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Introduction: New York City is one of the areas most affected by the COVID-19 pandemic in the United States. Healthcare workers are among those at high risk of contracting the virus, and a vital source of information and trust in vaccines to the community. Methods: This study was conducted about attitudes towards COVID-19 vaccination among healthcare workers at a public hospital in New York City during the beginning of COVID-19 vaccination. 428 hospital employees responded. Results: Several factors were significantly associated with vaccine attitudes, including demographics such as gender (p = 0.002), age (p = 0.005), race (p< 0.001) and home location (p< 0.001), role within the hospital (p< 0.001), knowledge about the virus (p< 0.001) and confidence in and expectations about personal protective equipment and behaviors (p< 0.001). Structural equation modeling revealed that the most predictive factors were prior vaccine attitudes and concern with the speed of testing and approval of the vaccines (p< 0.001). Multivariate analysis reinforced these, while also identifying perceived personal risk as significant (p = 0.033). Conclusions: Several modifiable factors that reflect confidence in science, scientific knowledge, personal risk perception, experience and medical authority are correlated with vaccine attitudes, indicating that a holistic educational approach to improve trust in science is likely to be effective in long-term reduction in vaccine hesitancy.
Federico Ciardi; Vidya Menon; Jamie Jensen; Masood Shariff; Anjana Pillai; Usha Venugopal; Moiz Kasubhai; Vihren Dimitrov; Balavenkatesh Kanna; Brian Poole. Knowledge, Attitudes and Perceptions of COVID-19 Vaccination among Healthcare Workers of an Inner-City Hospital in New York. Vaccines 2021, 9, 516 .
AMA StyleFederico Ciardi, Vidya Menon, Jamie Jensen, Masood Shariff, Anjana Pillai, Usha Venugopal, Moiz Kasubhai, Vihren Dimitrov, Balavenkatesh Kanna, Brian Poole. Knowledge, Attitudes and Perceptions of COVID-19 Vaccination among Healthcare Workers of an Inner-City Hospital in New York. Vaccines. 2021; 9 (5):516.
Chicago/Turabian StyleFederico Ciardi; Vidya Menon; Jamie Jensen; Masood Shariff; Anjana Pillai; Usha Venugopal; Moiz Kasubhai; Vihren Dimitrov; Balavenkatesh Kanna; Brian Poole. 2021. "Knowledge, Attitudes and Perceptions of COVID-19 Vaccination among Healthcare Workers of an Inner-City Hospital in New York." Vaccines 9, no. 5: 516.
Background Dynamics of humoral immune responses to SARS-CoV-2 antigens following infection suggests an initial decay of antibody followed by subsequent stabilization. We aim to understand the longitudinal humoral responses to SARS-CoV-2 nucleocapsid (N) protein and spike (S) protein and to evaluate their correlation to clinical symptoms among healthcare workers (HCW). Methods In this cross-sectional longitudinal cohort study done in two phases over four months, HCW underwent serial qualitative serology testing for anti-N antibody, quantitative MSH-ELISA to detect Receptor Binding Domain and full-length S reactive antibodies and completed online surveys about COVID-19 related symptoms and healthcare/community exposure. Results Anti-N antibody positivity was 27% and anti-S positivity was 28% in Phase 1. In Phase 2 anti-S titres were higher in symptomatic than in asymptomatic positive subjects in Phase 1. Marginally higher titers were seen in asymptomatic compared to the symptomatic positive subgroup in Phase 2. A positive correlation was noted between age, number and duration of symptoms, and Phase 1 anti-S antibody titre. A strong correlation was observed between Phase 1 titers and decay of anti-S antibody titres between the two phases. Significant correlation with rate of decay was also noted with fever, GI symptoms, and total number and duration of COVID-19 symptoms. Conclusions Higher initial anti-S antibody titres were associated with larger number and longer duration of symptoms as well as faster decay during the two time points. Key Points Question What is the decay rate of neutralizing antibodies among SARS-CoV-2 infected healthcare workers? Findings In this cohort study that included 178 healthcare workers, over a 4-month period following the COVID-19 pandemic, participants had an initial rise in anti-nucleocapsid (N) and anti-spike (S) antibodies, which was followed by decay and stabilization of the titres. Significant correlation with rate of decay was noted with the symptomatic participants. Meaning A strong correlation is observed in the decay of anti-S antibody titres based on symptomology, thus eluding to the fact that continued recommendations for infection protection and COVID-19 vaccine campaigns are necessary.
Vidya Menon; Masood A Shariff; Victor Perez Gutierrez; Juan M Carreño; Bo Yu; Muzamil Jawed; Marcia Gossai; Elisenda Valdez; Anjana Pillai; Usha Venugopal; Moiz Kasubhai; Vihren Dimitrov; Florian Krammer. High Initial Titres of Anti-Spike Antibodies following SARS-CoV-2 Infection is Associated with Faster Decay Rates at Four Months Follow-Up. 2021, 1 .
AMA StyleVidya Menon, Masood A Shariff, Victor Perez Gutierrez, Juan M Carreño, Bo Yu, Muzamil Jawed, Marcia Gossai, Elisenda Valdez, Anjana Pillai, Usha Venugopal, Moiz Kasubhai, Vihren Dimitrov, Florian Krammer. High Initial Titres of Anti-Spike Antibodies following SARS-CoV-2 Infection is Associated with Faster Decay Rates at Four Months Follow-Up. . 2021; ():1.
Chicago/Turabian StyleVidya Menon; Masood A Shariff; Victor Perez Gutierrez; Juan M Carreño; Bo Yu; Muzamil Jawed; Marcia Gossai; Elisenda Valdez; Anjana Pillai; Usha Venugopal; Moiz Kasubhai; Vihren Dimitrov; Florian Krammer. 2021. "High Initial Titres of Anti-Spike Antibodies following SARS-CoV-2 Infection is Associated with Faster Decay Rates at Four Months Follow-Up." , no. : 1.
Background Taxi drivers are prone to developing cardiovascular disease (CVD) risk factors by adopting poor health behaviors due to their work environment. The population of Hispanic taxi drivers in inner city South Bronx, NYC, have not been studied. The goal of our qualitative study is to understand the perception, knowledge, behavior and barriers that influence CVD risk in overweight and obese inner-city Hispanic drivers. Methods A cross-sectional qualitative study was conducted among community-based taxi drivers in South Bronx, NYC. Hispanic taxi drivers with body mass index of greater than 25 kg/m2 were screened and recruited for the study. Focus groups were organized to evaluate CVD and obesity risk factors through open-ended questions. The discussions were recorded, transcribed and analyzed using standard qualitative techniques. The Health Belief Model framework was applied to understand and evaluate likelihood of promoting health behaviors in this population based on the findings from the focus groups. Results We conducted 3 focus groups (N = 25) and themes that emerged were evaluated. Through the Health Belief Model framework, Hispanic taxi driver participants reported demanding and stressful work shifts, barriers to better nutrition and good health, poor support systems, and low self-efficacy in overcoming barriers to improve their risk for CVD, due to lower perceived benefits and greater perceived barriers. Conclusions Inner-city Hispanic NYC taxi drivers have several contributing factors and barriers leading to a poor CVD risk and high body weight profile. Understanding their knowledge, perception and barriers the drivers face in improving their CVD risk, underscores the importance of community outreach programs to develop a framework in empowering and improving the health of this population.
Balavenkatesh Kanna; Aijan Ukudeyeva; Mohammad Faiz; Euripides Roques; Tina Washington; Leandro Ramirez; Masood A. Shariff; Maria Espejo. Qualitative study of knowledge, perception, behavior and barriers associated with cardiovascular disease risk among overweight and obese Hispanic taxi drivers of South Bronx, NYC. BMC Public Health 2020, 20, 1 -10.
AMA StyleBalavenkatesh Kanna, Aijan Ukudeyeva, Mohammad Faiz, Euripides Roques, Tina Washington, Leandro Ramirez, Masood A. Shariff, Maria Espejo. Qualitative study of knowledge, perception, behavior and barriers associated with cardiovascular disease risk among overweight and obese Hispanic taxi drivers of South Bronx, NYC. BMC Public Health. 2020; 20 (1):1-10.
Chicago/Turabian StyleBalavenkatesh Kanna; Aijan Ukudeyeva; Mohammad Faiz; Euripides Roques; Tina Washington; Leandro Ramirez; Masood A. Shariff; Maria Espejo. 2020. "Qualitative study of knowledge, perception, behavior and barriers associated with cardiovascular disease risk among overweight and obese Hispanic taxi drivers of South Bronx, NYC." BMC Public Health 20, no. 1: 1-10.
Balavenkatesh Kanna; Masood Shariff. A novel approach to clinical practice by using a shared decision-making model to target cardiovascular risk: The YANKEES study. http://isrctn.com/ 2019, 1 .
AMA StyleBalavenkatesh Kanna, Masood Shariff. A novel approach to clinical practice by using a shared decision-making model to target cardiovascular risk: The YANKEES study. http://isrctn.com/. 2019; ():1.
Chicago/Turabian StyleBalavenkatesh Kanna; Masood Shariff. 2019. "A novel approach to clinical practice by using a shared decision-making model to target cardiovascular risk: The YANKEES study." http://isrctn.com/ , no. : 1.
Minimally invasive coronary surgery approach for coronary artery bypass grafting is a safe and reproducible procedure for multivessel revascularization. This study reviewed a single surgeon's experience with minimally invasive coronary surgery coronary artery bypass grafting, including operative time, number of bypasses, and conversion to sternotomy. A prospective database of consecutive minimally invasive coronary surgery coronary artery bypass grafting procedures from 2005 to 2013 was reviewed. A small anterolateral left thoracotomy allowed left internal mammary artery harvest, proximal anastomoses on the ascending aorta, and distal coronary anastomoses. Early cases were compared with the later cases, focusing on grafting strategies that led to a standardized approach with Propensity Score Matching analysis. Seven hundred consecutive cases were divided into early (1–200) and late (201–700) groups. In the late group, the number of triple-vessel disease patients trended higher (50% vs. 57%, P = 0.0674) and the number of bypasses increased (2.3 ± 0.8 vs. 2.7 ± 1.0, P < 0.0001). Conversion to sternotomy significantly decreased between the groups (6% vs. 0.6%, P < 0.0001). There was no difference in rate of postoperative complications between the groups except for prolonged intubation (10% vs. 5%, P = 0.0236) and shortened length of stay (5.9 ± 6.7 vs. 5.5 ± 6.0, P = 0.0268). Propensity score matching analysis (n = 177) was significant for total bypass performed and time per bypass (P < 0.05). The late group was further divided into subgroups of one hundred each (subgroup 1 through 5). Operative times differed significantly (subgroup 1: 249 ± 71.2, subgroup 2: 259 ± 85.8, subgroup 3: 244 ± 71.0, subgroup 4: 270 ± 58.4, and subgroup 5: 246 ± 47.9, P < 0.005). As experience with minimally invasive coronary surgery coronary artery bypass grafting increased, the ideal sequence of steps to optimize surgical outcome was defined. The number of bypassed vessels increased and the operative time and conversion to sternotomy decreased.
Peter A. Andrawes; Masood A. Shariff; John P. Nabagiez; Richard Steward; Basem Azab; Natasha Povar; Mirala Sarza; Seleshi Demissie; Scott M. Sadel; Michele Nichols; Joseph T. McGinn. Evolution of Minimally Invasive Coronary Artery Bypass Grafting. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 2018, 13, 81 -90.
AMA StylePeter A. Andrawes, Masood A. Shariff, John P. Nabagiez, Richard Steward, Basem Azab, Natasha Povar, Mirala Sarza, Seleshi Demissie, Scott M. Sadel, Michele Nichols, Joseph T. McGinn. Evolution of Minimally Invasive Coronary Artery Bypass Grafting. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 2018; 13 (2):81-90.
Chicago/Turabian StylePeter A. Andrawes; Masood A. Shariff; John P. Nabagiez; Richard Steward; Basem Azab; Natasha Povar; Mirala Sarza; Seleshi Demissie; Scott M. Sadel; Michele Nichols; Joseph T. McGinn. 2018. "Evolution of Minimally Invasive Coronary Artery Bypass Grafting." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 2: 81-90.
Masood A. Shariff; Daniel Martingano; Usman Khan; Nikhil Goyal; Raman Sharma; Syed B. Rizvi; Kourosh T. Asgarian; Apurva Motivala; John P. Nabagiez. Left Ventricular Outflow Tract Pseudoaneurysm after Aortic Valve Replacement. AORTA 2016, 3, 167 -171.
AMA StyleMasood A. Shariff, Daniel Martingano, Usman Khan, Nikhil Goyal, Raman Sharma, Syed B. Rizvi, Kourosh T. Asgarian, Apurva Motivala, John P. Nabagiez. Left Ventricular Outflow Tract Pseudoaneurysm after Aortic Valve Replacement. AORTA. 2016; 3 (5):167-171.
Chicago/Turabian StyleMasood A. Shariff; Daniel Martingano; Usman Khan; Nikhil Goyal; Raman Sharma; Syed B. Rizvi; Kourosh T. Asgarian; Apurva Motivala; John P. Nabagiez. 2016. "Left Ventricular Outflow Tract Pseudoaneurysm after Aortic Valve Replacement." AORTA 3, no. 5: 167-171.
Elderly patients with unstable coronary artery disease (CAD) have better outcomes with coronary revascularization than conservative treatment. With the improvement in percutaneous coronary intervention (PCI) techniques using drug eluting-stents, this became an attractive option in elderly. Minimally invasive coronary artery bypass grafting (MICS-CABG) is a safe and effective alternative to conventional CABG. We aimed to explore the long-term outcomes after PCI vs MICS-CABG in ≥75 year-old patients with severe CAD. A total of 1454 elderly patients (≥75 year-old patients) underwent coronary artery revascularization between January 2005 and December 2009. Patients were selected in the study if they have one of the Class-I indications for CABG. Groups were divided according to the type of procedure, PCI or MICS-CABG, and 5 year follow-up. Among 175 elderly patients, 109 underwent PCI and 66 had MICS-CABG. There was no significant difference observed in both groups with long-term all-cause mortality (31 PCI vs 21% MICS-CABG, p=0.151) and the overall 5 year survival was similar on Kaplan-Meier curve (Log rank p=0.318). The average length of stay in hospital was significantly shorter in the PCI than in the MICS-CABG group (4.3 vs 7.8 days, p<0.001). Only 4.7% of the PCI group were discharged to rehabilitation facility compared with 43.9% of the MICS-CABG group (p<0.001). The rate of repeat revascularization was significantly higher in the PCI group than in the MICS-CABG group (15 vs 3%, p=0.014). Among elderly patients, long-term all-cause mortality is similar after PCI and MICS-CABG. However, there is a significantly higher rate of repeat revascularization after PCI.
Emad A. Barsoum; Basem Azab; Nileshkumar Patel; Jonathan Spagnola; Masood A. Shariff; Umar Kaleem; Rewais Morcus; Deepak Asti; Joseph T. McGinn; James Lafferty; Donald A. Mccord. Long-term Outcome after Percutaneous Coronary Intervention Compared with Minimally Invasive Coronary Artery Bypass Surgery in the Elderly. The Open Cardiovascular Medicine Journal 2016, 10, 11 -18.
AMA StyleEmad A. Barsoum, Basem Azab, Nileshkumar Patel, Jonathan Spagnola, Masood A. Shariff, Umar Kaleem, Rewais Morcus, Deepak Asti, Joseph T. McGinn, James Lafferty, Donald A. Mccord. Long-term Outcome after Percutaneous Coronary Intervention Compared with Minimally Invasive Coronary Artery Bypass Surgery in the Elderly. The Open Cardiovascular Medicine Journal. 2016; 10 (1):11-18.
Chicago/Turabian StyleEmad A. Barsoum; Basem Azab; Nileshkumar Patel; Jonathan Spagnola; Masood A. Shariff; Umar Kaleem; Rewais Morcus; Deepak Asti; Joseph T. McGinn; James Lafferty; Donald A. Mccord. 2016. "Long-term Outcome after Percutaneous Coronary Intervention Compared with Minimally Invasive Coronary Artery Bypass Surgery in the Elderly." The Open Cardiovascular Medicine Journal 10, no. 1: 11-18.
Neuroendocrine tumors that arise in an extragonadal teratoma are extremely rare. Somatic-type malignancy, defined as any sarcoma, carcinoma, leukemia, or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. Our case represents a mediastinal mass that was incidentally found in a patient with syncope. Surgical resection confirmed mature teratoma with neuroendocrine features.
Peter A. Andrawes; Masood A. Shariff; Qing Chang; Fanyi Kong; Frank M. Rosell. Mediastinal Teratoma with Neuroendocrine Features in 34-Year-Old Male with Syncope. Case Reports in Surgery 2015, 2015, 1 -5.
AMA StylePeter A. Andrawes, Masood A. Shariff, Qing Chang, Fanyi Kong, Frank M. Rosell. Mediastinal Teratoma with Neuroendocrine Features in 34-Year-Old Male with Syncope. Case Reports in Surgery. 2015; 2015 ():1-5.
Chicago/Turabian StylePeter A. Andrawes; Masood A. Shariff; Qing Chang; Fanyi Kong; Frank M. Rosell. 2015. "Mediastinal Teratoma with Neuroendocrine Features in 34-Year-Old Male with Syncope." Case Reports in Surgery 2015, no. : 1-5.
Background: Coronary artery bypass grafting with aortic valve replacement (AVR) or mitral valve replacement (MVR) is traditionally performed via sternotomy. Minimally invasive coronary surgery (MICS) and minimally invasive valve surgery have been successfully performed independently. Patients with critical right coronary artery (RCA) stenosis not amenable to percutaneous intervention are candidates for valve replacement and single vessel coronary artery bypass. We present our series of six patients who underwent a concomitant valve and single vessel intervention via right thoracotomy.Methods: Between January 2011 and June 2013, six patients underwent right thoracotomy with valve replacement and single vessel bypass. Four aortic and two mitral valves were replaced and all received single vessel RCA bypass using reversed saphenous vein graft. Thoracotomy was via right anterior approach for AVR and right lateral for MVR. The patients were assessed postoperatively for overall outcomes.Results: The average age was 74 years (range 69-81); two patients were elective (AVR-1; MVR-1) and four were urgent (AVR-3; MVR-1). For MICS AVR and MICS MVR, the average cardiopulmonary bypass time was 171 ± 30 and 169 ± 7 minutes and the average aortic cross-clamp time was 122 ± 36 and 112 ± 2 minutes, respectively. Three patients were discharged home, one patient to a nursing home, and two to rehab. No patients required conversion to sternotomy; one patient developed atrial fibrillation, and one sepsis. Conclusion: Concomitant valve replacement and single bypass grafting via right anterior mini-thoracotomy is a viable option for select patients, particularly in non-stentable RCA stenosis. In the appropriate patient population, combined coronary artery bypass grafting and valve surgery can be safely performed via right thoracotomy.
Masood A Shariff; Laura Klingbeil; Daniel Martingano; Robert F Carlucci; Rami Michael; Jonathan Davila; Scott M Sadel; John P Nabagiez; Joseph T McGinn Jr.. Minimally Invasive Valve Surgery and Single Vessel Coronary Artery Bypass via Limited Anterior Right Thoracotomy. The Heart Surgery Forum 2015, 18, 266 -270.
AMA StyleMasood A Shariff, Laura Klingbeil, Daniel Martingano, Robert F Carlucci, Rami Michael, Jonathan Davila, Scott M Sadel, John P Nabagiez, Joseph T McGinn Jr.. Minimally Invasive Valve Surgery and Single Vessel Coronary Artery Bypass via Limited Anterior Right Thoracotomy. The Heart Surgery Forum. 2015; 18 (6):266-270.
Chicago/Turabian StyleMasood A Shariff; Laura Klingbeil; Daniel Martingano; Robert F Carlucci; Rami Michael; Jonathan Davila; Scott M Sadel; John P Nabagiez; Joseph T McGinn Jr.. 2015. "Minimally Invasive Valve Surgery and Single Vessel Coronary Artery Bypass via Limited Anterior Right Thoracotomy." The Heart Surgery Forum 18, no. 6: 266-270.
Left ventricular outflow tract pseudoaneurysm is an uncommon complication following aortic valve replacement (AVR), occurring most frequently secondary to endocarditis. We present a case of a 47-year-old female with a history of intravenous drug abuse and a past surgical history of two AVRs (2001 and 2009 with aortic root replacement for endocarditis) who presented with symptoms of lower extremity weakness. Subsequent radiologic imaging revealed the presence of a left ventricular outflow tract pseudoaneurysm, which was surgically managed with a homologous conduit.
Masood A. Shariff; Daniel Martingano; Usman Khan; Nikhil Goyal; Raman Sharma; Syed B. Rizvi; Apurva Motivala; Kourosh T. Asgarian; John P. Nabagiez. Left Ventricular Outflow Tract Pseudoaneurysm after Aortic Valve Replacement. AORTA 2015, 3, 167 -171.
AMA StyleMasood A. Shariff, Daniel Martingano, Usman Khan, Nikhil Goyal, Raman Sharma, Syed B. Rizvi, Apurva Motivala, Kourosh T. Asgarian, John P. Nabagiez. Left Ventricular Outflow Tract Pseudoaneurysm after Aortic Valve Replacement. AORTA. 2015; 3 (5):167-171.
Chicago/Turabian StyleMasood A. Shariff; Daniel Martingano; Usman Khan; Nikhil Goyal; Raman Sharma; Syed B. Rizvi; Apurva Motivala; Kourosh T. Asgarian; John P. Nabagiez. 2015. "Left Ventricular Outflow Tract Pseudoaneurysm after Aortic Valve Replacement." AORTA 3, no. 5: 167-171.
Basem Azab; Ariful Alam; Masood Shariff; Wolf K. Von Waagner; Alina Bhat; Osama Souied; Laura Klingbeil; Antonio I. Picon; Scott W. Bloom. Tu1799 The Elevated Pretreatment Mean Platelet Volume As a Predictor of Poor Overall Survival in Pancreatic Cancer Patients. Gastroenterology 2015, 148, 1 -1185.
AMA StyleBasem Azab, Ariful Alam, Masood Shariff, Wolf K. Von Waagner, Alina Bhat, Osama Souied, Laura Klingbeil, Antonio I. Picon, Scott W. Bloom. Tu1799 The Elevated Pretreatment Mean Platelet Volume As a Predictor of Poor Overall Survival in Pancreatic Cancer Patients. Gastroenterology. 2015; 148 (4):1-1185.
Chicago/Turabian StyleBasem Azab; Ariful Alam; Masood Shariff; Wolf K. Von Waagner; Alina Bhat; Osama Souied; Laura Klingbeil; Antonio I. Picon; Scott W. Bloom. 2015. "Tu1799 The Elevated Pretreatment Mean Platelet Volume As a Predictor of Poor Overall Survival in Pancreatic Cancer Patients." Gastroenterology 148, no. 4: 1-1185.
Primary cardiac sarcomas are rare tumors with a median survival of 6–12 months. Data suggest that an aggressive multidisciplinary approach may improve patient outcome. We present the case of a male who underwent resection of cardiac sarcoma three times from the age of 32 to 34. This report discusses the malignant nature of cardiac sarcoma and the importance of postoperative multidisciplinary care.
Masood A. Shariff; Juan A. Abreu; Farida Durrani; Eddie Daniele; Kimberly C. Bowman; Scott Sadel; Kourosh T. Asgarian; Joseph T. McGinn; John P. Nabagiez. Hyperplastic Cardiac Sarcoma Recurrence. Case Reports in Surgery 2015, 2015, 1 -4.
AMA StyleMasood A. Shariff, Juan A. Abreu, Farida Durrani, Eddie Daniele, Kimberly C. Bowman, Scott Sadel, Kourosh T. Asgarian, Joseph T. McGinn, John P. Nabagiez. Hyperplastic Cardiac Sarcoma Recurrence. Case Reports in Surgery. 2015; 2015 (5):1-4.
Chicago/Turabian StyleMasood A. Shariff; Juan A. Abreu; Farida Durrani; Eddie Daniele; Kimberly C. Bowman; Scott Sadel; Kourosh T. Asgarian; Joseph T. McGinn; John P. Nabagiez. 2015. "Hyperplastic Cardiac Sarcoma Recurrence." Case Reports in Surgery 2015, no. 5: 1-4.
We designed a prospective observational study targeting a selective population of patients undergoing elective coronary artery bypass grafting with normal systolic function. In this study we looked at the prevalence of pre-operative microvolt T-wave alternans and if it predicts atrial fibrillation after surgery. The inclusion criteria included all patients referred to the cardiothoracic outpatient clinic for elective bypass, who can perform aerobic exercise, with a recent exercise stress test exercising at least to 85% of the maximal predicted heart rate (220 - age) and with non-limiting chest pain at maximal exercise. Twenty patients met the inclusion/exclusion criteria between May 2008 and February 2010. The hospital course of those patients was followed, and in-hospital events were recorded. Nine out twenty (45%) of patients had a non-negative microvolt T-wave alternans tracing. Six patients (30%) developed new onset atrial fibrillation post surgery. Patients with non-negative microvolt level T-wave alternans are more likely to develop atrial fibrillation post coronary artery bypass grafting then patients with negative microvolt level T-wave alternans (p=0.05). This pilot study provides the first clinical evidence that patients with ischemic heart disease and normal systolic function have a high prevalence of abnormal microvolt T-wave alternans and might be at higher risk of sudden cardiac death. In addition our results show that microvolt level T-wave alternans predicts post coronary artery bypass grafting new onset atrial fibrillation.
G Khoueiry; M Abdallah; Masood Shariff; M Kowalski; J Lafferty. Microvolt T-wave alternans in patients undergoing elective coronary artery bypass grafting: a pilot study. Heart, lung and vessels 2015, 7, 27 -34.
AMA StyleG Khoueiry, M Abdallah, Masood Shariff, M Kowalski, J Lafferty. Microvolt T-wave alternans in patients undergoing elective coronary artery bypass grafting: a pilot study. Heart, lung and vessels. 2015; 7 (1):27-34.
Chicago/Turabian StyleG Khoueiry; M Abdallah; Masood Shariff; M Kowalski; J Lafferty. 2015. "Microvolt T-wave alternans in patients undergoing elective coronary artery bypass grafting: a pilot study." Heart, lung and vessels 7, no. 1: 27-34.
Minimally Invasive CABG (MICS CABG), performed through a small left thoracotomy, is associated with excellent feasibility and outcomes, high graft patency rates and, when compared to conventional CABG, faster recovery, less transfusions, and lower infection rates. However, it is an advanced technique limited to expert centres; consequently, questions have been raised regarding diffusability. We looked at the outcomes of teaching MICS CABG, including procedural adoption numbers.
M. Ruel; D. Une; H. Lapierre; E. Wallace; B. Sohmer; B. Cavanagh; E. Meyer; Masood Shariff; J.T. McGinn. IS MINIMALLY INVASIVE CABG TEACHABLE? Canadian Journal of Cardiology 2014, 30, S161 .
AMA StyleM. Ruel, D. Une, H. Lapierre, E. Wallace, B. Sohmer, B. Cavanagh, E. Meyer, Masood Shariff, J.T. McGinn. IS MINIMALLY INVASIVE CABG TEACHABLE? Canadian Journal of Cardiology. 2014; 30 (10):S161.
Chicago/Turabian StyleM. Ruel; D. Une; H. Lapierre; E. Wallace; B. Sohmer; B. Cavanagh; E. Meyer; Masood Shariff; J.T. McGinn. 2014. "IS MINIMALLY INVASIVE CABG TEACHABLE?" Canadian Journal of Cardiology 30, no. 10: S161.
Carotid artery stenosis and coronary artery disease share common risk factors and often coexist in the same patient. Currently, no consensus exists regarding the optimal treatment strategy for patients with concomitant severe coronary and carotid disease. We reviewed the results of our experience performing off-pump coronary artery bypass grafting (CABG) within 24 hours of carotid endarterectomy (CEA) in this select patient population. In this single institution retrospective study we identified patients who underwent CEA followed by CABG from March 2001 to March 2012. Preoperative, intraoperative, and postoperative data were collected and analyzed. Ninety patients underwent CEA followed by off-pump CABG. The duration between CEA and CABG was 1.8 ± 5.6 days with 80 (89%) within 24 hours. Mean age was 69 ± 9 years, 68% male. Perioperative comorbidities included hypertension (87%), diabetes (50%), previous myocardial infarction (24%), peripheral arterial disease (20%), and strokes and transient ischemic attack (16%). Extensive aortic atherosclerosis was noted in 15 patients (17%). The average number of vessels bypassed was 3.4 ± 1.0, and the average number of proximal vein aortotomies was 1.7 ± 0.92. Post-CEA surgical outcomes were myocardial infarction (1%), acute embolic cerebrovascular accident (1%), left upper extremity weakness (1%), and hypoglossal nerve injury (1%). Post-CABG surgical outcomes included atrial fibrillation (34%), anemia (12%), pneumothorax (7%), and postoperative bleeding (4%). No post-CABG cerebrovascular accident was identified. Patients were discharged 7.5 ± 3.5 days after CEA. Twenty-four hour staged CEA followed by CABG minimizes myocardial infarction post-CEA while minimizing cerebrovascular accident post-CABG in patients with concomitant severe coronary and carotid artery disease.
John P. Nabagiez; Kimberly C. Bowman; Masood A. Shariff; Juan A. Abreu; Anurag Singh; Wolf Von Waagner; Muhammad A. Khan; Kuldeep Singh; Joseph T. McGinn. Twenty-Four Hour Staged Carotid Endarterectomy Followed by Off-Pump Coronary Bypass Grafting for Patients With Concomitant Carotid and Coronary Disease. The Annals of Thoracic Surgery 2014, 98, 1613 -1618.
AMA StyleJohn P. Nabagiez, Kimberly C. Bowman, Masood A. Shariff, Juan A. Abreu, Anurag Singh, Wolf Von Waagner, Muhammad A. Khan, Kuldeep Singh, Joseph T. McGinn. Twenty-Four Hour Staged Carotid Endarterectomy Followed by Off-Pump Coronary Bypass Grafting for Patients With Concomitant Carotid and Coronary Disease. The Annals of Thoracic Surgery. 2014; 98 (5):1613-1618.
Chicago/Turabian StyleJohn P. Nabagiez; Kimberly C. Bowman; Masood A. Shariff; Juan A. Abreu; Anurag Singh; Wolf Von Waagner; Muhammad A. Khan; Kuldeep Singh; Joseph T. McGinn. 2014. "Twenty-Four Hour Staged Carotid Endarterectomy Followed by Off-Pump Coronary Bypass Grafting for Patients With Concomitant Carotid and Coronary Disease." The Annals of Thoracic Surgery 98, no. 5: 1613-1618.
Ischaemic heart disease is the leading cause of death in the elderly population. Coronary artery bypass graft (CABG) surgery via sternotomy remains the standard of care for patients with multivessel coronary artery disease (CAD). Minimally invasive cardiac surgery (MICS)-CABG via left thoracotomy has been used as an alternative to sternotomy. The aim of our study was to assess the overall survival after MICS-CABG and sternotomy-CABG in elderly patients with CAD. This observational study included patients who underwent coronary bypass from 2005 to 2008. Patients 75 years and older (n = 159) were included in the final analysis. Each arm was further divided into the MICS-CABG group or sternotomy-CABG group. Primary outcome and overall survival were obtained from our records and the social security death index. Among patients 75 years and older (159 patients), MICS-CABG had a significantly lower 5-year all-cause mortality than sternotomy-CABG (19.7 vs 47.7%, P < 0.001). Similarly, Kaplan–Meier curves showed significantly higher overall survival in the MICS-CABG group compared with sternotomy-CABG (log-rank P = 0.014). After adjusting for confounders, MICS-CABG demonstrated a lower mortality than sternotomy-CABG (HR 0.51, 95% confidence interval 0.26–0.97, P = 0.04). For patients less than 75 years old, MICS and sternotomy groups had similar survival according to both uni- and multivariate analyses. The adjusted models demonstrated that MICS-CABG has a significantly better long-term survival than sternotomy-CABG despite slightly differing baseline characteristics. Further studies are needed to compare the short- and long-term outcomes of the two approaches among the elderly population.
Emad A. Barsoum; Basem Azab; Neeraj Shah; Nileshkumar Patel; Masood A. Shariff; James Lafferty; John P. Nabagiez; Joseph T. McGinn. Long-term mortality in minimally invasive compared with sternotomy coronary artery bypass surgery in the geriatric population (75 years and older patients). European Journal of Cardio-Thoracic Surgery 2014, 47, 862 -867.
AMA StyleEmad A. Barsoum, Basem Azab, Neeraj Shah, Nileshkumar Patel, Masood A. Shariff, James Lafferty, John P. Nabagiez, Joseph T. McGinn. Long-term mortality in minimally invasive compared with sternotomy coronary artery bypass surgery in the geriatric population (75 years and older patients). European Journal of Cardio-Thoracic Surgery. 2014; 47 (5):862-867.
Chicago/Turabian StyleEmad A. Barsoum; Basem Azab; Neeraj Shah; Nileshkumar Patel; Masood A. Shariff; James Lafferty; John P. Nabagiez; Joseph T. McGinn. 2014. "Long-term mortality in minimally invasive compared with sternotomy coronary artery bypass surgery in the geriatric population (75 years and older patients)." European Journal of Cardio-Thoracic Surgery 47, no. 5: 862-867.
Basem Azab; Ariful Alam; Masood A. Shariff; Wolf K. Von Waagner; Antonio I. Picon; Scott W. Bloom. Tu1629 Negative Impact of Elevated Pre-Treatment Albumin/Globulin Ratio on Survival in Pancreatic Cancer Patients With Normal Serum Albumin. Gastroenterology 2014, 146, 1 -1092.
AMA StyleBasem Azab, Ariful Alam, Masood A. Shariff, Wolf K. Von Waagner, Antonio I. Picon, Scott W. Bloom. Tu1629 Negative Impact of Elevated Pre-Treatment Albumin/Globulin Ratio on Survival in Pancreatic Cancer Patients With Normal Serum Albumin. Gastroenterology. 2014; 146 (5):1-1092.
Chicago/Turabian StyleBasem Azab; Ariful Alam; Masood A. Shariff; Wolf K. Von Waagner; Antonio I. Picon; Scott W. Bloom. 2014. "Tu1629 Negative Impact of Elevated Pre-Treatment Albumin/Globulin Ratio on Survival in Pancreatic Cancer Patients With Normal Serum Albumin." Gastroenterology 146, no. 5: 1-1092.
Floating right heart thrombus, also known as "emboli in transit" is a potentially fatal condition, of varying etiology and usually coexisting with massive pulmonary embolism. Although the mortality rate is as high as 40%, there are no established therapeutic guidelines. A case is presented of an 84 year old female with a history of colon cancer and coronary artery disease who presented with sudden onset unresponsiveness. She was intubated in the ED and started on intravenous pressor support. A free floating large right ventricular thrombus and dilated right ventricle were noted on transthoracic echocardiogram (TTE). She was managed medically with good short term outcome. Floating right heart thrombus is a rare occurrence. Recognition of signs and symptoms along with early TTE is critical for diagnosis and consideration of treatment modality. The existing literature does not offer a clear consensus for management of pulmonary embolism with co-existing mobile intra-cardiac thrombus. Choice of treatment is crucial and should be considered on a case-by-case basis after careful assessment of indications, contraindications, risks and benefits.
Vratika Agarwal; Nikhil Nalluri; Masood A. Shariff; Muhammad S. Akhtar; Yefim Olkovsky; Paul E. Kitsis; John P. Nabagiez. Large embolus in transit – An unresolved therapeutic dilemma (case report and review of literature). Heart & Lung 2014, 43, 152 -154.
AMA StyleVratika Agarwal, Nikhil Nalluri, Masood A. Shariff, Muhammad S. Akhtar, Yefim Olkovsky, Paul E. Kitsis, John P. Nabagiez. Large embolus in transit – An unresolved therapeutic dilemma (case report and review of literature). Heart & Lung. 2014; 43 (2):152-154.
Chicago/Turabian StyleVratika Agarwal; Nikhil Nalluri; Masood A. Shariff; Muhammad S. Akhtar; Yefim Olkovsky; Paul E. Kitsis; John P. Nabagiez. 2014. "Large embolus in transit – An unresolved therapeutic dilemma (case report and review of literature)." Heart & Lung 43, no. 2: 152-154.
ObjectiveMinimally invasive coronary artery bypass grafting is safe and widely applicable, and may be associated with fewer transfusions and infections, and better recovery than standard coronary artery bypass grafting. However, graft patency rates remain unknown. The Minimally Invasive Coronary Artery Bypass Grafting Patency Study prospectively evaluated angiographic graft patency 6 months after minimally invasive coronary artery bypass grafting.MethodsIn this dual-center study, 91 patients were prospectively enrolled to undergo minimally invasive coronary artery bypass grafting via a 4- to 7-cm left thoracotomy approach. The left internal thoracic artery, the ascending aorta for proximal anastomoses, and all coronary targets were directly accessed without endoscopic or robotic assistance. The study primary outcome was graft patency at 6 months, using 64-slice computed tomography angiography. Secondary outcomes included conversions to sternotomy and major adverse cardiovascular events (Clinical Trial Registration Unique identifier: NCT01334866).ResultsThe mean age of patients was 64 ± 8 years, the mean ejection fraction was 51% ± 11%, and there were 10 female patients (11%) in the study. Surgeries were performed entirely off-pump in 68 patients (76%). Complete revascularization was achieved in all patients, and the median number of grafts was 3. There was no perioperative mortality, no conversion to sternotomy, and 2 reopenings for bleeding. Transfusion occurred in 24 patients (26%). The median length of hospital stay was 4 days, and all patients were followed to 6 months, with no mortality or major adverse cardiovascular events. Six-month computed tomography angiographic graft patency was 92% for all grafts and 100% for left internal thoracic artery grafts.ConclusionsMinimally invasive coronary artery bypass grafting is safe, feasible, and associated with excellent outcomes and graft patency at 6 months post-surgery
Marc Ruel; Masood Shariff; Harry Lapierre; Nikhil Goyal; Carole Dennie; Scott M. Sadel; Benjamin Sohmer; Joseph T. McGinn. Results of the minimally invasive coronary artery bypass grafting angiographic patency study. The Journal of Thoracic and Cardiovascular Surgery 2014, 147, 203 -209.
AMA StyleMarc Ruel, Masood Shariff, Harry Lapierre, Nikhil Goyal, Carole Dennie, Scott M. Sadel, Benjamin Sohmer, Joseph T. McGinn. Results of the minimally invasive coronary artery bypass grafting angiographic patency study. The Journal of Thoracic and Cardiovascular Surgery. 2014; 147 (1):203-209.
Chicago/Turabian StyleMarc Ruel; Masood Shariff; Harry Lapierre; Nikhil Goyal; Carole Dennie; Scott M. Sadel; Benjamin Sohmer; Joseph T. McGinn. 2014. "Results of the minimally invasive coronary artery bypass grafting angiographic patency study." The Journal of Thoracic and Cardiovascular Surgery 147, no. 1: 203-209.
Neutrophil lymphocyte ratio (NLR) is a predictor of major adverse cardiovascular outcomes. Our study explores the value of NLR in predicting long-term mortality after minimally invasive coronary artery bypass surgery (MICS) via lateral left-thoracotomy versus conventional sternotomy coronary artery bypass grafting (CABG) surgery. A total of 1126 consecutive patients (729 sternotomy CABG and 397 MICS) from a single tertiary center between 2005 and 2008 were followed until 2011. We stratified the patients into equal tertiles according to preoperative NLR. The primary outcome, all-cause mortality, was compared among the NLR tertiles. Out of the 1126 patients included in the study, 1030 (91%) patients underwent off-pump CABG . The first (NLR <2.3) tertile had a significantly lower 5-year mortality (30/371 =8%) in comparison to the second (NLR =2.3-3.4) and third (NLR ≥3.5) tertiles (49/375 =13% and 75/380 =20%), respectively with p < 0.0001. After multivariate adjustment, NLR was a significant independent predictor of mortality (hazard ratio [HR] per each unit increase of NLR was 1.05, 95% confidence interval [CI] 1.01-1.10, p = 0.008). MICS and sternotomy CABG groups with NLR <3 had similar mortality (21/221 =9.5% and 40/403 =9.9%), p = 1. However among patients with NLR ≥3, MICS had a significantly lower mortality (23/176 =13.1%) compared to the sternotomy CABG (70/326 =21.5%), p = 0.02. According to the multivariate analysis of patients with NLR ≥3, MICS had a significantly lower mortality compared to sternotomy CABG (HR = 0.44, 95% CI 0.24-0.78, p = 0.005). Elevated preoperative NLR is an independent predictor of long-term mortality after CABG. Among the patients with NLR ≥ 3, MICS was associated with a significantly improved survival compared with sternotomy CABG.
Basem Azab; Masood A Shariff; Rana Bachir; John P Nabagiez; Joseph T McGinn. Elevated preoperative neutrophil/lymphocyte ratio as a predictor of increased long-term survival in minimal invasive coronary artery bypass surgery compared to sternotomy. Journal of Cardiothoracic Surgery 2013, 8, 193 -193.
AMA StyleBasem Azab, Masood A Shariff, Rana Bachir, John P Nabagiez, Joseph T McGinn. Elevated preoperative neutrophil/lymphocyte ratio as a predictor of increased long-term survival in minimal invasive coronary artery bypass surgery compared to sternotomy. Journal of Cardiothoracic Surgery. 2013; 8 (1):193-193.
Chicago/Turabian StyleBasem Azab; Masood A Shariff; Rana Bachir; John P Nabagiez; Joseph T McGinn. 2013. "Elevated preoperative neutrophil/lymphocyte ratio as a predictor of increased long-term survival in minimal invasive coronary artery bypass surgery compared to sternotomy." Journal of Cardiothoracic Surgery 8, no. 1: 193-193.