Pese a sus ventajas, los agroquímicos son controversiales por el impacto negativo en el medioambiente ¹ . La aplicación excesiva de pesticidas desarrolla resistencia de las plagas y como daño colateral perjudica a organismos benéficos para el ambiente ³ . Además, la permanencia de estas sustancias en el subsuelo y mantos acuíferos presenta riesgos para el ambiente y la salud humana ⁴ . Entonces, tienen una alta actividad carcinogénica y teratogénica; así como dosis elevadas y una alta exposición a compuestos organofosforados interfieren en la regulación hormonal ³ y se han asociado a diversos trastornos crónicos no transmisibles y no diagnosticados que afectan el sistema cardiovascular, hepático, renal, nervioso y reproductivo. Un ejemplo es la enfermedad renal crónica de etiología desconocida y el síndrome del intestino permeable, trastornos frecuentes en varios países de América Central, partes de Mesoamérica, el sur de Europa, en India y China ⁴ , ⁵ .

Epigenetic regulation is a key component of stress responses, acclimatization and adaptation processes in plants. DNA methylation is a stable mark plausible for the inheritance of epigenetic traits, such that it is a potential scheme for plant breeding. However, the effect of modulators of stress responses, as hydrogen peroxide (H₂O₂), in the methylome status has not been elucidated. A transgenic tobacco model to the CchGLP gene displayed high H₂O₂ endogen levels correlated with biotic and abiotic stresses resistance. The present study aimed to determine the DNA methylation status changes in the transgenic model to obtain more information about the molecular mechanism involved in resistance phenotypes. The Whole-genome bisulfite sequencing analysis revealed a minimal impact of overall levels and distribution of methylation. A total of 9432 differential methylated sites were identified in distinct genome regions, most of them in CHG context, with a trend to hypomethylation. Of these, 1117 sites corresponded to genes, from which 83 were also differentially expressed in the plants. Several genes were associated with respiration, energy, and calcium signaling. The data obtained highlighted the relevance of the H₂O₂ in the homeostasis of the system in stress conditions, affecting at methylation level and suggesting an association of the H₂O₂ in the physiological adaptation to stress functional linkages may be regulated in part by DNA methylation.

The current rise in global energy demand and environmental degradation has highlighted the need to use renewable energy as an alternative to fossil fuels. Ricinus communis L. (castor bean oil) has emerged as a promising source for biofuels production due to high oil content (45–55%), ability to grow on marginal soils, and resistance to adverse conditions. This review analyzes 93 relevant studies from 2019 to 2025, selected by the PRISMA method (Preferred Reporting Items for Systematic reviews and Meta-Analyses) from databases such as Google Scholar and Web of Science. There were identified that agronomic techniques such as optimized plant spacing, balanced fertilization, and elicitation can significantly increase productivity. Among the production methods used, heterogeneous catalysis (96.8%) and enzymatic processes (90%) stand up for their sustainability and efficiency. However, the main limitation remains the high viscosity of castor biodiesel (14–18 mm²/s at 40 °C), which exceeds international quality standards. Even so, castor biodiesel offers excellent lubricity (reduces injection wear by 20%), has standard oxidative stability, and has a relatively low cetane number (38–42), which poses challenges for ignition quality. Improvement strategies such as blending, enzymatic modification, and additive incorporation have shown potential to mitigate these limitations. The review also addresses environmental benefits, regulatory challenges, and market opportunities where the castor biodiesel offers competitive advantages. Enhancing research and innovation, supported by targeted public policies and technical standards, is essential to overcome current barriers and enable the commercial adoption of castor biodiesel as part of a more sustainable and diversified energy future.