A typhoon is a restrictive factor in the development of floating wind power in China. However, the influences of multistage typhoon wind and waves on offshore wind turbines have not yet been studied. Based on Typhoon Mangkhut, in this study, the characteristics of the motion response and structural loads of an offshore wind turbine are investigated during the travel process. For this purpose, a framework is established and verified for investigating the typhoon-induced effects of offshore wind turbines, including a multistage typhoon wave field and a coupled dynamic model of offshore wind turbines. On this basis, the motion response and structural loads of different stages are calculated and analyzed systematically. The results show that the maximum response does not exactly correspond to the maximum wave or wind stage. Considering only the maximum wave height or wind speed may underestimate the motion response during the traveling process of the typhoon, which has problems in guiding the anti-typhoon design of offshore wind turbines. In addition, the coupling motion between the floating foundation and turbine should be considered in the safety evaluation of the floating offshore wind turbine under typhoon conditions.