This study investigates the effects of welding velocity on weldability of dissimilar cast/rolled high-entropy alloys and the applicability of cryogenic temperatures. Cast HEA side of dissimilar weld metal (WM) indicates a larger dendrite packet and dendrite arm spacing (DAS) than rolled WM. Size difference is associated with epitaxial growth from each base metal (BM). As the welding velocity increases (6–10 m min⁻¹), shrinkage voids and DASs decreases. Dissimilar welds show tensile properties comparable to cast BM, where there are tensile fractures of dissimilar welds. Cryogenic properties of dissimilar welds are superior to those of room-temperature welds, because deformation twins and dislocation densities are significantly formed at 77 K. Therefore, dissimilar welds can be applied to the production of cryogenic products.