This research addresses the complex challenge of integrating modern public transport into historic medieval city centers. These unique urban environments are characterized by narrow streets, protected heritage status, and topographical constraints, which are incompatible with conventional transit vehicles. The introduction of standard bus routes often aggravates traffic congestion and fails to meet the specific mobility needs of residents and visitors. This paper suggests that autonomous electric buses represent a viable and sustainable solution, capable of navigating these constrained environments while aligning with modern energy efficiency goals. The central challenge lies in the optimal selection of an autonomous electric bus that can operate safely and efficiently within the tight streets of historic city centers while satisfying the travel demands of passengers. To address this, a comprehensive study was conducted, analyzing resident mobility patterns—including key routes and hourly passenger loads—and the specific geometric constraints of the road network. Based on this empirical data, a vehicle dynamics model was developed in Matlab^®. This model simulates various operational scenarios by calculating the instantaneous forces (rolling resistance, aerodynamic drag, inertial forces) and the corresponding power required for different electric bus configurations to follow pre-established speed profiles. The core of this research is an optimization analysis, designed to identify the balance between minimizing total energy consumption and maximizing the quality of passenger service. The findings provide a quantitative framework and clear procedures for urban planners to select the most suitable autonomous transit system, ensuring that the chosen solution enhances mobility and accessibility without compromising the unique character of historic cities.