José C J M D S Menezes

Dr. José C J M D S Menezes

Esteem Industries Pvt Ltd.
orcid

Research Focus & Metrics

Academic Career Length

18Years (2009-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 February 2011 in European Journal of Medicinal Chemistry
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Journal Article
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JMJosé C J M D S Menezes
José C J M D S Menezes
SKShrivallabh P. Kamat
Shrivallabh P. Kamat
JCJosé Cavaleiro
José Cavaleiro
Alexandra GasparAlexandra Gaspar
Alexandra Gaspar
JGJorge Garrido
Jorge Garrido
Fernanda BorgesFernanda Borges
Fernanda Borges

13 October 2015 in Critical Reviews in Food Science and Nutrition
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Journal Article
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JMJosé C J M D S Menezes
José C J M D S Menezes
BOBarbora Orlikova
Barbora Orlikova
FMFranck Morceau
Franck Morceau
MDMarc Diederich
Marc Diederich
Flavonoids and their derivatives are polyphenolic secondary metabolites with an extensive spectrum of pharmacological activities, including antioxidants, antitumor, anti-inflammatory, and antiviral activities. These flavonoids can also act as chemopreventive agents by their interaction with different proteins and can play a vital role in chemotherapy, suggesting a positive correlation between a lower risk of cancer and a flavonoid-rich diet. These agents interfere with the main hallmarks of cancer by various individual mechanisms, such as inhibition of cell growth and proliferation by arresting the cell cycle, induction of apoptosis and differentiation, or a combination of these mechanisms. This review is an effort to highlight the therapeutic potential of natural and synthetic flavonoids as anticancer agents in leukemia treatment with respect to the structure–activity relationship (SAR) and their molecular mechanisms. Induction of cell death mechanisms, production of reactive oxygen species, and drug resistance mechanisms, including p-glycoprotein efflux, are among the best-described effects triggered by the flavonoid polyphenol family.

31 January 2017 in RSC Advances
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Journal Article
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JMJosé C J M D S Menezes
José C J M D S Menezes
Arylidene indanone (AI) scaffolds are considered as the rigid cousins of chalcones, incorporating the α,β-unsaturated ketone system of chalcones forming a cyclic 5 membered ring. They are generally synthesized from 1-indanone and benzaldehydes via an aldol reaction. The furnished molecules have been explored as inhibitors of cholinesterases towards the treatment of Alzheimer’s disease, as tubulin depolymerizing agents, as inhibitors of breast cancer and leukemia, inhibitors of dual specificity phosphatase (DUSP), as antimalarials, and for many other uses. This review is an effort to highlight the biochemical effects of arylidene indanones designed from natural or known drug compounds, discuss their structure–activity relationships (SAR), and correlate them with related chalcones providing insights for further development of this scaffold.

29 May 2019 in Future Medicinal Chemistry
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Journal Article
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JMJosé C J M D S Menezes
José C J M D S Menezes
MDMarc Diederich
Marc Diederich
Natural coumarins and their derivatives isolated from various plants or microorganisms have inherent antioxidant, antibacterial, antifungal, antiviral and anticancer properties among many biologica...

1 November 2019 in European Journal of Medicinal Chemistry
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Journal Article
Closed access
JMJosé C J M D S Menezes
José C J M D S Menezes
MDMarc Diederich
Marc Diederich

1 May 2021 in Science of The Total Environment
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Journal Article
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JMJosé C J M D S Menezes
José C J M D S Menezes
VCVinícius R. Campos
Vinícius R. Campos