Brain-machine interfaces (BMIs) provide a new assistive strategy aimed at restoring mobility in severely paralyzed patients. Yet, no study in animals or in human subjects has indicated that long-term BMI training could induce any type of clinical recovery. Eight chronic (3–13 years) spinal cord injury (SCI) paraplegics were subjected to long-term training (12 months) with a multi-stage BMI-based gait neurorehabilitation paradigm aimed at restoring locomotion. This paradigm combined intense immersive virtual reality training, enriched visual-tactile feedback and walking with two EEG-controlled robotic actuators, including a custom-designed lower limb exoskeleton capable of delivering tactile feedback to subjects. Following 12 months of training with this paradigm, all eight patients experienced neurological improvements in somatic sensation (pain localization, fine/crude touch and proprioceptive sensing) in multiple dermatomes. Patients also regained voluntary motor control in key muscles below the SCI level, as measured by EMGs, resulting in marked improvement in their walking index. As a result, 50% of these patients were upgraded to an incomplete paraplegia classification. Neurological recovery was paralleled by the reemergence of lower limb motor imagery at cortical level. We hypothesize that this unprecedented neurological recovery results from both cortical and spinal cord plasticity triggered by long-term BMI usage.

Spinal cord injuries disrupt bidirectional communication between the patient’s brain and body. Here, we demonstrate a new approach for reproducing lower limb somatosensory feedback in paraplegics by remapping missing leg/foot tactile sensations onto the skin of patients’ forearms. A portable haptic display was tested in eight patients in a setup where the lower limbs were simulated using immersive virtual reality (VR). For six out of eight patients, the haptic display induced the realistic illusion of walking on three different types of floor surfaces: beach sand, a paved street or grass. Additionally, patients experienced the movements of the virtual legs during the swing phase or the sensation of the foot rolling on the floor while walking. Relying solely on this tactile feedback, patients reported the position of the avatar leg during virtual walking. Crossmodal interference between vision of the virtual legs and tactile feedback revealed that patients assimilated the virtual lower limbs as if they were their own legs. We propose that the addition of tactile feedback to neuroprosthetic devices is essential to restore a full lower limb perceptual experience in spinal cord injury (SCI) patients, and will ultimately, lead to a higher rate of prosthetic acceptance/use and a better level of motor proficiency.

Objective: To review the state of the art of robotic-aided hand physiotherapy for post-stroke rehabi...

This paper presents the first comprehensive tutorial on a promising research field located at the frontier of two well-established domains, neurosciences and wireless communications, motivated by the ongoing efforts to define the Sixth Generation of Mobile Networks (6G). In particular, this tutorial first provides a novel integrative approach that bridges the gap between these two seemingly disparate fields. Then, we present the state-of-the-art and key challenges of these two topics. In particular, we propose a novel systematization that divides the contributions into two groups, one focused on what neurosciences will offer to future wireless technologies in terms of new applications and systems architecture (Neurosciences for Wireless Networks), and the other on how wireless communication theory and next-generation wireless systems can provide new ways to study the brain (Wireless Networks for Neurosciences). For the first group, we explain concretely how current scientific understanding of the brain would enable new applications within the context of a new type of service that we dub brain-type communications and that has more stringent requirements than human- and machine-type communication. In this regard, we expose the key requirements of brain-type communication services and discuss how future wireless networks can be equipped to deal with such services. Meanwhile, for the second group, we thoroughly explore modern communication systems paradigms, including Internet of Bio-Nano Things and wireless-integrated brain-machine interfaces, in addition to highlighting how complex systems tools can help bridging the upcoming advances of wireless technologies and applications of neurosciences. Brain-controlled vehicles are then presented as our case study to demonstrate for both groups the potential created by the convergence of neurosciences and wireless communications, probably in 6G. In summary, this tutorial is expected to provide a largely missing articulation between neurosciences and wireless communications while delineating concrete ways to move forward in such an interdisciplinary endeavor.

Cyborg insects are a major part of the vision of future interactions of the living world and technology, including but not limited to the Internet of Living Things (IoLT). They are crawling or flying insects with additional electronic circuitry allowing remote control of their movement and collection of sensory data. In this critical review, we survey the historical development of cyborg insects engineering, from the first backpacks on insects used for communication and sensing, to different methods of control and actuation of insects’ locomotion. We review the suggested applications of cyborg insects ranging from military use to agriculture, pointing out the problematic connotations of swarms and cyborgs in these contexts. We address the applications and the narratives around engineered insects from the perspective of philosophy, economy, law, and politics. We add perspectives on emancipatory potential of cyborg technology and where the future of it could lie.