Mahendra Rai

Dr. Mahendra Rai

orcid

Research Focus & Metrics

Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2009 in Biotechnology Advances
Verified
Journal Article
Closed access
MRMahendra Rai
Mahendra Rai
AYAlka Yadav
Alka Yadav
AGAniket K Gade
Aniket K Gade

18 May 2015 in Molecules
Verified
Journal Article
Open access
PDF file
GFGianluigi Franci
Gianluigi Franci
Annarita FalangaAnnarita Falanga
Annarita Falanga
Stefania GaldieroStefania Galdiero
Stefania Galdiero
LPLuciana Palomba
Luciana Palomba
MRMahendra Rai
Mahendra Rai
Massimiliano GaldieroMassimiliano Galdiero
Massimiliano Galdiero
Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Currently nanotechnology and nanomaterials are fully integrated in common applications and objects that we use every day. In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to summarize the emerging efforts to address current challenges and solutions in the treatment of infectious diseases, particularly the use of nanosilver antimicrobials.

11 February 2012 in Journal of Applied Microbiology
Verified
Journal Article
Open access
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MRMahendra Rai
Mahendra Rai
SDS.D. Deshmukh
S.D. Deshmukh
AIA.P. Ingle
A.P. Ingle
AGAniket K Gade
Aniket K Gade
In the present scenario, pharmaceutical and biomedical sectors are facing the challenges of continuous increase in the multidrug‐resistant (MDR) human pathogenic microbes. Re‐emergence of MDR microbes is facilitated by drug and/or antibiotic resistance, which is acquired way of microbes for their survival and multiplication in uncomfortable environments. MDR bacterial infections lead to significant increase in mortality, morbidity and cost of prolonged treatments. Therefore, development, modification or searching the antimicrobial compounds having bactericidal potential against MDR bacteria is a priority area of research. Silver in the form of various compounds and bhasmas have been used in Ayurveda to treat several bacterial infections since time immemorial. As several pathogenic bacteria are developing antibiotic resistance, silver nanoparticles are the new hope to treat them. This review discusses the bactericidal potential of silver nanoparticles against the MDR bacteria. This multiactional nanoweapon can be used for the treatment and prevention of drug‐resistant microbes.

1 December 2009 in Nanomedicine: Nanotechnology, Biology and Medicine
Verified
Journal Article
Closed access
MGMonali Gajbhiye
Monali Gajbhiye
JKJayendra Kesharwani
Jayendra Kesharwani
AIAvinash Ingle
Avinash Ingle
AGAniket K Gade
Aniket K Gade
MRMahendra Rai
Mahendra Rai

3 March 2012 in Applied Microbiology and Biotechnology
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Journal Article
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MRMahendra Rai
Mahendra Rai
AIAvinash Ingle
Avinash Ingle

5 December 2013 in Applied Microbiology and Biotechnology
Verified
Journal Article
Closed access
PDF file
Avinash IngleAvinash Ingle
Avinash Ingle
NDNelson Duran
Nelson Duran
MRMahendra Rai
Mahendra Rai