Filomena Loffredo

Dr. Filomena Loffredo

Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, via Pansini 80131, Napoli, Italy
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Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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MQMaria Quarto
Maria Quarto
Mariagabriella PuglieseMariagabriella Pugliese
Mariagabriella Pugliese
Giuseppe La VerdeGiuseppe La Verde
Giuseppe La Verde
Filomena LoffredoFilomena Loffredo
Filomena Loffredo
VRVincenzo Roca
Vincenzo Roca
Indoor radon concentrations were measured in dwellings of the Puglia region in Southern Italy using LR-115 passive detectors. The results show that the radon concentrations varied from 15 ± 2 to 2166 ± 133 Bq/m3 with a geometric mean of 114 Bq/m3 and a geometric standard deviation of 2.3. An analysis on the factors affecting radon concentration such as age of the dwellings, floors, and stories, was performed. The mean effective dose to inhabitants has been calculated and found to be 8.2 mSv/y. Finally, for estimation of cancer risks, the lifetime risk and lung cancer cases per years per million have been calculated.

23 September 2013 in Radiation Oncology
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Journal Article
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LCLaura Cella
Laura Cella
Vittoria D'AvinoVittoria D'Avino
Vittoria D'Avino
RLRaffaele Liuzzi
Raffaele Liuzzi
MCManuel Conson
Manuel Conson
FDFrancesca Doria
Francesca Doria
RPRoberto Pacelli
Roberto Pacelli
The risk of radio-induced gastrointestinal (GI) complications is affected by several factors other than the dose to the rectum such as patient characteristics, hormonal or antihypertensive therapy, and acute rectal toxicity. Purpose of this work is to study clinical and dosimetric parameters impacting on late GI toxicity after prostate external beam radiotherapy (RT) and to establish multivariate normal tissue complication probability (NTCP) model for radiation-induced GI complications.

1 July 2017 in Translational Cancer Research
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CGCarmine Garzillo
Carmine Garzillo
Mariagabriella PuglieseMariagabriella Pugliese
Mariagabriella Pugliese
Filomena LoffredoFilomena Loffredo
Filomena Loffredo
MQMaria Quarto
Maria Quarto
Background: Radon and its decay products are the main source of natural ionizing radiation and they represent the major contributor to the internal dose to human life. The aim of this study was to assess a potential relationship between indoor radon exposure and the incidence of lung cancer worldwide. Methods: A systematic literature search was carried out in PubMed, Web of Science, and Google Scholar to identify relevant studies published in English conducted in the last 15 years until January 2016. Summary relative risks (RR) and the corresponding 95% confidence intervals (CIs) were calculated using a random-effects model and the influence of moderators using a mixed-effects model. Heterogeneity was assessed using the Q, I2 and H2 tests, and the source of heterogeneity was detected by meta-regression analysis. Publication bias was evaluated with Egger’s regression symmetry test and the contour-enhanced funnel plot. Leave-one-out sensitivity analysis was performed. Results: Twenty-five lung cancer studies (case-control studies) with 13,569 cases and 22,701 controls were included. Indoor radon exposure was significantly associated with increased risk for lung cancer (RR, 1.19; 95% CI, 1.02–1.39). Study location analysis showed that radon exposure was associated with increased risk for lung cancer from 40 degrees absolute latitude (RR, 1.09; 95% CI, 0.92–1.31), to 50 degrees (RR 1.26; 95% CI, 1.08–1.48), to 60 degrees (RR, 1.46; 95% CI, 1.12–1.91). Conclusions: Indoor radon exposure may be associated with increased risk for lung cancer.

1 June 2017 in Journal of Environmental Radioactivity
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Closed access
FSFederica Savino
Federica Savino
MPM. Pugliese
M. Pugliese
MQM. Quarto
M. Quarto
Paola AdamoPaola Adamo
Paola Adamo
Filomena LoffredoFilomena Loffredo
Filomena Loffredo
VRV. Roca
V. Roca

24 February 2021 in Life
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Filomena LoffredoFilomena Loffredo
Filomena Loffredo
FSFederica Savino
Federica Savino
RARoberto Amato
Roberto Amato
AIAlfredo Irollo
Alfredo Irollo
FGFrancesco Gargiulo
Francesco Gargiulo
Maria QuartoMaria Quarto
Maria Quarto
Radon is a major source of ionizing radiation exposure for the general population. It is known that exposure to radon is a risk factor for the onset of lung cancer. In this study, the results of a radon survey conducted in all districts of a Public Healthcare in Italy, are reported. Measurements of indoor radon were performed using nuclear track detectors, CR-39. The entire survey was conducted according to a well-established quality assurance program. The annual effective dose and excess lifetime cancer risk were also calculated. Results show that the radon concentrations varied from 7 ± 1 Bq/m3 and 5148 ± 772 Bq/m3, with a geometric mean of 67 Bq/m3 and geometric standard deviation of 2.5. The annual effective dose to workers was found to be 1.6 mSv/y and comparable with the worldwide average. In Italy, following the transposition of the European Directive 59/2013, great attention was paid to the radon risk in workplaces. The interest of the workers of the monitored sites was very high and this, certainly contributed to the high return rate of the detectors after exposure and therefore, to the presence of few missing data. Although it was not possible to study the factors affecting radon concentrations, certainly the main advantage of this study is that it was the first in which an entire public health company was monitored in regards to all the premises on the underground and ground floor.

17 March 2013 in Radiation Protection Dosimetry
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MQMaria Quarto
Maria Quarto
MPMariagabriella Pugliese
Mariagabriella Pugliese
Filomena LoffredoFilomena Loffredo
Filomena Loffredo
VRVincenzo Roca
Vincenzo Roca
In this study, the indoor radon concentrations have been measured in 93 dwellings of the Penisola Sorrentina, using LR115 detectors. The detectors were placed in the bedrooms and living rooms for two consecutive semesters starting from December 2010 to December 2011. The annual average indoor radon concentrations vary from 25 to 722 Bq m−3, with a mean value of 132±114 Bq m−3. Correlation between indoor radon measurements and same building characteristics was also studied. Based on the obtained results, the mean annual effective dose of 2.4 mSv y−1 received by inhabitants was estimated.