Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal support and metabolism. Thus, a tight regulation of oligodendroglial cell specification, proliferation, and myelination is required for correct neuronal connectivity and function. Here, we review the role of epigenetic modifications in oligodendroglial lineage cells. First, we briefly describe the epigenetic modalities of gene regulation, which are known to have a role in oligodendroglial cells. We then address how epigenetic enzymes and/or marks have been associated with oligodendrocyte progenitor specification, survival and proliferation, differentiation, and finally, myelination. We finally mention how environmental cues, in particular, neuronal signals, are translated into epigenetic modifications, which can directly influence oligodendroglial biology.

5.8K Views. The City University of New York. MALDI Imaging mass spectrometry is a unique advancement in the field of metabolomics that allows us to measure and visualize relative metabolite abundance and distribution, which are indicative of organisms, physiological and pathological conditions. The main advantage of MALDI Imaging is its ability to detect metabolites in C2 without the need of labeling. Demonstrating the procedure, we have you Sami Sauma, a graduate student from Dr.Patricia Casita's lab.Yuki Chen and Kelly Veerasam... Jove

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