This page has only limited features, please log in for full access.
The growing competitiveness in the automotive industry and the strict standards to which it is subject, require high quality standards. For this, quality tools such as the failure mode and effects analysis (FMEA) are applied to quantify the risk of potential failure modes. However, for qualitative defects with subjectivity and associated uncertainty, and the lack of specialized technicians, it revealed the inefficiency of the visual inspection process, as well as the limitations of the FMEA that is applied to it. The fuzzy set theory allows dealing with the uncertainty and subjectivity of linguistic terms and, together with the expert systems, allows modeling of the knowledge involved in tasks that require human expertise. In response to the limitations of FMEA, a fuzzy FMEA system was proposed. Integrated in the design, measure, analyze, improve and control (DMAIC) cycle, the proposed system allows the representation of expert knowledge and improves the analysis of subjective failures, hardly detected by visual inspection, compared to FMEA. The fuzzy FMEA system was tested in a real case study at an industrial manufacturing unit. The identified potential failure modes were analyzed and a fuzzy risk priority number (RPN) resulted, which was compared with the classic RPN. The main results revealed several differences between both. The main differences between fuzzy FMEA and classical FMEA come from the non-linear relationship between the variables and in the attribution of an RPN classification that assigns linguistic terms to the results, thus allowing a strengthening of the decision-making regarding the mitigation actions of the most “important” failure modes.
Radu Godina; Beatriz Silva; Pedro Espadinha-Cruz. A DMAIC Integrated Fuzzy FMEA Model: A Case Study in the Automotive Industry. Applied Sciences 2021, 11, 3726 .
AMA StyleRadu Godina, Beatriz Silva, Pedro Espadinha-Cruz. A DMAIC Integrated Fuzzy FMEA Model: A Case Study in the Automotive Industry. Applied Sciences. 2021; 11 (8):3726.
Chicago/Turabian StyleRadu Godina; Beatriz Silva; Pedro Espadinha-Cruz. 2021. "A DMAIC Integrated Fuzzy FMEA Model: A Case Study in the Automotive Industry." Applied Sciences 11, no. 8: 3726.
For decades, industrial companies have been collecting and storing high amounts of data with the aim of better controlling and managing their processes. However, this vast amount of information and hidden knowledge implicit in all of this data could be utilized more efficiently. With the help of data mining techniques unknown relationships can be systematically discovered. The production of semiconductors is a highly complex process, which entails several subprocesses that employ a diverse array of equipment. The size of the semiconductors signifies a high number of units can be produced, which require huge amounts of data in order to be able to control and improve the semiconductor manufacturing process. Therefore, in this paper a structured review is made through a sample of 137 papers of the published articles in the scientific community regarding data mining applications in semiconductor manufacturing. A detailed bibliometric analysis is also made. All data mining applications are classified in function of the application area. The results are then analyzed and conclusions are drawn.
Pedro Espadinha-Cruz; Radu Godina; Eduardo Rodrigues. A Review of Data Mining Applications in Semiconductor Manufacturing. Processes 2021, 9, 305 .
AMA StylePedro Espadinha-Cruz, Radu Godina, Eduardo Rodrigues. A Review of Data Mining Applications in Semiconductor Manufacturing. Processes. 2021; 9 (2):305.
Chicago/Turabian StylePedro Espadinha-Cruz; Radu Godina; Eduardo Rodrigues. 2021. "A Review of Data Mining Applications in Semiconductor Manufacturing." Processes 9, no. 2: 305.
The growing competitiveness of the market has put pressure on companies to improve their customer relationship management strategies. In an era where mass marketing techniques are inadequate, lead management is at the forefront to provide a customized approach to customer acquisition. For this, lead management depends on the correct selection of leads and decision making on what type of approach to take to satisfy the requirements of customers. However, currently, firms are faced with massive quantity of data regarding customers and prospects. Data mining is a solution to cope with this problem, providing a robust approach to massive quantity of data and its complexity. In literature, there is a lack of documented applications of these techniques in lead management. In this sense, we propose a methodology that aims to improve efficiency on the distinct maturity stages of leads management. Also, the methodology aids in support the decision-making regarding the segmentation of leads. This research suggests the application of data mining techniques in the optimization of leads management processes, from capture to conversion, with the objective of improving customer conversion effectiveness. A case study was conducted in a telecommunications company. It was possible to implement the proposed method to estimate the probability of conversion for each lead. With this, was possible to segment the offer to each type of lead.
P. Espadinha-Cruz; A. Fernandes; A. Grilo. Lead management optimization using data mining: A case in the telecommunications sector. Computers & Industrial Engineering 2021, 154, 107122 .
AMA StyleP. Espadinha-Cruz, A. Fernandes, A. Grilo. Lead management optimization using data mining: A case in the telecommunications sector. Computers & Industrial Engineering. 2021; 154 ():107122.
Chicago/Turabian StyleP. Espadinha-Cruz; A. Fernandes; A. Grilo. 2021. "Lead management optimization using data mining: A case in the telecommunications sector." Computers & Industrial Engineering 154, no. : 107122.
Pedro Espadinha-Cruz; António Grilo; António Gonçalves Coelho; António Mourão. An axiomatic design framework to design interoperable buyer–supplier dyads. Enterprise Information Systems 2019, 13, 1392 -1426.
AMA StylePedro Espadinha-Cruz, António Grilo, António Gonçalves Coelho, António Mourão. An axiomatic design framework to design interoperable buyer–supplier dyads. Enterprise Information Systems. 2019; 13 (10):1392-1426.
Chicago/Turabian StylePedro Espadinha-Cruz; António Grilo; António Gonçalves Coelho; António Mourão. 2019. "An axiomatic design framework to design interoperable buyer–supplier dyads." Enterprise Information Systems 13, no. 10: 1392-1426.
The current competitive environment demands cooperative arrangements like buyer-supplier dyads to struggle for the success of supply chains. Managing inter-firm relationships is a decisive and highly demanding activity, whereas business interoperability (BI) is key to achieve meaningful interactions to create value. Nonetheless, cooperation issues due to lack of interoperability constrain the success buyer-supplier dyads. Problems ranging from technical to strategical perspectives of BI may lead to problems like lack of coordination which decrease the supply chain surplus. Interoperability literature provides several contributions and frameworks to deal with different interoperability issues. Nonetheless, it is missing a cohesive framework allowing one to address inter-firm relationships in the full scope of BI. The present paper proposes a framework to support the analysis of interoperability conditions in buyer-supplier dyads. A case study was conducted to demonstrate the framework, and what decisions are required to improve or scale-up cooperation.
Pedro Espadinha-Cruz; António Grilo. The Business Interoperability Decomposition Framework to analyse buyer-supplier dyads. Computers in Industry 2019, 109, 165 -181.
AMA StylePedro Espadinha-Cruz, António Grilo. The Business Interoperability Decomposition Framework to analyse buyer-supplier dyads. Computers in Industry. 2019; 109 ():165-181.
Chicago/Turabian StylePedro Espadinha-Cruz; António Grilo. 2019. "The Business Interoperability Decomposition Framework to analyse buyer-supplier dyads." Computers in Industry 109, no. : 165-181.
Rheumatoid arthritis (RA) is an autoimmune disorder whose treatment is mostly restricted to pain and symptom management and to the delay of joint destruction. Mesenchymal stem/stromal cells from the umbilical cord tissue (UC-MSCs) have previously been proven to be immunomodulatory and more efficient than bone marrow-derived MSCs in causing remission of local and systemic arthritic manifestations in vivo. Given the paracrine nature of UC-MSC activity, their application as active substances can be replaced by their secretome, thus avoiding allogeneic rejection and safety issues related to unwanted grafting. In this work, we aimed at demonstrating the viability of applying the 3D-primed UC-MSC secretome for the amelioration of arthritic signs. A proteomic analysis was performed to both, media conditioned by UC-MSC monolayer (CM2D) and 3D cultures (CM3D). The analysis of relevant trophic factors confirmed secretome profiles with very significant differences in terms of therapeutic potential. Whereas, CM3D was characterised by a prevailing expression of anti-inflammatory cytokines such as IL-10 and LIF, along with trophic factors involved in different mechanisms leading to tissue regeneration, such as PDGF-BB, FGF-2, I-309, SCF, and GM-CSF; CM2D presented relatively higher levels of IL-6, MCP-1, and IL-21, with recognised pro-inflammatory roles in joint disease and pleiotropic effects in the progression of rheumatoid arthritis (RA). Accordingly, different motogenic effects over mouse chondrocytes and distinct capacities of inducing glycosaminoglycan synthesis in vitro were observed between CM3D and CM2D. Finally, the evaluation of arthritic manifestations in vivo, using an adjuvant-induced model for arthritis (AIA), suggested a significantly higher therapeutic potential of CM3D over CM2D and even UC-MSCs. Histological analysis confirmed a faster remission of local and systemic arthritic manifestations of CM3D-treated animals. Overall, the results show that the use of UC-MSC CM3D is a viable and better strategy than direct UC-MSC administration for counteracting AIA-related signs. This strategy represents a novel MSC-based but nonetheless cell-free treatment for arthritic conditions such as those characterising RA.
Joana P. Miranda; Sérgio P. Camões; Maria Manuela Gaspar; Joana Rodrigues; Manuela Carvalheiro; Rita N. Bárcia; Pedro Espadinha da Cruz; Helder Cruz; Sandra Simões; Jorge Miguel Santos. The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis. Frontiers in Immunology 2019, 10, 18 .
AMA StyleJoana P. Miranda, Sérgio P. Camões, Maria Manuela Gaspar, Joana Rodrigues, Manuela Carvalheiro, Rita N. Bárcia, Pedro Espadinha da Cruz, Helder Cruz, Sandra Simões, Jorge Miguel Santos. The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis. Frontiers in Immunology. 2019; 10 ():18.
Chicago/Turabian StyleJoana P. Miranda; Sérgio P. Camões; Maria Manuela Gaspar; Joana Rodrigues; Manuela Carvalheiro; Rita N. Bárcia; Pedro Espadinha da Cruz; Helder Cruz; Sandra Simões; Jorge Miguel Santos. 2019. "The Secretome Derived From 3D-Cultured Umbilical Cord Tissue MSCs Counteracts Manifestations Typifying Rheumatoid Arthritis." Frontiers in Immunology 10, no. : 18.
Pedro Espadinha-Cruz; Antonio Grilo. A Simulation Approach to Select Interoperable Solutions in Supply Chain Dyads. Blockchain Technology and Innovations in Business Processes 2015, 149 -158.
AMA StylePedro Espadinha-Cruz, Antonio Grilo. A Simulation Approach to Select Interoperable Solutions in Supply Chain Dyads. Blockchain Technology and Innovations in Business Processes. 2015; ():149-158.
Chicago/Turabian StylePedro Espadinha-Cruz; Antonio Grilo. 2015. "A Simulation Approach to Select Interoperable Solutions in Supply Chain Dyads." Blockchain Technology and Innovations in Business Processes , no. : 149-158.
Pedro Espadinha-Cruz; António Gonçalves-Coelho; António Mourão; Antonio Grilo. Re-design of an Interoperable Buyer-seller Automotive Relationship Aided by Computer Simulation. Procedia CIRP 2015, 34, 98 -105.
AMA StylePedro Espadinha-Cruz, António Gonçalves-Coelho, António Mourão, Antonio Grilo. Re-design of an Interoperable Buyer-seller Automotive Relationship Aided by Computer Simulation. Procedia CIRP. 2015; 34 ():98-105.
Chicago/Turabian StylePedro Espadinha-Cruz; António Gonçalves-Coelho; António Mourão; Antonio Grilo. 2015. "Re-design of an Interoperable Buyer-seller Automotive Relationship Aided by Computer Simulation." Procedia CIRP 34, no. : 98-105.
Supply Chain Management has become a tactic asset for the current global competition situation. Innovative strategies such as Lean, Agile, Resilient and Green emerged as a response, requiring high levels of cooperation and of great complexity. However, the strategic alignment of operations with partners in supply chains is affected by lack of interoperability. The present work provides a framework to enhance SC competitiveness and performance by assessing interoperable SCM Practices applied in automotive industry.
Pedro Espadinha-Cruz; Antonio Grilo; Virgilio Machado. Fuzzy evaluation model to assess interoperability in LARG Supply Chains. 2012 9th International Conference on Fuzzy Systems and Knowledge Discovery 2012, 75 -79.
AMA StylePedro Espadinha-Cruz, Antonio Grilo, Virgilio Machado. Fuzzy evaluation model to assess interoperability in LARG Supply Chains. 2012 9th International Conference on Fuzzy Systems and Knowledge Discovery. 2012; ():75-79.
Chicago/Turabian StylePedro Espadinha-Cruz; Antonio Grilo; Virgilio Machado. 2012. "Fuzzy evaluation model to assess interoperability in LARG Supply Chains." 2012 9th International Conference on Fuzzy Systems and Knowledge Discovery , no. : 75-79.
Pedro Espadinha-Cruz; Izunildo Cabral. Information Model for LARGeSCM Interoperable Practices. 34th International Conference on INFORMATION TECHNOLOGY INTERFACES 2012, 23 -28.
AMA StylePedro Espadinha-Cruz, Izunildo Cabral. Information Model for LARGeSCM Interoperable Practices. 34th International Conference on INFORMATION TECHNOLOGY INTERFACES. 2012; ():23-28.
Chicago/Turabian StylePedro Espadinha-Cruz; Izunildo Cabral. 2012. "Information Model for LARGeSCM Interoperable Practices." 34th International Conference on INFORMATION TECHNOLOGY INTERFACES , no. : 23-28.
Antonio Grilo; Izunildo Cabral; Rogerio Puga-Leal; Virgilio Machado; Pedro Espadinha da Cruz. DECISION-MAKING MODELS FOR INTEROPERABLE LEAN, AGILE, RESILIENT AND GREEN SUPPLY CHAINS. 2011, 1 .
AMA StyleAntonio Grilo, Izunildo Cabral, Rogerio Puga-Leal, Virgilio Machado, Pedro Espadinha da Cruz. DECISION-MAKING MODELS FOR INTEROPERABLE LEAN, AGILE, RESILIENT AND GREEN SUPPLY CHAINS. . 2011; ():1.
Chicago/Turabian StyleAntonio Grilo; Izunildo Cabral; Rogerio Puga-Leal; Virgilio Machado; Pedro Espadinha da Cruz. 2011. "DECISION-MAKING MODELS FOR INTEROPERABLE LEAN, AGILE, RESILIENT AND GREEN SUPPLY CHAINS." , no. : 1.