The water-level fluctuation zone (WLFZ) of the Three Gorges Reservoir is a serious landslide-prone area. However, current remote sensing methods for landslide mapping and detection in the WLFZ are insufficient because of difficulties in data acquisition and lack of facade information. We proposed a novel shipborne mobile photogrammetry approach for 3D mapping and landslide detection in the WLFZ for the first time, containing a self-designed shipborne hardware platform and a data acquisition and processing workflow. To evaluate the accuracy and usability of the resultant 3D models in the WLFZ, four bundle block adjustment (BBA) control configurations were developed and adopted. In the four configurations, the raw Global Navigation Satellite System (GNSS) data, the raw GNSS data and fixed camera height, the GCPs extracted from aerial photogrammetric products, and the mobile Light Detection and Ranging (LiDAR) point cloud were used. A comprehensive accuracy assessment of the 3D models was conducted, and the comparative results indicated the BBA with GCPs extracted from the aerial photogrammetric products was the most practical configuration (RMSE 2.00 m in plane, RMSE 0.46 m in height), while the BBA with the mobile LiDAR point cloud as a control provided the highest georeferencing accuracy (RMSE 0.59 m in plane, RMSE 0.40 m in height). Subsequently, the landslide detection ability of the proposed approach was compared with multisource remote sensing images through visual interpretation, which showed that the proposed approach provided the highest landslide detection rate and unique advantages in small landslide detection as well as in steep terrains due to the more detailed features of landslides provided by the shipborne 3D models. The approach is an effective and flexible supplement to traditional remote sensing methods.