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Lasiodiplodan is a β-glucan polymer with different interesting characteristics, including therapeutic properties. It is an extracellular product, which is produced by the filamentous fungus Lasiodiplodia theobromae, using glucose as a substrate. In the present work, the production of lasiodiplodan was studied by the utilization of sugarcane straw as a low-cost carbon source. Glucose-rich sugarcane straw hydrolysate was obtained by a sequential pretreatment with dilute nitric acid (1% v/v) and sodium hydroxide (1% w/v), followed by enzymatic hydrolysis. The fermentation process was conducted by the cultivation of the strain Lasiodiplodia theobromae CCT3966 in sugarcane straw hydrolysate in a shake flask at 28 °C for 114 h. It was found that hydrolysate obtained after enzymatic hydrolysis contained 47.10 gL−1 of glucose. Fermentation experiments of lasiodiplodan synthesis showed that the peak yield and productivity of 0.054 gg−1 glucose consumed and 0.016 gL−1 h−1, respectively, were obtained at 72 h fermentation time. Fungal growth, glucose consumption, and lasiodiplodan production from sugarcane straw hydrolysate presented a similar pattern to kinetic models. The study on the chemical structure of lasiodiplodan produced showed it had a β-glucan construction. The current study revealed that sugarcane straw is a promising substrate for the production of lasiodiplodan.
Peyman Abdeshahian; Jesús Jiménez Ascencio; Rafael R. Philippini; Felipe Antonio Fernandes Antunes; Avinash P. Ingle; Mojgan Abdeshahian; Júlio César dos Santos; Silvio Silvério da Silva. Fermentative Production of Lasiodiplodan by Lasiodiplodia theobromae CCT3966 from Pretreated Sugarcane Straw. Sustainability 2021, 13, 9697 .
AMA StylePeyman Abdeshahian, Jesús Jiménez Ascencio, Rafael R. Philippini, Felipe Antonio Fernandes Antunes, Avinash P. Ingle, Mojgan Abdeshahian, Júlio César dos Santos, Silvio Silvério da Silva. Fermentative Production of Lasiodiplodan by Lasiodiplodia theobromae CCT3966 from Pretreated Sugarcane Straw. Sustainability. 2021; 13 (17):9697.
Chicago/Turabian StylePeyman Abdeshahian; Jesús Jiménez Ascencio; Rafael R. Philippini; Felipe Antonio Fernandes Antunes; Avinash P. Ingle; Mojgan Abdeshahian; Júlio César dos Santos; Silvio Silvério da Silva. 2021. "Fermentative Production of Lasiodiplodan by Lasiodiplodia theobromae CCT3966 from Pretreated Sugarcane Straw." Sustainability 13, no. 17: 9697.
The awareness of global warming, fossil scarcity and pollution are some current eminent burdens which are necessary to be acknowledged in order to find alternative solutions to mitigate its detrimental impacts. Taking this into account, this article focuses on displaying a historical overview, critical trends, recent challenges and employment of vegetal biomass as feedstock for the sustainable and environmentally friendly production of promising microbial-derived molecules through fermentative strategies. Among, bioethanol, xylitol, biopolymers, biosurfactants, organic acids and others such as butanol, butanediol, single cell protein and biopigments will be elucidated. Nevertheless, each one of these biomolecules presents specific applications.
F.A.F Antunes; T.M. Rocha; R.R. Philippini; S.E. Martiniano; C.A. Prado; E. Mier-Alba; A.F. Hernandez-Perez; F.M. Jofre; P. Abdeshahian; D.R. Ribeaux; M.J. Castro-Alonso; T.R. Balbino; K.J. Dussán; D.D.V. Da Silva; J.P. De Souza; S. Sanchez-Muñoz; R. Reyes-Guzman; A.P. Ingle; M.G.A. Felipe; J.C. Santos; S.S. Da Silva. The Potential of Vegetal Biomass for Biomolecules Production. Reference Module in Earth Systems and Environmental Sciences 2021, 1 .
AMA StyleF.A.F Antunes, T.M. Rocha, R.R. Philippini, S.E. Martiniano, C.A. Prado, E. Mier-Alba, A.F. Hernandez-Perez, F.M. Jofre, P. Abdeshahian, D.R. Ribeaux, M.J. Castro-Alonso, T.R. Balbino, K.J. Dussán, D.D.V. Da Silva, J.P. De Souza, S. Sanchez-Muñoz, R. Reyes-Guzman, A.P. Ingle, M.G.A. Felipe, J.C. Santos, S.S. Da Silva. The Potential of Vegetal Biomass for Biomolecules Production. Reference Module in Earth Systems and Environmental Sciences. 2021; ():1.
Chicago/Turabian StyleF.A.F Antunes; T.M. Rocha; R.R. Philippini; S.E. Martiniano; C.A. Prado; E. Mier-Alba; A.F. Hernandez-Perez; F.M. Jofre; P. Abdeshahian; D.R. Ribeaux; M.J. Castro-Alonso; T.R. Balbino; K.J. Dussán; D.D.V. Da Silva; J.P. De Souza; S. Sanchez-Muñoz; R. Reyes-Guzman; A.P. Ingle; M.G.A. Felipe; J.C. Santos; S.S. Da Silva. 2021. "The Potential of Vegetal Biomass for Biomolecules Production." Reference Module in Earth Systems and Environmental Sciences , no. : 1.
Nanotechnology is a new and developing branch that has revolutionized the world by its applications in various fields including medicine and agriculture. In nanotechnology, nanoparticles play an important role in diagnostics, drug delivery, and therapy. The synthesis of nanoparticles by fungi is a novel, cost-effective and eco-friendly approach. Among fungi, Fusarium spp. play an important role in the synthesis of nanoparticles and can be considered as a nanofactory for the fabrication of nanoparticles. The synthesis of silver nanoparticles (AgNPs) from Fusarium, its mechanism and applications are discussed in this review. The synthesis of nanoparticles from Fusarium is the biogenic and green approach. Fusaria are found to be a versatile biological system with the ability to synthesize nanoparticles extracellularly. Different species of Fusaria have the potential to synthesise nanoparticles. Among these, F. oxysporum has demonstrated a high potential for the synthesis of AgNPs. It is hypothesised that NADH-dependent nitrate reductase enzyme secreted by F. oxysporum is responsible for the reduction of aqueous silver ions into AgNPs. The toxicity of nanoparticles depends upon the shape, size, surface charge, and the concentration used. The nanoparticles synthesised by different species of Fusaria can be used in medicine and agriculture.Nanotechnology is a new and developing branch that has revolutionized the world by its applications in various fields including medicine and agriculture. In nanotechnology, nanoparticles play an important role in diagnostics, drug delivery, and therapy. The synthesis of nanoparticles by fungi is a novel, cost-effective and eco-friendly approach. Among fungi, Fusarium spp. play an important role in the synthesis of nanoparticles and can be considered as a nanofactory for the fabrication of nanoparticles. The synthesis of silver nanoparticles (AgNPs) from Fusarium, its mechanism and applications are discussed in this review. The synthesis of nanoparticles from Fusarium is the biogenic and green approach. Fusaria are found to be a versatile biological system with the ability to synthesize nanoparticles extracellularly. Different species of Fusaria have the potential to synthesise nanoparticles. Among these, F. oxysporum has demonstrated a high potential for the synthesis of AgNPs. It is hypothesised that NADH-dependent nitrate reductase enzyme secreted by F. oxysporum is responsible for the reduction of aqueous silver ions into AgNPs. The toxicity of nanoparticles depends upon the shape, size, surface charge, and the concentration used. The nanoparticles synthesised by different species of Fusaria can be used in medicine and agriculture.Fusarium; synthesis; nanoparticles; mechanism; medicine; agriculture; nanofactory; toxicity
Mahendra Rai; Shital Bonde; Patrycja Golinska; Joanna Trzcińska-Wencel; Aniket Gade; Kamel Abd-Elsalam; Sudhir Shende; Swapnil Gaikwad; Avinash Ingle. Fusarium as a Novel Fungus for the Synthesis of Nanoparticles: Mechanism and Applications. Journal of Fungi 2021, 7, 139 .
AMA StyleMahendra Rai, Shital Bonde, Patrycja Golinska, Joanna Trzcińska-Wencel, Aniket Gade, Kamel Abd-Elsalam, Sudhir Shende, Swapnil Gaikwad, Avinash Ingle. Fusarium as a Novel Fungus for the Synthesis of Nanoparticles: Mechanism and Applications. Journal of Fungi. 2021; 7 (2):139.
Chicago/Turabian StyleMahendra Rai; Shital Bonde; Patrycja Golinska; Joanna Trzcińska-Wencel; Aniket Gade; Kamel Abd-Elsalam; Sudhir Shende; Swapnil Gaikwad; Avinash Ingle. 2021. "Fusarium as a Novel Fungus for the Synthesis of Nanoparticles: Mechanism and Applications." Journal of Fungi 7, no. 2: 139.
The ubiquitous nature of lignocellulosic biomass on planet earth and its economic viability attracted a great deal of attention from researchers and becomes foremost feedstock for biofuel production particularly bioethanol. However, due to complexity in structure, its pretreatment is essentially required prior to actual use. In the present study, a promising approach has been proposed through the development of acid-functionalized magnetic nanocatalysts. Two different acid-functionalized magnetic nanocatalysts i.e. alkylsulfonic acid functionalized magnetic nanoparticles (Fe3O4-MNPs-Si-AS) and butylcarboxylic acid functionalized magnetic nanoparticles (Fe3O4-MNPs-Si-BCOOH) were developed and their efficacy was studied in the pretreatment of sugarcane straw at varying concentrations (100, 200, 300, 400, 500 mg/g of straw). The enhanced concentration dependent production of sugar (xylose) was reported in case of both the nanocatalysts. The maximum 17.06 g/L for Fe3O4-MNPs-Si-AS and 15.40 g/L for Fe3O4-MNPs-Si-BCOOH sugar was reported at 500 mg which is comparatively higher than normal acid (H2SO4) (14.63 g/L) and non-treated (0.24 g/L) sugarcane straw. Further, both the nanocatalysts were recovered by applying an external magnetic field and reused for the next two subsequent cycles of pretreatment. It was observed that with every reuse of nanocatalysts the concentration of sugar production was reduced. Moreover, generation of very less amount of toxic inhibitors was reported in the hemicellulosic hydrolyzate obtained in the present study. Considering these facts, it is believed that such nanocatalysts can be used as an effective, eco-friendly and economically viable alternative to the conventional pretreatment agents like mineral acids.
Avinash P. Ingle; Rafael Philippini; Yasmin Cristhine De Souza Melo; Silvio Silvério Da Silva. Acid-functionalized magnetic nanocatalysts mediated pretreatment of sugarcane straw: an eco-friendly and cost-effective approach. Cellulose 2020, 27, 7067 -7078.
AMA StyleAvinash P. Ingle, Rafael Philippini, Yasmin Cristhine De Souza Melo, Silvio Silvério Da Silva. Acid-functionalized magnetic nanocatalysts mediated pretreatment of sugarcane straw: an eco-friendly and cost-effective approach. Cellulose. 2020; 27 (12):7067-7078.
Chicago/Turabian StyleAvinash P. Ingle; Rafael Philippini; Yasmin Cristhine De Souza Melo; Silvio Silvério Da Silva. 2020. "Acid-functionalized magnetic nanocatalysts mediated pretreatment of sugarcane straw: an eco-friendly and cost-effective approach." Cellulose 27, no. 12: 7067-7078.
The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose. Initially, iron oxide (Fe3 O4)MNPs were synthesised, which further modified by applying silica coating (Fe3 O4 [email protected]) and functionalised with alkylsulfonic acid (Fe3 O4 [email protected]@AS), butylcarboxylic acid (Fe3 O4 [email protected]@BCOOH) and sulphonic acid (Fe3 O4 [email protected]@SO3 H) groups. The Fourier transform infrared analysis confirmed the presence of above-mentioned acid functional groups on MNPs. Similarly, X-ray diffraction pattern and energy dispersive X-ray spectroscopy analysis confirmed the crystalline nature and elemental composition of MNPs, respectively. TEM micrographs showed the synthesis of spherical and polydispersed nanoparticles having diameter size in the range of 20–80 nm. Cellobiose hydrolysis was used as a model reaction to evaluate the catalytic efficacy of acid-functionalised nanoparticles. A maximum 74.8% cellobiose conversion was reported in case of Fe3 O4 [email protected]@SO3 H in first cycle of hydrolysis. Moreover, thus used acid-functionalised MNPs were magnetically separated and reused. In second cycle of hydrolysis, Fe3 O4 [email protected]@SO3 H showed 49.8% cellobiose conversion followed by Fe3 O4 [email protected]@AS (45%) and Fe3 O4 [email protected]@BCOOH (18.3%). However, similar pattern was reported in case of third cycle of hydrolysis. The proposed approach is considered as rapid and convenient. Moreover, reuse of acid-functionalised MNPs makes the process economically viable.
Avinash P. Ingle; Rafael R. Philippini; Mahendra Rai; Silvio Silvério da Silva. Catalytic hydrolysis of cellobiose using different acid‐functionalised Fe 3 O 4 magnetic nanoparticles. IET Nanobiotechnology 2019, 14, 40 -46.
AMA StyleAvinash P. Ingle, Rafael R. Philippini, Mahendra Rai, Silvio Silvério da Silva. Catalytic hydrolysis of cellobiose using different acid‐functionalised Fe 3 O 4 magnetic nanoparticles. IET Nanobiotechnology. 2019; 14 (1):40-46.
Chicago/Turabian StyleAvinash P. Ingle; Rafael R. Philippini; Mahendra Rai; Silvio Silvério da Silva. 2019. "Catalytic hydrolysis of cellobiose using different acid‐functionalised Fe 3 O 4 magnetic nanoparticles." IET Nanobiotechnology 14, no. 1: 40-46.
Pretreatment is an inevitable step in the bioethanol / biochemicals production process in which lignocellulosic biomass (LB) is converted to fermentable sugars. It has a large impact on process cost, constituting approximately 40% of total processing cost of bioethanol or biochemical production. Several physical, chemical, physicochemical, and biological pretreatment approaches are available but there are certain limitations to the use of all of these methods on a large scale, which mainly include high processing costs, the generation of toxic inhibitors, and the detoxification of the inhibitors generated. These limitations collectively restrict the use of the existing methods and warrants for the development of a novel, efficient, cost‐effective, and ecofriendly approach for the pretreatment of LB. In this context, nanotechnology‐based pretreatment methods, involving the use of various nanomaterials, have been proposed. The smaller size of nanomaterials makes them more efficient in penetrating the cell walls of LB and hence such nanomaterials can readily interact with the lignocellulosic components at low severity to release carbohydrates to be used for bioethanol and / or biochemical production. This review provides a brief description of various existing pretreatment methods and their advantages and disadvantages. It also presents a critical overview of the application of various nanotechnological methods in the pretreatment of different lignocellulosic substrates. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Avinash P. Ingle; Anuj K. Chandel; Felipe A. F. Antunes; Mahendra Rai; Silvio S. Da Silva. New trends in application of nanotechnology for the pretreatment of lignocellulosic biomass. Biofuels, Bioproducts and Biorefining 2018, 13, 776 -788.
AMA StyleAvinash P. Ingle, Anuj K. Chandel, Felipe A. F. Antunes, Mahendra Rai, Silvio S. Da Silva. New trends in application of nanotechnology for the pretreatment of lignocellulosic biomass. Biofuels, Bioproducts and Biorefining. 2018; 13 (3):776-788.
Chicago/Turabian StyleAvinash P. Ingle; Anuj K. Chandel; Felipe A. F. Antunes; Mahendra Rai; Silvio S. Da Silva. 2018. "New trends in application of nanotechnology for the pretreatment of lignocellulosic biomass." Biofuels, Bioproducts and Biorefining 13, no. 3: 776-788.
The extensive consumption of fossil fuels due to ever increasing global population leads to the depletion in its resources all over the world. Moreover, these fuels are playing a major role in creating environmental pollution. As a renewable energy alternative resources, utilization of biomass resources for the production of biofuels attracted a great deal of attention from every corner of the world. Various conventional approaches including chemical, thermochemical, biological methods, etc. have been developed but certain limitations in the smooth application of these methods create pressing need to investigate rapid and environment friendly approaches for sustainable biofuel production. In this context, nanotechnological approaches are found as more promising. Nanotechnologies represent one of the most fascinating techno-scientific revolutions ever undertaken in various sectors including biofuel and bioenergy. Various nanomaterials in the form nanocatalysts play an important role in catalytic degradation of different lignocellulosic biomass into fermentable sugars, which are further used for bioethanol production. Similarly, the production of biodiesel and biogas through nanotechnological approaches has attained a great deal of attention. In this chapter, we have mainly focused on recent trends and applications of nanotechnology in biofuel production. In addition, conventional methods commonly used for biofuel production are also discussed in brief.
Avinash P. Ingle; Priti Paralikar; Silvio Silverio Da Silva; Mahendra Rai. Nanotechnology-Based Developments in Biofuel Production: Current Trends and Applications. Sustainable Biotechnology- Enzymatic Resources of Renewable Energy 2018, 289 -305.
AMA StyleAvinash P. Ingle, Priti Paralikar, Silvio Silverio Da Silva, Mahendra Rai. Nanotechnology-Based Developments in Biofuel Production: Current Trends and Applications. Sustainable Biotechnology- Enzymatic Resources of Renewable Energy. 2018; ():289-305.
Chicago/Turabian StyleAvinash P. Ingle; Priti Paralikar; Silvio Silverio Da Silva; Mahendra Rai. 2018. "Nanotechnology-Based Developments in Biofuel Production: Current Trends and Applications." Sustainable Biotechnology- Enzymatic Resources of Renewable Energy , no. : 289-305.
Catalytic conversion (hydrolysis) of carbohydrate polymers present in the lignocellulosic biomass into fermentable sugars is a key step in the production of bioethanol. Although, acid and enzymatic catalysts are conventionally used for the catalysis of various lignocellulosic biomass, recently application of immobilized enzymes (biocatalysts) have been considered as the most promising approach. Immobilization of different biocatalysts such as cellulase, β-glucosidase, cellobiose, xylanase, laccase, etc. on support materials including nanomaterials to form nanobiocatalyst increases catalytic efficacy and stability of enzymes. Moreover, immobilization of biocatalysts on magnetic nanoparticles (magnetic nanobiocatalysts) facilitates easy recovery and reuse of biocatalysts. Therefore, utilization of nanobiocatalysts for catalysis of lignocellulosic biomass is helpful for the development of cost-effective and ecofriendly approach. In this review, we have discussed various conventional methods of hydrolysis and their limitations. Special emphasis has been made on nanobiocatalysts used for hydrolysis of lignocellulosic biomass. Moreover, the other most important aspects, like nanofiltration of biomass, conversion of lignocellulose to nanocellulose, and toxicological issues associated with application of nanomaterials are also discussed.
Mahendra Rai; Avinash P. Ingle; Raksha Pandit; Priti Paralikar; Jayanta Kumar Biswas; Silvio Silverio Da Silva. Emerging role of nanobiocatalysts in hydrolysis of lignocellulosic biomass leading to sustainable bioethanol production. Catalysis Reviews 2018, 61, 1 -26.
AMA StyleMahendra Rai, Avinash P. Ingle, Raksha Pandit, Priti Paralikar, Jayanta Kumar Biswas, Silvio Silverio Da Silva. Emerging role of nanobiocatalysts in hydrolysis of lignocellulosic biomass leading to sustainable bioethanol production. Catalysis Reviews. 2018; 61 (1):1-26.
Chicago/Turabian StyleMahendra Rai; Avinash P. Ingle; Raksha Pandit; Priti Paralikar; Jayanta Kumar Biswas; Silvio Silverio Da Silva. 2018. "Emerging role of nanobiocatalysts in hydrolysis of lignocellulosic biomass leading to sustainable bioethanol production." Catalysis Reviews 61, no. 1: 1-26.
Ginger (Zingiber officinale Rosc.) is a tropical plant cultivated all over the world due to its culinary and medicinal properties. It is one of the most important spices commonly used in food, which increases its commercial value. However, soft rot (rhizome rot) is a common disease of ginger caused by fungi such as Pythium and Fusarium spp. It is the most destructive disease of ginger, which can reduce the production by 50 to 90%. Application of chemical fungicides is considered as an effective method to control soft rot of ginger but extensive use of fungicides pose serious risk to environmental and human health. Therefore, the development of ecofriendly and economically viable alternative approaches for effective management of soft rot of ginger such diseases is essentially required. An acceptable approach that is being actively investigated involves nanotechnology, which can potentially be used to control Pythium and Fusarium. The present review is aimed to discuss worldwide status of soft rot associated with ginger, the traditional methods available for the management of Pythium and Fusarium spp. and most importantly, the role of various nanomaterials in the management of soft rot of ginger. Moreover, possible antifungal mechanisms for chemical fungicides, biological agents and nanoparticles have also been discussed.
Mahendra Rai; Avinash P. Ingle; Priti Paralikar; Netravati Anasane; Rajendra Gade; Pramod Ingle. Effective management of soft rot of ginger caused by Pythium spp. and Fusarium spp.: emerging role of nanotechnology. Applied Microbiology and Biotechnology 2018, 102, 6827 -6839.
AMA StyleMahendra Rai, Avinash P. Ingle, Priti Paralikar, Netravati Anasane, Rajendra Gade, Pramod Ingle. Effective management of soft rot of ginger caused by Pythium spp. and Fusarium spp.: emerging role of nanotechnology. Applied Microbiology and Biotechnology. 2018; 102 (16):6827-6839.
Chicago/Turabian StyleMahendra Rai; Avinash P. Ingle; Priti Paralikar; Netravati Anasane; Rajendra Gade; Pramod Ingle. 2018. "Effective management of soft rot of ginger caused by Pythium spp. and Fusarium spp.: emerging role of nanotechnology." Applied Microbiology and Biotechnology 102, no. 16: 6827-6839.
Crop losses mainly occur due to biotic factors, which include soil-borne phytopathogens, insect pests, parasites, and predators. The major loss of food in the food industry is due to its spoilage by various microorganisms. With advancement in nanotechnology, the use of nanoparticles in food and agriculture crop yield can be improved. In this context, copper nanoparticles (CuNPs) have attracted a great deal of attention from all over the world due to their broad-spectrum antimicrobial activity. Copper is one of the key micronutrients, which plays an important role in growth and development of plants. CuNP-based fertilizer and herbicide can be used in agriculture. The small size of CuNPs facilitates their easy absorption by the plants. CuNPs can be promisingly used in the food packaging to avoid the growth of food spoilage microorganisms. The use of CuNP-based agar packaging materials has substantial potential to increase the shelf-life of food. The present review focuses on the application of Cu and CuNPs in food and agriculture. Moreover, antimicrobial and pesticidal properties of CuNPs are also discussed.
Mahendra Rai; Avinash P. Ingle; Raksha Pandit; Priti Paralikar; Sudhir Shende; Indarchand Gupta; Jayanta K. Biswas; Silvio Silvério da Silva. Copper and copper nanoparticles: role in management of insect-pests and pathogenic microbes. Nanotechnology Reviews 2018, 7, 303 -315.
AMA StyleMahendra Rai, Avinash P. Ingle, Raksha Pandit, Priti Paralikar, Sudhir Shende, Indarchand Gupta, Jayanta K. Biswas, Silvio Silvério da Silva. Copper and copper nanoparticles: role in management of insect-pests and pathogenic microbes. Nanotechnology Reviews. 2018; 7 (4):303-315.
Chicago/Turabian StyleMahendra Rai; Avinash P. Ingle; Raksha Pandit; Priti Paralikar; Sudhir Shende; Indarchand Gupta; Jayanta K. Biswas; Silvio Silvério da Silva. 2018. "Copper and copper nanoparticles: role in management of insect-pests and pathogenic microbes." Nanotechnology Reviews 7, no. 4: 303-315.
Swapnil Gaikwad; Avinash P. Ingle; Felipe A. F. Antunes; Julio C. Dos Santos; Mahendra Rai; Silvio Silvério Da Silva. Cellulase Enzyme Immobilization on Magnetic Nanoparticles for Clean Sugar Production from Cellulose. Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology 2018, 1 .
AMA StyleSwapnil Gaikwad, Avinash P. Ingle, Felipe A. F. Antunes, Julio C. Dos Santos, Mahendra Rai, Silvio Silvério Da Silva. Cellulase Enzyme Immobilization on Magnetic Nanoparticles for Clean Sugar Production from Cellulose. Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology. 2018; ():1.
Chicago/Turabian StyleSwapnil Gaikwad; Avinash P. Ingle; Felipe A. F. Antunes; Julio C. Dos Santos; Mahendra Rai; Silvio Silvério Da Silva. 2018. "Cellulase Enzyme Immobilization on Magnetic Nanoparticles for Clean Sugar Production from Cellulose." Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology , no. : 1.
Background: Nanotechnology has demonstrated great potential for the cure of bone infections through the development of antibacterial nanomaterials. The bone diseases include many skeletal- related illnesses such as arthritis, bone cancer, osteosarcoma and osteoarthritis, which are the major causes of mortality in human beings. Moreover, there are no effective treatment strategies available for such bone diseases. However, these limitations create pressing need to search safe and efficient novel drugs for clinical treatments. In this context, nanotechnology- based targeted drug delivery is widely proposed as an effective treatment strategy. Objective: Recently, various nanomaterials have been extensively used in the management of bone diseases. Therefore, we aimed to write a comprehensive review on the role of nanotechnology in bone diseases. Methods: We searched Google and PubMed portals extensively concerning literature of the following subjects so as to get latest updated information related to current developments in the field of nanotechnology in the context of bone diseases. Results: In the present review, we have discussed the role of the various nanomaterials, which can be promisingly used in the diagnosis and treatment of dentistry and bone cancer. Further, biomedical applications of nanomaterials like imaging, diagnostic, drug delivery and their use as regenerative bone substitutes have also been discussed. Conclusions: Considering the recent advances in the field, it can be concluded that the development of nano-based approaches can be possible, which will play important role in the diagnosis and treatment of bone diseases, bone regeneration, and tissue reconstruction.
Avinash P. Ingle; Mahendra Rai. Nanotechnology in the Management of Bone Diseases and as Regenerative Medicine. Current Nanoscience 2018, 14, 95 -103.
AMA StyleAvinash P. Ingle, Mahendra Rai. Nanotechnology in the Management of Bone Diseases and as Regenerative Medicine. Current Nanoscience. 2018; 14 (2):95-103.
Chicago/Turabian StyleAvinash P. Ingle; Mahendra Rai. 2018. "Nanotechnology in the Management of Bone Diseases and as Regenerative Medicine." Current Nanoscience 14, no. 2: 95-103.
Nanotechnology has evolved as an outstanding versatile technology expected to become ubiquitous and to revolutionize the functionality of products in various sectors. The hallmarks of nanomaterials are higher surface area to volume ratio and greater interfacial nature that pave way to their unique fascinating features and functionalities. The environmental fate and behaviour of nanoparticles entail bioavailability, uptake, internalization, and toxicity, which are conditioned by and interactions of the chemistry of both the nanomaterial and the ambient aquatic environment, and the biology of the organisms. Oxidative stress is a predictive paradigm for ambient nanomaterials’ toxicity. Nanoparticles can cross trophic boundaries via bioconcentration and biomagnifications through food chain. Majority of the nanotoxicological studies undertaken so far are descriptive or ‘‘proof-of-principle’’ experiments, which have tried to document toxic effects on individual organisms, bearing hardly any concrete ecological implications. To bridge the knowledge gap an urgent need is to undertake comprehensive studies for unveiling interactions and effects of NPs on different species belonging to different trophic levels of the aquatic ecosystem, and their toxicological responses from genetic to systemic levels. The life cycle assessment and ecological risk assessment of engineered nanomaterials are imperatives for the establishment and implementation of effective and protective regulatory policy. This chapter provides an illustrated account of promises and pitfalls of nanomaterials on an ecotoxicological canvas, with a focus on their toxic effects on life at hierarchical levels of both biological and ecological organization.
Jayanta Kumar Biswas; Mahendra Rai; Avinash P. Ingle; Monojit Mondal; Soumyajit Biswas. Nano-bio Interactions and Ecotoxicity in Aquatic Environment: Plenty of Room at the Bottom but Tyranny at the Top! Nanomaterials: Ecotoxicity, Safety, and Public Perception 2018, 19 -36.
AMA StyleJayanta Kumar Biswas, Mahendra Rai, Avinash P. Ingle, Monojit Mondal, Soumyajit Biswas. Nano-bio Interactions and Ecotoxicity in Aquatic Environment: Plenty of Room at the Bottom but Tyranny at the Top! Nanomaterials: Ecotoxicity, Safety, and Public Perception. 2018; ():19-36.
Chicago/Turabian StyleJayanta Kumar Biswas; Mahendra Rai; Avinash P. Ingle; Monojit Mondal; Soumyajit Biswas. 2018. "Nano-bio Interactions and Ecotoxicity in Aquatic Environment: Plenty of Room at the Bottom but Tyranny at the Top!" Nanomaterials: Ecotoxicity, Safety, and Public Perception , no. : 19-36.
Nanomaterials have been benefiting human by their wide applications in different fields. Till date, many types of natural and engineered nanomaterials have been reported. Each of them has specific characteristics, which are helpful in deciding their use for particular application. Although they are beneficial to the human beings, there is probability of their harmful effects on the ecosystem. After the desired use of the nanomaterials, they are routinely disposed of into the environment either intentionally or unintentionally. This scenario can create the harmful environment for the whole ecosystem. The ecotoxicity of nanomaterials is an imperative point to be considered for the safety of flora and fauna. Hence, with argument on their characteristics and applications, their safety for human and environment should also be considered. Therefore, the present chapter introduces the nanomaterials, encompasses the discussion on major types of nanomaterials, which are being available naturally and others that are synthesized artificially. The parameters which make nanoparticles harmful to ecosystem have also been discussed. Moreover, the special emphasis is given on how the scientific community can deal the situation to avoid the harmful effects of nanoparticles so that it can be beneficial to mankind without causing any damage to ecosystem.
Mahendra Rai; Indarchand Gupta; Avinash P. Ingle; Jayanta Kumar Biswas; Olga V. Sinitsyna. Nanomaterials: What Are They, Why They Cause Ecotoxicity, and How This Can Be Dealt With? Nanomaterials: Ecotoxicity, Safety, and Public Perception 2018, 3 -18.
AMA StyleMahendra Rai, Indarchand Gupta, Avinash P. Ingle, Jayanta Kumar Biswas, Olga V. Sinitsyna. Nanomaterials: What Are They, Why They Cause Ecotoxicity, and How This Can Be Dealt With? Nanomaterials: Ecotoxicity, Safety, and Public Perception. 2018; ():3-18.
Chicago/Turabian StyleMahendra Rai; Indarchand Gupta; Avinash P. Ingle; Jayanta Kumar Biswas; Olga V. Sinitsyna. 2018. "Nanomaterials: What Are They, Why They Cause Ecotoxicity, and How This Can Be Dealt With?" Nanomaterials: Ecotoxicity, Safety, and Public Perception , no. : 3-18.
Mahendra Rai; Dipali Nagaonkar; Avinash P. Ingle; Sreekanth Thota; Debbie C. Crans. Metal Nanoparticles as Therapeutic Agents: A Paradigm Shift in Medicine. Metal Nanoparticles 2017, 33 -48.
AMA StyleMahendra Rai, Dipali Nagaonkar, Avinash P. Ingle, Sreekanth Thota, Debbie C. Crans. Metal Nanoparticles as Therapeutic Agents: A Paradigm Shift in Medicine. Metal Nanoparticles. 2017; ():33-48.
Chicago/Turabian StyleMahendra Rai; Dipali Nagaonkar; Avinash P. Ingle; Sreekanth Thota; Debbie C. Crans. 2017. "Metal Nanoparticles as Therapeutic Agents: A Paradigm Shift in Medicine." Metal Nanoparticles , no. : 33-48.
Ocular diseases including various anterior and posterior segment diseases are considered as the major cause of blindness all over the world. However, efficient delivery of ocular drugs is always a great challenge to researchers and ophthalmologists due to the complex structure and physiology of the eye. The conventional treatment strategies comprising eye drops, injections, and implants may be insufficient in some cases and have severe side effects and/or low bioavailability. In this context, nanotechnology as novel and emerging technology can play important role in development of potential and highly specific strategies for ocular disease treatments. Different nanomaterials-based drug delivery will be useful in overcoming the ocular barriers and control release of drugs. In this chapter, we have discussed various anterior and posterior segment diseases of eye and also focused on the recent advancement in nanomaterial-based systems for efficient drug delivery in various ocular diseases.
Avinash P. Ingle; Priti Paralikar; Alex Grupenmacher; Felipe Hering Padovani; Marilia Trindade Ferrer; Mahendra Rai; Monica Alves. Nanotechnological Interventions for Drug Delivery in Eye Diseases. Nanotechnology Applied To Pharmaceutical Technology 2017, 279 -306.
AMA StyleAvinash P. Ingle, Priti Paralikar, Alex Grupenmacher, Felipe Hering Padovani, Marilia Trindade Ferrer, Mahendra Rai, Monica Alves. Nanotechnological Interventions for Drug Delivery in Eye Diseases. Nanotechnology Applied To Pharmaceutical Technology. 2017; ():279-306.
Chicago/Turabian StyleAvinash P. Ingle; Priti Paralikar; Alex Grupenmacher; Felipe Hering Padovani; Marilia Trindade Ferrer; Mahendra Rai; Monica Alves. 2017. "Nanotechnological Interventions for Drug Delivery in Eye Diseases." Nanotechnology Applied To Pharmaceutical Technology , no. : 279-306.
Nanotechnology is promising science, which plays an important role in revolutionizing the medical and pharmaceutical fields in near future. The widespread applications of nanotechnology have already offered advantages to biomedical problem including wound healing. Generally, wound healing is a complex process; it involves coordinated interactions of diverse immunological and biological processes. However, the long-term wounds remain a challenging clinical problem due to huge chances of secondary infection by different microbes. In this context, various nanoparticles and nanobased formulations are attracting interest for their clinical applications because of their potential biological properties such as antibacterial activity, anti-inflammatory effects and wound healing efficacy. In this chapter, we have focused on role of nanotechnology, particularly the applications of various nanoparticles and their nanoformulations in the management of wound infections. The nanoformulations can be effectively used as therapeutic treatment in wound infections. However, before use of such nanoformulations, in-depth studies on toxicity need to be performed.
Avinash P. Ingle; Priti Paralikar; Raksha Pandit; Netravati Anasane; Indarchand Gupta; Mahendra Rai; Marco Chaud; Carolina Alves Dos Santos. Nanoformulations for Wound Infections. Nanotechnology Applied To Pharmaceutical Technology 2017, 223 -246.
AMA StyleAvinash P. Ingle, Priti Paralikar, Raksha Pandit, Netravati Anasane, Indarchand Gupta, Mahendra Rai, Marco Chaud, Carolina Alves Dos Santos. Nanoformulations for Wound Infections. Nanotechnology Applied To Pharmaceutical Technology. 2017; ():223-246.
Chicago/Turabian StyleAvinash P. Ingle; Priti Paralikar; Raksha Pandit; Netravati Anasane; Indarchand Gupta; Mahendra Rai; Marco Chaud; Carolina Alves Dos Santos. 2017. "Nanoformulations for Wound Infections." Nanotechnology Applied To Pharmaceutical Technology , no. : 223-246.
Now-a-days development of microbial resistancce have become one of the most pressing global public health concerns. It is estimated that about 2 million people are infected in USA with multidrug resistant bacteria and out of these, about 23,000 die per year. In Europe, the number of deaths associated with infection caused by MDR bacteria is about 25,000 per year, However, the situation in Asia and other devloping countries is more critical. Considering the increasing rate of antibiotic resistance in various pathogens, it is estimated that MDR organisms can kill about 10 million people every year by 2050. The use of antibiotics in excessive and irresponsible manner is the main reason towards its ineffectiveness. However, in this context, promising application of nanotechnology in our everyday life has generated a new avenue for the development of potent antimicrobial materials and compounds (nanoantimicrobials) capable of dealing with microbial resistance. The devlopement and safe incorporation of nanoantimicrobials will bring a new revolution in health sector. In this review, we have critically focused on current worldwide situation of antibiotic resistance. In addition, the role of various nanomaterials in the management of microbial resistance and the possible mechanisms for antibacterial action of nanoparticles alone and nanoparticle-antibiotcs conjuagte are also discussed.
Mahendra Rai; Avinash P. Ingle; Raksha Pandit; Priti Paralikar; Indarchand Gupta; Marco V. Chaud; Carolina Alves dos Santos. Broadening the spectrum of small-molecule antibacterials by metallic nanoparticles to overcome microbial resistance. International Journal of Pharmaceutics 2017, 532, 139 -148.
AMA StyleMahendra Rai, Avinash P. Ingle, Raksha Pandit, Priti Paralikar, Indarchand Gupta, Marco V. Chaud, Carolina Alves dos Santos. Broadening the spectrum of small-molecule antibacterials by metallic nanoparticles to overcome microbial resistance. International Journal of Pharmaceutics. 2017; 532 (1):139-148.
Chicago/Turabian StyleMahendra Rai; Avinash P. Ingle; Raksha Pandit; Priti Paralikar; Indarchand Gupta; Marco V. Chaud; Carolina Alves dos Santos. 2017. "Broadening the spectrum of small-molecule antibacterials by metallic nanoparticles to overcome microbial resistance." International Journal of Pharmaceutics 532, no. 1: 139-148.
Flower-shaped copper nanoparticles were synthesised by a green and ecofriendly chemical reduction approach using copper sulphate and cytyltrimethal ammonium bromide. The UV–vis spectrophotometer analysis showed maximum absorption at about 552 nm, which is specifically reported for copper nanoparticles. The crystal lattice structure of copper nanoflowers was confirmed by X-ray diffraction analysis. Further, the transmission electron microscopic studies revealed the flower shape copper nanoparticles in the size range of 100–500 nm. The stability of thus synthesised copper nanoflowers was assessed by zeta potential analysis, which was found to be 35 mV indicating the most stable nature of nanoflowers. The antifungal activity of these copper nanoflowers was evaluated by Kirby–Bauer disk diffusion method against selected common plant pathogenic fungi. It was found that the chemosynthesised copper nanoflowers demonstrated significant inhibitory activity against the plant pathogenic Aspergillus niger, Fusarium moniliforme, F. culmorum, F. oxysporum and F. tricinctum. The maximum antifungal activity was shown against A. niger followed by F. moniliforme, F. oxysporum and F. tricinctum, whereas the minimum activity was reported against F. culmorum. Similarly, the effect of the copper nanoflowers was also evaluated in combination with commercial antifungal agent (ketoconazole), which demonstrated the enhanced activity of antifungal agent.
Avinash P. Ingle; Mahendra Rai. Copper nanoflowers as effective antifungal agents for plant pathogenic fungi. IET Nanobiotechnology 2017, 11, 546 -551.
AMA StyleAvinash P. Ingle, Mahendra Rai. Copper nanoflowers as effective antifungal agents for plant pathogenic fungi. IET Nanobiotechnology. 2017; 11 (5):546-551.
Chicago/Turabian StyleAvinash P. Ingle; Mahendra Rai. 2017. "Copper nanoflowers as effective antifungal agents for plant pathogenic fungi." IET Nanobiotechnology 11, no. 5: 546-551.
Harshal Sonar; Dipali Nagaonkar; Avinash P. Ingle; Mahendra Rai. Mycosynthesized Silver Nanoparticles as Potent Growth Inhibitory Agents Against Selected Waterborne Human Pathogens. CLEAN – Soil, Air, Water 2017, 45, 1 .
AMA StyleHarshal Sonar, Dipali Nagaonkar, Avinash P. Ingle, Mahendra Rai. Mycosynthesized Silver Nanoparticles as Potent Growth Inhibitory Agents Against Selected Waterborne Human Pathogens. CLEAN – Soil, Air, Water. 2017; 45 (4):1.
Chicago/Turabian StyleHarshal Sonar; Dipali Nagaonkar; Avinash P. Ingle; Mahendra Rai. 2017. "Mycosynthesized Silver Nanoparticles as Potent Growth Inhibitory Agents Against Selected Waterborne Human Pathogens." CLEAN – Soil, Air, Water 45, no. 4: 1.