Industry 4.0 introduces smart solutions throughout the company’s supply chain, including manual assembly, where the goal is to ensure shorter work cycle time, increase productivity and quality, while minimizing costs. Following the principles of this paradigm, this paper proposes a digital transformation of the manual assembly process by implementing a multi-criterial algorithm (MCA) for adjusting and configuring a human-centered smart manual assembly workstation to ensure efficient and ergonomic performance of the manual assembly process. The MCA takes into account various influential parameters, such as the anthropometry of the individual worker, gender, complexity of the assembly process, product characteristics, and product structure. The efficiency of the MCA was verified both in the laboratory environment with the time analysis and in the virtual environment using Digital Human Modelling through several ergonomic analyses. The results of the implementation of the MCA on a manual assembly workstation support the digital (re)design of the manual assembly process with the aim of creating an efficient and ergonomically suitable workstation for each worker, thus increasing the productivity and efficiency of the human-centered manual assembly process.

Due to increasing competition in the global market and to meet the need for rapid changes in product variability, it is necessary to introduce self-configurable and smart solutions within the entire process chain, including manual assembly to ensure the more efficient and ergonomic performance of the manual assembly process. This paper presents a smart assembly system including newly developed smart manual assembly workstation controlled by a smart algorithm. The smart assembly workstation is self-configurable according to the anthropometry of the individual worker, the complexity of the assembly process, the product characteristics, and the product structure. The results obtained by a case study show that is possible to organize manual assembly process with rapid adaptation of the smart assembly system to new products and workers characteristics, to achieve ergonomic working conditions through Digital Human Modelling (DHM), to minimize assembly time, and to prevent error during the assembly process. The proposed system supports the manual assembly process redesign to ensure a better working environment and aims to have an important value for applying the smart algorithms to manual assembly workstations in human-centered manufacturing systems.