Assessing exposure to fine particulate matter (PM_2.5) across disadvantaged communities is understudied, and the air monitoring network is inadequate. We leveraged emerging low-cost sensors (PurpleAir) and engaged community residents to develop a community-based monitoring program across disadvantaged communities (high proportions of low-income and minority populations) in Southern California. We recruited 22 households from 8 communities to measure residential outdoor PM_2.5 concentrations from June 2021 to December 2021. We identified the spatial and temporal patterns of PM_2.5 measurements as well as the relationship between the total PM_2.5 measurements and diesel PM emissions. We found that communities with a higher percentage of Hispanic and African American population and higher rates of unemployment, poverty, and housing burden were exposed to higher PM_2.5 concentrations. The average PM_2.5 concentrations in winter (25.8 µg/m³) were much higher compared with the summer concentrations (12.4 µg/m³). We also identified valuable hour-of-day and day-of-week patterns among disadvantaged communities. Our results suggest that the built environment can be targeted to reduce the exposure disparity. Integrating low-cost sensors into a citizen-science-based air monitoring program has promising applications to resolve monitoring disparity and capture “hotspots” to inform emission control and urban planning policies, thus improving exposure assessment and promoting environmental justice.

Exposure to fine particulate matter (PM_2.5) has been reported to increase the risks of chronic kidney disease. However, limited research has assessed the effect of PM_2.5 and its constituents on renal function, and the underlying mechanism has not been well characterized. We aimed to evaluate the association of PM_2.5 and its constituents with kidney indicators and to explore the roles of systematic oxidative stress and inflammation in the association. We conducted a longitudinal panel study among 35 healthy adults before-, intra- and after-the 2019 Wuhan Military World Games. We repeatedly measured 6 renal function parameters and 5 circulating biomarkers of oxidative stress and inflammation at 6 rounds of follow-ups. We monitored hourly personal PM_2.5 concentrations with 3 consecutive days and measured 10 metals (metalloids) and 16 polycyclic aromatic hydrocarbons (PAHs) components. The linear mixed-effect models were applied to examine the association between PM_2.5 and renal function parameters, and the mediation analysis was performed to explore potential bio-pathways. PM_2.5 concentrations across Wuhan showed a slight decrease during the Military Games. We observed significant associations between elevated blood urea nitrogen (BUN) levels and PM_2.5 and its several metals and PAHs components. For an interquartile range (IQR) increase of PM_2.5, BUN increased 0.42 mmol/L (95% CI: 0.14 to 0.69). On average, an IQR higher of lead (Pb), cadmium (Cd), arsenic (As), selenium (Se), thallium (Tl) and Indeno (1,2,3-cd) pyrene (IPY) were associated with 0.90, 0.65, 0.29, 0.27, 0.26 and 0.90 mmol/L increment of BUN, respectively. Moreover, superoxide dismutase was positively associated with PM_2.5 and mediated 18.24% association. Our research indicated that exposure to PM_2.5 might affect renal function by activating oxidative stress pathways, in which the constituents of Pb, Cd, As, Se, Tl and IPY might contribute to the associations.