The endoplasmic reticulum (ER) is a fascinating network of tubules through which secretory and transmembrane proteins enter unfolded and exit as either folded or misfolded proteins, after which they are directed either toward other organelles or to degradation, respectively. The ER redox environment dictates the fate of entering proteins, and the level of redox signaling mediators modulates the level of reactive oxygen species (ROS). Accumulating evidence suggests the interrelation of ER stress and ROS with redox signaling mediators such as protein disulfide isomerase (PDI)-endoplasmic reticulum oxidoreductin (ERO)-1, glutathione (GSH)/glutathione disuphide (GSSG), NADPH oxidase 4 (Nox4), NADPH-P450 reductase (NPR), and calcium. Here, we reviewed persistent ER stress and protein misfolding-initiated ROS cascades and their significant roles in the pathogenesis of multiple human disorders, including neurodegenerative diseases, diabetes mellitus, atherosclerosis, inflammation, ischemia, and kidney and liver diseases.

The security and privacy of healthcare enterprises (HEs) are crucial because they maintain sensitive information. Because of the unique functional requirement of omni-inclusiveness, HEs are expected to monitor patients, allowing for connectivity with vehicular ad hoc networks (VANETs). In the absence of literature on security provisioning frameworks that connect VANETs and HEs, this paper presents a smart zero-knowledge proof and statistical fingerprinting-based trusted secure communication framework for a fog computing environment. A zero-knowledge proof is used for vehicle authentication, and statistical fingerprinting is employed to secure communication between VANETs and HEs. Authenticity verification of the operations is performed at the on-board unit (OBU) fitted in the vehicle based on the service executions at the resident hardware platform. The processor clock cycles are acquired from the service executions in a complete sandboxed environment. The calculated cycles assist in developing the blueprint signature for the particular OBU of the vehicle. Hence, the fingerprint signature helps build trust and plays a key role in authenticating the vehicle's horizontal movement to everything or to different sections of the HEs. In an environment enabled for fog computing, our novel model can provide efficient remote monitoring.