Objective: The purpose of this paper is to establish fabrication method of cyclic olefin copolymer(COC)-based neural electrode utilizing standard polymer fabrication and semiconductor fabrication technique. Methods: The fabrication started with preparing COC pellets into COC films by compression molding. Metal layers were deposited on the COC film and attached to a silicon wafer. Laser ablation was used to cut the outer edges and mark alignment keys. The metal layers were patterned using standard photolithography procedures. Finally, the isolated electrodes were laminated. To ensure that the resulting electrode is safe and suitable for long-term implants, in vitro biocompatibility test, impedance evaluation, accelerated soak test, and repeated bend test were conducted. Results: Cytotoxicity test and elution test confirmed the biocompatibility. The basic performance was not hindered compared to other polymer-based electrodes, and the longevity of the electrode was validated by accelerated soak test. However, repeated bend test revealed that the material might not be suitable for applications where constant bending is required. Conclusion: The COC-based neural electrode was successfully fabricated. The material showed many merits such as biocompatibility, thermoplasticity, low water absorption rate, and high transparency, but should be limited to applications where repeated bending is not required. Significance: Electrical circuits in implantable prosthetic devices must be hermetically encapsulated for a long period of time. Material such as COC with extremely low water absorption rate could have a significant impact on the longevity of these devices.

This paper describes a 5.8 Gb/s adaptive integrating duobinary decision-feedback equalizer (DFE) for use in next-generation multi-drop memory interface. The proposed receiver combines traditional interface techniques like the integrated signaling and the duobinary signaling, in which the duobinary signal is generated by current integration in the receiver. It can address issues such as input data dependence during integration, need for precursor equalization, high equalizer gain boosting, and sensitivity to high-frequency noise. The proposed receiver also alleviates DFE critical timing to provide gain in speed, and embed DFE taps in duobinary decoding to provide gain in power and area. The adaptation for adjusting the equalizer common-mode level, duobinary zero level, tap coefficient values, and timing recovery is incorporated. The proposed DFE receiver was fabricated in a 45 nm CMOS process, whose measurement results indicated that it worked at 5.8 Gb/s speed in a four-drop channel configuration with seven slave ICs, and the bathtub curve shows 36% open for 10 ^-10 bit error rate.

A number of research attempts to understand and modulate sensory and motor skills that are beyond the capability of humans have been underway. They have mainly been expounded in rodent models, where numerous reports of controlling movement to reach target locations by brain stimulation have been achieved. However, in the case of birds, although basic research on movement control has been conducted, the brain nuclei that are triggering these movements have yet to be established. In order to fully control flight navigation in birds, the basic central nervous system involved in flight behavior should be understood comprehensively, and functional maps of the birds’ brains to study the possibility of flight control need to be clarified. Here, we established a stable stereotactic surgery to implant multi-wire electrode arrays and electrically stimulated several nuclei of the pigeon’s brain. A multi-channel electrode array and a wireless stimulation system were implanted in thirteen pigeons. The pigeons’ flight trajectories on electrical stimulation of the cerebral nuclei were monitored and analyzed by a 3D motion tracking program to evaluate the behavioral change, and the exact stimulation site in the brain was confirmed by the postmortem histological examination. Among them, five pigeons were able to induce right and left body turns by stimulating the nuclei of the tractus occipito-mesencephalicus (OM), nucleus taeniae (TN), or nucleus rotundus (RT); the nuclei of tractus septo-mesencephalicus (TSM) or archistriatum ventrale (AV) were stimulated to induce flight aviation for flapping and take-off with five pigeons.

Retinal prosthesis is one of the key strategies for tackling retinitis pigmentosa – a group of genetic disorders that can cause blindness. However, further advancement of retinal implant is hindered by some technical limitations. Current state-of-the-art retinal implants failed within two-three years after implant and showed a significant decrement in their visual acuity. The purpose of this investigation is to search for a material that is better suited for the packaging of retinal implants. Specifically, the study was conducted under the assumption that image acquisition is done internally, i.e. without the use of an external camera. Polydimethylsiloxane (PDMS) and polyimide (PI) are some of the most commonly used materials in implantable devices. In addition, colorless transparent polyimide (CPI) was studied to overcome the optical limitations of PI. Finally, liquid crystal polymer (LCP) and cyclic olefin copolymer (COC) were added in the comparison due to their promising results regarding their expected longevity. In this experiment, PDMS, CPI, and COC outperformed the other materials in optical transparency. Considering the excellent encapsulation properties due to thermoplasticity while being able to be fabricated into a micro-lens array, we believe COC is worth further in-depth investigation for further advancement in the field of a retinal prosthesis.

Micro-lens array is a great example of bio-mimetic technology which was inspired by compound eyes found in insects and is used in lasers, optical communication, and 3D imaging. In this study, a micro-lens array was fabricated from cyclic olefin copolymer using a cost-effective method: compression molding and thermal reflow. Also, a light screen was installed between lenses to reduce the optical interference for clearer individual images. Cyclic olefin copolymer-based micro-lens array showed good optical results under a standard optical microscope. By placing the fabricated micro-lens array directly on an image sensor, it was observed that the light screen shows significant improvement in image quality. Also, the point spread function was analyzed to confirm the optical performance and the effectiveness of the micro-lens array with the light screen installed.

Purpose: We aimed to evaluate the effect of self-training using a virtual reality head-mounted display simulator on the acquisition of surgical skills for holmium laser enucleation surgery.Methods: Thirteen medical students without surgical skills for holmium laser enucleation of the prostate were trained using multimedia to learn the technique via simulator manipulation. Thereafter, participants performed the technique on a virtual benign prostatic hyperplasia model A (test A). After a 1-week wash-out period, they underwent self-training using a simulator and performed the technique on model B (test B). Subsequently, participants were asked to respond to Training Satisfaction Questions. Video footage of hand movements and endoscope view were recorded during tests A and B for later review by 2 expert surgeons. A 20-step Assessment Checklist, 6-domain Global Rating Scale, and a Pass Rating were used to compare performance on tests A and B.Results: Thirteen participants completed both tests A and B. The 20-step Assessment Checklist and 6-domain Global Rating Scale evaluation results showed significantly improved scores in test B than in test A (P<0.05). No evaluator rated participants as passed after test A, but 11 participants (84.6%) passed after test B. Ten participants (76.9%) indicated that the simulator was helpful in acquiring surgical skills for holmium laser enucleation of the prostate.Conclusions: The virtual reality head-mounted display holmium laser enucleation of the prostate simulator was effective for surgical skill training. This simulator may help to shorten the learning curve of this technique in real clinical practice in the future.