Entrepreneurial orientation has recently been touted as a tool for solving enterprise failures in emerged and emerging economies especially during and after an epidemic. This study aims at understanding the impact of entrepreneurial orientation on enterprise performance in the Ghanaian food processing industry by assessing the mediating effects of innovation types and intellectual property. Data were collected from 702 owners/managers in the food processing industry via survey questionnaires. The data were analyzed using the partial least squares structural equation modeling (PLS-SEM) to test the hypothesis via the Smart PLS software. The findings show that entrepreneurial orientation, innovation types, and intellectual property positively and significantly influenced enterprise performance. Furthermore, the results indicated that the mediation effects of innovation types and intellectual property were full and partial, respectively. Useful policy implications are further proposed and discussed based on the study results.