The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring\ud compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1. Due\ud to its prebiotic nature to living cells in biodiversity, it is an highly privileged motif for the\ud development of molecules of biological and pharmaceutical interest. This present work deals with\ud the exploration of chemistry and medicinal diversity of pyrimidine which might pave way to long\ud await discovery in therapeutic medicine for future drug design

In the quest for environmental remediation which involves eco-friendly synthetic routes, we herein report synthesis and modeling of silver nanoparticles (Ag NPs) and silver/nickel allied bimetallic nanoparticles (Ag/Ni NPs) using plant-extract reduction method. Secondary metabolites in the leaf extract of Canna indica acted as reducing agent. Electronic transitions resulted in emergence of surface plasmon resonance in the regions of 416 nm (Ag NPs) and 421 nm (Ag/Ni NPs) during optical measurements. Further characterizations were done using TEM and EDX. Antimicrobial activity of the nanoparticles against clinical isolates was highly significant as P<0.05. These findings suggest application of Ag NPs as antibacterial agent against E. coli, S. pyogenes, and antifungal agent against C. albicans. Possible antibacterial drugs against S. pyogenes and E. coli can also be designed using Ag/Ni nanohybrid based on their strong inhibition activities. Similarly, the enhanced SPR in the nanoparticles is suggested for applications in optical materials, as good absorbers and scatters of visible light. Theoretical model clarified that the experiment observation on the relationship between metallic nanoparticles penetration through peptidoglycan layers and the activeness of microbial species depends on the nature of the nanoparticles and pore size of the layer.

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.

We report the plant-mediated synthesis, structural investigation, optical properties and theoretical modelling of a triclinic (anorthic) phase AgCoPO4 nanoparticles for the first time. As part of green chemistry, the secondary metabolites in the leaf extract of Canna indica were engaged as the reducing/capping agent for the metal nanoparticles. X-ray diffraction (XRD) revealed the presence of an anorthic AgCoPO4 phase, crystallised in a triclinic structure with P -1 space group. Optical studies using UV-vis spectroscopy and photoluminescence are reported. Transmission electron microscopy suggests the formation of quasi-nanocube morphology, unlike the conventional spherically-shaped nanoparticles via plant-mediated reduction method. Elemental composition of the nanohybrid was confirmed by energy-dispersive x-ray spectroscopy (E.D.S.). Evidence of crystallinity was supported by selected area electron diffraction (SAED). Study of the dynamic anisotropy of the nanohybrid at optimised state suggests its proposed application as optical material in colourimetric metal nanoparticles-mediated sensors.