This study was conducted to investigate the effect of carotenoid, oligosaccharide and anthocyanin supplementation in broiler diets under Escherichia coli lipopolysaccharide (LPS) challenge. Ross 308 chickens were fed 5 diets: basal diet (control diet), diet supplemented with β-glucan in 0.05% (positive control) and diets with 0.5% carotenoid-, oligosaccharide- or anthocyanin contents. On the 26th days of age, chickens were challenged intraperitoneally 2 mg LPS per kg of body weight. 12 h after injection, birds were euthanized, then spleen and ileum samples were collected. LPS induced increased relative mRNA expression of splenic (p = 0.0445) and ileal (p = 0.0435) interleukin-1β (IL-1β), which was lower in the spleen in carotenoid (p = 0.0114), oligosaccharide (p = 0.0497) and anthocyanin (p = 0.0303)-treated chickens compared to LPS-injected control birds. Dietary supplementation of carotenoids also decreased relative gene expression of splenic interleukin-6 (IL-6) (p = 0.0325). In the ileum, β-glucan supplementation showed lower relative mRNA expression of toll-like receptor 5 (TLR-5) (p = 0.0387) compared to anthocyanin treatment. Gene expression of both splenic and ileal interferon-α (IFN-α), interferon-γ (IFN-γ), toll-like receptor 4 (TLR-4) and toll-like receptor 5 (TLR-5) were not influenced by dietary supplements. In conclusion, carotenoids, oligosaccharides and anthocyanins could partially mitigate the immune stress caused by LPS challenge. All of the compounds impacted longer villus height (p < 0.0001), villus height:crypt depth ratios were higher after β-glucan (p < 0.0001) and anthocyanin (p = 0.0063) supplementations and thickened mucosa was observed in β-glucan (p < 0.0001), oligosaccharide (p < 0.0001) and anthocyanin (p = 0.048) treatments. All of these findings could represent a more effective absorption of nutrients.

Heat stress (HS) can have detrimental effects on intestinal integrity and can jeopardize the digestibility performance in pigs. With prolonged exposure to heat, some thermoregulatory processes in pigs are potential causes for electrolyte imbalance. The adverse effects of HS on mineral digestibility and electrolyte balance are not widely studied and information on its abatement through vitamin and micro-mineral supplementation in combinations above the recommended level in pigs is limited. The aim of this study is to research this area. Thirty-six Danbred hybrid barrows (65.1 ± 2.81kg) were distributed among the four treatments (n = 9 per treatment): (1) thermo-neutral (19.5 ± 0.9 °C, RH- 85.9 ± 7.3%)+ control diet (TC) (NRC, 2012), (2) HS (28.9 ± 0.9 °C, RH- 60.4 ± 4.3%) + control diet (HC), (3) HS +diet with elevated levels of vitamins (vitamin E and C) and micro-minerals (Zn and Se) (HT1), and (4) HS + diet with further elevation of vitamins and micro-minerals (HT2). Plasma samples were collected on days 7 and 21 of the experiment to investigate electrolyte concentration. During the experimental period, feces samples were collected from pigs placed in digestibility cages (six pigs from each treatment) to investigate the digestibility of Ca, P, Na, Se, and Zn. HS did not decrease the digestibility of minerals, but elevated supplementation of the selected vitamins and trace minerals improved it significantly. HS caused a significant decrease of Cl⁻ (p < 0.01) in plasma, indicating an imbalance. In conclusion, pigs can have some resilience against heat stress in terms of mineral digestibility. Proper vitamin and trace mineral supplementation are key factors in the ability of pigs to overcome the negative effects of HS.

This chapter presents the expected climate scenario in corn-producing areas and suggests alternative strategies for producing resilient forage for dairy cattle in dry continental climate zones. The consideration of irrigating corn for silage production arises due to the alterations in climate. However, it is anticipated that different crop rotations will suffice to sustain the forage supply on intensive dairy farms without requiring additional water resources in the dry season, including drought-resistant crops, early-cut whole-crop cereals, and intense annual ryegrass alongside corn and sorghum. Crop management and crop rotation strategies adapted to local and weather conditions are critical to maintaining milk production. Due to the high digestibility, digestible NDF, and undigestible NDF of the early cut, intensively growing grass silages, rye silage (harvested at the boot stage or earlier), triticale, barley, and wheat silage (harvested at boot-early heading stage) could increase dairy cows’ dry matter intake and milk production under heat-stress conditions. As a result, cattle feed will contain more ingredients than it does today to cope with climate change in cattle feeding.

In the twenty-first century, animal agriculture worldwide faces challenges such as the growing demand for safe and healthy animal-derived foodstuffs (e.g., pork); furthermore, the rising environmental pollution from livestock production and global climate change. It is now clear that these problems can only be addressed with holistic solutions based on the principles of sustainability and the One Health concept. Therefore, the aim of this chapter is to present the key elements of sustainability and the One Health concepts and evaluate various feed additives used in the feed industry, as well as practical pig feeding strategies, based on the principles of sustainability and One Health. Based on the analysis of the data of more than 130 references, the following most important conclusions were drawn: (1) Promising alternatives to unsustainable growth promoters include postbiotics, parabiotics, and phytobiotics; however, it is important to emphasize that further validation on the farm is required. (2) To achieve sustainable pork production, it is necessary to implement special feeding solutions for sows and piglets that minimize the need for medication. (3) Sustainable feeding strategies are particularly important during the weaning phase. Methods are now available that support the optimal development and functioning of the gastrointestinal tract, thereby preventing gastrointestinal disorders such as postweaning diarrhea.

Global warming is one of the major challenges for mankind, with animal breeding one of the most affected sectors in the agricultural industry. High ambient temperatures negatively affect all domestic animals. While it is true that pork and dairy production suffer the consequences of heat waves, it is actually the poultry industry which is hit the hardest by the heat stress poultry must endure due to hotter weather. Consequently, we have a fundamental interest in reducing and/or eliminating the negative effects of climate change, i.e. prolonged high ambient temperatures. The aim of this chapter is to present the adverse effects of heat stress on energy metabolism, anti- and pro-oxidant capacity and production in birds. A further goal is to show how various feed additives (e.g. vitamin A, C and E, selenium, zinc, betaine, plant extract, and probiotics) can reduce the negative effects of heat stress. Based on the large number of recent scientific findings, the following conclusions were drawn: Using fat in the diet (up to 5%) can reduce heat production in livestock. Vitamins (e.g. A, E and C) are capable of reacting with free radicals. Vitamin E and Vitamin C, Zn, and Se supplementation improved antioxidant parameters. Antioxidant potential of vitamins and micro minerals is more efficient in combination under heat stress in poultry nutrition. Plant extracts (e.g. oregano) could decrease the negative effects of heat stress on antioxidant enzyme activity due to its antioxidant constituents. Betaine reduces heat production in animals at high ambient temperatures. While acute heat stress induces a drop in feed intake, with the resulting increased nutrient demand leading to weight loss, if heat stress is prolonged, adaptation will occur. Probiotics and vitamins (C and E) seem to be the most effective means to reduce the negative effects of heat stress.