Purpose: Knowledge of the hemodynamics in the vascular system is important to understand and treat vascular pathology. The present study aimed to evaluate the hemodynamics in the human carotid artery bifurcation measured by four-dimensional (4D) flow magnetic resonance imaging (MRI) as compared to computational fluid dynamics (CFD). Methods: This protocol used MRI data of 12 healthy volunteers for the 3D vascular models and 4D flow MRI measurements for the boundary conditions in CFD simulation. We compared the velocities measured at the carotid bifurcation and the 3D velocity streamlines of the carotid arteries obtained by these two methods. Results: There was a good agreement for both maximum and minimum velocity values between the 2 methods for velocity magnitude at the bifurcation plane. However, on the 3D blood flow visualization, secondary flows, and recirculation regions are of poorer quality when visualized through the 4D flow MRI. Conclusion: 4D flow MRI and CFD show reasonable agreement in demonstrated velocity magnitudes at the carotid artery bifurcation. However, the visualization of blood flow at the recirculation regions and the assessment of secondary flow characteristics should be enhanced for the use of 4D flow MRI in clinical situations.

A multimodality approach was applied using four-dimensional flow magnetic resonance imaging (4D flow MRI), time-of-flight magnetic resonance angiography (TOF-MRA) signal intensity gradient (SIG), and computational fluid dynamics (CFD) to investigate the 3D blood flow characteristics and wall shear stress (WSS) of the cerebral arteries. TOF-MRA and 4D flow MRI were performed on the major cerebral arteries in 16 healthy volunteers (mean age 34.7 ± 7.6 years). The flow rate measured with 4D flow MRI in the internal carotid artery, middle cerebral artery, and anterior cerebral artery were 3.8, 2.5, and 1.2 mL/s, respectively. The 3D blood flow pattern obtained through CFD and 4D flow MRI on the cerebral arteries showed reasonable consensus. CFD delivered much greater resolution than 4D flow MRI. TOF-MRA SIG and CFD WSS of the major cerebral arteries showed reasonable consensus with the locations where the WSS was relatively high. However, the visualizations were very different between TOF-MRA SIG and CFD WSS at the internal carotid artery bifurcations, the anterior cerebral arteries, and the anterior communicating arteries. 4D flow MRI, TOF-MRA SIG, and CFD are complementary methods that can provide additional insight into the hemodynamics of the human cerebral artery.

Assessment of carotid bulb hemodynamics using four-dimensional (4D) flow magnetic resonance imaging (MRI) requires accurate segmentation of recirculation regions that is frequently hampered by limited resolution. This study aims to improve the accuracy of 4D flow MRI carotid bulb segmentation and subsequent recirculation regions analysis. Time-of-flight (TOF) MRI and 4D flow MRI were performed on bilateral carotid artery bifurcations in seven healthy volunteers. TOF-MRI data was segmented into 3D geometry for computational fluid dynamics (CFD) simulations. ITK-SNAP segmentation software was included in the workflow for the semi-automatic generation of 4D flow MRI angiographic data. This study compared the velocities calculated at the carotid bifurcations and the 3D blood flow visualization at the carotid bulbs obtained by 4D flow MRI and CFD. By applying ITK-SNAP segmentation software, an obvious improvement in the 4D flow MRI visualization of the recirculation regions was observed. The 4D flow MRI images of the recirculation flow characteristics of the carotid artery bulbs coincided with the CFD. A reasonable agreement was found in terms of velocity calculated at the carotid bifurcation between CFD and 4D flow MRI. However, the dispersion of velocity data points relative to the local errors of measurement in 4D flow MRI remains. Our proposed strategy showed the feasibility of improving recirculation regions segmentation and the potential for reliable blood flow visualization in 4D flow MRI. However, quantitative analysis of recirculation regions in 4D flow MRI with ITK-SNAP should be enhanced for use in clinical situations.

Magnetic resonance imaging (MRI) represents one modality in atherosclerosis risk assessment, by permitting the classification of carotid plaques into either high- or low-risk lesions. Although MRI is generally used for observing the impact of atherosclerosis on vessel lumens, it can also show both the size and composition of itself, as well as plaque information, thereby providing information beyond that of simple stenosis. Software systems are a valuable aid in carotid artery stenosis assessment wherein commercial software is readily available but is not accessible to all practitioners because of its often high cost. This study focuses on the development of a software system designed entirely for registration, marking, and 3D visualization of the wall and lumen, using freely available open-source tools and libraries. It was designed to be free from “feature bloat” and avoid “feature-creep.” The image loading and display module of the modified QDCM library was improved by a minimum of 10,000%. A Bezier function was used in order to smoothen the curve of the polygon (referring to the shape formed by the marked points) by interpolating additional points between the marked points. This smoother curve led to a smoother 3D view of the lumen and wall.

Carotid artery geometry has been suggested as a risk factor for atherosclerotic carotid disease. Although normal aging and disease development can both lead to geometric changes in the arteries, the exact nature of this phenomenon remains elusive. The aim of our study was to investigate carotid artery geometric changes in a longitudinal study. We conducted a retrospective study of 114 subjects who underwent carotid contrast-enhanced magnetic resonance angiography at our clinic at baseline (2005 to 2007) and after 10 years. The right (Rev#2–1) carotid arteries were segmented using semi-automated methods to obtain various measurements of carotid artery geometry. For each patient, these parameters were assessed at both time points, including bifurcation angle, internal carotid artery angle, vessel diameter, and circumference. The median age for the total patient population (n = 114) at baseline was 59.06 ± 10.40 years. Mean time interval between baseline magnetic resonance angiography and magnetic resonance angiography after 10 years of these patients was 129.18 ± 7.77 months. For the whole group, there was a significant increase in the bifurcation angle (p < 0.05) over a 10-year period. A significant increase was also noted in the diameter and circumference of the common carotid artery (p < 0.05). However, the other vessel diameters and circumferences (bulb carotid, internal carotid) as well as the internal carotid angle did not significantly change (p ≥ 0.05). The diameter and circumference of the common carotid artery and bifurcation angle significantly increased over a decade of life.

Mục tiêu: Nghiên cứu đặc điểm hình ảnh cộng hưởng từ ung thư cổ tử cung trước xạ trị và khảo sát những thay đổi hình ảnh sau xạ trị từ đó góp phần đánh giá hiệu quả điều trị. Đối tượng, phương pháp: 48 bệnh nhân ung thư cổ tử cung được điều trị bằng hoá xạ trị đồng thời kết hợp với xạ áp sát tại Bệnh viên Trung ương Huế từ tháng 6/2023 đến 8/2024. Phân tích đặc điểm hình ảnh cộng hưởng từ trước và sau điều trị. Kết quả: Độ tuổi trung bình 52,15 ± 10,1. Ung thư biểu mô vảy 89,6%, ung thư biểu mô tuyến 10,4%. Khối u cổ tử cung trước điều trị có thường đặc điểm: tăng tín hiệu trên T2 (75%), hạn chế khuếch tán (100%), ngấm thuốc kém hơn cơ tử cung (89,6%). Sau điều trị hầu hết các khối u đáp ứng tốt với giảm kích thước, mức độ xâm lấn, giảm tín hiệu trên T2W và giảm mức độ khuếch tán. Tỉ lệ đáp ứng một phần và hoàn toàn chiếm 95,8%. Biến chứng thường gặp nhất được ghi nhận là biến chứng tại đường tiết niệu và tiêu hoá với tỉ lệ 10,4%. Kết luận: Cộng hưởng từ là kỹ thuật hình ảnh hữu hiệu để đánh giá hiệu quả điều trị ung thư cổ tử cung.