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Mr. Francisco Cavalcante
Federal University of Ceará

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Research Keywords & Expertise

0 Biocatalysis
0 Biodiesel
0 Biofuels
0 Nanomaterials
0 Enzyme immobilization

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Review article
Published: 14 April 2021 in International Journal of Biological Macromolecules
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Chitosan is one of the most abundant natural polymer worldwide, and due to its inherent characteristics, its use in industrial processes has been extensively explored. Because it is biodegradable, biocompatible, non-toxic, hydrophilic, cheap, and has good physical-chemical stability, it is seen as an excellent alternative for the replacement of synthetic materials in the search for more sustainable production methodologies. Thus being, a possible biotechnological application of Chitosan is as a direct support for enzyme immobilization. However, its applicability is quite specific, and to overcome this issue, alternative pretreatments are required, such as chemical and physical modifications to its structure, enabling its use in a wider array of applications. This review aims to present the topic in detail, by exploring and discussing methods of employment of Chitosan in enzymatic immobilization processes with various enzymes, presenting its advantages and disadvantages, as well as listing possible chemical modifications and combinations with other compounds for formulating an ideal support for this purpose. First, we will present Chitosan emphasizing its characteristics that allow its use as enzyme support. Furthermore, we will discuss possible physicochemical modifications that can be made to Chitosan, mentioning the improvements obtained in each process. These discussions will enable a comprehensive comparison between, and an informed choice of, the best technologies concerning enzyme immobilization and the application conditions of the biocatalyst.

ACS Style

Yale Luck Nunes; Fernando Lima de Menezes; Isamayra Germano de Sousa; Antônio Luthierre Gama Cavalcante; Francisco Thálysson Tavares Cavalcante; Katerine da Silva Moreira; André Luiz Barros de Oliveira; Gabrielly Ferreira Mota; José Erick Da Silva Souza; Italo Rafael De Aguiar Falcão; Thales Guimaraes Rocha; Roberta Bussons Rodrigues Valério; Pierre Basílio Almeida Fechine; Maria Cristiane Martins de Souza; José C.S. dos Santos. Chemical and physical Chitosan modification for designing enzymatic industrial biocatalysts: How to choose the best strategy? International Journal of Biological Macromolecules 2021, 181, 1124 -1170.

AMA Style

Yale Luck Nunes, Fernando Lima de Menezes, Isamayra Germano de Sousa, Antônio Luthierre Gama Cavalcante, Francisco Thálysson Tavares Cavalcante, Katerine da Silva Moreira, André Luiz Barros de Oliveira, Gabrielly Ferreira Mota, José Erick Da Silva Souza, Italo Rafael De Aguiar Falcão, Thales Guimaraes Rocha, Roberta Bussons Rodrigues Valério, Pierre Basílio Almeida Fechine, Maria Cristiane Martins de Souza, José C.S. dos Santos. Chemical and physical Chitosan modification for designing enzymatic industrial biocatalysts: How to choose the best strategy? International Journal of Biological Macromolecules. 2021; 181 ():1124-1170.

Chicago/Turabian Style

Yale Luck Nunes; Fernando Lima de Menezes; Isamayra Germano de Sousa; Antônio Luthierre Gama Cavalcante; Francisco Thálysson Tavares Cavalcante; Katerine da Silva Moreira; André Luiz Barros de Oliveira; Gabrielly Ferreira Mota; José Erick Da Silva Souza; Italo Rafael De Aguiar Falcão; Thales Guimaraes Rocha; Roberta Bussons Rodrigues Valério; Pierre Basílio Almeida Fechine; Maria Cristiane Martins de Souza; José C.S. dos Santos. 2021. "Chemical and physical Chitosan modification for designing enzymatic industrial biocatalysts: How to choose the best strategy?" International Journal of Biological Macromolecules 181, no. : 1124-1170.

Review
Published: 12 March 2021 in Electrochem
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Among the many biological entities employed in the development of biosensors, enzymes have attracted the most attention. Nanotechnology has been fostering excellent prospects in the development of enzymatic biosensors, since enzyme immobilization onto conductive nanostructures can improve characteristics that are crucial in biosensor transduction, such as surface-to-volume ratio, signal response, selectivity, sensitivity, conductivity, and biocatalytic activity, among others. These and other advantages of nanomaterial-based enzymatic biosensors are discussed in this work via the compilation of several reports on their applications in different industrial segments. To provide detailed insights into the state of the art of this technology, all the relevant concepts around the topic are discussed, including the properties of enzymes, the mechanisms involved in their immobilization, and the application of different enzyme-derived biosensors and nanomaterials. Finally, there is a discussion around the pressing challenges in this technology, which will be useful for guiding the development of future research in the area.

ACS Style

Francisco Cavalcante; Italo de A. Falcão; José Da S. Souza; Thales Rocha; Isamayra de Sousa; Antônio Cavalcante; André de Oliveira; Maria de Sousa; José dos Santos. Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications. Electrochem 2021, 2, 149 -184.

AMA Style

Francisco Cavalcante, Italo de A. Falcão, José Da S. Souza, Thales Rocha, Isamayra de Sousa, Antônio Cavalcante, André de Oliveira, Maria de Sousa, José dos Santos. Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications. Electrochem. 2021; 2 (1):149-184.

Chicago/Turabian Style

Francisco Cavalcante; Italo de A. Falcão; José Da S. Souza; Thales Rocha; Isamayra de Sousa; Antônio Cavalcante; André de Oliveira; Maria de Sousa; José dos Santos. 2021. "Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications." Electrochem 2, no. 1: 149-184.

Chapter
Published: 28 February 2021 in Green Organic Reactions
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Biofuels have been gaining prominence as alternative technologies to reduce the use of fossil fuels, which are causing major environmental problems such as increasing the greenhouse effect. The design new systems for producing clean, sustainable energy are needed. In this perspective, advances in technologies that increase production of raw materials, reduced costs, and greater efficiency are the great challenge. In this context, nanoparticles are gaining considerable prominence as a platform for designing highly efficient industrial systems. In addition, nanoparticles become quite versatile due to their properties such as small size, high surface area, surface charge, surface chemistry, solubility, and multi-functionality. Here, we review some of the successes with the nanotechnology systems to produce biofuels (as biodiesel, biogas, biohydrogen, bioethanol, algal-derived fuels, jet fuels, and others) together with recent technologies, catalysts and reactors. However, some problems that these nanotechnology systems for biofuels may cause will be discussed, for example production, feedstocks, process design, separation, and purification. Finally, some solutions are proposed, such as types of nanomaterials that have been used in these nanosystems. This chapter gives a comprehensive review of the current challenges and future research directions in the preparation of nanotechnology systems for biofuels production are discussed.

ACS Style

Francisco Thálysson Tavares Cavalcante; Katerine da Silva Moreira; Paula Jéssyca Morais Lima; Rodolpho Ramilton De Castro Monteiro; Bruna Bandeira Pinheiro; Carlos Alberto Chaves Girão Neto; Kimberle Paiva dos Santos; Maria Cristiane Martins de Souza; Rita Karolinny Chaves de Lima; José Cleiton Sousa dos Santos. Nanotechnology Systems for Biofuels Production. Green Organic Reactions 2021, 445 -471.

AMA Style

Francisco Thálysson Tavares Cavalcante, Katerine da Silva Moreira, Paula Jéssyca Morais Lima, Rodolpho Ramilton De Castro Monteiro, Bruna Bandeira Pinheiro, Carlos Alberto Chaves Girão Neto, Kimberle Paiva dos Santos, Maria Cristiane Martins de Souza, Rita Karolinny Chaves de Lima, José Cleiton Sousa dos Santos. Nanotechnology Systems for Biofuels Production. Green Organic Reactions. 2021; ():445-471.

Chicago/Turabian Style

Francisco Thálysson Tavares Cavalcante; Katerine da Silva Moreira; Paula Jéssyca Morais Lima; Rodolpho Ramilton De Castro Monteiro; Bruna Bandeira Pinheiro; Carlos Alberto Chaves Girão Neto; Kimberle Paiva dos Santos; Maria Cristiane Martins de Souza; Rita Karolinny Chaves de Lima; José Cleiton Sousa dos Santos. 2021. "Nanotechnology Systems for Biofuels Production." Green Organic Reactions , no. : 445-471.

Chapter
Published: 28 February 2021 in Green Organic Reactions
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Chitosan is a natural polysaccharide derived from chitin and extracted from agroindustrial residues such as the exoskeleton of crustaceous and other animals. Considered as one of the most abundant organic materials in nature, it has been widely used in several applications of industrial interest, mainly for its environmentally sustainable properties like biodegradability, biocompatibility, non-toxicity, and renewability. Due to the presence of amino groups in their chemical structure, chitosan has great versatility of modifications and formulations for industrial applications, such as controlled release, surface modification, and preparation of nanoparticles. Here, we review some of the successes with chitosan nanoparticles as biomedical applications and their preparation, ionic cross-linked emulsified chitosan, absorption and bioavailability, delivery systems, quality monitoring, and wastewater treatment. However, some problems that these chitosan nanoparticles may cause will be discussed, for example, mechanical resistance, dissolution, and hydrophilicity/hydrophobicity under certain conditions. Finally, some solutions are proposed, like crosslinking agents, and physicochemical modifications, to manipulate particle size and stability. This chapter gives a comprehensive review of the advantages and recent developments in the formulation of chitosan nanoparticles as an alternative for sustainable agriculture.

ACS Style

André Luiz Barros de Oliveira; Francisco Thálysson Tavares Cavalcante; Katerine da Silva Moreira; Paula Jéssyca Morais Lima; Rodolpho Ramilton De Castro Monteiro; Bruna Bandeira Pinheiro; Kimberle Paiva dos Santos; José Cleiton Sousa dos Santos. Chitosan Nanoparticle: Alternative for Sustainable Agriculture. Green Organic Reactions 2021, 95 -132.

AMA Style

André Luiz Barros de Oliveira, Francisco Thálysson Tavares Cavalcante, Katerine da Silva Moreira, Paula Jéssyca Morais Lima, Rodolpho Ramilton De Castro Monteiro, Bruna Bandeira Pinheiro, Kimberle Paiva dos Santos, José Cleiton Sousa dos Santos. Chitosan Nanoparticle: Alternative for Sustainable Agriculture. Green Organic Reactions. 2021; ():95-132.

Chicago/Turabian Style

André Luiz Barros de Oliveira; Francisco Thálysson Tavares Cavalcante; Katerine da Silva Moreira; Paula Jéssyca Morais Lima; Rodolpho Ramilton De Castro Monteiro; Bruna Bandeira Pinheiro; Kimberle Paiva dos Santos; José Cleiton Sousa dos Santos. 2021. "Chitosan Nanoparticle: Alternative for Sustainable Agriculture." Green Organic Reactions , no. : 95-132.

Review article
Published: 09 November 2020 in Fuel
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The rising global demand for sustainable energy resources is resulting in an accelerated increase in biodiesel consumption. In this sense, studies aimed at tackling process hurdles in biodiesel production have been continuously carried out. In order to reduce energy consumption and the amount of wastewater generated, as well as to avoid the production of inefficient end products, classes of enzymes, especially lipases, are being successfully explored as substitutes to chemical catalysts. This article highlights several aspects of lipase-catalyzed biodiesel production. The recent advances and the future perspectives of mechanisms that could circumvent the well-known problems inherent in these systems are presented and discussed, such as the low-stability and the pricing of biocatalysts. According to the literature, alternative solutions include the use of low-cost, unconventional raw materials, new supports, the elucidation of mechanisms of lipase immobilization, and optimal designs and operational settings for bioreactors. Finally, there is a discussion around the necessary steps to enable an economically-viable industrial production.

ACS Style

Francisco Thálysson Tavares Cavalcante; Francisco Simao Neto; Italo Rafael De Aguiar Falcão; José Erick Da Silva Souza; Lourembergue Saraiva De Moura Junior; Patrick Da Silva Sousa; Thales Guimaraes Rocha; Isamayra Germano de Sousa; Pedro Henrique De Lima Gomes; Maria Cristiane Martins de Souza; José C.S. dos Santos. Opportunities for improving biodiesel production via lipase catalysis. Fuel 2020, 288, 119577 .

AMA Style

Francisco Thálysson Tavares Cavalcante, Francisco Simao Neto, Italo Rafael De Aguiar Falcão, José Erick Da Silva Souza, Lourembergue Saraiva De Moura Junior, Patrick Da Silva Sousa, Thales Guimaraes Rocha, Isamayra Germano de Sousa, Pedro Henrique De Lima Gomes, Maria Cristiane Martins de Souza, José C.S. dos Santos. Opportunities for improving biodiesel production via lipase catalysis. Fuel. 2020; 288 ():119577.

Chicago/Turabian Style

Francisco Thálysson Tavares Cavalcante; Francisco Simao Neto; Italo Rafael De Aguiar Falcão; José Erick Da Silva Souza; Lourembergue Saraiva De Moura Junior; Patrick Da Silva Sousa; Thales Guimaraes Rocha; Isamayra Germano de Sousa; Pedro Henrique De Lima Gomes; Maria Cristiane Martins de Souza; José C.S. dos Santos. 2020. "Opportunities for improving biodiesel production via lipase catalysis." Fuel 288, no. : 119577.

Original article
Published: 15 May 2020 in 3 Biotech
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In this work, the concept of lipase cocktail has been proposed in the ultrasound-assisted hydrolysis of coconut oil. Lipase from Thermomyces lanuginosus (TLL), lipase from Rhizomucor miehei (RML), and lipase B from Candida antarctica (CALB) were evaluated as biocatalysts in different combinations. The best conversion (33.66%) was achieved using only RML; however, the best lipase cocktail (75% RML and 25% CALB) proposed by the triangular response surface was used to achieve higher conversions. At the best lipase cocktail, reaction parameters [temperature, biocatalyst content and molar ratio (water/oil)] were optimized by a Central Composite Design, allowing to obtain more than 98% of conversion in the hydrolysis of coconut oil in 3 h of incubation at 37 kHz, 300 W and 45 °C by using 20% of the lipase cocktail (w/w) and a molar ratio of 7.5:1 (water/oil). The lipase cocktail retained about 50% of its initial activity after three consecutive cycles of hydrolysis. To the authors’ knowledge, up to date, this communication is the first report in the literature for the ultrasound-assisted hydrolysis of coconut oil catalyzed by a cocktail of lipases. Under ultrasound irradiation, the concept of lipase cocktail was successfully applied, and this strategy could be useful for the other types of reactions using heterogeneous substrates.

ACS Style

José E. S. Souza; Rodolpho R. C. Monteiro; Thales G. Rocha; Katerine S. Moreira; Francisco T. T. Cavalcante; Ana K. De Sousa Braz; Maria C. M. de Souza; José C. S. dos Santos. Sonohydrolysis using an enzymatic cocktail in the preparation of free fatty acid. 3 Biotech 2020, 10, 1 -10.

AMA Style

José E. S. Souza, Rodolpho R. C. Monteiro, Thales G. Rocha, Katerine S. Moreira, Francisco T. T. Cavalcante, Ana K. De Sousa Braz, Maria C. M. de Souza, José C. S. dos Santos. Sonohydrolysis using an enzymatic cocktail in the preparation of free fatty acid. 3 Biotech. 2020; 10 (6):1-10.

Chicago/Turabian Style

José E. S. Souza; Rodolpho R. C. Monteiro; Thales G. Rocha; Katerine S. Moreira; Francisco T. T. Cavalcante; Ana K. De Sousa Braz; Maria C. M. de Souza; José C. S. dos Santos. 2020. "Sonohydrolysis using an enzymatic cocktail in the preparation of free fatty acid." 3 Biotech 10, no. 6: 1-10.