Social mixture has become an urban policy in Chile and Latin America. Although the corresponding initiatives seek to reduce the segregation of social classes, we still do not know whether, under the conditions of mixture and environment over which these neighbourhoods are built, it is possible (or not) to promote pluri-classist sociabilities. Using two social integration projects and a mixed methodology this article intends to fill this gap. The results suggest that due to the type of diversity promoted by these neighbourhoods, as well as because of their peripheral location in homogeneous environments, the sociabilities they produce are not diverse enough to work, for example, the so-called neighbourhood effect. The findings also reveal the importance of designing common spaces between residents, spaces that have the capacity to minimize metropolitan habitus that the middle classes deploy. It concludes with suggestions to improve and expand the social mix approach in housing policies.

La mixtura social y el clasismo parecen ser procesos antagónicos que limitan el desarrollo de una ciudad socioeconómicamente heterogénea. Este artículo busca entender la manera en que se configura la convivencia al interior de los vecindarios de ingresos mixtos, focalizando su mirada en dos barrios de Integración Social en Chile. Sobre la base de entrevistas semiestruturadas, los resultados muestran la importancia de las diferencias de clase y la aspiración de movilidad social en las disputas entre residentes. No obstante el clasismo, la convivencia en estos lugares se mantiene estable por una serie de mecanismos sociales y espaciales, entre los que cuenta la escasa sociabilidad, una definición común de buen vecino y modelos de distribución socioeconómica interna que minimizan las diferencias. Se concluye analizando la fragilidad que adquiere la convivencia de estas comunidades de extraños en contextos de crisis. The social mix and classism seems to be antagonistic processes that limit the development of a socio-economically heterogeneous city. This article seeks to understand the way in which coexistence within mixed-income neighbourhoods is configured, focusing on two neighbourhoods of Social Integration in Chile. Based on semi-structured interviews, the results show the importance of class differences and the aspiration for social mobility in disputes between residents. Notwithstanding classism, coexistence in these places is stable due to a series of social and spatial mechanisms, including low sociability, a common definition of a good neighbour and internal socioeconomic distribution models which minimize differences. It concludes by analysing the fragility that coexistence of these strange communities acquires in crisis contexts. La mixité sociale et le classisme semblent être des processus antagonistes qui limitent le développement d'une ville socio-économiquement hétérogène. Cet article cherche à comprendre la manière dont la coexistence au sein des quartiers à revenus mixtes est configurée, en se concentrant sur deux quartiers d'intégration sociale au Chili. Sur la base d'entretiens semi-structurés, les résultats montrent l'importance des différences de classe et de l'aspiration à la mobilité sociale dans les conflits entre résidents. Malgré le classisme, la coexistence dans ces lieux est stable en raison d'une série de mécanismes sociaux et spatiaux, y compris une faible sociabilité, une définition commune d'un bon voisin et des modèles de distribution socio-économique internes qui minimisent les différences. Il conclut en analysant la fragilité que la coexistence de ces étranges communautés acquiert dans des contextes de crise. A mistura social e o classismo parecem ser processos antagônicos que limitam o desenvolvimento de uma cidade socioeconômica heterogênea. Este artigo procura entender como a coexistência é configurada em bairros de renda mista, com foco em dois bairros da Integração Social no Chile. Com base em entrevistas semiestruturadas, os resultados mostram a importância das diferenças de classe e a aspiração à mobilidade social nas disputas entre os residentes. Não obstante o classismo, a coexistência nesses locais é estável devido a uma série de mecanismos sociais e espaciais, entre os quais a baixa socialidade, uma definição comum de um bom vizinho e modelos de distribuição socioeconômica interna que minimizam as diferenças. Conclui analisando a fragilidade que a coexistência dessas comunidades de estranhos adquire em contextos de crise.

E16717 Background: Human gallbladder cancer research lacks in vitro models that can recapitulate the pathophysiology of the original tumor and normal epithelia. Organoids cultures emulate the tumor heterogeneity and have been successively used as translational models to evaluate clinical response to anticancer drug. Here, we established and characterized patients derived organoids culture (PDOs) from human gallbladder cancer patients. Methods: Fresh tissues obtained from gallbladder cancer patients who underwent cholecystectomy were digested with Collagenase/Dispase, filtered and then suspension cells were mixed with Matrigel (1:1) for organoids establishment. Cultures were maintained at 37°C and 5% CO2. The organoids were characterized through histopathology evaluation, immunohistochemistry, and ultra-deed targeted sequencing (TruSeq protocol, Illumina, TSACP; 25 genes). In addition, we evaluated the response of organoids to gemcitabine, cisplatin and Fluorouracil (5-FU), using the CellTiter-Glo 3D luminescence assay. Results: We have successfully established PDOs cultures from six patients with gallbladder adenocarcinoma with a 60% efficiency (6/10). The PDOs recapitulated the histological features and maintained the expression of CK19, Ki67, P53 as compared with the epithelia of primary tumors. Moreover, the PDOs maintained the mutational status of major driver genes, including TP53 and PIK3CA. Finally, tumor organoids showed differential response to standard chemotherapy treatment. GBC-PDO2 and GBC-PDO4 showed high resistant to gemcitabine (IC50 > 10μM), which suggests that the personalized treatment is necessary for generate better response. Conclusions: the established gallbladder tumor organoids exhibited similar histological and genomic features in relation to their original epithelia. PDOs can be considered a valuable tool for future research aimed to understand gallbladder cancer biology and for developing personalized-medicine approaches for advanced gallbladder cancer patients. (Funding Source: FONDECYT #1171463, FONDECYT #1170893 and Fondef IT16I10051).

The platformization of urban space is opening new frontiers of capital accumulation, particularly through short-term rentals. Airbnb plays a central role in this process by commodifying housing in tourist destinations. Despite its rapid growth, research on Airbnb in Latin America—especially in small tourist cities—remains limited and largely focused on metropolitan contexts. This article addresses this gap with the objective of analyzing how platform-mediated short-term rentals reorient housing markets beyond traditional urban cores. It is hypothesized that Airbnb expands housing commodification by extending tourism-oriented uses into new residential areas and by redistributing returns unevenly across actors. Using a quantitative and geospatial approach, the results reveal a strong presence of Airbnb in rural and natural areas, from which the highest returns are extracted, as well as a high concentration of accommodation supply among professional hosts. These dynamics reconfigure housing use toward asset-based logics, posing challenges for housing security and social and territorial sustainability in small tourist cities.