Recently, smart stents have been developed by integrating various sensors with intravascular stents for detecting vascular restenosis or monitoring intravascular biomedical conditions such as blood pressure or blood flow velocity. The information on biomedical signals is then transmitted to external monitoring systems via wireless communications. Due to the limited volumes of blood vessels and limited influence of blood flow, antennas with good radiation performance are required for intravascular applications. In this paper, we propose a stent antenna composed of multiple rings containing crowns and struts, where each ring is connected with one connector. Unlike a conventional stent, wherein each ring is connected with several connectors, the single connector prevents the random distribution of electrical current and thus achieves good radiation performance. The implantable stent antenna is designed for the frequency range of 2 to 3 GHz for minimum penetration loss in the human body and tissues. Mechanical FEM simulations were conducted to ensure that the mechanical deformation was within specific limits during balloon expansions. A prototype was fabricated with laser cutting techniques and its radiation performance experimentally characterized. It was demonstrated that the fabricated stent antenna had an omnidirectional radiation pattern for arbitrary receiving angles, a gain of 1.38 dBi, and a radiation efficiency of 74.5% at a resonant frequency of 2.07 GHz. The main contribution of this work was the manipulation of the current distributions of the stent for good EM radiation performances which needed to be further examined while inserted inside human bodies. These research results should contribute to the further development of implantable wireless communications and intravascular monitoring of biomedical signals such as blood pressure and blood flow velocity.

Atherosclerosis, a condition related to cholesterol build-up and thickening of the inner wall of the artery, narrows or occludes the artery lumen. The drug-eluting stent is a major breakthrough for the treatment of such coronary artery diseases. In recent years, another innovative variation of the drug-eluting stent with drug reservoirs has been introduced. It allows programmable drug delivery with spatial and temporal control and has several potential advantages over traditional drug-eluting stents. However, creating such reservoirs on the stent struts may weaken the stent scaffolding and compromise its mechanical integrity. In this paper, the effects of these micro-sized through-hole drug reservoirs on several key clinically relevant functional attributes of the depot stent were investigated. Finite element models were developed to predict the mechanical integrity of a balloon-expandable stent at various stages such as manufacturing and deployment, as well as the stent radial strength and fatigue life. Results show that (1) creating drug reservoirs on a stent could impact the stent fatigue resistance to some degree; (2) drug reservoirs on the stent crowns led to much greater loss in all key clinical attributes than reservoirs on other locations; (3) reservoir shape change resulted in little differences in all key clinical attributes; (4) for the same drug loading capacity, larger and fewer reservoirs yielded lower equivalent plastic strain and radial strength but higher fatigue safety factor; and (5) the proposed depot stent was proven to be a feasible design. Its total drug capacity could be tripled with acceptable marginal trade-off in key clinical attributes. These results can serve as the guidelines to help future stent designs to achieve the best combination of stent mechanical integrity and smart drug delivery in the future, thereby opening up a wide variety of new treatment potentials and opportunities.

A drug-eluting stent with rhombic-shaped drug reservoirs is proposed, aimed at providing long-term drug delivery and enhanced fatigue life. Unique rhombic-shaped reservoirs or channels on the stent struts can increase the total drug capacity and improve the stress distribution for longer fatigue life, without compromising other important clinical attributes. Our rhombic-shaped channel stent increases the total drug capacity by multiple times. Its fatigue safety factor, even with the large rhombic cutouts on the stent struts, could be 50% higher than that of the conventional drug-eluting stent. A pulsed fiber-optic laser and a series of expansions and heat treatments were used to make the first prototype of our rhombic-shaped channel stent. This new concept may open up a wide variety of new treatment options and opportunities for the medical industry in the future.