The SARS-CoV-2 pandemic is spreading rapidly and threatening lives all over the globe. Due to the pandemic, economies all over the world are in deep distress due to disruption in work and operations across all sectors. The present case study was performed for a private Indian manufacturing company that has been affected to a great extent due to this pandemic, as India has the second highest number of SARS-CoV-2 cases after the USA. The deeply troubled company’s current predicament is very complex, as various factors are responsible for the crisis. In order to restore the company back to normal functioning, these factors were studied and evaluated. A diagnostic survey was conducted to obtain data about current working conditions of company. Data from the survey were analyzed qualitatively and quantitatively to identify and evaluate the disruptive factors. Based on this analysis, problems in operational activities were identified and appropriate improvement actions (best practices) were proposed. Furthermore, the proposed improvement actions were assessed from a sustainability perspective to check their feasibility. The best practices framework was generalized to a three-step continuous improvement framework oriented around preparedness for future pandemic-like disruptions. The proposed framework may constitute an indication and set of best practices for consideration by other manufacturing companies that find themselves in a similar situation to the analyzed case study.