUN) project. European Journal of Nutrition 2018, 58, 3009 -3022.

AMA Style

Ligia J. Dominguez, Maira Bes-Rastrollo, Estefania Toledo, Alfredo Gea, Ujue Fresán, Mario Barbagallo, Miguel A. Martínez-González. Dietary fiber intake and mortality in a Mediterranean population: the “Seguimiento Universidad de Navarra” (SUN) project. European Journal of Nutrition. 2018; 58 (8):3009-3022.

Chicago/Turabian Style

Ligia J. Dominguez; Maira Bes-Rastrollo; Estefania Toledo; Alfredo Gea; Ujue Fresán; Mario Barbagallo; Miguel A. Martínez-González. 2018. "Dietary fiber intake and mortality in a Mediterranean population: the “Seguimiento Universidad de Navarra” (SUN) project." European Journal of Nutrition 58, no. 8: 3009-3022.

Review
Published: 07 June 2018
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Cognitive impairment results from a complex interplay of many factors. The most important independent predictor of cognitive decline is age but other contributing factors include demographic, genetic, socio-economic, and environmental parameters, including nutrition. The number of persons with cognitive decline and dementia will increase in the next decades in parallel with aging of the world population. Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions. Thus, nutritional approaches to prevent or slow cognitive decline could have a remarkable public health impact. Several dietary components and supplements have been examined in relation to their association with the development of cognitive decline. A number of studies have examined the role of dietary patterns on late-life cognition, with accumulating evidence that combinations of foods and nutrients may act synergistically to provide stronger benefit than those conferred by individual dietary components. Higher adherence to the Mediterranean dietary pattern has been associated with decreased cognitive decline and incident AD. Another dietary pattern with neuroprotective actions is the Dietary Approach to Stop Hypertension (DASH). The combination of these two dietary patterns has been associated with slower rates of cognitive decline and significant reduction in incident AD. This review evaluates the evidence for the effects of some dietary components, supplements, and dietary patterns as neuroprotective, with potential to delay cognitive decline and the onset of dementia.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Nutritional prevention of cognitive decline and dementia. 2018, 89, 276 -290.

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Nutritional prevention of cognitive decline and dementia. . 2018; 89 (2):276-290.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2018. "Nutritional prevention of cognitive decline and dementia." 89, no. 2: 276-290.

Expert review
Published: 15 January 2018 in Aging Clinical and Experimental Research
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Due to aging of the world population, older patients accessing health services are becoming continuously more frequent. This has increased the interest in assessing frailty and vulnerability in all specialties and general medicine. Although the term frailty has been recognized for over 30 years, there is not yet a universally recognized definition, and different care providers assess frailty and vulnerability with dissimilar tools, from very complex to very simple validated scales. Being treated with respect and dignity at the right time and place is the key message, as well as after undergoing a global evaluation both in urgency/emergency and in programmed surgery for all older surgical patients. Filling the gap will improve the results of any clinical intervention, both medical and surgical. Anesthesiologists, surgeons, hospitalists, and any member of the team of care providers must be trained into geriatric syndromes.

ACS Style

Mario Barbagallo; Ligia J. Dominguez; Menico Cucinotta. The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity? Aging Clinical and Experimental Research 2018, 30, 237 -239.

AMA Style

Mario Barbagallo, Ligia J. Dominguez, Menico Cucinotta. The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity? Aging Clinical and Experimental Research. 2018; 30 (3):237-239.

Chicago/Turabian Style

Mario Barbagallo; Ligia J. Dominguez; Menico Cucinotta. 2018. "The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity?" Aging Clinical and Experimental Research 30, no. 3: 237-239.

Book chapter
Published: 01 January 2018 in The Prevention of Cardiovascular Disease Through the Mediterranean Diet
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ACS Style

Ligia J. Dominguez; Mario Barbagallo. Not All Fats Are Unhealthy. The Prevention of Cardiovascular Disease Through the Mediterranean Diet 2018, 35 -58.

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Not All Fats Are Unhealthy. The Prevention of Cardiovascular Disease Through the Mediterranean Diet. 2018; ():35-58.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2018. "Not All Fats Are Unhealthy." The Prevention of Cardiovascular Disease Through the Mediterranean Diet , no. : 35-58.

Book chapter
Published: 01 January 2018 in The Prevention of Cardiovascular Disease Through the Mediterranean Diet
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ACS Style

Ignacio Ara; Mario Barbagallo; Maira Bes-Rastrollo; Ligia J. Dominguez; Alfredo Gea; María Soledad Hershey; Iva Marques-Lopes; Elena H. Martínez-Lapiscina; Mary K. Downer; Karen J. Murphy; Angeliki Papadaki; Ana Sánchez-Tainta; Almudena Sánchez-Villegas; Estefanía Toledo; Itziar Zazpe. List of Contributors. The Prevention of Cardiovascular Disease Through the Mediterranean Diet 2018, 1 .

AMA Style

Ignacio Ara, Mario Barbagallo, Maira Bes-Rastrollo, Ligia J. Dominguez, Alfredo Gea, María Soledad Hershey, Iva Marques-Lopes, Elena H. Martínez-Lapiscina, Mary K. Downer, Karen J. Murphy, Angeliki Papadaki, Ana Sánchez-Tainta, Almudena Sánchez-Villegas, Estefanía Toledo, Itziar Zazpe. List of Contributors. The Prevention of Cardiovascular Disease Through the Mediterranean Diet. 2018; ():1.

Chicago/Turabian Style

Ignacio Ara; Mario Barbagallo; Maira Bes-Rastrollo; Ligia J. Dominguez; Alfredo Gea; María Soledad Hershey; Iva Marques-Lopes; Elena H. Martínez-Lapiscina; Mary K. Downer; Karen J. Murphy; Angeliki Papadaki; Ana Sánchez-Tainta; Almudena Sánchez-Villegas; Estefanía Toledo; Itziar Zazpe. 2018. "List of Contributors." The Prevention of Cardiovascular Disease Through the Mediterranean Diet , no. : 1.

Journal article
Published: 16 November 2017 in Nutrients
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Inadequate magnesium (Mg) intake is associated with lower physical performance, but the relationship with frailty in older people is unclear. Therefore, we aimed to investigate whether higher dietary Mg intake is associated with a lower risk of frailty in a large cohort of North American individuals. Details regarding Mg intake were recorded through a food-frequency questionnaire (FFQ) and categorized as greater than/equal to Recommended Dietary Allowance (RDA) vs. lower. Frailty was defined using the Study of Osteoporotic Fractures index. Multivariable Cox’s regression analyses, calculating hazard ratios (HRs) with 95% confidence intervals (CIs), were undertaken by sex. In total, 4421 individuals with knee osteoarthritis or who were at high risk without frailty at baseline (mean age: 61.3, females = 58.0%) were followed for 8 years. After adjusting for 11 potential baseline confounders, reaching the RDA for Mg lowered risk of frailty among men (total n = 1857, HR = 0.51; 95% CI: 0.26–0.93), whilst no significant associations were found in women (total n = 2564). Each 100 mg of dietary Mg intake at baseline corresponded to a 22% reduction in men (HR = 0.78; 95% CI: 0.62–0.97; p = 0.03), but not in women (HR = 1.05; 95% CI: 0.89–1.23). In conclusion, higher dietary Mg intake appears to reduce the risk of frailty in men, but not in women.

ACS Style

Nicola Veronese; Brendon Stubbs; Stefania Maggi; Maria Notarnicola; Mario Barbagallo; Joseph Firth; Ligia J. Dominguez; Maria Gabriella Caruso. Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study. Nutrients 2017, 9, 1253 .

AMA Style

Nicola Veronese, Brendon Stubbs, Stefania Maggi, Maria Notarnicola, Mario Barbagallo, Joseph Firth, Ligia J. Dominguez, Maria Gabriella Caruso. Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study. Nutrients. 2017; 9 (11):1253.

Chicago/Turabian Style

Nicola Veronese; Brendon Stubbs; Stefania Maggi; Maria Notarnicola; Mario Barbagallo; Joseph Firth; Ligia J. Dominguez; Maria Gabriella Caruso. 2017. "Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study." Nutrients 9, no. 11: 1253.

Journal article
Published: 01 November 2017 in Journal of the American Medical Directors Association
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ACS Style

Ligia J. Dominguez; Mario Barbagallo. The Multidomain Nature of Malnutrition in Older Persons. Journal of the American Medical Directors Association 2017, 18, 908 -912.

AMA Style

Ligia J. Dominguez, Mario Barbagallo. The Multidomain Nature of Malnutrition in Older Persons. Journal of the American Medical Directors Association. 2017; 18 (11):908-912.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2017. "The Multidomain Nature of Malnutrition in Older Persons." Journal of the American Medical Directors Association 18, no. 11: 908-912.