Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer.

Objective: The aim of this study was to evaluate temperature variation induced by a diode laser in periodontal repair. Background Data: A diode laser operating with medium power can constitute an alternative device for bacterial reduction at periodontal pockets. This procedure will probably avoid any kind of undesirable thermal damage to the irradiated tissues. Methods: The temperature variation induced by a 810-nm diode laserwas investigated in an in vitro study, varying the soft tissue thickness, and in an in vivo study for soft periodontal and bone tissues. The laser powers used were 600 mW, 800 mW, 1.0 W, and 1.2 W, and the light was delivered by a 300-µm fiber. Results: The laser parameters and irradiation time used did not induce a temperature variation high enough to cause thermal irreversible damage to the periodontal tissues investigated. Conclusions: This study contributes to the establishment of thermally safe working parameters of a diode medium power laser.