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Dr. Henri Schroeder
University of Lorraine

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0 Behavioral Neuroscience
0 Cognitive Science
0 Neuroscience
0 biological psychology
0 Developmental neurotoxicology

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Short Biography

As an Associate Professor at the Lorraine University, I am working on the effects of early-life insults related to the environmental pollution on the developing brain. My current research interest concerns the characterization of the developmental toxicity on brain and behavior of early exposure to various pollutants like HBCDD, PAHs and DEP.

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Organ toxicity and mechanisms
Published: 29 June 2021 in Archives of Toxicology
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Limited studies in humans and in animal models have investigated the neurotoxic risks related to a gestational exposure to diesel exhaust particles (DEP) on the embryonic brain, especially those regarding monoaminergic systems linked to neurocognitive disorders. We previously showed that exposure to DEP alters monoaminergic neurotransmission in fetal olfactory bulbs and modifies tissue morphology along with behavioral consequences at birth in a rabbit model. Given the anatomical and functional connections between olfactory and central brain structures, we further characterized their impacts in brain regions associated with monoaminergic neurotransmission. At gestational day 28 (GD28), fetal rabbit brains were collected from dams exposed by nose-only to either a clean air or filtered DEP for 2 h/day, 5 days/week, from GD3 to GD27. HPLC dosage and histochemical analyses of the main monoaminergic systems, i.e., dopamine (DA), noradrenaline (NA), and serotonin (5-HT) and their metabolites were conducted in microdissected fetal brain regions. DEP exposure increased the level of DA and decreased the dopaminergic metabolites ratios in the prefrontal cortex (PFC), together with sex-specific alterations in the hippocampus (Hp). In addition, HVA level was increased in the temporal cortex (TCx). Serotonin and 5-HIAA levels were decreased in the fetal Hp. However, DEP exposure did not significantly modify NA levels, tyrosine hydroxylase, tryptophan hydroxylase or AChE enzymatic activity in fetal brain. Exposure to DEP during fetal life results in dopaminergic and serotonergic changes in critical brain regions that might lead to detrimental potential short-term neural disturbances as precursors of long-term neurocognitive consequences.

ACS Style

Estefania Bernal-Meléndez; Jacques Callebert; Pascaline Bouillaud; Marie-Annick Persuy; Benoit Olivier; Karine Badonnel; Pascale Chavatte-Palmer; Christine Baly; Henri Schroeder. Dopaminergic and serotonergic changes in rabbit fetal brain upon repeated gestational exposure to diesel engine exhaust. Archives of Toxicology 2021, 95, 3085 -3099.

AMA Style

Estefania Bernal-Meléndez, Jacques Callebert, Pascaline Bouillaud, Marie-Annick Persuy, Benoit Olivier, Karine Badonnel, Pascale Chavatte-Palmer, Christine Baly, Henri Schroeder. Dopaminergic and serotonergic changes in rabbit fetal brain upon repeated gestational exposure to diesel engine exhaust. Archives of Toxicology. 2021; 95 (9):3085-3099.

Chicago/Turabian Style

Estefania Bernal-Meléndez; Jacques Callebert; Pascaline Bouillaud; Marie-Annick Persuy; Benoit Olivier; Karine Badonnel; Pascale Chavatte-Palmer; Christine Baly; Henri Schroeder. 2021. "Dopaminergic and serotonergic changes in rabbit fetal brain upon repeated gestational exposure to diesel engine exhaust." Archives of Toxicology 95, no. 9: 3085-3099.

Journal article
Published: 08 March 2021 in Toxics
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The potent neurotoxicity of benzo[a]pyrene (B[a]P) has been suggested to be a susceptibility factor accelerating the onset of brain tumours and the emergence of neurobehavioural disturbances. B[a]P has been shown to be neurotoxic, acting directly on both the central and peripheral nervous systems, as well as indirectly via peripheral organs like liver and gut. By using a realistic B[a]P exposure scenario (0.02–200 mg/kg/day, 10 days) in mice, we elucidated brain-specific B[a]P metabolism and at identified hydroxylated B[a]P metabolites in serum which could be used as markers of cognitive impairment. Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself. At the same doses, mice exhibited a reduction in anxiety in both the elevated plus maze and the hole board apparatus. Concomitantly, B[a]P triggered dose-dependent changes in Nmda subunit expression (Nr1 and Nr2a/Nr2b) in areas involved in cognition. We detected 9-OH-B[a]P and 7,8-diol-B[a]P in serum at the level for which cognitive impairment was observed. We suggest that these metabolites may, in the future be exploited as potent biomarkers of B[a]P-induced cognitive impairments.

ACS Style

Lynda Cherif; Lei Cao-Lei; Sophie Farinelle; Claude Muller; Jonathan Turner; Henri Schroeder; Nathalie Grova. Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study. Toxics 2021, 9, 50 .

AMA Style

Lynda Cherif, Lei Cao-Lei, Sophie Farinelle, Claude Muller, Jonathan Turner, Henri Schroeder, Nathalie Grova. Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study. Toxics. 2021; 9 (3):50.

Chicago/Turabian Style

Lynda Cherif; Lei Cao-Lei; Sophie Farinelle; Claude Muller; Jonathan Turner; Henri Schroeder; Nathalie Grova. 2021. "Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study." Toxics 9, no. 3: 50.

Journal article
Published: 17 January 2019 in Particle and Fibre Toxicology
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Airborne pollution, especially from diesel exhaust (DE), is known to have a negative effect on the central nervous system in exposed human populations. However, the consequences of gestational exposure to DE on the fetal brain remain poorly explored, with various effects depending on the conditions of exposure, as well as little information on early developmental stages. We investigated the short-term effects of indirect DE exposure throughout gestation on the developing brain using a rabbit model. We analyzed fetal olfactory tissues at the end of gestation and tested behaviors relevant to pups’ survival at birth. Pregnant dams were exposed by nose-only inhalation to either clean air or DE with a content of particles (DEP) adjusted to 1 mg/m3 by diluting engine exhaust, for 2 h/day, 5 days/week, from gestational day 3 (GD3) to day 27 (GD27). At GD28, fetal olfactory mucosa, olfactory bulbs and whole brains were collected for anatomical and neurochemical measurements. At postnatal day 2 (PND2), pups born from another group of exposed or control female were examined for their odor-guided behavior in response to the presentation of the rabbit mammary pheromone 2-methyl-3-butyn-2-ol (2MB2). At GD28, nano-sized particles were observed in cilia and cytoplasm of the olfactory sensory neurons in the olfactory mucosa and in the cytoplasm of periglomerular cells in the olfactory bulbs of exposed fetuses. Moreover, cellular and axonal hypertrophies were observed throughout olfactory tissues. Concomitantly, fetal serotoninergic and dopaminergic systems were affected in the olfactory bulbs. Moreover, the neuromodulatory homeostasis was disturbed in a sex-dependent manner in olfactory tissues. At birth, the olfactory sensitivity to 2MB2 was reduced in exposed PND2 pups. Gestational exposure to DE alters olfactory tissues and affects monoaminergic neurotransmission in fetuses’ olfactory bulbs, resulting in an alteration of olfactory-based behaviors at birth. Considering the anatomical and functional continuum between the olfactory system and other brain structures, and due to the importance of monoamine neurotransmission in the plasticity of neural circuits, such alterations could participate to disturbances in higher integrative structures, with possible long-term neurobehavioral consequences.

ACS Style

Estefanía Bernal-Meléndez; Marie-Christine Lacroix; Pascaline Bouillaud; Jacques Callebert; Benoit Olivier; Marie-Annick Persuy; Didier Durieux; Delphine Rousseau-Ralliard; Josiane Aioun; Flemming Cassee; Anne Couturier-Tarrade; Sarah Valentino; Pascale Chavatte-Palmer; Henri Schroeder; Christine Baly. Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring. Particle and Fibre Toxicology 2019, 16, 1 -17.

AMA Style

Estefanía Bernal-Meléndez, Marie-Christine Lacroix, Pascaline Bouillaud, Jacques Callebert, Benoit Olivier, Marie-Annick Persuy, Didier Durieux, Delphine Rousseau-Ralliard, Josiane Aioun, Flemming Cassee, Anne Couturier-Tarrade, Sarah Valentino, Pascale Chavatte-Palmer, Henri Schroeder, Christine Baly. Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring. Particle and Fibre Toxicology. 2019; 16 (1):1-17.

Chicago/Turabian Style

Estefanía Bernal-Meléndez; Marie-Christine Lacroix; Pascaline Bouillaud; Jacques Callebert; Benoit Olivier; Marie-Annick Persuy; Didier Durieux; Delphine Rousseau-Ralliard; Josiane Aioun; Flemming Cassee; Anne Couturier-Tarrade; Sarah Valentino; Pascale Chavatte-Palmer; Henri Schroeder; Christine Baly. 2019. "Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring." Particle and Fibre Toxicology 16, no. 1: 1-17.

Journal article
Published: 01 November 2015 in Neurotoxicology and Teratology
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The present study investigated the developmental neurotoxicity of an early exposure to α-HBCDD through the ingestion of contaminated hen's egg in pregnant and lactating Wistar female rats. Hens were given α-HBCDD-contaminated feed (40 ng/g fresh matter) for 5 and 10 days, which produced eggs with HBCDD content of 33 and 102 ng/glipid weight, respectively. Female rats were administered daily p.o. with an appropriate volume of the whole egg from the day of fertilization (GD0) to the weaning day for pups (PND21). Fetuses and pups were thus exposed continuously to α-HBCDD via the dam over a whole 42-day period that included both gestation and lactation. The administered egg volume was calculated on the basis of daily egg consumption in humans (0.7 egg/person/day) and duration of gestation and lactation in both species, which led animals to be exposed to α-HBCDD at levels of 22 and 66 ng/kg/day, respectively. Neurobehavioral development of pups was investigated from PND3 to PND25 using various tasks including the righting reflex (PND4), the grasping reflex (PND5), the negative geotaxis (PND9), the forelimb grip strength test (PND10) and the locomotor coordination test (PND20). Pup ultrasonic vocalizations were also recorded daily from PND4 to PND14. After weaning, behaviors related to spontaneous locomotor activity and anxiety were examined in the open-field (PND25) and in an elevated-plus maze (PND26), respectively. The results showed a significant decrease in body weight of pups exposed to the lower HBCDD level from PND3 to PND28, whereas the weight of rat pups given 66 ng/kg/day of HBCDD was not different from controls. During the first 3 weeks of life, impairments in motor maturation of pups were observed in a dose-dependent manner depending on the test, whereas no significant differences were reported between male and female pups. At PND26, the anxiety level of female rats exposed to the lowest dose of HBCDD (22 ng/kg/day) was significantly reduced whereas it remained unchanged in males. No significant variations were measured in rats exposed to the higher level of HBCDD (66 ng/kg/day). These results suggest the potent developmental neurotoxicity of an early chronic exposure to the HBCDD α-isomer through the ingestion of hen's eggs contaminated with this pollutant and question the long-lasting consequences of this exposure on behavior abilities and brain functioning in adulthood.

ACS Style

Nicolas Maurice; Jean-Charles Olry; Ronan Cariou; Gaud Dervilly-Pinel; Bruno LE Bizec; Angélique Travel; Catherine Jondreville; Henri Schroeder. Short-term effects of a perinatal exposure to the HBCDD α-isomer in rats: Assessment of early motor and sensory development, spontaneous locomotor activity and anxiety in pups. Neurotoxicology and Teratology 2015, 52, 170 -180.

AMA Style

Nicolas Maurice, Jean-Charles Olry, Ronan Cariou, Gaud Dervilly-Pinel, Bruno LE Bizec, Angélique Travel, Catherine Jondreville, Henri Schroeder. Short-term effects of a perinatal exposure to the HBCDD α-isomer in rats: Assessment of early motor and sensory development, spontaneous locomotor activity and anxiety in pups. Neurotoxicology and Teratology. 2015; 52 ():170-180.

Chicago/Turabian Style

Nicolas Maurice; Jean-Charles Olry; Ronan Cariou; Gaud Dervilly-Pinel; Bruno LE Bizec; Angélique Travel; Catherine Jondreville; Henri Schroeder. 2015. "Short-term effects of a perinatal exposure to the HBCDD α-isomer in rats: Assessment of early motor and sensory development, spontaneous locomotor activity and anxiety in pups." Neurotoxicology and Teratology 52, no. : 170-180.

Journal article
Published: 01 May 2015 in Neurotoxicology and Teratology
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ACS Style

Nicolas Maurice; Jean-Charles Olry; Ronan Cariou; Philippe Marchand; Gaud Dervilly-Pinel; Bruno Le Bizec; Angélique Travel; Catherine Jondreville; Henri Schroeder. Assessment of the short-term neurobehavioral toxicity of a perinatal exposure to the hexabromocyclododecane (HBCDD) α-isomer in rats. Neurotoxicology and Teratology 2015, 49, 123 .

AMA Style

Nicolas Maurice, Jean-Charles Olry, Ronan Cariou, Philippe Marchand, Gaud Dervilly-Pinel, Bruno Le Bizec, Angélique Travel, Catherine Jondreville, Henri Schroeder. Assessment of the short-term neurobehavioral toxicity of a perinatal exposure to the hexabromocyclododecane (HBCDD) α-isomer in rats. Neurotoxicology and Teratology. 2015; 49 ():123.

Chicago/Turabian Style

Nicolas Maurice; Jean-Charles Olry; Ronan Cariou; Philippe Marchand; Gaud Dervilly-Pinel; Bruno Le Bizec; Angélique Travel; Catherine Jondreville; Henri Schroeder. 2015. "Assessment of the short-term neurobehavioral toxicity of a perinatal exposure to the hexabromocyclododecane (HBCDD) α-isomer in rats." Neurotoxicology and Teratology 49, no. : 123.

Journal article
Published: 01 May 2015 in Neurotoxicology and Teratology
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ACS Style

Julie Peiffer; Marie-Josèphe Decret; Hervé Nunge; Guido Rychen; Frédéric Cosnier; Henri Schroeder. Short- and long-term neurobehavioral toxicity of fluorene after a nose-only exposure during the lactating period (14 days) in F1 Wistar rats. Neurotoxicology and Teratology 2015, 49, 146 -147.

AMA Style

Julie Peiffer, Marie-Josèphe Decret, Hervé Nunge, Guido Rychen, Frédéric Cosnier, Henri Schroeder. Short- and long-term neurobehavioral toxicity of fluorene after a nose-only exposure during the lactating period (14 days) in F1 Wistar rats. Neurotoxicology and Teratology. 2015; 49 ():146-147.

Chicago/Turabian Style

Julie Peiffer; Marie-Josèphe Decret; Hervé Nunge; Guido Rychen; Frédéric Cosnier; Henri Schroeder. 2015. "Short- and long-term neurobehavioral toxicity of fluorene after a nose-only exposure during the lactating period (14 days) in F1 Wistar rats." Neurotoxicology and Teratology 49, no. : 146-147.

Journal article
Published: 01 September 2014 in Toxicology Letters
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ACS Style

Nathalie Grova; Emilie M. Hardy; Guillaume Salquebre; Henri Schroeder; Brice M.R. Appenzeller. Tetrahydroxylated-benzo[a]pyrene isomer analysis after hydrolysis of DNA-adducts isolated from white blood cells. Toxicology Letters 2014, 229, S125 .

AMA Style

Nathalie Grova, Emilie M. Hardy, Guillaume Salquebre, Henri Schroeder, Brice M.R. Appenzeller. Tetrahydroxylated-benzo[a]pyrene isomer analysis after hydrolysis of DNA-adducts isolated from white blood cells. Toxicology Letters. 2014; 229 ():S125.

Chicago/Turabian Style

Nathalie Grova; Emilie M. Hardy; Guillaume Salquebre; Henri Schroeder; Brice M.R. Appenzeller. 2014. "Tetrahydroxylated-benzo[a]pyrene isomer analysis after hydrolysis of DNA-adducts isolated from white blood cells." Toxicology Letters 229, no. : S125.

Journal article
Published: 01 July 2014 in NeuroToxicology
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International audienceHumans are exposed to polycyclic aromatic hydrocarbons (PAHs), a family of ubiquitous neurotoxic pollutants, mainly through ingestion of contaminated food. Developing organisms can be exposed also to PAHs due to the ability of these compounds to pass through the placental barrier as well as through the breast milk. Previous animal studies have reported that the exposure of rats to a 16 PAH mixture at environmental doses strictly limited to gestation did not induce any long-lasting consequences, whereas gestational and lactational PAH exposure induced long-term behavioral and cerebral metabolic effects. In the present study, short-term effects of exposures to the same PAH mixture during gestation, or during gestation and lactation, were assessed by evaluating motor and sensory development of rat pups, and by measuring cerebral cytochrome oxidase activity (a marker of energetic metabolism) in different brain areas. Brain levels of PAHs and some monohydroxylated metabolites were also evaluated in pups at birth and at 21 days of postnatal life. No significant short-term modifications of behavioral development and of cerebral metabolism were observed following an early PAH exposure whatever the dose and the period of exposure. Surprisingly, the same brain levels of concentration of PAHs and metabolites were observed in control and exposed pups in both studies. These analytical results raise the difficulty in overcoming environmental contamination of control animals and the choice of such controls in experimental studies which focus on neurotoxicity of exposure to low levels of pollutants

ACS Style

Guillemette Crépeaux; Nathalie Grova; Pascaline Bouillaud-Kremarik; Nurgul Sikhayeva; Guillaume Salquèbre; Guido Rychen; Rachid Soulimani; Brice Appenzeller; Henri Schroeder. Short-term effects of a perinatal exposure to a 16 polycyclic aromatic hydrocarbon mixture in rats: Assessment of early motor and sensorial development and cerebral cytochrome oxidase activity in pups. NeuroToxicology 2014, 43, 90 -101.

AMA Style

Guillemette Crépeaux, Nathalie Grova, Pascaline Bouillaud-Kremarik, Nurgul Sikhayeva, Guillaume Salquèbre, Guido Rychen, Rachid Soulimani, Brice Appenzeller, Henri Schroeder. Short-term effects of a perinatal exposure to a 16 polycyclic aromatic hydrocarbon mixture in rats: Assessment of early motor and sensorial development and cerebral cytochrome oxidase activity in pups. NeuroToxicology. 2014; 43 ():90-101.

Chicago/Turabian Style

Guillemette Crépeaux; Nathalie Grova; Pascaline Bouillaud-Kremarik; Nurgul Sikhayeva; Guillaume Salquèbre; Guido Rychen; Rachid Soulimani; Brice Appenzeller; Henri Schroeder. 2014. "Short-term effects of a perinatal exposure to a 16 polycyclic aromatic hydrocarbon mixture in rats: Assessment of early motor and sensorial development and cerebral cytochrome oxidase activity in pups." NeuroToxicology 43, no. : 90-101.

Journal article
Published: 30 September 2013 in NeuroToxicology
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Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse disease induced by HR ingestion. So, the present study was conducted to assess the brain metabolome and the behavioural performances of mice fed with a 9%-HR-based diet for 21 days. By the end of the period of exposure, mice were investigated for motor activity and coordination, anxiety level, learning and memory performances, social behaviour and rewarding properties of for the plant. Thus, the animals were sacrificed and the brain metabolome was studied using 1H NMR spectroscopy. HR-exposed mice displayed a motor hyperactivity in several tasks, a less resignation in the forced swimming test, and paradigm place preference for the plant. A bootstrap-based regularized canonical analysis performed on merged behavioural and metabolic datasets showed a clear relationship in HR-treated mice between an increase in cerebral scyllo-inositol, an increased motor activity, and seemingly rewarding properties of HR. These results underlie the interest of such a dual approach to characterize functional end-points of a pathophysiological model of the Australian stringhalt in equine species.

ACS Style

Céline Domange; Henri Schroeder; Nicolas Violle; Julie Peiffer; Cécile Canlet; Alain Paris; Nathalie Priymenko. Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. NeuroToxicology 2013, 38, 74 -83.

AMA Style

Céline Domange, Henri Schroeder, Nicolas Violle, Julie Peiffer, Cécile Canlet, Alain Paris, Nathalie Priymenko. Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. NeuroToxicology. 2013; 38 ():74-83.

Chicago/Turabian Style

Céline Domange; Henri Schroeder; Nicolas Violle; Julie Peiffer; Cécile Canlet; Alain Paris; Nathalie Priymenko. 2013. "Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse." NeuroToxicology 38, no. : 74-83.

Research article
Published: 20 August 2013 in PLOS ONE
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Fluorene is one of the most abundant polycyclic aromatic hydrocarbons in air and may contribute to the neurobehavioral alterations induced by the environmental exposure of humans to PAHs. Since no data are available on fluorene neurotoxicity, this study was conducted in adult rats to assess the behavioral toxicity of repeated fluorene inhalation exposure. Male rats (n = 18/group) were exposed nose-only to 1.5 or 150 ppb of fluorene 6 hours/day for 14 consecutive days, whereas the control animals were exposed to non-contaminated air. At the end of the exposure, animals were tested for activity and anxiety in an open-field and in an elevated-plus maze, for short-term memory in a Y-maze, and for spatial learning in an eight-arm maze. The results showed that the locomotor activity and the learning performances of the animals were unaffected by fluorene. In parallel, the fluorene-exposed rats showed a lower level of anxiety than controls in the open-field, but not in the elevated-plus maze, which is probably due to a possible difference in the aversive feature of the two mazes. In the same animals, increasing blood and brain levels of fluorene monohydroxylated metabolites (especially the 2-OH fluorene) were detected at both concentrations (1.5 and 150 ppb), demonstrating the exposure of the animals to the pollutant and showing the ability of this compound to be metabolized and to reach the cerebral compartment. The present study highlights the possibility for a 14-day fluorene exposure to induce some specific anxiety-related behavioral disturbances, and argues in favor of the susceptibility of the adult brain when exposed to volatile fluorene.

ACS Style

Julie Peiffer; Frederic Cosnier; Nathalie Grova; Hervé Nunge; Guillaume Salquèbre; Marie-Josèphe Decret; Benoît Cossec; Guido Rychen; Brice M. R. Appenzeller; Henri Schroeder. Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats. PLOS ONE 2013, 8, e71413 .

AMA Style

Julie Peiffer, Frederic Cosnier, Nathalie Grova, Hervé Nunge, Guillaume Salquèbre, Marie-Josèphe Decret, Benoît Cossec, Guido Rychen, Brice M. R. Appenzeller, Henri Schroeder. Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats. PLOS ONE. 2013; 8 (8):e71413.

Chicago/Turabian Style

Julie Peiffer; Frederic Cosnier; Nathalie Grova; Hervé Nunge; Guillaume Salquèbre; Marie-Josèphe Decret; Benoît Cossec; Guido Rychen; Brice M. R. Appenzeller; Henri Schroeder. 2013. "Neurobehavioral Toxicity of a Repeated Exposure (14 Days) to the Airborne Polycyclic Aromatic Hydrocarbon Fluorene in Adult Wistar Male Rats." PLOS ONE 8, no. 8: e71413.

Book chapter
Published: 09 December 2011 in Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring
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ACS Style

Céline Domange; Alain Paris; Henri Schroeder; Nathalie Priymenko. Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease. Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring 2011, 1 .

AMA Style

Céline Domange, Alain Paris, Henri Schroeder, Nathalie Priymenko. Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease. Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring. 2011; ():1.

Chicago/Turabian Style

Céline Domange; Alain Paris; Henri Schroeder; Nathalie Priymenko. 2011. "Power of a Metabonomic Approach to Investigate an Unknown Nervous Disease." Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring , no. : 1.

Journal article
Published: 04 July 2011 in Toxicology Letters
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Polybrominated diphenyl ethers (PBDEs) are flame retardants. Because of their high lipophilicity and persistence, PBDEs bioaccumulate in all abiotic and biological matrices. The aim of this study was to investigate the long-term neurobehavioral and physiological effects of exposure to environmental doses of PBDE-99 in adult rats. Rats received a daily administration of PBDE-99 for 90 days by oral gavage at 0.15, 1.5 and 15 μg/kg, doses which are relevant of human exposure. Before and after the 90 days of exposure, behavioral tests including the open-field and the elevated plus-maze tests for locomotor activity and anxiety, and the Morris water maze for spatial learning were conducted. Physiological measures such as body weight, food and water consumption, organs weight, hepatic enzymes levels and PBDE-99 concentration in adipose tissue were also evaluated at the end of exposure. There was no effect on body weight, food and water consumption, organs weight, hepatic enzymes levels despite rising PBDE-99 concentration in adipose tissue with the doses tested. Moreover, there was no effect on locomotor activity and exploration, and spatial learning. Deleterious effects of PBDE-99 at high doses have often been highlighted in many studies after an acute dose whereas exposure during 90 days at realistic doses would have no significant effect in adult rats.

ACS Style

Stéphanie Daubié; Jean-François Bisson; Robert Lalonde; Henri Schroeder; Guido Rychen. Neurobehavioral and physiological effects of low doses of polybrominated diphenyl ether (PBDE)-99 in male adult rats. Toxicology Letters 2011, 204, 57 -63.

AMA Style

Stéphanie Daubié, Jean-François Bisson, Robert Lalonde, Henri Schroeder, Guido Rychen. Neurobehavioral and physiological effects of low doses of polybrominated diphenyl ether (PBDE)-99 in male adult rats. Toxicology Letters. 2011; 204 (1):57-63.

Chicago/Turabian Style

Stéphanie Daubié; Jean-François Bisson; Robert Lalonde; Henri Schroeder; Guido Rychen. 2011. "Neurobehavioral and physiological effects of low doses of polybrominated diphenyl ether (PBDE)-99 in male adult rats." Toxicology Letters 204, no. 1: 57-63.

Conference abstract
Published: 05 October 2008 in Toxicology Letters
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ACS Style

Julie Peiffer; Catherine Strazielle; Henri Schroeder. Investigation of the brain distribution of the neuronal cytochrome oxidase activity in adult mice submitted to a subacute benzo(a)pyrene administration. Toxicology Letters 2008, 180, S40 -40.

AMA Style

Julie Peiffer, Catherine Strazielle, Henri Schroeder. Investigation of the brain distribution of the neuronal cytochrome oxidase activity in adult mice submitted to a subacute benzo(a)pyrene administration. Toxicology Letters. 2008; 180 ():S40-40.

Chicago/Turabian Style

Julie Peiffer; Catherine Strazielle; Henri Schroeder. 2008. "Investigation of the brain distribution of the neuronal cytochrome oxidase activity in adult mice submitted to a subacute benzo(a)pyrene administration." Toxicology Letters 180, no. : S40-40.

Conference abstract
Published: 05 October 2008 in Toxicology Letters
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ACS Style

Beatriz Labelle-Alvarez; Guido Rychen; Cyril Feidt; Alain Paris; Henri Schroeder; Cécile Canlet. Cerebral consequences of an oral chronic administration of goat milk contaminated with polycyclic aromatic hydrocarbons (PAHs) or a polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), polychlorobiphenyls (PCBs) mixture in adult rats: A metabonomic and behavioural study. Toxicology Letters 2008, 180, S124 .

AMA Style

Beatriz Labelle-Alvarez, Guido Rychen, Cyril Feidt, Alain Paris, Henri Schroeder, Cécile Canlet. Cerebral consequences of an oral chronic administration of goat milk contaminated with polycyclic aromatic hydrocarbons (PAHs) or a polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), polychlorobiphenyls (PCBs) mixture in adult rats: A metabonomic and behavioural study. Toxicology Letters. 2008; 180 ():S124.

Chicago/Turabian Style

Beatriz Labelle-Alvarez; Guido Rychen; Cyril Feidt; Alain Paris; Henri Schroeder; Cécile Canlet. 2008. "Cerebral consequences of an oral chronic administration of goat milk contaminated with polycyclic aromatic hydrocarbons (PAHs) or a polychlorodibenzo-p-dioxins (PCDDs), polychlorodibenzofurans (PCDFs), polychlorobiphenyls (PCBs) mixture in adult rats: A metabonomic and behavioural study." Toxicology Letters 180, no. : S124.

Conference abstract
Published: 05 October 2008 in Toxicology Letters
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ACS Style

Cao Lei; Nathalie Grova; Henri Schroeder; Claude P. Muller. Effects of an oral subacute administration of benzo(a)pyrene on cerebral CYP1A1 expression and anxiety-related behaviour in adult mice. Toxicology Letters 2008, 180, S40 .

AMA Style

Cao Lei, Nathalie Grova, Henri Schroeder, Claude P. Muller. Effects of an oral subacute administration of benzo(a)pyrene on cerebral CYP1A1 expression and anxiety-related behaviour in adult mice. Toxicology Letters. 2008; 180 ():S40.

Chicago/Turabian Style

Cao Lei; Nathalie Grova; Henri Schroeder; Claude P. Muller. 2008. "Effects of an oral subacute administration of benzo(a)pyrene on cerebral CYP1A1 expression and anxiety-related behaviour in adult mice." Toxicology Letters 180, no. : S40.