Epistasis Detection (ED) was widely used for identifying potential risk disease variants in the human genome. A statistically meaningful ED typically requires a more extensive dataset to detect complex disease-associated Single Nucleotide Polymorphisms (SNPs), but a single institution generally possesses limited genome data. Thus, it is necessary to collect multi-institutional genome data to carry out research together. However, concerns regarding privacy and trustworthiness impede the sharing of massive genome data. Therefore, this study proposes a novel federated ED framework with the sequence perturbation privacy-preserving method to address the limitation of distributed data sharing (FedED-SegNAS). Firstly, to address the lack of interpretability in deep learning models, integrate fuzzy logic into Convolutional Neural Networks (CNNs), promoting the capabilities of CNN to represent the ambiguities of genomic data with high interpretability and reasonable accuracy. Secondly, consider using the Neural Architecture Search (NAS) method to optimize the federated neural architecture. Specifically, selecting the Particle Swarm Optimization (PSO) algorithm to automatically search the optimal neural architecture at different stages in federated learning based on adaptive multi-objectives decreases the communication cost and improves communication efficiency. Furthermore, to ensure the security of the parameter transfer process, design the sequence perturbation privacy-preserving method, grouping the upload and download parameters of federated learning and randomly perturbing the group number so that the attacker cannot obtain the corresponding result between the group number and parameters. Its rationality and security have been proven. The experiments conducted on a range of datasets demonstrate the superiority of the framework over state-of-the-art epistasis detection methods. FedED-SegNAS can reduce network complexity while protecting genome data security.

Augmented Intelligence of Things (AIoT) combines augmented intelligence algorithms with the massive data collected by IoT devices, enabling more advanced decision-making. The typical application of AIoT is Edge Computing (EC), which provides computational and storage resources at the edge to support vehicle decision-making for computation tasks. With the development of EC, task offloading has become a hopeful paradigm for assisting the time-sensitive tasks of resource-limited vehicles, such as emergency rescue vehicles, by deploying at Roadside Units (RSUs). However, the effectiveness of task offloading for emergency vehicles is hindered by the timeliness of trajectory data and the concern regarding vehicle location. Therefore, this study introduces a Secure Task Offloading scheme relying on real-time trajectory prediction, named STODRL. Firstly, this study proposes a temporal differential privacy method to disturb vehicular location information to avoid suffering from malicious stealing. Secondly, a vehicular trajectory prediction method using the Temporal Convolutional Network (TCN) is designed to improve task offloading precision by offering supplemental trajectory information. Moreover, the scheme employs a reinforcement learning method to offload computational requests effectively and avoid dimensional disasters. Simulated results validate that STODRL outperforms existing methods, significantly reducing task completion delay and ensuring the security of location information.

Generative artificial intelligence has become the focus of the intelligent education field, especially in the generation of personalized learning resources. Current learning resource generation methods recommend customized courses based on learning styles and interests, improving learning efficiency. However, these methods cannot generate personalized tutorials according to learners’ preferences, nor can they adjust tutorial content as moods or levels of knowledge change. Therefore, this study develops an intelligent tutorial-generating system (Self-GT) for self-aid learning, integrating cognitive computing and generative learning to capture learners’ dynamic preferences. The critical components of Self-GT are the tutorial-generating model based on cyclic deep reinforcement learning (RL) and the multimodal knowledge graph containing complex relationships. Specifically, the proposed RL model dynamically explores learners’ preferences from the temporal dimension, enabling RL agents to express learning behavior characteristics accurately and generate personalized tutorials. Then, relying on the internal self-developed education base and external Internet sources, a multimodal knowledge graph with multiple self-defined relationships is designed to enhance the precision of tutorial generation. Finally, the experimental results indicate that the Self-GT performs well in generating tutorials and has been successfully applied in the generating tutorial for “Hospital Network Architecture Planning and Design.”

Objective: Deep learning algorithms have long been involved in the diagnosis of severe neurological disorders that interfere with patients’ everyday tasks, such as Parkinson’s disease (PD). The most effective imaging modality for detecting the condition is DaTscan, a variety of single-photon emission computerized tomography (SPECT) imaging method. The goal is to create a convolutional neural network that can specifically identify the region of interest following feature extraction.Methods: The study comprised a total of 1,390 DaTscan imaging groups with PD and normal classes. The architecture of DenseNet-121 is leveraged with a soft-attention block added before the final classification layer. For visually analyzing the region of interest (ROI) from the images after classification, Soft Attention Maps and feature map representation are used.Outcomes: The model obtains an overall accuracy of 99.2% and AUC-ROC score 99%. A sensitivity of 99.2%, specificity of 99.4% and f1-score of 99.1% is achieved that surpasses all prior research findings. Soft-attention map and feature map representation aid in highlighting the ROI, with a specific attention on the putamen and caudate regions.Conclusion: With the deep learning framework adopted, DaTscan images reveal the putamen and caudate areas of the brain, which aid in the distinguishing of normal and PD cohorts with high accuracy and sensitivity.

With a growing security threat in wireless communication networks, a promising method for secure next-generation networks is a zero-trust framework focusing on authentication schemes. How to analyze the risks involved in authentication is a challenge. This study quantifies authentication risks within the zero-trust framework and introduces a privacy domain prevention-control theory. The theory encompasses dynamic privacy risk assessment, intelligent risk classification, and automated selection of privacy protection schemes. First, a dynamic privacy risk assessment method, based on physical entity relationships, is proposed to evaluate all privacy risks. Second, a five-category risk classification method is designed to categorize privacy risks, facilitating the selection of prevention-control schemes, with its rationality mathematically validated. Additionally, an Analytical Hierarchy Process (AHP)-based method is introduced to guide the optimal selection of prevention-control schemes for various scenarios. Finally, the practical application of the theory in medicine multi-modal computing scene of wireless body area networks demonstrates its effectiveness. The experimental results also show the superiority and feasibility of the proposed methods.