MOF-composites are porous materials with a large surface area and functionalized with other types of materials (metallic nanoparticles, oxides, zeolites, etc. ), affording optimal and chemically stable structures for wastewater remediation.
1 November 2007 in European Journal of Pharmaceutical Sciences
Food security is the main concern of government due to malnutrition worldwide. The aim of this study was to assess macronutrients and amino acids in five species of grasshoppers, consumed in rural and urban communities. Samples were captured in different agro climatic environment conditions, wherever vegetation grows, and the macronutrients were raw, analyzed in dry basis by the AOAC methods and amino acids by cation exchange chromatography. The obtained data showed a high protein content, ranging from 70% to 75%; lipids 4% to 6%; minerals 3% to 5%; fiber 6% to 8% and soluble carbohydrates 6% to 18%, including essential amino acids that play an important role in human metabolism, with tryptophan as limiting factor. The different species of the studied grasshoppers are high in proteins, essential macromolecules for human life that decrease protein-energy malnutrition; the excess of amino acids after releasing the amino group will provide energy, as well as soluble carbohydrates. They also have minerals that are needed to prevent anemia, and fiber, non-digestible carbohydrates essential in a healthy diet. In conclusion, the daily consumption of 5 or 6 grasshoppers is a good source of nutrients that will provide optimal health to population.
Objective: The main purpose of this article is to show the valuable characteristics that liotropic liquid crystal systems possess to be employed as new drug delivery systems. Significance: Colloidal aqueous dispersions of lyotropic liquid crystal mesophases such as the identified as cubosomes and hexosomes, and so on, have received considerable attention due to their unique nanostructures and their thermodynamic properties, which provide the potential as a sustained drug release matrix. Additionally, their large surface area and similarity with the liquid crystal structures of intercellular lipids of stratum corneum enhances the interaction with the skin and mucous, increasing the potential for topical drug delivery efficiency of biopharmaceutical class II drugs as the antifungal ketoconazole. Methods: This article presents the results in morphological characteristics, particle size, ζ potential, flow, thermal behavior and drug release studies of hexosomes containing ketoconazole (LHLC-K) obtained with glycerol monooleate, propylene glycol monolaurate, poloxamer, and water mixtures. Results: This colloidal system exhibits a Newtonian-type flow and a hexagonal nanostructure with a median particle size of 107 ± 20 nm and ζ potential of +4.45 ± 0.50 mV. Through differential scanning calorimetry studies, the LHLC-K demonstrated physical and chemical stability for more than six months and mesophasic thermal reversibility between 10 and 50 °C. Finally, LHLC-K releases ketoconazole following a kinetics described by the first order model. Conclusions: Physicochemical properties of the hexosomes containing ketoconazole are important for topical mycosis treatment administration, conditions of storage, and for its incorporation into the formulation of semi-solid dosage forms.