In the face of global climate change and rapid urbanization, the Pearl River Delta is confronted with frequent river floods and heavy rainfall, which leads to substantial economic losses and casualties. Enhancing the role of blue-green space in rain-flood resilience is crucial for mitigating such damages in this new era. Firstly, based on an analysis of the current status quo of blue-green space in the Pearl River Delta and the identification of potential areas at risk from rain and floods, this paper elucidates that resilient blue-green space in the Pearl River Delta should be guided by a systematic, bottom-line, and forward-looking orientation while considering spatial characteristics such as multi-scale network connectivity, redundancy and diversity/multi-functionality. Secondly, an optimization route is proposed based on steps of analysis of existing blue-green space, identification of inundated areas prone to rain and flood damage and optimization of blue-green spaces. Strategies for optimizing blue-green space are put forth including enhancing water corridor connectivity, optimizing ecological barriers and corridors, as well as constructing water gates to control hydrological flow direction. Simulation results demonstrate that under similar rain-flood disaster conditions, optimized blue-green space exhibits smaller sizes and lower depths of potential inundated areas compared to the original ones.