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In this work of quercetin's anti-proliferation action on A. flavus, we revealed that quercetin can effectively hamper the proliferation of A. flavus in dose-effect and time-effect relationships. We tested whether quercetin induced apoptosis in A. flavus via various detection methods, such as phosphatidylserine externalization and Hoechst 33342 staining. The results showed that quercetin had no effect on phosphatidylserine externalization and cell nucleus in A. flavus. Simultaneously, quercetin reduced the levels of reactive oxygen species (ROS). For a better understanding of the molecular mechanism of the A. flavus response to quercetin, the RNA-Seq was used to explore the transcriptomic profiles of A. flavus. According to transcriptome sequencing data, quercetin inhibits the proliferation and aflatoxin biosynthesis by regulating the expression of development-related genes and aflatoxin production-related genes. These results will provide some theoretical basis for quercetin as an anti-mildew agent resource.
Xiu-Mei Li; Zhong-Yuan Li; Ya-Dong Wang; Jin-Quan Wang; Pei-Long Yang. Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus. Toxins 2019, 11, 154 .
AMA StyleXiu-Mei Li, Zhong-Yuan Li, Ya-Dong Wang, Jin-Quan Wang, Pei-Long Yang. Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus. Toxins. 2019; 11 (3):154.
Chicago/Turabian StyleXiu-Mei Li; Zhong-Yuan Li; Ya-Dong Wang; Jin-Quan Wang; Pei-Long Yang. 2019. "Quercetin Inhibits the Proliferation and Aflatoxins Biosynthesis of Aspergillus flavus." Toxins 11, no. 3: 154.
Bao-Hua Xu; Jin-Quan Wang; Jian Sun; Ying Huang; Jun-Ping Zhang; Xiang-Ping Zhang; Suo-Jiang Zhang. ChemInform Abstract: Fixation of CO2into Cyclic Carbonates Catalyzed by Ionic Liquids: A Multi-Scale Approach. ChemInform 2015, 46, 1 .
AMA StyleBao-Hua Xu, Jin-Quan Wang, Jian Sun, Ying Huang, Jun-Ping Zhang, Xiang-Ping Zhang, Suo-Jiang Zhang. ChemInform Abstract: Fixation of CO2into Cyclic Carbonates Catalyzed by Ionic Liquids: A Multi-Scale Approach. ChemInform. 2015; 46 (11):1.
Chicago/Turabian StyleBao-Hua Xu; Jin-Quan Wang; Jian Sun; Ying Huang; Jun-Ping Zhang; Xiang-Ping Zhang; Suo-Jiang Zhang. 2015. "ChemInform Abstract: Fixation of CO2into Cyclic Carbonates Catalyzed by Ionic Liquids: A Multi-Scale Approach." ChemInform 46, no. 11: 1.
This experiment was conducted to investigate the effects of oral administration of monosodium glutamate (MSG) on expression of genes for hepatic lipid and nitrogen metabolism in piglets. A total of 24 newborn pigs were assigned randomly into one of four treatments (n = 6/group). The doses of oral MSG administration, given at 8:00 and 18:00 to sow-reared piglets between 0 and 21 days of age, were 0 (control), 0.06 (low dose), 0.5 (intermediate dose), and 1 (high dose) g/kg body weight/day. At the end of the 3-week treatment, serum concentrations of total protein and high-density lipoprotein cholesterol in the intermediate dose group were elevated than those in the control group (P < 0.05). Hepatic mRNA levels for fatty acid synthase, acetyl-coA carboxylase, insulin-like growth factor-1, glutamate–oxaloacetate transaminase, and glutamate–pyruvate transaminase were higher in the middle-dose group (P < 0.05), compared with the control group. MSG administration did not affect hepatic mRNA levels for hormone-sensitive lipase or carnitine palmitoyl transferase-1. We conclude that oral MSG administration alters hepatic expression of certain genes for lipid and nitrogen metabolism in suckling piglets.
Gang Chen; Jun Zhang; Yuzhe Zhang; Peng Liao; Tiejun Li; Lixiang Chen; Yulong Yin; Jinquan Wang; Guoyao Wu. Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets. Amino Acids 2013, 46, 245 -250.
AMA StyleGang Chen, Jun Zhang, Yuzhe Zhang, Peng Liao, Tiejun Li, Lixiang Chen, Yulong Yin, Jinquan Wang, Guoyao Wu. Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets. Amino Acids. 2013; 46 (1):245-250.
Chicago/Turabian StyleGang Chen; Jun Zhang; Yuzhe Zhang; Peng Liao; Tiejun Li; Lixiang Chen; Yulong Yin; Jinquan Wang; Guoyao Wu. 2013. "Oral MSG administration alters hepatic expression of genes for lipid and nitrogen metabolism in suckling piglets." Amino Acids 46, no. 1: 245-250.