Moringa oleifera tree is indigenous and highly abundant in Indonesia and its seeds are widely known to be used as a natural coagulant for treating wastewater. Wastewater from tapioca starch industry, particularly in Indonesia, which contains high organic matters, was revealed by high biochemical oxygen demand (BOD) and chemical oxygen demand (COD) value. In this study the combination of powdered M. oleifera seed and natural filter media was studied. A laboratory scale of tapioca starch wastewater (TSW) treatment was designed using a continuous two-stage clarifier tanks filled with sand or coconut fibre combined with the addition of powdered M. oleifera seed.