In China, the first to carry out in situ synthesis of DNA to prepare gene chip unit has done a lot of basic research work in the aspects of in situ synthesis of DNA, preparation of gene chip and modification of nucleic acid.More than 30 SCI papers were published in journals such as "Chinese Science", "Science bulletin", "Langmuir", "Carbon" and "Nanotechnology". Among them, 11 patents for invention have been applied for by the first applicant, among which 7 have been authorized. Among them, the domestic silicon alkylation reagents replace imported phosphorous acid amide reagent preparation of amino modified oligonucleotides nucleic acid probe has been for small mass production and sales, users reflect the good product quality, and the synthesis of modified probe on the market there is a difference performance, at present the product has been included in the 2005 national key new product (certificate number is: 2005 ed105019).Proposed methods similar to Illumina company's collection of in-situ synthesis and point-sampling methods to prepare gene chips (ZL03112772.X) and published papers on "Colloids and Surfaces B: Biointerfaces" and "Journal of Nanoscience and Nanotechnology".The "research technology based on acrylamide modified nucleic acid" proposed and implemented has been successful in the preparation of DNA chips, and has been applied by more than 10 institutions as a SNP screening platform, and 8 SCI papers have been published.