Dario Costanza

Dr. Dario Costanza

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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28 May 2021 in PLOS ONE
Verified
Journal Article
Open access
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CCChiara Caterino
Chiara Caterino
FAFederica Aragosa
Federica Aragosa
GVGiovanni Della Valle
Giovanni Della Valle
DCDario Costanza
Dario Costanza
FLFrancesco Lamagna
Francesco Lamagna
GERARDO FATONEGERARDO FATONE
GERARDO FATONE
Introduction: Osteoarthritis is a progressive degenerative joint disease which is high prevalent in dogs. In the late stage of the disease, it determines chronic neuropathic pain which leads to reduced quality-of-life in affected patients. To date it has not yet been identified a specific treatment, but it has been proved that nutraceutical and dietary supplements may play an important role in controlling inflammation and pain. The aim of this study was to evaluate, by the use of force plate gait analysis, the clinical efficacy of Boswellia and Curcuvet® combined with conventional nutraceutical therapy compared with conventional nutraceutical alone in dogs affected by osteoarthritis.Materials and methods: Twenty client-owned dogs, over 12 months old and 20 kg of body-weight, with a confirmed diagnosis of Osteoarthritis, were included in this randomized, double-blinded study. The dogs were randomly divided into two groups: the first group (A) received a conventional nutraceutical (consisted in a preparation of glucosamine, chondroitin sulfate, fish-oil containing 80% of omega 3-fatty acid, vitamin C and E, saccharomyces Cerevisiae) with a combination of acid boswellic and Curcuvet®, while the second group (B) received a conventional nutraceutical. All the enrolled dogs underwent a washout period before starting the treatment with nutraceuticals products which were the only admitted treatment over the study period. A full orthopaedic and neurologic examination, and force plate gait analysis were performed before starting the treatment, at 45, 90, and 60 days post-treatment. Ground reaction forces were recorded and analyzed.Results: Twenty dogs were enrolled in the study. In both groups there was an increasing values of ground reaction forces. These results might indicate that both nutraceutical products determined a better condition in terms of pain feeling but that effect is much more visible after 60 days from the end of the administration in treated group.Discussion: In conclusion Curcuvet in combination with Boswellic acid could be considered a valid aid in a multimodal treatment for canine osteoarthritis.

12 March 2021 in Animals
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Journal Article
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CMChiara Montano
Chiara Montano
Luigi AulettaLuigi Auletta
Luigi Auletta
AGAdelaide Greco
Adelaide Greco
DCDario Costanza
Dario Costanza
PCPierpaolo Coluccia
Pierpaolo Coluccia
MPmaria pia pasolini
maria pia pasolini
The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study’s risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.

11 August 2021 in PLOS ONE
Verified
Journal Article
Open access
PDF file
GVGiovanni Della Valle
Giovanni Della Valle
CCChiara Caterino
Chiara Caterino
FAFederica Aragosa
Federica Aragosa
FMFABIANA MICIELI
FABIANA MICIELI
DCDario Costanza
Dario Costanza
GERARDO FATONEGERARDO FATONE
GERARDO FATONE
Cranial cruciate ligament failure is one of the principal causes of canine lameness. Several surgical procedures were proposed to achieve joint stabilisation; among these, the Modified Maquet Procedure involves using a titanium foam wedge to achieve and maintain the tibial tuberosity advancement. The force-plate analysis provides to objectively assess normal and abnormal gait and the outcome of different surgical techniques. The study evaluates the outcome of limbs that underwent Modified Maquet Procedure using land-force plate analysis comparing the operated limb with its healthy contralateral one as a control. Thirty-five dogs with unilateral cranial cruciate ligament rupture were evaluated. Outcome after surgery was assessed by orthopaedic and radiographic evaluations and force plate gait analysis performed before surgery, at 15, 30 and 90 days after surgery. For objective comparison of ground reaction forces, data of operated limb were compared to contralateral limb on each time control and Symmetry Index at 90 days was determined. Healing radiographic signs, minor and major complication were reported. A significant improvement in ground reaction forces was reached in all the treated limbs between set time intervals. The median percentage increase in ground reaction forces was constant from 15 to 90 days, with a Symmetry Index >9 in 54.2% of patients suggesting a normal gait symmetry. A complete bone healing was noticed at 90 days follow-up radiographic assessment. We experienced three major (8.5%) and one minor (2.8%) complications. To the Authors’ knowledge, this is the first study in the veterinary literature that assessed outcomes of dogs undergoing Modified Maquet Procedure for the treatment of cranial cruciate ligament rupture using force plate gait analysis and healthy contralateral limb as a control group. Our results confirm that Modified Maquet Procedure is an effective method to stabilise the stifle joint.

8 December 2022 in Veterinary Radiology & Ultrasound
Verified
Journal Article
Closed access
DCDario Costanza
Dario Costanza
AGAdelaide Greco
Adelaide Greco
Diego PiantedosiDiego Piantedosi
Diego Piantedosi
Dario BruzzeseDario Bruzzese
Dario Bruzzese
MPmaria pia pasolini
maria pia pasolini
LMLeonardo Meomartino
Leonardo Meomartino

7 February 2021 in Veterinary Radiology & Ultrasound
Verified
Journal Article
Closed access
PDF file
DCDario Costanza
Dario Costanza
MPMaria Pia Pasolini
Maria Pia Pasolini
AGAdelaide Greco
Adelaide Greco
GMGiuseppina Mennonna
Giuseppina Mennonna
Luigi AulettaLuigi Auletta
Luigi Auletta
LMLeonardo Meomartino
Leonardo Meomartino

20 January 2022 in Veterinary Radiology & Ultrasound
Verified
Journal Article
Open access
PDF file
DCDario Costanza
Dario Costanza
PCPierpaolo Coluccia
Pierpaolo Coluccia
ECErica Castiello
Erica Castiello
AGAdelaide Greco
Adelaide Greco
LMLeonardo Meomartino
Leonardo Meomartino
High costs for installing, maintaining, and updating a standard picture archiving and communication system (PACS) can be prohibitive for small/medium‐sized veterinary facilities. The aims of this prospective, exploratory study were to describe the design, implementation, and author experiences for 1 year's use of a low‐cost PACS based on network‐attached storage. The system described here was easily installed and resiliently stored redundant copies of data. It excellently balanced data recovery, system speed, security, and available memory for storage. A virtual private network also allowed off‐site data review. This system can also be used for future off‐site backup of data in the cloud.