Obesity poses a serious global public health challenge, particularly among middle-aged, and elderly college staff. This study aims to explore the associated factors of obesity by analyzing the metabolic indicators of 1756 university staff from Minzu University of China, Beijing. Venous blood samples were collected, and blood metabolic indicators were analyzed. The results indicate that middle-aged faculty members are more susceptible to obesity compared to their younger counterparts. Multiple linear regression analysis revealed that BMI values increase with age (B = 0.074, P < .001), uric acid (B = 0.008, P < .001), alanine transaminase (B = 0.043, P < .001), low-density lipoprotein (B = 1.941, P < .001), triglycerides (B = 0.544, P < .001), total cholesterol (TC, B = −1.582, P < .001), and other factors, while decreasing with the increase of high-density lipoprotein (B = −1.493, P < .001). In light of these findings, it is recommended that middle-aged and elderly college staff undergo regular blood indicator checks and enhance weight management to mitigate the risk of obesity and promote their overall health.

Patients with depressive disorder with migraine (DDWM) are common, yet the neural mechanisms and brain function changes associated with this comorbidity remain partially understood. This study explores regional homogeneity (ReHo) abnormalities in resting-state functional magnetic resonance imaging (fMRI) and cognitive function in DDWM patients. We recruited 29 patients with DDWM, 34 patients with depressive disorder without migraine (DDWOM), and 43 matched healthy controls (HC). All participants underwent rs-fMRI scans, and imaging data were analyzed using ReHo. Cognitive function was assessed with the Repeatable Battery for the Assessment of Neuropsychological Status. We also employed support vector machine (SVM) analysis to evaluate whether abnormal ReHo values could distinguish DDWM. he DDWM group exhibited significantly lower ReHo values in the left cuneus and left calcarine compared to the DDWOM group. ReHo values in these regions were negatively correlated with pain scores on the Visual Analogue Scale (r = − 0.3628, p = 0.0001; r = − 0.3142, p = 0.001) and positively correlated with the List_Recall score on RBANS (r = 0.260, p = 0.007). SVM analysis indicated that the left cuneus ReHo value could distinguish DDWM from DDWOM with 78.09% accuracy, 87.66% sensitivity, and 74.33% specificity. The left cuneus and left calcarine are potential biomarkers for migraine symptoms in DDWM, with the left cuneus affecting cognitive function related to memory.