Open access articleCurrently autonomous or self-driving vehicles are at the heart of academia and industry\ud research because of its multi-faceted advantages that includes improved safety, reduced congestion,lower emissions and greater mobility. Software is the key driving factor underpinning autonomy within which planning algorithms that are responsible for mission-critical decision making hold a significant position. While transporting passengers or goods from a given origin to a given destination, motion planning methods incorporate searching for a path to follow, avoiding obstacles and generating the best trajectory that ensures safety, comfort and efficiency. A range of different planning approaches have been proposed in the literature.\ud The purpose of this paper is to review existing approaches and then compare and contrast different methods employed for the motion planning of autonomous on-road driving that consists of (1) finding a path, (2) searching for the safest manoeuvre and (3) determining the most feasible trajectory. Methods developed by researchers in each of these three levels exhibit varying levels of complexity and performance accuracy. This paper presents a critical evaluation of each of these methods, in terms of their advantages/disadvantages, inherent limitations, feasibility, optimality, handling of obstacles and testing operational environments. Based on a critical review of existing methods, research challenges to address current limitations are identified and future research directions are suggested so as to enhance the performance of planning algorithms at all three levels. Some promising areas of future focus have been identified as the use of vehicular communications (V2V and V2I) and the incorporation of transport engineering aspects in order to improve the look-ahead horizon of current sensing\ud technologies that are essential for planning with the aim of reducing the total cost of\ud driverless vehicles. This critical review on planning techniques presented in this paper, along with the associated discussions on their constraints and limitations, seek to assist researchers in accelerating development in the emerging field of autonomous vehicle research

The dynamic effect in two-phase flow in porous media indicated by a dynamic coefficient τ depends on a number of factors (e.g. medium and fluid properties). Varying these parameters parametrically in mathematical models to compute τ incurs significant time and computational costs. To circumvent this issue, we present an artificial neural network (ANN)-based technique for predicting τ over a range of physical parameters of porous media and fluid that affect the flow. The data employed for training the ANN algorithm have been acquired from previous modeling studies. It is observed that ANN modeling can appropriately characterize the relationship between the changes in the media and fluid properties, thereby ensuring a reliable prediction of the dynamic coefficient as a function of water saturation. Our results indicate that a double-hidden-layer ANN network performs better in comparison to the single-hidden-layer ANN models for the majority of the performance tests carried out. While single-hidden-layer ANN models can reliably predict complex dynamic coefficients (e.g. water saturation relationships) at high water saturation content, the double-hidden-layer neural network model outperforms at low water saturation content. In all the cases, the single- and double-hidden-layer ANN models are better predictors in comparison to the regression models attempted in this work.

The objective of an accident-mapping algorithm is to snap traffic accidents onto the correct road segments. Assigning accidents onto the correct segments facilitate to robustly carry out some key analyses in accident research including the identification of accident hot-spots, network-level risk mapping and segment-level accident risk modelling. Existing risk mapping algorithms have some severe limitations: (i) they are not easily 'transferable' as the algorithms are specific to given accident datasets; (ii) they do not perform well in all road-network environments such as in areas of dense road network; and (iii) the methods used do not perform well in addressing inaccuracies inherent in and type of road environment. The purpose of this paper is to develop a new accident mapping algorithm based on the common variables observed in most accident databases (e.g. road name and type, direction of vehicle movement before the accident and recorded accident location). The challenges here are to: (i) develop a method that takes into account uncertainties inherent to the recorded traffic accident data and the underlying digital road network data, (ii) accurately determine the type and proportion of inaccuracies, and (iii) develop a robust algorithm that can be adapted for any accident set and road network of varying complexity. In order to overcome these challenges, a distance based pattern-matching approach is used to identify the correct road segment. This is based on vectors containing feature values that are common in the accident data and the network data. Since each feature does not contribute equally towards the identification of the correct road segments, an ANN approach using the single-layer perceptron is used to assist in "learning" the relative importance of each feature in the distance calculation and hence the correct link identification. The performance of the developed algorithm was evaluated based on a reference accident dataset from the UK confirming that the accuracy is much better than other methods.

The use of data-driven high-throughput analytical techniques, which has given rise to computational oncology, is undisputed. The widespread use of machine learning (ML) and mathematical modeling (MM)-based techniques is widely acknowledged. These two approaches have fueled the advancement in cancer research and eventually led to the uptake of telemedicine in cancer care. For diagnostic, prognostic, and treatment purposes concerning different types of cancer research, vast databases of varied information with manifold dimensions are required, and indeed, all this information can only be managed by an automated system developed utilizing ML and MM. In addition, MM is being used to probe the relationship between the pharmacokinetics and pharmacodynamics (PK/PD interactions) of anti-cancer substances to improve cancer treatment, and also to refine the quality of existing treatment models by being incorporated at all steps of research and development related to cancer and in routine patient care. This review will serve as a consolidation of the advancement and benefits of ML and MM techniques with a special focus on the area of cancer prognosis and anticancer therapy, leading to the identification of challenges (data quantity, ethical consideration, and data privacy) which are yet to be fully addressed in current studies.

The safety, mobility, environmental, energy, and economic benefits of transportation systems, which are the focus of recent connected vehicle (CV) programs, are potentially dramatic. However, realization of these benefits largely hinges on the timely integration of digital technology into upcoming as well as existing transportation infrastructure. CVs must be enabled to broadcast and receive data to and from other CVs [vehicle-to-vehicle (V2V) communication], to and from infrastructure [vehicle-to-infrastructure (V2I) communication], and to and from other road users, such as bicyclists or pedestrians (vehicle-to-other road users communication). Further, the infrastructure and transportation agencies that manage V2I-focused applications must be able to collect, process, distribute, and archive these data quickly, reliably, and securely. This paper focuses on V2I applications and investigates current digital roadway infrastructure initiatives. It highlights the importance of including digital infrastructure investment alongside investment in more traditional transportation infrastructure to keep up with the auto industry’s push toward increasing intervehicular communication. By studying current CV testbeds and smart-city initiatives, this paper identifies digital infrastructure components (i.e., communication options and computing infrastructure) being used by public agencies. It also examines public agencies’ limited budgeting for digital infrastructure and finds that current expenditure is inadequate for realizing the potential benefits of V2I applications. Finally, the paper presents a set of recommendations, based on a review of current practices and future needs, designed to guide agencies responsible for transportation infrastructure. It stresses the importance of collaboration for establishing national and international platforms for the planning, deployment, and management of digital infrastructure to support connected transportation systems across political jurisdictions.