Traditional electronic pianos mostly adopt a gantry type and a large number of rigid keys, and most keyboard sensors of the electronic piano require additional power supply during playing, which poses certain challenges for portable electronic products. Here, we demonstrated a fluorinated ethylene propylene (FEP)-based electret nanogenerator (ENG), and the output electrical performances of the ENG under different external pressures and frequencies were systematically characterized. At a fixed frequency of 4 Hz and force of 4 N with a matched load resistance of 200 MΩ, an output power density of 20.6 mW/cm² could be achieved. Though the implementation of a signal processing circuit, ENG-based, self-powered pressure sensors have been demonstrated for self-powered, flexible electronic pianos. This work provides a new strategy for electret nanogenerators for self-powered sensor networks and portable electronics.