The primary focus of autonomous driving research is to improve driving accuracy and reliability. While great progress has been made, state-of-the-art algorithms still fail at times and some of these failures are due to the faults in sensors. Such failures may have fatal consequences. It therefore is important that automated cars foresee problems ahead as early as possible. By using real-world data and artificial injection of different types of sensor faults to the healthy signals, data models can be trained using machine learning techniques. This paper proposes a novel fault detection, isolation, identification and prediction (based on detection) architecture for multi-fault in multi-sensor systems, such as autonomous vehicles.Our detection, identification and isolation platform uses two distinct and efficient deep neural network architectures and obtained very impressive performance. Utilizing the sensor fault detection system’s output, we then introduce our health index measure and use it to train the health index forecasting network.