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Prof. MARIO BARBAGALLO
University of Palermo (Italy)

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0 Aging
0 Hypertension
0 Magnesium
0 Type 2 Diabetes
0 cognitive decline

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Hypertension
Magnesium
Aging
Type 2 Diabetes
cognitive decline

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Review
Published: 12 June 2021 in Nutrients
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The average life expectancy of the world population has increased remarkably in the past 150 years and it is still increasing. A long life is a dream of humans since the beginning of time but also a dream is to live it in good physical and mental condition. Nutrition research has focused on recent decades more on food combination patterns than on individual foods/nutrients due to the possible synergistic/antagonistic effects of the components in a dietary model. Various dietary patterns have been associated with health benefits, but the largest body of evidence in the literature is attributable to the traditional dietary habits and lifestyle followed by populations from the Mediterranean region. After the Seven Countries Study, many prospective observational studies and trials in diverse populations reinforced the beneficial effects associated with a higher adherence to the Mediterranean diet in reference to the prevention/management of age-associated non-communicable diseases, such as cardiovascular and metabolic diseases, neurodegenerative diseases, cancer, depression, respiratory diseases, and fragility fractures. In addition, the Mediterranean diet is ecologically sustainable. Therefore, this immaterial world heritage constitutes a healthy way of eating and living respecting the environment.

ACS Style

Ligia Dominguez; Giovanna Di Bella; Nicola Veronese; Mario Barbagallo. Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity. Nutrients 2021, 13, 2028 .

AMA Style

Ligia Dominguez, Giovanna Di Bella, Nicola Veronese, Mario Barbagallo. Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity. Nutrients. 2021; 13 (6):2028.

Chicago/Turabian Style

Ligia Dominguez; Giovanna Di Bella; Nicola Veronese; Mario Barbagallo. 2021. "Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity." Nutrients 13, no. 6: 2028.

Review
Published: 20 April 2021 in Metabolites
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Studies on vitamin/hormone D deficiency have received a vast amount of attention in recent years, particularly concerning recommendations, guidelines, and treatments. Moreover, vitamin D’s role as a hormone has been confirmed in various enzymatic, metabolic, physiological, and pathophysiological processes related to many organs and systems in the human body. This growing interest is mostly due to the evidence that modest-to-severe vitamin D deficiency is widely prevalent around the world. There is broad agreement that optimal vitamin D status is necessary for bones, muscles, and one’s general health, as well as for the efficacy of antiresorptive and anabolic bone-forming treatments. Food supplementation with vitamin D, or the use of vitamin D supplements, are current strategies to improve vitamin D levels and treat deficiency. This article reviews consolidated and emerging concepts about vitamin D/hormone D metabolism, food sources, deficiency, as well as the different vitamin D supplements available, and current recommendations on the proper use of these compounds.

ACS Style

Ligia Dominguez; Mario Farruggia; Nicola Veronese; Mario Barbagallo. Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites 2021, 11, 255 .

AMA Style

Ligia Dominguez, Mario Farruggia, Nicola Veronese, Mario Barbagallo. Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment. Metabolites. 2021; 11 (4):255.

Chicago/Turabian Style

Ligia Dominguez; Mario Farruggia; Nicola Veronese; Mario Barbagallo. 2021. "Vitamin D Sources, Metabolism, and Deficiency: Available Compounds and Guidelines for Its Treatment." Metabolites 11, no. 4: 255.

Editorial
Published: 05 March 2021 in Nutrients
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Macro- and micro-element deficiencies are widely diffused in older people

ACS Style

Nicola Veronese; Mario Barbagallo. Magnesium and Micro-Elements in Older Persons. Nutrients 2021, 13, 847 .

AMA Style

Nicola Veronese, Mario Barbagallo. Magnesium and Micro-Elements in Older Persons. Nutrients. 2021; 13 (3):847.

Chicago/Turabian Style

Nicola Veronese; Mario Barbagallo. 2021. "Magnesium and Micro-Elements in Older Persons." Nutrients 13, no. 3: 847.

Review
Published: 30 January 2021 in Nutrients
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Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer’s disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

ACS Style

Mario Barbagallo; Nicola Veronese; Ligia Dominguez. Magnesium in Aging, Health and Diseases. Nutrients 2021, 13, 463 .

AMA Style

Mario Barbagallo, Nicola Veronese, Ligia Dominguez. Magnesium in Aging, Health and Diseases. Nutrients. 2021; 13 (2):463.

Chicago/Turabian Style

Mario Barbagallo; Nicola Veronese; Ligia Dominguez. 2021. "Magnesium in Aging, Health and Diseases." Nutrients 13, no. 2: 463.

Review
Published: 08 January 2021 in Nutrients
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Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells. Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune cells involves Mg transport systems, such as the melastatin-like transient receptor potential 7 channel, the solute carrier family, and the magnesium transporter 1 (MAGT1). The functional importance of Mg transport in immunity was unknown until the description of the primary immunodeficiency XMEN (X-linked immunodeficiency with Mg defect, Epstein–Barr virus infection, and neoplasia) due to a genetic deficiency of MAGT1 characterized by chronic Epstein–Barr virus infection. This and other research reporting associations of Mg deficit with viral and bacterial infections indicate a possible role of Mg deficit in the recent coronavirus disease 2019 (COVID-19) and its complications. In this review, we will discuss the importance of Mg for the immune system and for infectious diseases, including the recent pandemic of COVID-19.

ACS Style

Ligia J. Dominguez; Nicola Veronese; Fernando Guerrero-Romero; Mario Barbagallo. Magnesium in Infectious Diseases in Older People. Nutrients 2021, 13, 180 .

AMA Style

Ligia J. Dominguez, Nicola Veronese, Fernando Guerrero-Romero, Mario Barbagallo. Magnesium in Infectious Diseases in Older People. Nutrients. 2021; 13 (1):180.

Chicago/Turabian Style

Ligia J. Dominguez; Nicola Veronese; Fernando Guerrero-Romero; Mario Barbagallo. 2021. "Magnesium in Infectious Diseases in Older People." Nutrients 13, no. 1: 180.

Review
Published: 31 December 2020 in Nutrients
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Hypertension is a complex condition in which various actors and mechanisms combine, resulting in cardiovascular and cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, and health expenses worldwide. In recent decades, there has been an exceptional number of experimental, epidemiological, and clinical studies confirming a close relationship between magnesium deficit and high blood pressure. Multiple mechanisms may help to explain the bulk of evidence supporting a protective effect of magnesium against hypertension and its complications. Hypertension increases sharply with advancing age, hence older persons are those most affected by its negative consequences. They are also more frequently at risk of magnesium deficiency by multiple mechanisms, which may, at least in part, explain the higher frequency of hypertension and its long-term complications. The evidence for a favorable effect of magnesium on hypertension risk emphasizes the importance of broadly encouraging the intake of foods such as vegetables, nuts, whole cereals and legumes, optimal dietary sources of magnesium, and avoiding processed foods, which are very poor in magnesium and other fundamental nutrients, in order to prevent hypertension. In some cases, when diet is not enough to maintain an adequate magnesium status, magnesium supplementation may be of benefit and has been shown to be well tolerated.

ACS Style

Ligia J. Dominguez; Nicola Veronese; Mario Barbagallo. Magnesium and Hypertension in Old Age. Nutrients 2020, 13, 139 .

AMA Style

Ligia J. Dominguez, Nicola Veronese, Mario Barbagallo. Magnesium and Hypertension in Old Age. Nutrients. 2020; 13 (1):139.

Chicago/Turabian Style

Ligia J. Dominguez; Nicola Veronese; Mario Barbagallo. 2020. "Magnesium and Hypertension in Old Age." Nutrients 13, no. 1: 139.

Journal article
Published: 31 December 2020 in Nutrients
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Hypertension is the strongest independent modifiable risk factor for cardiovascular disease. We aimed to investigate the association of magnesium intake with incident hypertension in a Mediterranean population, and the potential modification of this association by body mass index BMI. We assessed 14,057 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (67.0% women) initially free of hypertension. At baseline, a validated 136-item food frequency questionnaire was administered. We used Cox models adjusted for multiple socio-demographic, anthropometric, and lifestyle factors, and prevalent conditions present at baseline. Among a mean 9.6 years of follow-up we observed 1406 incident cases of medically diagnosed hypertension. An inverse association in multivariable-adjusted models was observed for progressively higher magnesium intake up to 500 mg/d vs. intake < 200 mg/d, which was greater among those with a BMI > 27 kg/m2. Lean participants with magnesium intake < 200 mg/d vs. >200 mg/d also had a higher risk of incident hypertension. Adherence to the Mediterranean diet did not modify these associations. In conclusion, dietary magnesium intake < 200 mg/d was independently associated with a higher risk of developing hypertension in a Mediterranean cohort, stronger for overweight/obese participants. Our results emphasize the importance of encouraging the consumption of magnesium-rich foods (vegetables, nuts, whole cereals, legumes) in order to prevent hypertension.

ACS Style

Ligia J. Dominguez; Alfredo Gea; Liz Ruiz-Estigarribia; Carmen Sayón-Orea; Ujue Fresán; Mario Barbagallo; Miguel Ruiz-Canela; Miguel A. Martínez-González. Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project. Nutrients 2020, 13, 125 .

AMA Style

Ligia J. Dominguez, Alfredo Gea, Liz Ruiz-Estigarribia, Carmen Sayón-Orea, Ujue Fresán, Mario Barbagallo, Miguel Ruiz-Canela, Miguel A. Martínez-González. Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project. Nutrients. 2020; 13 (1):125.

Chicago/Turabian Style

Ligia J. Dominguez; Alfredo Gea; Liz Ruiz-Estigarribia; Carmen Sayón-Orea; Ujue Fresán; Mario Barbagallo; Miguel Ruiz-Canela; Miguel A. Martínez-González. 2020. "Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project." Nutrients 13, no. 1: 125.

Journal article
Published: 29 March 2020 in Sustainability
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Background: The Geriatric Unit of the University of Palermo developed the “Passiata Day” model, a green exercise intervention consisting of a one-hour walk, once/week, in a city park. The purpose of this study was to assess body balance in older people who walked regularly compared to sedentary people. Methods: 106 older people (75 women and 31 men; mean age: 72.3 ± 8.2 years) without fall history were invited to participate voluntarily in this natural environment walking program. After six months, both the participants who had taken part regularly in the walk (i.e., the physical activity group (PAG; n = 72; 54 women and 18 men; mean age: 70.7 ± 7.2 years)), and who had not accepted to be included in the outdoor walking program (i.e., the sedentary group (SG; n = 34; 21 women and 13 men; mean age: 75.5 ± 9.4 years)), performed a stabilometric test with open eyes (OE) and with closed eyes (CE). Results: Our preliminary results showed significant differences between groups on the ellipse sway area both in the OE (p < 0.05) and in CE condition (p < 0.01). Moreover, we found a significant difference on sway along the frontal plane both in the OE (p < 0.05) and in the CE condition (p < 0.01), and on sway along the sagittal plane for the test with CE (p < 0.01). Conclusion: Based on our preliminary findings, we suggest that walking regularly in an outdoor setting could lead to a greater body balance in older people and could be recommended by geriatricians for preventing the risk of falls. The next step will be to investigate the effect of an experimental outdoor walking program structured in terms of intensity, frequency and volume.

ACS Style

Giuseppe Battaglia; Valerio Giustino; Giuseppe Messina; Mariangela Faraone; Jessica Brusa; Anna Bordonali; Mario Barbagallo; Antonio Palma; Ligia-Juliana Dominguez. Walking in Natural Environments as Geriatrician’s Recommendation for Fall Prevention: Preliminary Outcomes from the “Passiata Day” Model. Sustainability 2020, 12, 2684 .

AMA Style

Giuseppe Battaglia, Valerio Giustino, Giuseppe Messina, Mariangela Faraone, Jessica Brusa, Anna Bordonali, Mario Barbagallo, Antonio Palma, Ligia-Juliana Dominguez. Walking in Natural Environments as Geriatrician’s Recommendation for Fall Prevention: Preliminary Outcomes from the “Passiata Day” Model. Sustainability. 2020; 12 (7):2684.

Chicago/Turabian Style

Giuseppe Battaglia; Valerio Giustino; Giuseppe Messina; Mariangela Faraone; Jessica Brusa; Anna Bordonali; Mario Barbagallo; Antonio Palma; Ligia-Juliana Dominguez. 2020. "Walking in Natural Environments as Geriatrician’s Recommendation for Fall Prevention: Preliminary Outcomes from the “Passiata Day” Model." Sustainability 12, no. 7: 2684.

Editorial
Published: 23 October 2019 in European Geriatric Medicine
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Mario Barbagallo; Ligia J. Dominguez. Gerontology is essential to the identity of geriatric medicine. European Geriatric Medicine 2019, 10, 835 -837.

AMA Style

Mario Barbagallo, Ligia J. Dominguez. Gerontology is essential to the identity of geriatric medicine. European Geriatric Medicine. 2019; 10 (6):835-837.

Chicago/Turabian Style

Mario Barbagallo; Ligia J. Dominguez. 2019. "Gerontology is essential to the identity of geriatric medicine." European Geriatric Medicine 10, no. 6: 835-837.

Encyclopedia
Published: 22 June 2019 in Reference Module in Biomedical Sciences
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Aging of the world populations embodies a remarkable success of humankind and a source of challenge. Aging is a complex, continuous, multifactorial process that is accompanied by a progressive loss of physical and mental functions and the onset of various age-related diseases, which are not caused by aging per se. Currently, an increasing number of people are asking to arrive at advanced age in good health overcoming the modifications elicited by aging (the dream of remaining young forever). In the past decades there have been remarkable advances in the understanding of the aging process from results of biogerontological research in experimental models, that is, life extension through genetic manipulation or caloric restriction, which have not yet demonstrated to prolong human life. Therefore, adhesion to a healthy lifestyle (i.e., smoking cessation, a balanced diet, regular physical and mental activity) is still the most prudent, clinically validated advice to promote healthy aging.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Anti-aging: Myth or Reality. Reference Module in Biomedical Sciences 2019, 1 .

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Anti-aging: Myth or Reality. Reference Module in Biomedical Sciences. 2019; ():1.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2019. "Anti-aging: Myth or Reality." Reference Module in Biomedical Sciences , no. : 1.

Encyclopedia
Published: 06 June 2019 in Reference Module in Biomedical Sciences
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Thyroid disorders are more frequent in old age, especially in women. Overt thyroid dysfunction may manifest as aging itself or as age-associated disorders of other organs. Therefore, an accurate clinical suspicion is essential for their detection in elders with multiple comorbidities, malnutrition, and chronic polypharmacy. Because chronic diseases are more prevalent in old age, nonthyroidal illness is also common in this age group. Most thyroid nodules in older persons are benign, yet a comprehensive individualized evaluation is needed in order to timely detect malignancy. While there is still debate on the decision to treat or not to treat subclinical thyroid disorders, current recommendations indicate the necessity of considering treatment on an individual bases, balancing the possible benefit on quality of life versus the risks in the older person. Extended screening and treatment in the community population aged 65 years and over is discouraged, but screening on at-risk populations is recommended.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Thyroid Disorders in Old Age. Reference Module in Biomedical Sciences 2019, 1 .

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Thyroid Disorders in Old Age. Reference Module in Biomedical Sciences. 2019; ():1.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2019. "Thyroid Disorders in Old Age." Reference Module in Biomedical Sciences , no. : 1.

Encyclopedia
Published: 21 March 2019 in Reference Module in Biomedical Sciences
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The world average life expectancy has increased remarkably in the past century and continues to increase relentlessly. A long life is desirable but best if lived in good physical and mental health. Among the various dietary patterns, a large body of research data suggest that the traditional dietary habits and lifestyle unique to the Mediterranean region are associated with lower incidence of chronic diseases and improve longevity. Starting with the first data from the Seven Countries Study, numerous observational, prospective, and trial-based investigations in different populations have thereafter supported the benefits of adhering to the Mediterranean dietary pattern regarding reduced mortality, and prevention and treatment of age-associated chronic disorders, such as cardiovascular and metabolic diseases, some types of cancer, neurodegenerative diseases, depression, hip fractures, and frailty. Furthermore, Mediterranean diet is also sustainable; hence, this intangible heritage configures a healthy way of eating and of living in harmony with the environment.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Mediterranean Diet and Longevity. Reference Module in Biomedical Sciences 2019, 1 .

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Mediterranean Diet and Longevity. Reference Module in Biomedical Sciences. 2019; ():1.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2019. "Mediterranean Diet and Longevity." Reference Module in Biomedical Sciences , no. : 1.

Journal article
Published: 01 January 2019 in Internal Medicine: Open Access
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Magnesium and Health, Mario Barbagallo and Ligia J Dominguez

ACS Style

Mario Barbagallo; Ligia J Dominguez. Magnesium and Health. Internal Medicine: Open Access 2019, 09, 1 -2.

AMA Style

Mario Barbagallo, Ligia J Dominguez. Magnesium and Health. Internal Medicine: Open Access. 2019; 09 (02):1-2.

Chicago/Turabian Style

Mario Barbagallo; Ligia J Dominguez. 2019. "Magnesium and Health." Internal Medicine: Open Access 09, no. 02: 1-2.

Chapter
Published: 14 November 2018 in Healthy Ageing and Longevity
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Reduced Magnesium (Mg) intake is a frequent cause of Mg deficit with age. A decreased intestinal Mg absorption and an increased Mg loss may also contribute, as well as the use of medicaments. Furthermore, Mg requirements may be higher with aging. Alterations of Mg metabolism with age, cellular Mg transport systems and problems with measurement methods are discussed. Mg contained in water is more bio-available than Mg in food and it is a possible alternative to Mg supplementation in the correction of Mg deficiencies. Mild to moderate Mg deficits are generally asymptomatic and clinical signs are usually absent or non-specific. Hyperemotionality, tremor, asthenia, sleep disorders, and amnesic and cognitive disturbances are frequent in older adults, and may be often overlooked or confused with age-related symptoms. Chronic Mg deficiency results in oxidative stress and chronic, low-grade inflammation, which may be linked to several age-related diseases, and to the aging process itself. Mg deficit-related conditions may involve different tissues and organs, including hypertension and cardiovascular diseases, diabetes mellitus and metabolic syndrome, asthma and airways constrictive syndromes, depression and psychiatric disorders, Alzheimer’s disease and neuromuscular diseases (chronic fatigue, muscle pain, fibromyalgia), fragility fractures, and cancer. Keeping an optimal Mg balance throughout life might help to prevent some chronic disease associated to aging, and to extend healthy life. This needs to be proven by future studies.

ACS Style

Mario Barbagallo; Ligia J. Dominguez. Magnesium Role in Health and Longevity. Healthy Ageing and Longevity 2018, 235 -264.

AMA Style

Mario Barbagallo, Ligia J. Dominguez. Magnesium Role in Health and Longevity. Healthy Ageing and Longevity. 2018; ():235-264.

Chicago/Turabian Style

Mario Barbagallo; Ligia J. Dominguez. 2018. "Magnesium Role in Health and Longevity." Healthy Ageing and Longevity , no. : 235-264.

Review
Published: 07 June 2018
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Cognitive impairment results from a complex interplay of many factors. The most important independent predictor of cognitive decline is age but other contributing factors include demographic, genetic, socio-economic, and environmental parameters, including nutrition. The number of persons with cognitive decline and dementia will increase in the next decades in parallel with aging of the world population. Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions. Thus, nutritional approaches to prevent or slow cognitive decline could have a remarkable public health impact. Several dietary components and supplements have been examined in relation to their association with the development of cognitive decline. A number of studies have examined the role of dietary patterns on late-life cognition, with accumulating evidence that combinations of foods and nutrients may act synergistically to provide stronger benefit than those conferred by individual dietary components. Higher adherence to the Mediterranean dietary pattern has been associated with decreased cognitive decline and incident AD. Another dietary pattern with neuroprotective actions is the Dietary Approach to Stop Hypertension (DASH). The combination of these two dietary patterns has been associated with slower rates of cognitive decline and significant reduction in incident AD. This review evaluates the evidence for the effects of some dietary components, supplements, and dietary patterns as neuroprotective, with potential to delay cognitive decline and the onset of dementia.

ACS Style

Ligia J. Dominguez; Mario Barbagallo. Nutritional prevention of cognitive decline and dementia. 2018, 89, 276 -290.

AMA Style

Ligia J. Dominguez, Mario Barbagallo. Nutritional prevention of cognitive decline and dementia. . 2018; 89 (2):276-290.

Chicago/Turabian Style

Ligia J. Dominguez; Mario Barbagallo. 2018. "Nutritional prevention of cognitive decline and dementia." 89, no. 2: 276-290.

Journal article
Published: 16 November 2017 in Nutrients
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Inadequate magnesium (Mg) intake is associated with lower physical performance, but the relationship with frailty in older people is unclear. Therefore, we aimed to investigate whether higher dietary Mg intake is associated with a lower risk of frailty in a large cohort of North American individuals. Details regarding Mg intake were recorded through a food-frequency questionnaire (FFQ) and categorized as greater than/equal to Recommended Dietary Allowance (RDA) vs. lower. Frailty was defined using the Study of Osteoporotic Fractures index. Multivariable Cox’s regression analyses, calculating hazard ratios (HRs) with 95% confidence intervals (CIs), were undertaken by sex. In total, 4421 individuals with knee osteoarthritis or who were at high risk without frailty at baseline (mean age: 61.3, females = 58.0%) were followed for 8 years. After adjusting for 11 potential baseline confounders, reaching the RDA for Mg lowered risk of frailty among men (total n = 1857, HR = 0.51; 95% CI: 0.26–0.93), whilst no significant associations were found in women (total n = 2564). Each 100 mg of dietary Mg intake at baseline corresponded to a 22% reduction in men (HR = 0.78; 95% CI: 0.62–0.97; p = 0.03), but not in women (HR = 1.05; 95% CI: 0.89–1.23). In conclusion, higher dietary Mg intake appears to reduce the risk of frailty in men, but not in women.

ACS Style

Nicola Veronese; Brendon Stubbs; Stefania Maggi; Maria Notarnicola; Mario Barbagallo; Joseph Firth; Ligia J. Dominguez; Maria Gabriella Caruso. Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study. Nutrients 2017, 9, 1253 .

AMA Style

Nicola Veronese, Brendon Stubbs, Stefania Maggi, Maria Notarnicola, Mario Barbagallo, Joseph Firth, Ligia J. Dominguez, Maria Gabriella Caruso. Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study. Nutrients. 2017; 9 (11):1253.

Chicago/Turabian Style

Nicola Veronese; Brendon Stubbs; Stefania Maggi; Maria Notarnicola; Mario Barbagallo; Joseph Firth; Ligia J. Dominguez; Maria Gabriella Caruso. 2017. "Dietary Magnesium and Incident Frailty in Older People at Risk for Knee Osteoarthritis: An Eight-Year Longitudinal Study." Nutrients 9, no. 11: 1253.

Review
Published: 30 December 2016 in Clinical and Translational Allergy
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The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA—disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.

ACS Style

J. Bousquet; P. W. Hellings; I. Agache; A. Bedbrook; C. Bachert; K. C. Bergmann; M. Bewick; C. Bindslev-Jensen; S. Bosnic-Anticevitch; C. Bucca; D. P. Caimmi; P. A. M. Camargos; G. W. Canonica; T. Casale; N. H. Chavannes; A. A. Cruz; G. De Carlo; R. Dahl; P. Demoly; P. Devillier; J. Fonseca; W. J. Fokkens; N. A. Guldemond; T. Haahtela; M. Illario; J. Just; T. Keil; L. Klimek; P. Kuna; D. Larenas-Linnemann; M. Morais-Almeida; J. Mullol; R. Murray; R. Naclerio; R. E. O’Hehir; N. G. Papadopoulos; R. Pawankar; P. Potter; D. Ryan; B. Samolinski; H. J. Schunemann; A. Sheikh; F. E. R. Simons; C. Stellato; A. Todo-Bom; P. V. Tomazic; A. Valiulis; E. Valovirta; M. T. Ventura; M. Wickman; I. Young; A. Yorgancioglu; T. Zuberbier; W. Aberer; C. A. Akdis; M. Akdis; I. Annesi-Maesano; J. Ankri; I. J. Ansotegui; J. M. Anto; S. Arnavielhe; A. Asarnoj; H. Arshad; F. Avolio; I. Baiardini; C. Barbara; M. Barbagallo; E. D. Bateman; B. Beghé; E. H. Bel; K. S. Bennoor; M. Benson; A. Z. Białoszewski; T. Bieber; L. Bjermer; H. Blain; F. Blasi; A. L. Boner; M. Bonini; S. Bonini; I. Bosse; J. Bouchard; L. P. Boulet; R. Bourret; P. J. Bousquet; F. Braido; Andrew Briggs; C. E. Brightling; J. Brozek; R. Buhl; C. Bunu; E. Burte; A. Bush; F. Caballero-Fonseca; M. A. Calderon; T. Camuzat; V. Cardona; P. Carreiro-Martins; A. M. Carriazo; K. H. Carlsen; W. Carr; A. M. Cepeda Sarabia; M. Cesari; L. Chatzi; R. Chiron; T. Chivato; E. Chkhartishvili; A. G. Chuchalin; K. F. Chung; G. Ciprandi; J. Correia de Sousa; L. Cox; G. Crooks; A. Custovic; S. E. Dahlen; U. Darsow; T. Dedeu; D. Deleanu; J. A. Denburg; G. De Vries; A. Didier; A. T. Dinh-Xuan; D. Dokic; H. Douagui; G. Dray; R. Dubakiene; S. R. Durham; G. Du Toit; M. S. Dykewicz; P. Eklund; Y. El-Gamal; E. Ellers; R. Emuzyte; J. Farrell; A. Fink Wagner; A. Fiocchi; M. Fletcher; F. Forastiere; M. Gaga; A. Gamkrelidze; B. Gemicioğlu; J. E. Gereda; R. Gerth van Wick; S. González Diaz; I. Grisle; L. Grouse; Z. Gutter; M. A. Guzmán; B. Hellquist-Dahl; J. Heinrich; F. Horak; J. O’. B. Hourihane; M. Humbert; M. Hyland; G. Iaccarino; E. J. Jares; C. Jeandel; S. L. Johnston; G. Joos; O. Jonquet; K. S. Jung; M. Jutel; I. Kaidashev; M. Khaitov; O. Kalayci; A. F. Kalyoncu; P. Kardas; P. K. Keith; M. Kerkhof; H. A. M. Kerstjens; N. Khaltaev; M. Kogevinas; V. Kolek; G. H. Koppelman; M. L. Kowalski; M. Kuitunen; I. Kull; V. Kvedariene; B. Lambrecht; S. Lau; D. Laune; L. T. T. Le; P. Lieberman; B. Lipworth; J. Li; R. Louis; C. Lupinek; W. MacNee; Y. Magar; A. Magnan; B. Mahboub; D. Maier; I. Majer; J. Malva; P. Manning; E. De Manuel Keenoy; G. D. Marshall; M. R. Masjedi; E. Mathieu-Dupas; M. Maurer; S. Mavale-Manuel; E. Melén; E. Melo-Gomes; E. O. Meltzer; J. Mercier; H. Merk; N. Miculinic; F. Mihaltan; B. Milenkovic; J. Millot-Keurinck; Y. Mohammad; I. Momas; R. Mösges; A. Muraro; L. Namazova-Baranova; R. Nadif; H. Neffen; K. Nekam; A. Nieto; B. Niggemann; L. Nogueira-Silva; M. Nogues; T. D. Nyembue; K. Ohta; Y. Okamoto; K. Okubo; M. Olive-Elias; S. Ouedraogo; P. Paggiaro; I. Pali-Schöll; S. Palkonen; P. Panzner; A. Papi; H. S. Park; G. Passalacqua; S. Pedersen; A. M. Pereira; O. Pfaar; R. Picard; B. Pigearias; I. Pin; D. Plavec; W. Pohl; T. A. Popov; F. Portejoie; D. Postma; L. K. Poulsen; D. Price; K. F. Rabe; F. Raciborski; G. Roberts; C. Robalo-Cordeiro; F. Rodenas; L. Rodriguez-Mañas; C. Rolland; M. Roman Rodriguez; A. Romano; J. Rosado-Pinto; N. Rosario; M. Rottem; M. Sanchez-Borges; J. Sastre-Dominguez; G. K. Scadding; N. Scichilone; P. Schmid-Grendelmeier; E. Serrano; M. Shields; V. Siroux; J. C. Sisul; I. Skrindo; H. A. Smit; D. Solé; T. Sooronbaev; O. Spranger; R. Stelmach; P. J. Sterk; T. Strandberg; J. Sunyer; C. Thijs; M. Triggiani; R. Valenta; A. Valero; M. van Eerd; E. van Ganse; M. van Hague; O. Vandenplas; L. L. Varona; B. Vellas; G. Vezzani; T. Vazankari; G. Viegi; T. Vontetsianos; M. Wagenmann; S. Walker; D. Y. Wang; U. Wahn; T. Werfel; B. Whalley; D. M. Williams; S. Williams; N. Wilson; J. Wright; B. P. Yawn; P. K. Yiallouros; O. M. Yusuf; A. Zaidi; H. J. Zar; M. E. Zernotti; L. Zhang; N. Zhong; M. Zidarn. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clinical and Translational Allergy 2016, 6, 1 -14.

AMA Style

J. Bousquet, P. W. Hellings, I. Agache, A. Bedbrook, C. Bachert, K. C. Bergmann, M. Bewick, C. Bindslev-Jensen, S. Bosnic-Anticevitch, C. Bucca, D. P. Caimmi, P. A. M. Camargos, G. W. Canonica, T. Casale, N. H. Chavannes, A. A. Cruz, G. De Carlo, R. Dahl, P. Demoly, P. Devillier, J. Fonseca, W. J. Fokkens, N. A. Guldemond, T. Haahtela, M. Illario, J. Just, T. Keil, L. Klimek, P. Kuna, D. Larenas-Linnemann, M. Morais-Almeida, J. Mullol, R. Murray, R. Naclerio, R. E. O’Hehir, N. G. Papadopoulos, R. Pawankar, P. Potter, D. Ryan, B. Samolinski, H. J. Schunemann, A. Sheikh, F. E. R. Simons, C. Stellato, A. Todo-Bom, P. V. Tomazic, A. Valiulis, E. Valovirta, M. T. Ventura, M. Wickman, I. Young, A. Yorgancioglu, T. Zuberbier, W. Aberer, C. A. Akdis, M. Akdis, I. Annesi-Maesano, J. Ankri, I. J. Ansotegui, J. M. Anto, S. Arnavielhe, A. Asarnoj, H. Arshad, F. Avolio, I. Baiardini, C. Barbara, M. Barbagallo, E. D. Bateman, B. Beghé, E. H. Bel, K. S. Bennoor, M. Benson, A. Z. Białoszewski, T. Bieber, L. Bjermer, H. Blain, F. Blasi, A. L. Boner, M. Bonini, S. Bonini, I. Bosse, J. Bouchard, L. P. Boulet, R. Bourret, P. J. Bousquet, F. Braido, Andrew Briggs, C. E. Brightling, J. Brozek, R. Buhl, C. Bunu, E. Burte, A. Bush, F. Caballero-Fonseca, M. A. Calderon, T. Camuzat, V. Cardona, P. Carreiro-Martins, A. M. Carriazo, K. H. Carlsen, W. Carr, A. M. Cepeda Sarabia, M. Cesari, L. Chatzi, R. Chiron, T. Chivato, E. Chkhartishvili, A. G. Chuchalin, K. F. Chung, G. Ciprandi, J. Correia de Sousa, L. Cox, G. Crooks, A. Custovic, S. E. Dahlen, U. Darsow, T. Dedeu, D. Deleanu, J. A. Denburg, G. De Vries, A. Didier, A. T. Dinh-Xuan, D. Dokic, H. Douagui, G. Dray, R. Dubakiene, S. R. Durham, G. Du Toit, M. S. Dykewicz, P. Eklund, Y. El-Gamal, E. Ellers, R. Emuzyte, J. Farrell, A. Fink Wagner, A. Fiocchi, M. Fletcher, F. Forastiere, M. Gaga, A. Gamkrelidze, B. Gemicioğlu, J. E. Gereda, R. Gerth van Wick, S. González Diaz, I. Grisle, L. Grouse, Z. Gutter, M. A. Guzmán, B. Hellquist-Dahl, J. Heinrich, F. Horak, J. O’. B. Hourihane, M. Humbert, M. Hyland, G. Iaccarino, E. J. Jares, C. Jeandel, S. L. Johnston, G. Joos, O. Jonquet, K. S. Jung, M. Jutel, I. Kaidashev, M. Khaitov, O. Kalayci, A. F. Kalyoncu, P. Kardas, P. K. Keith, M. Kerkhof, H. A. M. Kerstjens, N. Khaltaev, M. Kogevinas, V. Kolek, G. H. Koppelman, M. L. Kowalski, M. Kuitunen, I. Kull, V. Kvedariene, B. Lambrecht, S. Lau, D. Laune, L. T. T. Le, P. Lieberman, B. Lipworth, J. Li, R. Louis, C. Lupinek, W. MacNee, Y. Magar, A. Magnan, B. Mahboub, D. Maier, I. Majer, J. Malva, P. Manning, E. De Manuel Keenoy, G. D. Marshall, M. R. Masjedi, E. Mathieu-Dupas, M. Maurer, S. Mavale-Manuel, E. Melén, E. Melo-Gomes, E. O. Meltzer, J. Mercier, H. Merk, N. Miculinic, F. Mihaltan, B. Milenkovic, J. Millot-Keurinck, Y. Mohammad, I. Momas, R. Mösges, A. Muraro, L. Namazova-Baranova, R. Nadif, H. Neffen, K. Nekam, A. Nieto, B. Niggemann, L. Nogueira-Silva, M. Nogues, T. D. Nyembue, K. Ohta, Y. Okamoto, K. Okubo, M. Olive-Elias, S. Ouedraogo, P. Paggiaro, I. Pali-Schöll, S. Palkonen, P. Panzner, A. Papi, H. S. Park, G. Passalacqua, S. Pedersen, A. M. Pereira, O. Pfaar, R. Picard, B. Pigearias, I. Pin, D. Plavec, W. Pohl, T. A. Popov, F. Portejoie, D. Postma, L. K. Poulsen, D. Price, K. F. Rabe, F. Raciborski, G. Roberts, C. Robalo-Cordeiro, F. Rodenas, L. Rodriguez-Mañas, C. Rolland, M. Roman Rodriguez, A. Romano, J. Rosado-Pinto, N. Rosario, M. Rottem, M. Sanchez-Borges, J. Sastre-Dominguez, G. K. Scadding, N. Scichilone, P. Schmid-Grendelmeier, E. Serrano, M. Shields, V. Siroux, J. C. Sisul, I. Skrindo, H. A. Smit, D. Solé, T. Sooronbaev, O. Spranger, R. Stelmach, P. J. Sterk, T. Strandberg, J. Sunyer, C. Thijs, M. Triggiani, R. Valenta, A. Valero, M. van Eerd, E. van Ganse, M. van Hague, O. Vandenplas, L. L. Varona, B. Vellas, G. Vezzani, T. Vazankari, G. Viegi, T. Vontetsianos, M. Wagenmann, S. Walker, D. Y. Wang, U. Wahn, T. Werfel, B. Whalley, D. M. Williams, S. Williams, N. Wilson, J. Wright, B. P. Yawn, P. K. Yiallouros, O. M. Yusuf, A. Zaidi, H. J. Zar, M. E. Zernotti, L. Zhang, N. Zhong, M. Zidarn. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clinical and Translational Allergy. 2016; 6 (1):1-14.

Chicago/Turabian Style

J. Bousquet; P. W. Hellings; I. Agache; A. Bedbrook; C. Bachert; K. C. Bergmann; M. Bewick; C. Bindslev-Jensen; S. Bosnic-Anticevitch; C. Bucca; D. P. Caimmi; P. A. M. Camargos; G. W. Canonica; T. Casale; N. H. Chavannes; A. A. Cruz; G. De Carlo; R. Dahl; P. Demoly; P. Devillier; J. Fonseca; W. J. Fokkens; N. A. Guldemond; T. Haahtela; M. Illario; J. Just; T. Keil; L. Klimek; P. Kuna; D. Larenas-Linnemann; M. Morais-Almeida; J. Mullol; R. Murray; R. Naclerio; R. E. O’Hehir; N. G. Papadopoulos; R. Pawankar; P. Potter; D. Ryan; B. Samolinski; H. J. Schunemann; A. Sheikh; F. E. R. Simons; C. Stellato; A. Todo-Bom; P. V. Tomazic; A. Valiulis; E. Valovirta; M. T. Ventura; M. Wickman; I. Young; A. Yorgancioglu; T. Zuberbier; W. Aberer; C. A. Akdis; M. Akdis; I. Annesi-Maesano; J. Ankri; I. J. Ansotegui; J. M. Anto; S. Arnavielhe; A. Asarnoj; H. Arshad; F. Avolio; I. Baiardini; C. Barbara; M. Barbagallo; E. D. Bateman; B. Beghé; E. H. Bel; K. S. Bennoor; M. Benson; A. Z. Białoszewski; T. Bieber; L. Bjermer; H. Blain; F. Blasi; A. L. Boner; M. Bonini; S. Bonini; I. Bosse; J. Bouchard; L. P. Boulet; R. Bourret; P. J. Bousquet; F. Braido; Andrew Briggs; C. E. Brightling; J. Brozek; R. Buhl; C. Bunu; E. Burte; A. Bush; F. Caballero-Fonseca; M. A. Calderon; T. Camuzat; V. Cardona; P. Carreiro-Martins; A. M. Carriazo; K. H. Carlsen; W. Carr; A. M. Cepeda Sarabia; M. Cesari; L. Chatzi; R. Chiron; T. Chivato; E. Chkhartishvili; A. G. Chuchalin; K. F. Chung; G. Ciprandi; J. Correia de Sousa; L. Cox; G. Crooks; A. Custovic; S. E. Dahlen; U. Darsow; T. Dedeu; D. Deleanu; J. A. Denburg; G. De Vries; A. Didier; A. T. Dinh-Xuan; D. Dokic; H. Douagui; G. Dray; R. Dubakiene; S. R. Durham; G. Du Toit; M. S. Dykewicz; P. Eklund; Y. El-Gamal; E. Ellers; R. Emuzyte; J. Farrell; A. Fink Wagner; A. Fiocchi; M. Fletcher; F. Forastiere; M. Gaga; A. Gamkrelidze; B. Gemicioğlu; J. E. Gereda; R. Gerth van Wick; S. González Diaz; I. Grisle; L. Grouse; Z. Gutter; M. A. Guzmán; B. Hellquist-Dahl; J. Heinrich; F. Horak; J. O’. B. Hourihane; M. Humbert; M. Hyland; G. Iaccarino; E. J. Jares; C. Jeandel; S. L. Johnston; G. Joos; O. Jonquet; K. S. Jung; M. Jutel; I. Kaidashev; M. Khaitov; O. Kalayci; A. F. Kalyoncu; P. Kardas; P. K. Keith; M. Kerkhof; H. A. M. Kerstjens; N. Khaltaev; M. Kogevinas; V. Kolek; G. H. Koppelman; M. L. Kowalski; M. Kuitunen; I. Kull; V. Kvedariene; B. Lambrecht; S. Lau; D. Laune; L. T. T. Le; P. Lieberman; B. Lipworth; J. Li; R. Louis; C. Lupinek; W. MacNee; Y. Magar; A. Magnan; B. Mahboub; D. Maier; I. Majer; J. Malva; P. Manning; E. De Manuel Keenoy; G. D. Marshall; M. R. Masjedi; E. Mathieu-Dupas; M. Maurer; S. Mavale-Manuel; E. Melén; E. Melo-Gomes; E. O. Meltzer; J. Mercier; H. Merk; N. Miculinic; F. Mihaltan; B. Milenkovic; J. Millot-Keurinck; Y. Mohammad; I. Momas; R. Mösges; A. Muraro; L. Namazova-Baranova; R. Nadif; H. Neffen; K. Nekam; A. Nieto; B. Niggemann; L. Nogueira-Silva; M. Nogues; T. D. Nyembue; K. Ohta; Y. Okamoto; K. Okubo; M. Olive-Elias; S. Ouedraogo; P. Paggiaro; I. Pali-Schöll; S. Palkonen; P. Panzner; A. Papi; H. S. Park; G. Passalacqua; S. Pedersen; A. M. Pereira; O. Pfaar; R. Picard; B. Pigearias; I. Pin; D. Plavec; W. Pohl; T. A. Popov; F. Portejoie; D. Postma; L. K. Poulsen; D. Price; K. F. Rabe; F. Raciborski; G. Roberts; C. Robalo-Cordeiro; F. Rodenas; L. Rodriguez-Mañas; C. Rolland; M. Roman Rodriguez; A. Romano; J. Rosado-Pinto; N. Rosario; M. Rottem; M. Sanchez-Borges; J. Sastre-Dominguez; G. K. Scadding; N. Scichilone; P. Schmid-Grendelmeier; E. Serrano; M. Shields; V. Siroux; J. C. Sisul; I. Skrindo; H. A. Smit; D. Solé; T. Sooronbaev; O. Spranger; R. Stelmach; P. J. Sterk; T. Strandberg; J. Sunyer; C. Thijs; M. Triggiani; R. Valenta; A. Valero; M. van Eerd; E. van Ganse; M. van Hague; O. Vandenplas; L. L. Varona; B. Vellas; G. Vezzani; T. Vazankari; G. Viegi; T. Vontetsianos; M. Wagenmann; S. Walker; D. Y. Wang; U. Wahn; T. Werfel; B. Whalley; D. M. Williams; S. Williams; N. Wilson; J. Wright; B. P. Yawn; P. K. Yiallouros; O. M. Yusuf; A. Zaidi; H. J. Zar; M. E. Zernotti; L. Zhang; N. Zhong; M. Zidarn. 2016. "ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle." Clinical and Translational Allergy 6, no. 1: 1-14.

Journal article
Published: 20 May 2016 in European Geriatric Medicine
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Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest group on falls and fracture prevention of the European union geriatric medicine society (EUGMS), in collaboration with the International association of gerontology and geriatrics for the European region (IAGG-ER), the European union of medical specialists (EUMS), the Fragility fracture network (FFN), the International osteoporosis foundation (IOF) – European society for clinical and economic aspects of osteoporosis and osteoarthritis (ECCEO), outlines its views on the main points in the current debate in relation to the primary and secondary prevention of falls, the diagnosis and treatment of bone fragility, and the place of combined falls and fracture liaison services for fracture prevention in older people.

ACS Style

H. Blain; T. Masud; P. Dargent-Molina; F.C. Martin; E. Rosendahl; N. van der Velde; J. Bousquet; A. Benetos; C. Cooper; J.A. Kanis; J.Y. Reginster; R. Rizzoli; B. Cortet; M. Barbagallo; K. Dreinhöfer; B. Vellas; S. Maggi; T. Strandberg; M.N. Alvarez; C. Annweiler; P.-L. Bernard; N. Beswetherick; H.A. Bischoff-Ferrari; F. Bloch; J. Boddaert; M. Bonnefoy; V. Bousson; I. Bourdel-Marchasson; A. Capisizu; H. Che; J.G. Clara; B. Combe; D. Delignieres; P. Eklund; M. Emmelot-Vonk; E. Freiberger; J.-B. Gauvain; N. Goswami; N. Guldemond; Á.C. Herrero; M.-E. Joël; A.B. Jónsdóttir; G. Kemoun; I. Kiss; H. Kolk; M.L. Kowalski; Š. Krajcík; Y.G. Kutsal; Fulvio Lauretani; J. Macijauskienė; M. Mellingsæter; J. Morel; F. Mourey; F. Nourashemi; C. Nyakas; F. Puisieux; P. Rambourg; A.G. Ramírez; K. Rapp; Y. Rolland; J. Ryg; O. Sahota; S. Snoeijs; Y. Stephan; E. Thomas; Chris Todd; J. Treml; R. Adachi; D. Agnusdei; J.-J. Body; V. Breuil; Olivier Bruyere; P. Burckardt; J.B. Cannata-Andia; J. Carey; D.-C. Chan; L. Chapuis; T. Chevalley; M. Cohen-Solal; B. Dawson-Hughes; E.M. Dennison; J.-P. Devogelaer; P. Fardellone; J.-M. Féron; A.D. Perez; D. Felsenberg; C. Glueer; N. Harvey; M. Hiligsman; M.K. Javaid; N.R. Jörgensen; D. Kendler; M. Kraenzlin; M. Laroche; E. Legrand; William Leslie; E. Lespessailles; E.M. Lewiecki; T. Nakamura; A. Papaioannou; C. Roux; S. Silverman; M.S. Henriquez; T. Thomas; S. Vasikaran; N.B. Watts; G. Weryha. A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement. European Geriatric Medicine 2016, 7, 519 -525.

AMA Style

H. Blain, T. Masud, P. Dargent-Molina, F.C. Martin, E. Rosendahl, N. van der Velde, J. Bousquet, A. Benetos, C. Cooper, J.A. Kanis, J.Y. Reginster, R. Rizzoli, B. Cortet, M. Barbagallo, K. Dreinhöfer, B. Vellas, S. Maggi, T. Strandberg, M.N. Alvarez, C. Annweiler, P.-L. Bernard, N. Beswetherick, H.A. Bischoff-Ferrari, F. Bloch, J. Boddaert, M. Bonnefoy, V. Bousson, I. Bourdel-Marchasson, A. Capisizu, H. Che, J.G. Clara, B. Combe, D. Delignieres, P. Eklund, M. Emmelot-Vonk, E. Freiberger, J.-B. Gauvain, N. Goswami, N. Guldemond, Á.C. Herrero, M.-E. Joël, A.B. Jónsdóttir, G. Kemoun, I. Kiss, H. Kolk, M.L. Kowalski, Š. Krajcík, Y.G. Kutsal, Fulvio Lauretani, J. Macijauskienė, M. Mellingsæter, J. Morel, F. Mourey, F. Nourashemi, C. Nyakas, F. Puisieux, P. Rambourg, A.G. Ramírez, K. Rapp, Y. Rolland, J. Ryg, O. Sahota, S. Snoeijs, Y. Stephan, E. Thomas, Chris Todd, J. Treml, R. Adachi, D. Agnusdei, J.-J. Body, V. Breuil, Olivier Bruyere, P. Burckardt, J.B. Cannata-Andia, J. Carey, D.-C. Chan, L. Chapuis, T. Chevalley, M. Cohen-Solal, B. Dawson-Hughes, E.M. Dennison, J.-P. Devogelaer, P. Fardellone, J.-M. Féron, A.D. Perez, D. Felsenberg, C. Glueer, N. Harvey, M. Hiligsman, M.K. Javaid, N.R. Jörgensen, D. Kendler, M. Kraenzlin, M. Laroche, E. Legrand, William Leslie, E. Lespessailles, E.M. Lewiecki, T. Nakamura, A. Papaioannou, C. Roux, S. Silverman, M.S. Henriquez, T. Thomas, S. Vasikaran, N.B. Watts, G. Weryha. A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement. European Geriatric Medicine. 2016; 7 (6):519-525.

Chicago/Turabian Style

H. Blain; T. Masud; P. Dargent-Molina; F.C. Martin; E. Rosendahl; N. van der Velde; J. Bousquet; A. Benetos; C. Cooper; J.A. Kanis; J.Y. Reginster; R. Rizzoli; B. Cortet; M. Barbagallo; K. Dreinhöfer; B. Vellas; S. Maggi; T. Strandberg; M.N. Alvarez; C. Annweiler; P.-L. Bernard; N. Beswetherick; H.A. Bischoff-Ferrari; F. Bloch; J. Boddaert; M. Bonnefoy; V. Bousson; I. Bourdel-Marchasson; A. Capisizu; H. Che; J.G. Clara; B. Combe; D. Delignieres; P. Eklund; M. Emmelot-Vonk; E. Freiberger; J.-B. Gauvain; N. Goswami; N. Guldemond; Á.C. Herrero; M.-E. Joël; A.B. Jónsdóttir; G. Kemoun; I. Kiss; H. Kolk; M.L. Kowalski; Š. Krajcík; Y.G. Kutsal; Fulvio Lauretani; J. Macijauskienė; M. Mellingsæter; J. Morel; F. Mourey; F. Nourashemi; C. Nyakas; F. Puisieux; P. Rambourg; A.G. Ramírez; K. Rapp; Y. Rolland; J. Ryg; O. Sahota; S. Snoeijs; Y. Stephan; E. Thomas; Chris Todd; J. Treml; R. Adachi; D. Agnusdei; J.-J. Body; V. Breuil; Olivier Bruyere; P. Burckardt; J.B. Cannata-Andia; J. Carey; D.-C. Chan; L. Chapuis; T. Chevalley; M. Cohen-Solal; B. Dawson-Hughes; E.M. Dennison; J.-P. Devogelaer; P. Fardellone; J.-M. Féron; A.D. Perez; D. Felsenberg; C. Glueer; N. Harvey; M. Hiligsman; M.K. Javaid; N.R. Jörgensen; D. Kendler; M. Kraenzlin; M. Laroche; E. Legrand; William Leslie; E. Lespessailles; E.M. Lewiecki; T. Nakamura; A. Papaioannou; C. Roux; S. Silverman; M.S. Henriquez; T. Thomas; S. Vasikaran; N.B. Watts; G. Weryha. 2016. "A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement." European Geriatric Medicine 7, no. 6: 519-525.

Journal article
Published: 31 August 2015 in International Journal of Diabetes and Clinical Research
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Persons with type 2 diabetes mellitus (DM2) have an increased incidence of cognitive decline and dementia. An increased cortical and subcortical atrophy has been found after controlling for vascular disease and inadequate cerebral circulation.

ACS Style

Mario Barbagallo. Diabetes and Dementia. International Journal of Diabetes and Clinical Research 2015, 2, 1 .

AMA Style

Mario Barbagallo. Diabetes and Dementia. International Journal of Diabetes and Clinical Research. 2015; 2 (4):1.

Chicago/Turabian Style

Mario Barbagallo. 2015. "Diabetes and Dementia." International Journal of Diabetes and Clinical Research 2, no. 4: 1.

Review article
Published: 07 April 2015 in Mediators of Inflammation
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Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). Fermented papaya (FPP, a product ofCarica papaya Linnfermentation with yeast) is a nutraceutical supplement with favorable effects on immunological, hematological, inflammatory, and OS parameters in chronic/degenerative diseases. We studied 40 patients (age 78.2 ± 1.1 years), 28 AD patients, and 12 controls. Urinary 8-OHdG was measured to assess OS. Twenty AD patients were supplemented with FPP (Immunage, 4.5 grams/day) for 6 months, while controls did not receive any treatment. At baseline, 8-OHdG was significantly higher in patients with AD versus controls (13.7 ± 1.61 ng/mL versus 1.6 ± 0.12 ng/mL,P<0.01). In AD patients FPP significantly decreased 8-OHdG (14.1 ± 1.7 ng/mL to 8.45 ± 1.1 ng/mL,P<0.01), with no significant changes in controls. AD is associated with increased OS, and FPP may be helpful to counteract excessive ROS in AD patients.

ACS Style

Mario Barbagallo; Francesco Marotta; Ligia J. Dominguez. Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder. Mediators of Inflammation 2015, 2015, 1 -6.

AMA Style

Mario Barbagallo, Francesco Marotta, Ligia J. Dominguez. Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder. Mediators of Inflammation. 2015; 2015 ():1-6.

Chicago/Turabian Style

Mario Barbagallo; Francesco Marotta; Ligia J. Dominguez. 2015. "Oxidative Stress in Patients with Alzheimer’s Disease: Effect of Extracts of Fermented Papaya Powder." Mediators of Inflammation 2015, no. : 1-6.