The aim of this study was to promote bioactivity of the PEEK surface using sulfuric acid and piranha solution. PEEK was functionalized by a sulfuric acid treatment for 90 s and by piranha solution for 60 and 90 s. Chemical modification of the PEEK surface was evaluated by infrared spectroscopy, contact angle analysis, cytotoxicity, cell adhesion and proliferation. The spectroscopy characteristic band associated with sulfonation was observed in all treated samples. PEEK with piranha solution 60 s showed an increase in the intensity of the bands, which was even more significant for the longer treatment (90 s). The introduction of the sulfonic acid functional group reduced the contact angle. In cytotoxicity assays, for all treatments, the number of viable cells was higher when compared to those of untreated PEEK. PEEK treated with sulfuric acid and piranha solution for 60 s were the treatments that showed the highest percentage of cell viability with no statistically significant differences between them. The modified surfaces had a greater capacity for inducing cell growth, indicative of effective cell adhesion and proliferation. The proposed chemical modifications are promising for the functionalization of PEEK-based implants, as they were effective in promoting bioactivation of the PEEK surface and in stimulating cell growth and proliferation.

This study aimed to achieve bioactivity on the PEEK surface using piranha solution through a lower functionalization time. For this purpose, the functionalization occurred with piranha solution and 98% sulfuric acid in the proportions of 1:2, 1:1, and 2:1 at periods of 30, 60, and 90 s. The samples treated for longer times at higher concentrations registered the characteristic spectroscopy band associated with sulfonation. Additionally, both chemical treatments allowed the opening of the aromatic ring, increasing the number of functional groups available and making the surface more hydrophilic. The piranha solution treatments with higher concentrations and longer times promoted greater heterogeneity in the surface pores, which affected the roughness of untreated PEEK. Furthermore, the treatments induced calcium deposition on the surface during immersion in SBF fluid. In conclusion, the proposed chemical modifications using sulfuric acid SPEEK 90 and, especially, the piranha solution PEEK-PS 2:1-90, were demonstrated to be promising in promoting the rapid bioactivation of PEEK-based implants.

This study aimed to develop meshes from the weaving of mono- and multifilament wet-spun chitosan (CS), for possible biomedical applications. In the wet-spinning process, CS solution (4% w/v) was extruded in a coagulation bath containing 70% sodium hydroxide solution (0.5 M), and 30% methanol was used. The multifilament thread was prepared by twisted of two and three monofilaments. CS threads obtained were characterized by tensile tests and scanning electron microscopy (SEM). Moreover, it was verified from the morphological tests that threads preserve the characteristics of the individual filaments and present typical “skin-core” microstructure obtained by wet spinning. CS woven meshes obtained were evaluated by optical microscopy (OM), tensile test, swelling degree, and in vitro enzymatic biodegradation. Mechanical properties, biodegradation rate, and amount of fluid absorbed of CS woven meshes were influenced by thread configuration. Hydrated CS meshes showed a larger elastic zone than the dry state. Therefore, CS woven meshes were obtained with modular properties from thread configuration used in weaving, suggesting potential applications in the biomedical field, like dressings, controlled drug delivery systems, or mechanical support.

Polyetheretherketone (PEEK) has been prominent in orthopedic implants; however, it is inert, preventing interaction between the implant and adjacent bone tissues. One way to overcome this characteristic is physical modification its on surface by particle leaching promoting greater osseointegration. The objective of this research was to develop and characterize the PEEK using a surface modification technique via particle leaching. For of the samples, a layer deposition of NaCl was used on PEEK. This was subjected to the pressure of 850 kg/cm2 by 390ºC for 20 minutes. After cooling, were subjected to leaching process particles. The results indicated a porous surface exhibiting uniform and homogeneous morphology with defined pores interconected, to in the range of 140-373 µm, with an average diameter of 273 µm. These evidenced the considerable NaCl removal after the leaching process, with cavities from ideal sizes which promotes adequate cellular accommodation and distinct roughness, giving an overall possibility of being able to obtain a material more able to receive the cells while also possibly presenting cell viability. Although the compressive strength presented low values, it can still be suitable for applications in areas with a reduced modulus of elasticity.

Com intuito de identificar o perfil tecnológico da UEPB e as pesquisas com potencial inovador, foram analisadas tecnologias protegidas, traçando o perfil tecnológico da instituição. Posteriormente, foram mapeadas as pesquisas com potencial inovador submetidos aos editais de iniciação científica e tecnológica nos anos de 2011-2021, a escolha foi de acordo com as grandes áreas da Capes e Classificação Internacional de Patentes (CIP). Foi identificado que a maior parte das tecnologias protegidas ocorreu na forma de patentes, seguindo pelo registro de software, não sendo observados outros tipos de proteção. Quanto ao perfil tecnológico, a área de Ciências da Saúde destaca-se em termos de produção tecnológica. Contudo, 76% das pesquisas possuem potencial inovador, podendo ser protegidas. Logo, é possível traçar o retrato tecnológico institucional por meio do monitoramento periódico dessas tecnologias, contribuindo para o planejamento de ações e visando a estimular a proteção intelectual e a transferência tecnológica na UEPB.

Com intuito de identificar o perfil tecnológico da UEPB e as pesquisas com potencial inovador, foram analisadas tecnologias protegidas, traçando o perfil tecnológico da instituição. Posteriormente, foram mapeadas as pesquisas com potencial inovador submetidos aos editais de iniciação científica e tecnológica nos anos de 2011-2021, a escolha foi de acordo com as grandes áreas da Capes e Classificação Internacional de Patentes (CIP). Foi identificado que a maior parte das tecnologias protegidas ocorreu na forma de patentes, seguindo pelo registro de software, não sendo observados outros tipos de proteção. Quanto ao perfil tecnológico, a área de Ciências da Saúde destaca-se em termos de produção tecnológica. Contudo, 76% das pesquisas possuem potencial inovador, podendo ser protegidas. Logo, é possível traçar o retrato tecnológico institucional por meio do monitoramento periódico dessas tecnologias, contribuindo para o planejamento de ações e visando a estimular a proteção intelectual e a transferência tecnológica na UEPB.