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Masatoki Kaneko
Graduate School of Nursing Science, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

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Journal article
Published: 09 May 2021 in Viruses
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Human cytomegalovirus (CMV) is the leading cause of neurological sequelae in infants. Understanding the risk factors of primary CMV infection is crucial in establishing preventive strategies. Thus, we conducted a retrospective cohort study to identify risk factors of vertical transmission among pregnant women with immunoglobulin (Ig) M positivity. The study included 456 pregnant women with IgM positivity. Information on age, parity, occupation, clinical signs, IgM levels, and IgG avidity index (AI) was collected. The women were divided into infected and non-infected groups. The two groups showed significant differences in IgM level, IgG AI, number of women with low IgG AI, clinical signs, and number of pregnant women with single parity. In the multiple logistic regression analysis, pregnant women with single parity and low IgG AI were independent predictors. Among 40 women who tested negative for IgG antibody in their previous pregnancy, 20 showed low IgG AI in their current pregnancy. Among the 20 women, 4 had vertical transmission. These results provide better understanding of the risk factors of vertical transmission in pregnant women with IgM positivity.

ACS Style

Masatoki Kaneko; Junsuke Muraoka; Kazumi Kusumoto; Toshio Minematsu. Low Maternal Immunoglobulin G Avidity and Single Parity as Adverse Implications of Human Cytomegalovirus Vertical Transmission in Pregnant Women with Immunoglobulin M Positivity. Viruses 2021, 13, 866 .

AMA Style

Masatoki Kaneko, Junsuke Muraoka, Kazumi Kusumoto, Toshio Minematsu. Low Maternal Immunoglobulin G Avidity and Single Parity as Adverse Implications of Human Cytomegalovirus Vertical Transmission in Pregnant Women with Immunoglobulin M Positivity. Viruses. 2021; 13 (5):866.

Chicago/Turabian Style

Masatoki Kaneko; Junsuke Muraoka; Kazumi Kusumoto; Toshio Minematsu. 2021. "Low Maternal Immunoglobulin G Avidity and Single Parity as Adverse Implications of Human Cytomegalovirus Vertical Transmission in Pregnant Women with Immunoglobulin M Positivity." Viruses 13, no. 5: 866.

Journal article
Published: 01 November 2020 in International Journal of Infectious Diseases
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ACS Style

Masatoki Kaneko; Masanao Ohhashi; Yoshinori Fujii; Toshio Minematsu; Kazumi Kusumoto. A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity. International Journal of Infectious Diseases 2020, 100, 1 -6.

AMA Style

Masatoki Kaneko, Masanao Ohhashi, Yoshinori Fujii, Toshio Minematsu, Kazumi Kusumoto. A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity. International Journal of Infectious Diseases. 2020; 100 ():1-6.

Chicago/Turabian Style

Masatoki Kaneko; Masanao Ohhashi; Yoshinori Fujii; Toshio Minematsu; Kazumi Kusumoto. 2020. "A multiple regression model for predicting a high cytomegalovirus immunoglobulin G avidity level in pregnant women with IgM positivity." International Journal of Infectious Diseases 100, no. : 1-6.

Journal article
Published: 16 October 2020 in Journal of Infection and Chemotherapy
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Introduction This study aimed to examine the immunity level against rubella in pregnant women of different birth cohorts. Methods In total, 512 pregnant women who visited a primary clinic between May 2019 and March 2020 were enrolled. Information in terms of the patients' hemagglutination inhibition (HI) titers, birthdate, obstetrical history, and vaccination history were collected. Participants were divided into three generational groups according to the vaccination policy in Japan. Publicly funded vaccination was administered twice as part of a routine program in group A (n = 11), once as part of a routine program and once in a catch-up program in group B (n = 181), and once in group C (n = 320). Results All groups had some women with negative rubella HI antibody titers (7.6% of all the women, 18.2% of group A, 9.4% of group B, and 6.3% of group C) and those with rubella HI antibody titers of ≤1:16 (45.1% of all women, 90.9% of group A, 56.4% of group B, and 37.2% of group C). Rubella HI antibody titers differed between the groups; group C had higher titers than that in group B. In groups B and C, the proportions of women with rubella HI antibody titers of ≤1:16 were not statistically different between primipara and multipara. Conclusions Our study showed that an increase in immunity to rubella, a vaccine-preventable disease, is nevertheless required among childbearing women to prevent rubella and congenital rubella syndrome.

ACS Style

Masatoki Kaneko; Minako Ichida; Yoshinori Fujii; Shunichi Noda; Masahiro Ohi. Differences in levels of rubella hemagglutination inhibition antibody titers according to birth cohort. Journal of Infection and Chemotherapy 2020, 27, 434 -438.

AMA Style

Masatoki Kaneko, Minako Ichida, Yoshinori Fujii, Shunichi Noda, Masahiro Ohi. Differences in levels of rubella hemagglutination inhibition antibody titers according to birth cohort. Journal of Infection and Chemotherapy. 2020; 27 (3):434-438.

Chicago/Turabian Style

Masatoki Kaneko; Minako Ichida; Yoshinori Fujii; Shunichi Noda; Masahiro Ohi. 2020. "Differences in levels of rubella hemagglutination inhibition antibody titers according to birth cohort." Journal of Infection and Chemotherapy 27, no. 3: 434-438.

Article
Published: 30 August 2019 in Journal of Psychosomatic Obstetrics & Gynecology
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Purpose: we aimed to estimate the anxiety levels of pregnant women following maternal serum screening for CMV infection. Materials and methods: In this case-control study conducted from April 2016 to June 2017, we enrolled all pregnant women referred to our hospital who were CMV immunoglobulin (Ig) M antibody positive (IgM-positive group, n = 51); further, those who were CMV IgG positive but IgM negative (IgM-negative group, n = 51) during the same period were included as study controls. Data were collected on patient characteristics, CMV IgM levels, and whether patients were accompanied by their partners during the first hospital visit after CMV IgM testing. The State-Trait Anxiety Inventory was used to assess anxiety levels. Results: Both groups were age matched [mean age (years): IgM-positive, 30 ± 4.2 and IgM-negative, 29.9 ± 4.6]. The mean state-anxiety score was higher in the IgM-positive group (53 ± 9.6) than in the IgM-negative group (38.5 ± 7.0, p < .05) with no between-group differences in trait-anxiety scores. Similarly, a higher number of women were accompanied by their partners in the IgM-positive group. The state-anxiety scores and CMV IgM levels were not correlated in the IgM-positive group. Conclusion: Counseling support is essential for IgM-positive pregnant women following serum screening, and the screening should be avoided if support systems are unavailable.

ACS Style

Kanako Uehara; Masatoki Kaneko; Ayaka Matsuoka; Mana Kuroki; Toshio Minematsu. A cross-sectional study on maternal anxiety levels after cytomegalovirus screening. Journal of Psychosomatic Obstetrics & Gynecology 2019, 41, 240 -245.

AMA Style

Kanako Uehara, Masatoki Kaneko, Ayaka Matsuoka, Mana Kuroki, Toshio Minematsu. A cross-sectional study on maternal anxiety levels after cytomegalovirus screening. Journal of Psychosomatic Obstetrics & Gynecology. 2019; 41 (3):240-245.

Chicago/Turabian Style

Kanako Uehara; Masatoki Kaneko; Ayaka Matsuoka; Mana Kuroki; Toshio Minematsu. 2019. "A cross-sectional study on maternal anxiety levels after cytomegalovirus screening." Journal of Psychosomatic Obstetrics & Gynecology 41, no. 3: 240-245.

Original article
Published: 27 May 2018 in Pediatrics International
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Background Intestinal disorders are common among very low birth weight infants. The purpose of this study was to evaluate the impact of prophylactic oral Gastrografin® (diatrizoate acid) on meconium‐related ileus (MRI) in extremely preterm infants. Methods This was a retrospective case‐control study of infants born extremely preterm at < 28 weeks of gestation and administered diatrizoate acid (prophylactic group) or not (control group) in the study periods 2007‐2014 and 2000‐2009, respectively. In the 2007‐2014 period, 120 infants received prophylactic diatrizoate acid solution. From the 165 infants in the control group, we selected 120 infants matched for gestational age. Cases of death before 72 hours of life or congenital abnormalities were excluded. Intestinal disorders, time until full enteral feeding, duration of hospital stay, mortality rate, and neurodevelopmental outcome were compared. Results MRI occurred in 6 infants in the control group and no infant in the prophylactic group (P = .039). Median time until full enteral feeding was 25 versus 22 days (P < .01), hospital stay was 142 versus 126 days (P < .01), and mortality rate for infants aged 24‐27 weeks was 8.2% versus 0% (P = .021), respectively. Conclusions Prophylactic oral diatrizoate acid reduced MRI in extremely preterm infants without side effects and decreased the mortality rate of infants born at 24‐27 weeks, and is thus beneficial in extremely preterm infants. This article is protected by copyright. All rights reserved.

ACS Style

Kaori Michikata; Yuki Kodama; Masatoki Kaneko; Hiroshi Sameshima; Tsuyomu Ikenoue; Seiro Machigashira; Motoi Mukai; Motofumi Torikai; Kazuhiko Nakame. Oral diatrizoate acid for meconium-related ileus in extremely preterm infants. Pediatrics International 2018, 60, 714 -718.

AMA Style

Kaori Michikata, Yuki Kodama, Masatoki Kaneko, Hiroshi Sameshima, Tsuyomu Ikenoue, Seiro Machigashira, Motoi Mukai, Motofumi Torikai, Kazuhiko Nakame. Oral diatrizoate acid for meconium-related ileus in extremely preterm infants. Pediatrics International. 2018; 60 (8):714-718.

Chicago/Turabian Style

Kaori Michikata; Yuki Kodama; Masatoki Kaneko; Hiroshi Sameshima; Tsuyomu Ikenoue; Seiro Machigashira; Motoi Mukai; Motofumi Torikai; Kazuhiko Nakame. 2018. "Oral diatrizoate acid for meconium-related ileus in extremely preterm infants." Pediatrics International 60, no. 8: 714-718.

Journal article
Published: 01 March 2017 in Journal of Infection and Chemotherapy
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Low IgG AI with IgM positivity at ≤14 weeks of gestation was a good indicator of congenital infection, which should prove useful in obstetric practice.

ACS Style

Masatoki Kaneko; Masanao Ohhashi; Toshio Minematsu; Junsuke Muraoka; Kazumi Kusumoto; Hiroshi Sameshima. Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection. Journal of Infection and Chemotherapy 2017, 23, 173 -176.

AMA Style

Masatoki Kaneko, Masanao Ohhashi, Toshio Minematsu, Junsuke Muraoka, Kazumi Kusumoto, Hiroshi Sameshima. Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection. Journal of Infection and Chemotherapy. 2017; 23 (3):173-176.

Chicago/Turabian Style

Masatoki Kaneko; Masanao Ohhashi; Toshio Minematsu; Junsuke Muraoka; Kazumi Kusumoto; Hiroshi Sameshima. 2017. "Maternal immunoglobulin G avidity as a diagnostic tool to identify pregnant women at risk of congenital cytomegalovirus infection." Journal of Infection and Chemotherapy 23, no. 3: 173-176.

Case reports
Published: 30 September 2015 in Journal of Obstetrics and Gynaecology Research
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We report a case of marked elevation of the procalcitonin level in umbilical blood and neonatal blood at birth. The mother did not perceive fetal motion. Antepartum fetal heart rate monitoring showed a loss of variability and absence of acceleration. No fetal breathing movement, fetal movement, or fetal tone were observed by ultrasonography. The female neonate was delivered by cesarean section at 25 weeks of gestation, with birthweight 774 g. The umbilical arterial pH value at birth was 7.29. Mild elevation in interleukin-6 and tumor necrosis factor-α in umbilical blood were observed. Cytochrome c showed a high level in umbilical and neonatal blood at birth. Placental histopathology revealed multiple fetal vessel thrombosis in the large stem villi and chorionic vessels. The neonate showed no infectious signs throughout the neonatal period. Computed tomography at 3 months of age revealed atrophy in the cerebrum and cerebellum. At 1 year after birth, the infant showed spastic quadriplegia. In this case, antepartum asphyxia due to fetal vessel thrombosis may have influenced the elevation of procalcitonin level in umbilical blood and neonatal blood at birth.

ACS Style

Masatoki Kaneko; Aya Yamauchi; Rie Yamashita; Yuichiro Sato; Yuki Kodama; Hiroshi Sameshima. Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report. Journal of Obstetrics and Gynaecology Research 2015, 41, 1839 -1842.

AMA Style

Masatoki Kaneko, Aya Yamauchi, Rie Yamashita, Yuichiro Sato, Yuki Kodama, Hiroshi Sameshima. Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report. Journal of Obstetrics and Gynaecology Research. 2015; 41 (11):1839-1842.

Chicago/Turabian Style

Masatoki Kaneko; Aya Yamauchi; Rie Yamashita; Yuichiro Sato; Yuki Kodama; Hiroshi Sameshima. 2015. "Did antepartum hypoxic insult caused by fetal vessel thrombosis influence the procalcitonin level in umbilical blood? A case report." Journal of Obstetrics and Gynaecology Research 41, no. 11: 1839-1842.

Journal article
Published: 21 March 2015 in Journal of Obstetrics and Gynaecology Research
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The aim of this study was to clarify the mortality and long‐term outcomes of extremely low‐birthweight infants according to the process of maternal or infant transport and indications for maternal transport.

ACS Style

Masatoki Kaneko; Rie Yamashita; Katsuhide Kai; Naoshi Yamada; Hiroshi Sameshima; Tsuyomu Ikenoue. Perinatal morbidity and mortality for extremely low-birthweight infants: A population-based study of regionalized maternal and neonatal transport. Journal of Obstetrics and Gynaecology Research 2015, 41, 1056 -1066.

AMA Style

Masatoki Kaneko, Rie Yamashita, Katsuhide Kai, Naoshi Yamada, Hiroshi Sameshima, Tsuyomu Ikenoue. Perinatal morbidity and mortality for extremely low-birthweight infants: A population-based study of regionalized maternal and neonatal transport. Journal of Obstetrics and Gynaecology Research. 2015; 41 (7):1056-1066.

Chicago/Turabian Style

Masatoki Kaneko; Rie Yamashita; Katsuhide Kai; Naoshi Yamada; Hiroshi Sameshima; Tsuyomu Ikenoue. 2015. "Perinatal morbidity and mortality for extremely low-birthweight infants: A population-based study of regionalized maternal and neonatal transport." Journal of Obstetrics and Gynaecology Research 41, no. 7: 1056-1066.