Alzheimer's disease (AD) is a neurodegenerative disorder that causes memory degradation and cognitive function impairment in elderly people. The irreversible and devastating cognitive decline brings large burdens on patients and society. So far, there is no effective treatment that can cure AD, but the process of early-stage AD can slow down. Early and accurate detection is critical for treatment. In recent years, deep-learning-based approaches have achieved great success in Alzheimer's disease diagnosis. The main objective of this paper is to review some popular conventional machine learning methods used for the classification and prediction of AD using Magnetic Resonance Imaging (MRI). The methods reviewed in this paper include support vector machine (SVM), random forest (RF), convolutional neural network (CNN), autoencoder, deep learning, and transformer. This paper also reviews pervasively used feature extractors and different types of input forms of convolutional neural network. At last, this review discusses challenges such as class imbalance and data leakage. It also discusses the trade-offs and suggestions about pre-processing techniques, deep learning, conventional machine learning methods, new techniques, and input type selection.

Osteoarthritis (OA), especially knee OA, is the most common form of arthritis, causing significant disability in patients worldwide. Manual diagnosis, segmentation, and annotations of knee joints remain as the popular method to diagnose OA in clinical practices, although they are tedious and greatly subject to user variation. Therefore, to overcome the limitations of the commonly used method as above, numerous deep learning approaches, especially the convolutional neural network (CNN), have been developed to improve the clinical workflow efficiency. Medical imaging processes, especially those that produce 3‐dimensional (3D) images such as MRI, possess ability to reveal hidden structures in a volumetric view. Acknowledging that changes in a knee joint is a 3D complexity, 3D CNN has been employed to analyse the joint problem for a more accurate diagnosis in the recent years. In this review, we provide a broad overview on the current 2D and 3D CNN approaches in the OA research field. We reviewed 74 studies related to classification and segmentation of knee osteoarthritis from the Web of Science database and discussed the various state‐of‐the‐art deep learning approaches proposed. We highlighted the potential and possibility of 3D CNN in the knee osteoarthritis field. We concluded by discussing the possible challenges faced as well as the potential advancements in adopting 3D CNNs in this field.

Epistasis Detection (ED) was widely used for identifying potential risk disease variants in the human genome. A statistically meaningful ED typically requires a more extensive dataset to detect complex disease-associated Single Nucleotide Polymorphisms (SNPs), but a single institution generally possesses limited genome data. Thus, it is necessary to collect multi-institutional genome data to carry out research together. However, concerns regarding privacy and trustworthiness impede the sharing of massive genome data. Therefore, this study proposes a novel federated ED framework with the sequence perturbation privacy-preserving method to address the limitation of distributed data sharing (FedED-SegNAS). Firstly, to address the lack of interpretability in deep learning models, integrate fuzzy logic into Convolutional Neural Networks (CNNs), promoting the capabilities of CNN to represent the ambiguities of genomic data with high interpretability and reasonable accuracy. Secondly, consider using the Neural Architecture Search (NAS) method to optimize the federated neural architecture. Specifically, selecting the Particle Swarm Optimization (PSO) algorithm to automatically search the optimal neural architecture at different stages in federated learning based on adaptive multi-objectives decreases the communication cost and improves communication efficiency. Furthermore, to ensure the security of the parameter transfer process, design the sequence perturbation privacy-preserving method, grouping the upload and download parameters of federated learning and randomly perturbing the group number so that the attacker cannot obtain the corresponding result between the group number and parameters. Its rationality and security have been proven. The experiments conducted on a range of datasets demonstrate the superiority of the framework over state-of-the-art epistasis detection methods. FedED-SegNAS can reduce network complexity while protecting genome data security.

With the increasing availability of diverse healthcare data sources, such as medical images and electronic health records, there is a growing need to effectively integrate and fuse this multimodal data for comprehensive analysis and decision-making. However, despite its potential, multimodal data fusion in healthcare remains limited. This review paper provides an overview of existing literature on multimodal data fusion in healthcare, covering 69 relevant works published between 2018 and 2024. It focuses on methodologies that integrate different data types to enhance medical analysis, including techniques for integrating medical images with structured and unstructured data, combining multiple image modalities, and other features. Additionally, the paper reviews various approaches to multimodal data fusion, such as early, intermediate, and late fusion methods, and examines the challenges and limitations associated with these techniques. The potential benefits and applications of multimodal data fusion in various diseases are highlighted, illustrating specific strategies employed in healthcare artificial intelligence (AI) model development. This research synthesizes existing information to facilitate progress in using multimodal data for improved medical diagnosis and treatment planning.

Computed Tomography (CT) is a widely use medical image modality in clinical medicine, because it produces excellent visualizations of fine structural details of the human body. In clinical procedures, it is desirable to acquire CT scans by minimizing the X-ray flux to prevent patients from being exposed to high radiation. However, these Low-Dose CT (LDCT) scanning protocols compromise the signal-to-noise ratio of the CT images because of noise and artifacts over the image space. Thus, various restoration methods have been published over the past 3 decades to produce high-quality CT images from these LDCT images. More recently, as opposed to conventional LDCT restoration methods, Deep Learning (DL)-based LDCT restoration approaches have been rather common due to their characteristics of being data-driven, high-performance, and fast execution. Thus, this study aims to elaborate on the role of DL techniques in LDCT restoration and critically review the applications of DL-based approaches for LDCT restoration. To achieve this aim, different aspects of DL-based LDCT restoration applications were analyzed. These include DL architectures, performance gains, functional requirements, and the diversity of objective functions. The outcome of the study highlights the existing limitations and future directions for DL-based LDCT restoration. To the best of our knowledge, there have been no previous reviews, which specifically address this topic.