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My main research interests are focusing on the role of dietary marine proteins and more recently on the role of berries and algae extracts in the prevention and treatment of dyslipidemia, insulin resistance and diabetes in various animal models and in healthy, dyslipidemic and insulin-resistant human subjects.
Exposure to persistent organic pollutants (POPs) is associated with insulin resistance while folic acid (FA) may offer a protective effect. However, the paternal contribution to metabolic phenotypes in offspring is not well known yet. Hence, we investigated whether maternal exposure to POPs affects glucose homeostasis and whether maternal FA supplementation counteracts POP effects transmitted via male descendants. Sprague–Dawley founder dams (F0) were fed a diet containing 2 or 6 mg/kg of FA and were force-fed with either a POP mixture or corn oil for 9 weeks. Subsequent male descendants did not receive any treatment. Blood glucose, plasma insulin and C-peptide were measured during an oral glucose tolerance test in males aged 90 and 180 days from generation 1 (F1), 2 (F2) and 3 (F3). Prenatal POP exposure increased fasting glucose in 90-day-old F1 males and C-peptide in 90-day-old F2 males. Prenatal FA supplementation decreased C-peptide in 90 and 180-day-old F1 males. In 180-day-old F3 males, FA supplementation counteracted POPs on fasting and postglucose C-peptide, indicating reduced insulin secretion. Prenatal exposure to an environmentally relevant POP mixture caused abnormalities in glucose homeostasis that are transmitted from one generation to the next through the paternal lineage. Prenatal FA supplementation counteracted some of the deleterious effects of POPs on glucose homeostasis.
Pauline Navarro; Mathieu Dalvai; Phanie L. Charest; Pauline Herst; Maryse Lessard; Bruno Marcotte; Nadine Leblanc; Sarah Kimmins; Jacquetta Trasler; Amanda MacFarlane; André Marette; Janice L. Bailey; Hélène Jacques. Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants. Environments 2021, 8, 24 .
AMA StylePauline Navarro, Mathieu Dalvai, Phanie L. Charest, Pauline Herst, Maryse Lessard, Bruno Marcotte, Nadine Leblanc, Sarah Kimmins, Jacquetta Trasler, Amanda MacFarlane, André Marette, Janice L. Bailey, Hélène Jacques. Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants. Environments. 2021; 8 (3):24.
Chicago/Turabian StylePauline Navarro; Mathieu Dalvai; Phanie L. Charest; Pauline Herst; Maryse Lessard; Bruno Marcotte; Nadine Leblanc; Sarah Kimmins; Jacquetta Trasler; Amanda MacFarlane; André Marette; Janice L. Bailey; Hélène Jacques. 2021. "Prenatal Exposure to Persistent Organic Pollutants and Maternal Folic Acid Supplementation: Their Impact on Glucose Homeostasis in Male Rat Descendants." Environments 8, no. 3: 24.
Sea cucumbers have been shown to have potential health benefits and are a rich source of several bioactive compounds, particularly triterpenoid saponins. However, most studies concentrate on the body wall, and little is known about the health effects of the coproducts. The objectives of this study were to determine the nutritional composition of a coproduct from the sea cucumber Cucumaria frondosa and the effects of the dietary consumption of this coproduct on cardiometabolic health in rats. Chemical, biochemical, and nutritional analyses were performed to characterize this coproduct. Forty (40) male Wistar rats were then equally divided into four groups and fed a purified control diet or a diet enriched with 0.5%, 1.5%, or 2.5% (by protein) of coproduct. After 28 days of feeding, the rats were sacrificed. Body and tissue weight, body composition, epididymal adipocyte diameter, plasma and hepatic lipids, glycemia, and insulinemia were measured at the end of the 28-day experiment. Analysis of the coproduct revealed high levels of protein, omega-3 fatty acids, minerals, and saponins. The 1.5% group had significantly smaller epididymal adipocytes vs. the control. We conclude that dietary administration of this sea cucumber coproduct at 1.5% doses decreases visceral adiposity, potentially decreasing the risk of cardiometabolic dysfunction. The coproduct’s saponin content may contribute to the observed effects, but the impact of other components cannot be ruled out.
Alan Ramalho; Nadine Leblanc; Marie-Gil Fortin; André Marette; André Tchernof; Hélène Jacques. Characterization of a Coproduct from the Sea Cucumber Cucumaria frondosa and Its Effects on Visceral Adipocyte Size in Male Wistar Rats. Marine Drugs 2020, 18, 530 .
AMA StyleAlan Ramalho, Nadine Leblanc, Marie-Gil Fortin, André Marette, André Tchernof, Hélène Jacques. Characterization of a Coproduct from the Sea Cucumber Cucumaria frondosa and Its Effects on Visceral Adipocyte Size in Male Wistar Rats. Marine Drugs. 2020; 18 (11):530.
Chicago/Turabian StyleAlan Ramalho; Nadine Leblanc; Marie-Gil Fortin; André Marette; André Tchernof; Hélène Jacques. 2020. "Characterization of a Coproduct from the Sea Cucumber Cucumaria frondosa and Its Effects on Visceral Adipocyte Size in Male Wistar Rats." Marine Drugs 18, no. 11: 530.
Prenatal exposure to persistent organic pollutants (POPs) has been associated with the development of metabolic syndrome-related diseases in offspring. According to epidemiological studies, father’s transmission of environmental effects in addition to mother’s can influence offspring health. Moreover, maternal prenatal dietary folic acid (FA) may beneficially impact offspring health. The objective is to investigate whether prenatal FA supplementation can overcome the deleterious effects of prenatal exposure to POPs on lipid homeostasis and inflammation in three generations of male rat descendants through the paternal lineage. Female Sprague-Dawley rats (F0) were exposed to a POPs mixture (or corn oil) +/− FA supplementation for 9 weeks before and during gestation. F1 and F2 males were mated with untreated females. Plasma and hepatic lipids were measured in F1, F2, and F3 males after 12-h fast. Gene expression of inflammatory cytokines was determined by qPCR in epididymal adipose tissue. In F1 males, prenatal POPs exposure increased plasma lipids at 14 weeks old and hepatic lipids at 28 weeks old and prenatal FA supplementation decreased plasma total cholesterol at 14 weeks old. Prenatal POPs exposure decreased plasma triglycerides at 14 weeks old in F2 males. No change was observed in inflammatory markers. Our results show an impact of the paternal lineage on lipid homeostasis in rats up to the F2 male generation. FA supplementation of the F0 diet, regardless of POPs exposure, lowered plasma cholesterol in F1 males but failed to attenuate the deleterious effects of prenatal POPs exposure on plasma and hepatic lipids in F1 males.
Pauline Navarro; Mathieu Dalvai; Phanie L. Charest; Pauline M. Herst; Maryse Lessard; Bruno Marcotte; Patricia L. Mitchell; Nadine Leblanc; Sarah Kimmins; Jacquetta Trasler; Amanda J. Macfarlane; André Marette; Janice Bailey; Hélène Jacques. Maternal folic acid supplementation does not counteract the deleterious impact of prenatal exposure to environmental pollutants on lipid homeostasis in male rat descendants. Journal of Developmental Origins of Health and Disease 2019, 11, 427 -437.
AMA StylePauline Navarro, Mathieu Dalvai, Phanie L. Charest, Pauline M. Herst, Maryse Lessard, Bruno Marcotte, Patricia L. Mitchell, Nadine Leblanc, Sarah Kimmins, Jacquetta Trasler, Amanda J. Macfarlane, André Marette, Janice Bailey, Hélène Jacques. Maternal folic acid supplementation does not counteract the deleterious impact of prenatal exposure to environmental pollutants on lipid homeostasis in male rat descendants. Journal of Developmental Origins of Health and Disease. 2019; 11 (4):427-437.
Chicago/Turabian StylePauline Navarro; Mathieu Dalvai; Phanie L. Charest; Pauline M. Herst; Maryse Lessard; Bruno Marcotte; Patricia L. Mitchell; Nadine Leblanc; Sarah Kimmins; Jacquetta Trasler; Amanda J. Macfarlane; André Marette; Janice Bailey; Hélène Jacques. 2019. "Maternal folic acid supplementation does not counteract the deleterious impact of prenatal exposure to environmental pollutants on lipid homeostasis in male rat descendants." Journal of Developmental Origins of Health and Disease 11, no. 4: 427-437.
Fish contains high quality proteins and essential nutrients including 25-hydroxyvitamin D (25(OH)D). Fish peptide consumption can lower cardiovascular disease (CVD) risk factors, and studies have shown an association between 25(OH)D deficiency, CVD and CVD risk factors, such as diabetes. This study investigated acute effects of a single dose of cholecalciferol (VitD3), bonito fish peptide hydrolysate (BPH), or a combination of both on CVD risk factors and whole blood gene expression levels. A randomized, crossover, placebo controlled trial was conducted in 22 adults. They ingested, in random order and at 7-day intervals, 1000 IU of VitD3, 3 g of BPH, a combination of both, or a placebo. A 180 min oral glucose tolerance test was performed. Differences in whole-genome expression levels after versus before each supplementation were computed for 18 subjects. We observed that 16, 1 and 5 transcripts were differentially expressed post- vs. pre-ingestion for VitD3, BPH or VitD3 + BPH treatments, respectively. VitD3-containing treatments affected the expression of the solute carrier family 25 member 20 (SLC25A20) gene involved in fatty acid oxidation, various transcription factors and genes related to glucose metabolism. These results suggest that VitD3 rapidly modulates genes related to CVD risk factors in blood while BPH seems to moderately modulate gene expression levels.
Frédéric Guénard; Hélène Jacques; Claudia Gagnon; André Marette; Marie-Claude Vohl. Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial. International Journal of Molecular Sciences 2019, 20, 1944 .
AMA StyleFrédéric Guénard, Hélène Jacques, Claudia Gagnon, André Marette, Marie-Claude Vohl. Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial. International Journal of Molecular Sciences. 2019; 20 (8):1944.
Chicago/Turabian StyleFrédéric Guénard; Hélène Jacques; Claudia Gagnon; André Marette; Marie-Claude Vohl. 2019. "Acute Effects of Single Doses of Bonito Fish Peptides and Vitamin D on Whole Blood Gene Expression Levels: A Randomized Controlled Trial." International Journal of Molecular Sciences 20, no. 8: 1944.
A non-thermal high hydrostatic pressure (HHP) technology in combination with polysaccharidases is proposed as a novel approach to improve the phytochemical extraction from red macroalgae. Two macroalgae species, Palmaria palmata and Solieria chordalis, were hydrolyzed with cellulase and hemicellulase (separately or in combination) under HHP (400 MPa, 20 min). The HHP-assisted enzymatic treatment improved the extraction of specific molecules such as proteins, polyphenols and polysaccharides, but their effects are highly dependent on the macroalgae species. Consequently, the antioxidant activity of extracted fractions was improved by over 2.8 times for the treatment with HHP with hemicellulase. Antioxidant activity was highly correlated with polysaccharide (89%) and protein (83%) contents for S. chordalis, and with polyphenol (65%) for P. palmata. Our experiments demonstrated, for the first time, the potential of HHP-assisted enzymatic extraction of various phytochemicals from red macroalgae and the fact that their effects are highly dependent on the macroalgae species used.
Shyam Suwal; Véronique Perreault; Alice Marciniak; Éric Tamigneaux; Éric Deslandes; Laurent Bazinet; Hélène Jacques; Lucie Beaulieu; Alain Doyen. Effects of high hydrostatic pressure and polysaccharidases on the extraction of antioxidant compounds from red macroalgae, Palmaria palmata and Solieria chordalis. Journal of Food Engineering 2019, 252, 53 -59.
AMA StyleShyam Suwal, Véronique Perreault, Alice Marciniak, Éric Tamigneaux, Éric Deslandes, Laurent Bazinet, Hélène Jacques, Lucie Beaulieu, Alain Doyen. Effects of high hydrostatic pressure and polysaccharidases on the extraction of antioxidant compounds from red macroalgae, Palmaria palmata and Solieria chordalis. Journal of Food Engineering. 2019; 252 ():53-59.
Chicago/Turabian StyleShyam Suwal; Véronique Perreault; Alice Marciniak; Éric Tamigneaux; Éric Deslandes; Laurent Bazinet; Hélène Jacques; Lucie Beaulieu; Alain Doyen. 2019. "Effects of high hydrostatic pressure and polysaccharidases on the extraction of antioxidant compounds from red macroalgae, Palmaria palmata and Solieria chordalis." Journal of Food Engineering 252, no. : 53-59.
We provide an overview of studies on seafood intake in relation to obesity, insulin resistance and type 2 diabetes. Overweight and obesity development is for most individuals the result of years of positive energy balance. Evidence from intervention trials and animal studies suggests that frequent intake of lean seafood, as compared with intake of terrestrial meats, reduces energy intake by 4–9 %, sufficient to prevent a positive energy balance and obesity. At equal energy intake, lean seafood reduces fasting and postprandial risk markers of insulin resistance, and improves insulin sensitivity in insulin-resistant adults. Energy restriction combined with intake of lean and fatty seafood seems to increase weight loss. Marinen-3 PUFA are probably of importance throughn-3 PUFA-derived lipid mediators such as endocannabinoids and oxylipins, but other constituents of seafood such as the fish proteinper se, trace elements or vitamins also seem to play a largely neglected role. A high intake of fatty seafood increases circulating levels of the insulin-sensitising hormone adiponectin. As compared with a high meat intake, high intake of seafood has been reported to reduce plasma levels of the hepatic acute-phase protein C-reactive protein level in some, but not all studies. More studies are needed to confirm the dietary effects on energy intake, obesity and insulin resistance. Future studies should be designed to elucidate the potential contribution of trace elements, vitamins and undesirables present in seafood, and we argue that stratification into responders and non-responders in randomised controlled trials may improve the understanding of health effects from intake of seafood.
Bjørn Liaset; Jannike Øyen; Hélène Jacques; Karsten Kristiansen; Lise Madsen. Seafood intake and the development of obesity, insulin resistance and type 2 diabetes. Nutrition Research Reviews 2019, 32, 146 -167.
AMA StyleBjørn Liaset, Jannike Øyen, Hélène Jacques, Karsten Kristiansen, Lise Madsen. Seafood intake and the development of obesity, insulin resistance and type 2 diabetes. Nutrition Research Reviews. 2019; 32 (1):146-167.
Chicago/Turabian StyleBjørn Liaset; Jannike Øyen; Hélène Jacques; Karsten Kristiansen; Lise Madsen. 2019. "Seafood intake and the development of obesity, insulin resistance and type 2 diabetes." Nutrition Research Reviews 32, no. 1: 146-167.
Cyclic fatty acid monomers (CFAM) generated through domestic or industrial heating of vegetable oils may alter liver enzymes and induce hepatomegaly and steatosis, but the underlying mechanisms are not clearly understood. This study aimed to assess the effects of CFAM on liver and plasma lipids and to determine whether these effects are modulated by dietary lipids. Thirty‐six (36) male Wistar rats were fed either of the four isoenergetic diets consisting of canola oil or soybean oil with/without 500 mg/100 g CFAM of total fat for 28 days. Rats fed CFAM had higher liver total lipids (p = 0.03) and triacylglycerols (TAG) (p = 0.02), but less hepatic phosphatidylcholine (p = 0.02) compared to those fed the non‐CFAM diets. CFAM did not alter liver phosphatidylethanolamine N‐methyltransferase (PEMT) activity and CTP: phosphocholine cytidylyltransferase (CT‐α) protein levels. Rats fed CFAM diets had higher levels of plasma total cholesterol (TC), VLDL + LDL cholesterol, higher ratio of TC to HDL cholesterol, and lower levels of HDL cholesterol compared with rats fed non‐CFAM diets (p < 0.05). Plasma alanine transaminase (ALT) was decreased with CFAM, but plasma insulin, glucose, and TAG did not vary among the four diet groups (p < 0.05). Rats fed canola oil and CFAM had higher plasma levels of aspartate transaminase (AST) and AST/ALT ratio compared with the other three diet groups. These results indicate that CFAM may provoke an accumulation of TAG in the liver related to a decrease in phosphatidylcholine (PC) levels, but the effect of CFAM on PC concentrations may not occur through impairment of the two main PC biosynthesis pathways.
Jean Mboma; Nadine Leblanc; Sereana Wan; René L. Jacobs; André Tchernof; Pascal Dubé; Paul Angers; Hélène Jacques. Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat. Food Science & Nutrition 2018, 6, 2092 -2103.
AMA StyleJean Mboma, Nadine Leblanc, Sereana Wan, René L. Jacobs, André Tchernof, Pascal Dubé, Paul Angers, Hélène Jacques. Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat. Food Science & Nutrition. 2018; 6 (8):2092-2103.
Chicago/Turabian StyleJean Mboma; Nadine Leblanc; Sereana Wan; René L. Jacobs; André Tchernof; Pascal Dubé; Paul Angers; Hélène Jacques. 2018. "Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat." Food Science & Nutrition 6, no. 8: 2092-2103.
This study assesses the effects of cyclic fatty acid monomers (CFAM) from heated vegetable oils on oxidative stress and inflammation. Wistar rats were fed either of the four diets for 28 days: canola oil (CO), canola oil and 0.5% CFAM (CC), soybean oil (SO), and soybean oil and 0.5% CFAM (SC). Markers of oxidative stress and inflammation were respectively determined by micro-LC-MS/MS and ELISA kits. ANOVA for a 2 x 2 factorial design was performed to determine the CFAM and oil effects and interactions between these two factors at P≦0.05. For significant interactions, a post hoc multiple comparison test was performed, i.e. Tukey HSD test. CFAM induced higher plasma levels of 15-F2t-IsoP (CC: 396 ± 43 ng/mL, SC: 465 ± 75 ng/mL vs. CO: 261 ± 23 ng/mL and SO: 288 ± 35 ng/mL, P<0.05). Rats fed the SC diet had higher plasma 2,3-dinor-15-F2t-IsoP (SC: 145 ± 9 ng/mL vs. CC: 84 ± 8 ng/mL , CO: 12 ± 1 ng/mL, and SO: 12 ± 1 ng/mL, P<0.05), urinary 2,3-dinor-15-F2t-IsoP (SC: 117 ± 12 ng/mL vs. CC: 67 ± 13 ng/mL, CO: 15 ± 2 ng/mL , and SO: 18 ± 4 ng/mL, P<0.05), and plasma IL-6 (SC: 57 ± 10 pg/mL vs. CC: 48 ± 11 pg/mL, CO: 46 ± 9 pg/mL, and SO: 44 ± 4 pg/mL, P<0.05) than the other three diet groups. These results indicate that CFAM increased the levels of markers of oxidative stress, and those effects are exacerbated by a CFAM-high-linoleic acid diet.
Jean Mboma; Nadine Leblanc; Paul Angers; Amandine Rocher; Claire Vigor; Camille Oger; Guillaume Reversat; Joseph Vercauteren; Jean Marie Galano; Thierry Durand; Hélène Jacques. Effects of Cyclic Fatty Acid Monomers from Heated Vegetable Oil on Markers of Inflammation and Oxidative Stress in Male Wistar Rats. Journal of Agricultural and Food Chemistry 2018, 66, 7172 -7180.
AMA StyleJean Mboma, Nadine Leblanc, Paul Angers, Amandine Rocher, Claire Vigor, Camille Oger, Guillaume Reversat, Joseph Vercauteren, Jean Marie Galano, Thierry Durand, Hélène Jacques. Effects of Cyclic Fatty Acid Monomers from Heated Vegetable Oil on Markers of Inflammation and Oxidative Stress in Male Wistar Rats. Journal of Agricultural and Food Chemistry. 2018; 66 (27):7172-7180.
Chicago/Turabian StyleJean Mboma; Nadine Leblanc; Paul Angers; Amandine Rocher; Claire Vigor; Camille Oger; Guillaume Reversat; Joseph Vercauteren; Jean Marie Galano; Thierry Durand; Hélène Jacques. 2018. "Effects of Cyclic Fatty Acid Monomers from Heated Vegetable Oil on Markers of Inflammation and Oxidative Stress in Male Wistar Rats." Journal of Agricultural and Food Chemistry 66, no. 27: 7172-7180.
The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period, significantly decreased the serum levels of isoleucine and valine, and during the postprandial state, a decreased level of lactate and increased levels of citrate and trimethylamine N-oxide were observed. The non-seafood diet significantly increased the fasting level of 26 lipid species including ceramides 18:1/14:0 and 18:1/23:0 and lysophosphatidylcholines 20:4 and 22:5, as compared to the lean-seafood diet. Thus, the lean-seafood diet decreased circulating isoleucine and valine levels, whereas the non-seafood diet elevated the levels of certain ceramides, metabolites that are associated with insulin-resistance.
Mette Schmedes; Claudia Balderas; Eli Kristin Aadland; Hélène Jacques; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Asle Holthe; Gunnar Mellgren; Jette Feveile Young; Ulrik Kræmer Sundekilde; Bjørn Liaset; Hanne Christine Bertram. The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. Nutrients 2018, 10, 598 .
AMA StyleMette Schmedes, Claudia Balderas, Eli Kristin Aadland, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Ulrik Kræmer Sundekilde, Bjørn Liaset, Hanne Christine Bertram. The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. Nutrients. 2018; 10 (5):598.
Chicago/Turabian StyleMette Schmedes; Claudia Balderas; Eli Kristin Aadland; Hélène Jacques; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Asle Holthe; Gunnar Mellgren; Jette Feveile Young; Ulrik Kræmer Sundekilde; Bjørn Liaset; Hanne Christine Bertram. 2018. "The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults." Nutrients 10, no. 5: 598.
The impact of dietary protein types on the gut microbiome is scarcely studied. The aim of the present study was therefore to examine the effects of lean-seafood and non-seafood proteins on the gut microbiome composition and activity and elucidate potential associations to cardiovascular disease (CVD) risk factors. A cross-over intervention study in which 20 healthy subjects consumed two diets that varied in protein source was conducted. 1H NMR spectroscopy and 16S rDNA sequencing analyses were applied to characterize fecal metabolites and gut microbiota composition, respectively. A twofold increase in fecal trimethylamine excretion was observed after the lean-seafood diet period. Circulating TAG and the total- to HDL cholesterol ratio as well as circulating TMAO levels were each associated with specific gut bacteria. Following the non-seafood diet period, a decreased relative abundance of Clostridium cluster IV and a tendency towards an increased Firmicutes/Bacteroidetes ratio were found. Lean-seafood and non-seafood diets differentially modulates the gut microbiome composition and activity. Furthermore, the gut microbiota composition seem to affect circulating TMAO levels and CVD risk factors. This article is protected by copyright. All rights reserved
Mette Schmedes; Asker Brejnrod; Eli Kristin Aadland; Pia Kiilerich; Karsten Kristiansen; Hélène Jacques; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Asle Holthe; Gunnar Mellgren; Jette Feveile Young; Ulrik Sundekilde; Bjørn Liaset; Hanne Christine Bertram. The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results from a Randomized Crossover Intervention Study. Molecular Nutrition & Food Research 2018, 63, e1700976 .
AMA StyleMette Schmedes, Asker Brejnrod, Eli Kristin Aadland, Pia Kiilerich, Karsten Kristiansen, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Ulrik Sundekilde, Bjørn Liaset, Hanne Christine Bertram. The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results from a Randomized Crossover Intervention Study. Molecular Nutrition & Food Research. 2018; 63 (1):e1700976.
Chicago/Turabian StyleMette Schmedes; Asker Brejnrod; Eli Kristin Aadland; Pia Kiilerich; Karsten Kristiansen; Hélène Jacques; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Asle Holthe; Gunnar Mellgren; Jette Feveile Young; Ulrik Sundekilde; Bjørn Liaset; Hanne Christine Bertram. 2018. "The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results from a Randomized Crossover Intervention Study." Molecular Nutrition & Food Research 63, no. 1: e1700976.
Plant-derived foods rich in polyphenols are associated with several cardiometabolic health benefits, such as reduced postprandial hyperglycaemia. However, their impact on whole-body insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp technique remains under-studied. We aimed to determine the effects of strawberry and cranberry polyphenols (SCP) on insulin sensitivity, glucose tolerance, insulin secretion, lipid profile, inflammation and oxidative stress markers in free-living insulin-resistant overweight or obese human subjects (n 41) in a parallel, double-blind, controlled and randomised clinical trial. The experimental group consumed an SCP beverage (333 mg SCP) daily for 6 weeks, whereas the Control group received a flavour-matched Control beverage that contained 0 mg SCP. At the beginning and at the end of the experimental period, insulin sensitivity was assessed by a hyperinsulinaemic-euglycaemic clamp, and glucose tolerance and insulin secretion by a 2-h oral glucose tolerance test (OGTT). Insulin sensitivity increased in the SCP group as compared with the Control group (+0·9 (sem 0·5)×10−3v. −0·5 (sem 0·5)×10−3 mg/kg per min per pmol, respectively, P=0·03). Compared with the Control group, the SCP group had a lower first-phase insulin secretion response as measured by C-peptide levels during the first 30 min of the OGTT (P=0·002). No differences were detected between the two groups for lipids and markers of inflammation and oxidative stress. A 6-week dietary intervention with 333 mg of polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects but was not effective in improving other cardiometabolic risk factors.
Martine Paquette; Ana S. Medina Larqué; S. J. Weisnagel; Yves Desjardins; Julie Marois; Geneviève Pilon; Stéphanie Dudonné; André Marette; Hélène Jacques. Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial. British Journal of Nutrition 2017, 117, 519 -531.
AMA StyleMartine Paquette, Ana S. Medina Larqué, S. J. Weisnagel, Yves Desjardins, Julie Marois, Geneviève Pilon, Stéphanie Dudonné, André Marette, Hélène Jacques. Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial. British Journal of Nutrition. 2017; 117 (4):519-531.
Chicago/Turabian StyleMartine Paquette; Ana S. Medina Larqué; S. J. Weisnagel; Yves Desjardins; Julie Marois; Geneviève Pilon; Stéphanie Dudonné; André Marette; Hélène Jacques. 2017. "Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial." British Journal of Nutrition 117, no. 4: 519-531.
This study was designed to determine whether marine-derived proteins other than cod could have beneficial effects on inflammation following muscle injury. Macrophage and neutrophil densities were measured from bupivacaine-injured tibialis anterior muscle of rats fed isoenergetic diets containing either shrimp hydrolysate (Shr), casein hydrolysate (CaH), or whole casein (Ca). In this study, Shr reduced ED1+-macrophages at day 2 (p=0.013), day 5 (p=0.006), and day 14 after injury (p=0.038) compared with Ca, indicating faster resolution of inflammation in Shr. Except for day 2 after injury where Shr led to lower ED1+-macrophages compared with CaH (p=0.006), both Shr and CaH responded similarly at days 5, 14, and 28 after injury. This findings suggest that beneficial effects of Shr on ED1+-cells might be related to generation of anti-inflammatory peptides through the hydrolysis process, in addition to its high content of anti-inflammatory amino acids. However, while increasing myofiber cross-sectional area in noninjured muscles compared with both Ca and CaH, Shr failed to have a positive effect in corresponding injured muscles. These data indicate that shrimp hydrolysate can facilitate resolution of inflammation after muscle injury mainly through modulating proinflammatory macrophage accumulation but have less effect on optimal recovery in terms of muscle mass and fiber size.
Junio Dort; Nadine Leblanc; Piotr Bryl; Marie-Gil Fortin; Marie-Elise Carbonneau; Charles Lavigne; Hélène Jacques. Shrimp Protein Hydrolysate Modulates the Timing of Proinflammatory Macrophages in Bupivacaine-Injured Skeletal Muscles in Rats. BioMed Research International 2016, 2016, 1 -13.
AMA StyleJunio Dort, Nadine Leblanc, Piotr Bryl, Marie-Gil Fortin, Marie-Elise Carbonneau, Charles Lavigne, Hélène Jacques. Shrimp Protein Hydrolysate Modulates the Timing of Proinflammatory Macrophages in Bupivacaine-Injured Skeletal Muscles in Rats. BioMed Research International. 2016; 2016 ():1-13.
Chicago/Turabian StyleJunio Dort; Nadine Leblanc; Piotr Bryl; Marie-Gil Fortin; Marie-Elise Carbonneau; Charles Lavigne; Hélène Jacques. 2016. "Shrimp Protein Hydrolysate Modulates the Timing of Proinflammatory Macrophages in Bupivacaine-Injured Skeletal Muscles in Rats." BioMed Research International 2016, no. : 1-13.
With the increasing rates of obesity, the prevalence of insulin resistance and its related diseases is likely to increase significantly in the coming years. It is therefore essential to find effective strategies to slow or prevent the progression of insulin resistance. Many intervention studies have shown that early intervention to improve insulin resistance successfully prevents progression to type 2 diabetes (T2D) (Crandall et al., Nat Clin Pract Endocrinol Metab 4:382–393, 2008). The composition of the diet is undoubtedly very important. While our understanding of the effects of fat and carbohydrates on glucose metabolism and insulin sensitivity has greatly increased over the past decades, the role of proteins and the mechanisms behind their effects are less well characterized. However, studies aiming to demystify their potential effects have shown promising results.
Véronique Ouellet; S. John Weisnagel; Denis R. Joanisse; Charles Lavigne; Junio Dort; André Marette; Hélène Jacques. Beneficial Impact of Cod Protein, l-Arginine, and Other Amino Acids on Insulin Sensitivity. L-Arginine in Clinical Nutrition 2016, 433 -447.
AMA StyleVéronique Ouellet, S. John Weisnagel, Denis R. Joanisse, Charles Lavigne, Junio Dort, André Marette, Hélène Jacques. Beneficial Impact of Cod Protein, l-Arginine, and Other Amino Acids on Insulin Sensitivity. L-Arginine in Clinical Nutrition. 2016; ():433-447.
Chicago/Turabian StyleVéronique Ouellet; S. John Weisnagel; Denis R. Joanisse; Charles Lavigne; Junio Dort; André Marette; Hélène Jacques. 2016. "Beneficial Impact of Cod Protein, l-Arginine, and Other Amino Acids on Insulin Sensitivity." L-Arginine in Clinical Nutrition , no. : 433-447.
Background: Recently we showed that lean seafood consumption reduced circulating triacylglycerol (TG) and VLDL concentrations and prevented an elevated total-to-HDL-cholesterol ratio relative to intake of a nonseafood diet. Objective: We aimed to elucidate whether diet-induced altered carbohydrate metabolism could be a contributing factor to the previously observed different lipoprotein patterns. Methods: This was a secondary outcome and explorative randomized controlled trial with a crossover design in 20 healthy adults (7 men and 13 women) that were 50.6 ± 3.4 (mean ± SEM) y old, weighed 75.7 ± 2.5 kg, and had a body mass index (BMI, in kg/m2) of 25.6 ± 0.7. After a 3-wk run-in period and separated by a 5-wk wash-out period, the participants consumed 2 balanced diets [in percentage of energy (energy%); 29% fat, 52% carbohydrates, 19% protein] for 4 wk. The diets varied in the main protein sources; 60 energy% of total protein was from either lean seafood or nonseafood sources. On the first and last day of each diet period, fasting and postprandial blood samples were collected before and after consumption of test meals (in energy%; 28% fat, 52% carbohydrates, 20% protein) with cod or lean beef. Results: The diets did not alter serum insulin and glucose concentrations. However, relative to the nonseafood diet period, the lean seafood diet period reduced postprandial C-peptide (P = 0.04) and lactate (P = 0.012) concentrations and fasting and postprandial TG/HDL-cholesterol ratios (P = 0.002). Hence, different postprandial lactate levels occurred at equal glucose concentrations. Conclusions: Even though the diets did not alter serum insulin and glucose concentrations, intake of the lean seafood compared with the nonseafood diet reduced postprandial concentrations of C-peptide and lactate and the TG/HDL-cholesterol ratio in healthy adults in a manner that may affect the long-term development of insulin resistance, type 2 diabetes, and cardiovascular disease. This trial was registered at www.clinicaltrials.gov as NCT01708681.
Eli K Aadland; Ingvild E Graff; Charles Lavigne; Øyvin Eng; Martine Paquette; Asle Holthe; Gunnar Mellgren; Lise Madsen; Hélène Jacques; Bjørn Liaset. Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design. The Journal of Nutrition 2016, 146, 1027 -1034.
AMA StyleEli K Aadland, Ingvild E Graff, Charles Lavigne, Øyvin Eng, Martine Paquette, Asle Holthe, Gunnar Mellgren, Lise Madsen, Hélène Jacques, Bjørn Liaset. Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design. The Journal of Nutrition. 2016; 146 (5):1027-1034.
Chicago/Turabian StyleEli K Aadland; Ingvild E Graff; Charles Lavigne; Øyvin Eng; Martine Paquette; Asle Holthe; Gunnar Mellgren; Lise Madsen; Hélène Jacques; Bjørn Liaset. 2016. "Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design." The Journal of Nutrition 146, no. 5: 1027-1034.
We previously demonstrated that a mild pre-natal/early post-natal iron-deficient anaemic (IDA) diet devoid of long-chain polyunsaturated fatty acids (LC-PUFA) affected development, neurophysiology, and cerebral lipid biochemistry of the guinea pigs' progeny. Impacts of dietary LC-PUFA on altered cerebral development resulting from pre-natal IDA are unknown. To address this health issue, impacts of mild gestational IDA in the presence of dietary LC-PUFA on the offsprings' neural maturation were studied in guinea pigs using auditory brainstem responses (ABRs) and assessments of brain fatty acids (FAs). Female guinea pigs (n = 10/group) were fed an iron sufficient (IS) or IDA diet (146 and 12.7 mg iron/kg, respectively) with physiological amounts of LC-PUFA, during the gestation and lactation periods. From post-natal day (PNd) 9 onwards, the IS + PUFA diet was given to both groups of weaned offspring. Cerebral tissue and offsprings' ABR were collected on PNd24. There was no difference in peripheral and brainstem transmission times (BTTs) between IS + PUFA and IDA + PUFA siblings (n = 10/group); the neural synchrony was also similar in both groups. Despite the absence of differences in auditory thresholds, IDA + PUFA siblings demonstrated a sensorineural hearing loss in the extreme range of frequencies (32, 4, and 2 kHz), as well as modified brain FA profiles compared to the IS + PUFA siblings. The present study reveals that siblings born from dams exposed to a moderate IDA diet including balanced physiological LC-PUFA levels during pregnancy and lactation demonstrate minor impairments of ABR compared to the control siblings, particularly on the auditory acuity, but not on neural synchrony, auditory nerve velocity and BTT.
Jean-Luc Jougleux; France M. Rioux; Michael W. Church; Sylvain Fiset; Hélène Jacques; Marc E. Surette. Dietary LC-PUFA in iron-deficient anaemic pregnant and lactating guinea pigs induce minor defects in the offsprings' auditory brainstem responses. Nutritional Neuroscience 2016, 19, 447 -460.
AMA StyleJean-Luc Jougleux, France M. Rioux, Michael W. Church, Sylvain Fiset, Hélène Jacques, Marc E. Surette. Dietary LC-PUFA in iron-deficient anaemic pregnant and lactating guinea pigs induce minor defects in the offsprings' auditory brainstem responses. Nutritional Neuroscience. 2016; 19 (10):447-460.
Chicago/Turabian StyleJean-Luc Jougleux; France M. Rioux; Michael W. Church; Sylvain Fiset; Hélène Jacques; Marc E. Surette. 2016. "Dietary LC-PUFA in iron-deficient anaemic pregnant and lactating guinea pigs induce minor defects in the offsprings' auditory brainstem responses." Nutritional Neuroscience 19, no. 10: 447-460.
Scope Proteins constitute an important part of the human diet, but understanding of the effects of different dietary protein sources on human metabolism is sparse. We aimed to elucidate diet‐induced metabolic changes through untargeted urinary metabolomics after four weeks of intervention with lean‐seafood or nonseafood diets. It is shown that lean‐seafood intake reduces urinary excretion of metabolites involved in mitochondrial lipid and energy metabolism possibly facilitating a higher lipid catabolism in healthy subjects. Methods In a randomized controlled trial with crossover design, 20 healthy subjects consumed two balanced diets that varied in main protein sources for 4 weeks. Morning spot urine samples were collected before and after each intervention period. Untargeted metabolomics based on 1H NMR spectroscopy and LC‐MS analyses were applied to characterize the urinary metabolic response to the interventions. Results The lean‐seafood diet period reduced the urinary level of l‐carnitine, 2,6‐dimethylheptanoylcarnitine, and N‐methyl‐2‐pyridone‐5‐carboxamide, relative to the nonseafood period. The dietary analysis revealed that the higher urinary level of trimethylamine‐N‐oxide after the lean‐seafood diet period and guanidinoacetate and 3‐methylhistidine after the nonseafood diet period was related to the endogenous content of these compounds in the diets. Conclusions Our data reveal that 4 weeks of lean‐seafood intake reduces urinary excretion of metabolites involved in mitochondrial lipid and energy metabolism possibly facilitating a higher lipid catabolism in healthy subjects after the lean‐seafood intake.
Mette Schmedes; Eli Kristin Aadland; Ulrik Kraemer Sundekilde; Hélène Jacques; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Asle Holthe; Gunnar Mellgren; Jette Feveile Young; Hanne Christine Bertram; Bjørn Liaset; Morten Rahr Clausen. Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular Nutrition & Food Research 2016, 60, 1661 -1672.
AMA StyleMette Schmedes, Eli Kristin Aadland, Ulrik Kraemer Sundekilde, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Hanne Christine Bertram, Bjørn Liaset, Morten Rahr Clausen. Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. Molecular Nutrition & Food Research. 2016; 60 (7):1661-1672.
Chicago/Turabian StyleMette Schmedes; Eli Kristin Aadland; Ulrik Kraemer Sundekilde; Hélène Jacques; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Asle Holthe; Gunnar Mellgren; Jette Feveile Young; Hanne Christine Bertram; Bjørn Liaset; Morten Rahr Clausen. 2016. "Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study." Molecular Nutrition & Food Research 60, no. 7: 1661-1672.
Background: Observational studies have strongly indicated an association between fish consumption and reduced risk of cardiovascular disease, but data from randomized controlled trials have been inconclusive.
Eli Kristin Aadland; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Martine Paquette; Asle Holthe; Gunnar Mellgren; Hélène Jacques; Bjørn Liaset. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design1,2. The American Journal of Clinical Nutrition 2015, 102, 582 -592.
AMA StyleEli Kristin Aadland, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Martine Paquette, Asle Holthe, Gunnar Mellgren, Hélène Jacques, Bjørn Liaset. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design1,2. The American Journal of Clinical Nutrition. 2015; 102 (3):582-592.
Chicago/Turabian StyleEli Kristin Aadland; Charles Lavigne; Ingvild Eide Graff; Øyvin Eng; Martine Paquette; Asle Holthe; Gunnar Mellgren; Hélène Jacques; Bjørn Liaset. 2015. "Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design1,2." The American Journal of Clinical Nutrition 102, no. 3: 582-592.
Background: We previously reported that fish proteins can alleviate metabolic syndrome (MetS) in obese animals and human subjects. Objectives: We tested whether a salmon peptide fraction (SPF) could improve MetS in mice and explored potential mechanisms of action. Methods: ApoB100 only, LDL receptor knockout male mice (LDLR−/−/ApoB100/100) were fed a high-fat and -sucrose (HFS) diet (25 g/kg sucrose). Two groups were fed 10 g/kg casein hydrolysate (HFS), and 1 group was additionally fed 4.35 g/kg fish oil (FO; HFS+FO). Two other groups were fed 10 g SPF/kg (HFS+SPF), and 1 group was additionally fed 4.35 g FO/kg (HFS+SPF+FO). A fifth (reference) group was fed a standard feed pellet diet. We assessed the impact of dietary treatments on glucose tolerance, adipose tissue inflammation, lipid homeostasis, and hepatic insulin signaling. The effects of SPF on glucose uptake, hepatic glucose production, and inducible nitric oxide synthase activity were further studied in vitro with the use of L6 myocytes, FAO hepatocytes, and J774 macrophages. Results: Mice fed HFS+SPF or HFS+SPF+FO diets had lower body weight (protein effect, P = 0.024), feed efficiency (protein effect, P = 0.018), and liver weight (protein effect, P = 0.003) as well as lower concentrations of adipose tissue cytokines and chemokines (protein effect, P ≤ 0.003) compared with HFS and HFS+FO groups. They also had greater glucose tolerance (protein effect, P < 0.001), lower activation of the mammalian target of rapamycin complex 1/S6 kinase 1/insulin receptor substrate 1 (mTORC1/S6K1/IRS1) pathway, and increased insulin signaling in liver compared with the HFS and HFS+FO groups. The HFS+FO, HFS+SPF, and HFS+SPF+FO groups had lower plasma triglycerides (protein effect, P = 0.003; lipid effect, P = 0.002) than did the HFS group. SPF increased glucose uptake and decreased HGP and iNOS activation in vitro. Conclusions: SPF reduces obesity-linked MetS features in LDLR−/−/ApoB100/100 mice. The anti-inflammatory and glucoregulatory properties of SPF were confirmed in L6 myocytes, FAO hepatocytes, and J774 macrophages.
Genevieve Chevrier; Patricia L Mitchell; Laurie-Eve Rioux; Fida Hasan; Tianyi Jin; Cyril Roland Roblet; Alain Doyen; Geneviève Pilon; Philippe St-Pierre; Charles Lavigne; Laurent Bazinet; Hélène Jacques; Tom Gill; Roger S McLeod; André Marette. Low-Molecular-Weight Peptides from Salmon Protein Prevent Obesity-Linked Glucose Intolerance, Inflammation, and Dyslipidemia in LDLR−/−/ApoB100/100 Mice. The Journal of Nutrition 2015, 145, 1415 -1422.
AMA StyleGenevieve Chevrier, Patricia L Mitchell, Laurie-Eve Rioux, Fida Hasan, Tianyi Jin, Cyril Roland Roblet, Alain Doyen, Geneviève Pilon, Philippe St-Pierre, Charles Lavigne, Laurent Bazinet, Hélène Jacques, Tom Gill, Roger S McLeod, André Marette. Low-Molecular-Weight Peptides from Salmon Protein Prevent Obesity-Linked Glucose Intolerance, Inflammation, and Dyslipidemia in LDLR−/−/ApoB100/100 Mice. The Journal of Nutrition. 2015; 145 (7):1415-1422.
Chicago/Turabian StyleGenevieve Chevrier; Patricia L Mitchell; Laurie-Eve Rioux; Fida Hasan; Tianyi Jin; Cyril Roland Roblet; Alain Doyen; Geneviève Pilon; Philippe St-Pierre; Charles Lavigne; Laurent Bazinet; Hélène Jacques; Tom Gill; Roger S McLeod; André Marette. 2015. "Low-Molecular-Weight Peptides from Salmon Protein Prevent Obesity-Linked Glucose Intolerance, Inflammation, and Dyslipidemia in LDLR−/−/ApoB100/100 Mice." The Journal of Nutrition 145, no. 7: 1415-1422.
Hélène Jacques. Dietary cod protein improves the IGF1-Akt/PKB signaling pathway in rat skeletal muscle during recovery from injury. International Journal of Food and Nutritional Science 2015, 2, 1 -7.
AMA StyleHélène Jacques. Dietary cod protein improves the IGF1-Akt/PKB signaling pathway in rat skeletal muscle during recovery from injury. International Journal of Food and Nutritional Science. 2015; 2 (5):1-7.
Chicago/Turabian StyleHélène Jacques. 2015. "Dietary cod protein improves the IGF1-Akt/PKB signaling pathway in rat skeletal muscle during recovery from injury." International Journal of Food and Nutritional Science 2, no. 5: 1-7.
Martine Paquette; S John Weisnagel; Yves Desjardins; Julie Marois; André Marette; Geneviève Pilon; Nadine Leblanc; Hélène Jacques. Beneficial Effects of a Polyphenol-Rich Supplement from Strawberry and Cranberry on Glucose Metabolism in Free-Living Insulin-Resistant Men and Women. Canadian Journal of Diabetes 2014, 38, S68 -S69.
AMA StyleMartine Paquette, S John Weisnagel, Yves Desjardins, Julie Marois, André Marette, Geneviève Pilon, Nadine Leblanc, Hélène Jacques. Beneficial Effects of a Polyphenol-Rich Supplement from Strawberry and Cranberry on Glucose Metabolism in Free-Living Insulin-Resistant Men and Women. Canadian Journal of Diabetes. 2014; 38 (5):S68-S69.
Chicago/Turabian StyleMartine Paquette; S John Weisnagel; Yves Desjardins; Julie Marois; André Marette; Geneviève Pilon; Nadine Leblanc; Hélène Jacques. 2014. "Beneficial Effects of a Polyphenol-Rich Supplement from Strawberry and Cranberry on Glucose Metabolism in Free-Living Insulin-Resistant Men and Women." Canadian Journal of Diabetes 38, no. 5: S68-S69.